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Displaying 20 of 73 results for "IL5RA"
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  1. Crystal structure of human Interleukin-5 in complex with its alpha receptor PDB

    ID: PDB:3VA2

    Description: Interleukin-5, Interleukin-5 receptor subunit

  2. Structure of a cytokine ligand-receptor complex PDB

    ID: PDB:3QT2

    Description: Interleukin-5 receptor subunit alpha

  3. Peripheral blood RNA gene expression profiling in patients with bacterial meningitis ArrayExpress

    ID: E-GEOD-40586

    Description: L1R2, IL18R1, IL18RAP, OLFM4, TLR5, CPA3, FCER1A, IL5RA, IL7R) and performed quantitative real-time (qRT) PCR.We identified the significant differences at p values of <0.05 in 8569 genes and after False Discovery Rate (FDR) correction, total of 5500 genes remained significant at p value of <0.01. Quantitative RT-PCR confirmed differential expression for selected genes. Functional annotation and network analysis indicated that most of the genes were related to activation of humoral and cellular immune responses (enrichment score 43). Those changes were found in adults and in children with BM compared to the healthy controls. Gene expression profile didn’t depend on the clinical outcome, but there was very strong influence by the type of the pathogen. This study demonstrates a strong functional genomic evidence of the over-active immune response during bacterial meningitis. This hyperactive response possibly explains the complicated clinical course of this disease. 22 bacterial meningitis patients and 18 healthy controls...

  4. HGU133A expression array data for diffuse large B cell lymphoma samples ArrayExpress

    ID: E-GEOD-57611

    Description: essor genes emerging from the analysis, CASP3 and IL5RA, were sequenced in 10 and 16 candidate cases, respectively. However, no mutations were found, pointing to a potential haploinsufficiency effect of these genes, considering their reduced expression in cases with deletions. This work thus describes differences and similarities in the landscape of genomic aberrations in the DLBCL subgroups in a large collection of cases, confirming already known targets, but also discovering novel copy number changes with possible pathogenetic relevance. Affymetrix HGU133A arrays were performed according to the manufacturer's directions on RNA extracted from cryopreserved lymph node biopsies of tumor samples....

  5. Affymetrix SNP array data for diffuse large B cell lymphoma samples ArrayExpress

    ID: E-GEOD-57277

    Description: essor genes emerging from the analysis, CASP3 and IL5RA, were sequenced in 10 and 16 candidate cases, respectively. However, no mutations were found, pointing to a potential haploinsufficiency effect of these genes, considering their reduced expression in cases with deletions. This work thus describes differences and similarities in the landscape of genomic aberrations in the DLBCL subgroups in a large collection of cases, confirming already known targets, but also discovering novel copy number changes with possible pathogenetic relevance. Affymetrix SNP arrays were performed according to the manufacturer's directions on DNA extracted from cryopreserved lymph node biopsies of tumor samples....

  6. CRYSTAL STRUCTURE OF THE COMPLEX OF PDZ2 OF SYNTENIN WITH AN INTERLEUKIN 5 RECEPTOR ALPHA PEPTIDE. PDB

    ID: PDB:1OBX

    Description: SYNTENIN 1, INTERLEUKIN 5 RECEPTOR ALPHA

  7. IL5RA_MOUSE UniProt:Swiss-Prot

    ID: P21183

    Description: Interleukin-5 receptor subunit alpha Extracellular Helical Cytoplasmic Fib...

  8. cytokine receptor complex PDB

    ID: PDB:2B5I

    Description: Interleukin-2, Interleukin-2 receptor beta chain, Cytokine receptor common...

  9. Homo sapiens : Interleukin 10 receptor alpha chain (IL-10RA) Raw sequence reads BioProject

    ID: PRJNA315881

    Keywords: raw sequence reads

    Access Type: download

  10. CRYSTAL STRUCTURE OF THE COMPLEX OF THE PDZ TANDEM OF SYNTENIN WITH AN INTERLEUKIN 5 RECEPTOR ALPHA PEPTIDE. PDB

    ID: PDB:1OBZ

    Description: SYNTENIN 1, INTERLEUKIN 5 RECEPTOR ALPHA

  11. Crystal structure of the hexameric human IL-6/IL-6 alpha receptor/gp130 complex PDB

    ID: PDB:1P9M

    Description: Interleukin-6 receptor beta chain, Interleukin-6, Interleukin-6 <

  12. CRYSTAL STRUCTURE OF HUMAN CYTOMEGALOVIRUS IL-10 BOUND TO SOLUBLE HUMAN IL-10R1 PDB

    ID: PDB:1LQS

    Description: INTERLEUKIN-10 RECEPTOR ALPHA CHAIN, INTERLEUKIN-10-LIKE PROTEIN

  13. Peripheral blood RNA gene expression profiling in patients with bacterial meningitis BioProject

    ID: PRJNA174349

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: L1R2, IL18R1, IL18RAP, OLFM4, TLR5, CPA3, FCER1A, IL5RA, IL7R) and performed quantitative real-time (qRT) PCR.We identified the significant differences at p values of <0.05 in 8569 genes and after False Discovery Rate (FDR) correction, total of 5500 genes remained significant at p value of <0.01. Quantitative RT-PCR confirmed differential expression for selected genes. Functional annotation and network analysis indicated that most of the genes were related to activation of humoral and cellular immune responses (enrichment score 43). Those changes were found in adults and in children with BM compared to the healthy controls. Gene expression profile didn’t depend on the clinical outcome, but there was very strong influence by the type of the pathogen. This study demonstrates a strong functional genomic evidence of the over-active immune response during bacterial meningitis. This hyperactive response possibly explains the complicated clinical course of this disease. Overall design: 22 bacterial meningitis patients and 18 healthy controls...
  14. IL-6R identifies early differentiated human effector memory CD8+ T cells that potently expand and produce IL-2 and IL-13 BioProject

    ID: PRJNA151037

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: ) CD8+ T cells that expressed high levels of IL-6 receptor in human peripheral blood. These cells which also expressed high levels of IL-7Ra (referred to as IL-6R high IL-7Rahigh cells) had the a distinct gene expression profil...
  15. Affymetrix SNP array data for diffuse large B cell lymphoma samples BioProject

    ID: PRJNA246168

    Keywords: Variation

    Access Type: download

    dataset.description: essor genes emerging from the analysis, CASP3 and IL5RA, were sequenced in 10 and 16 candidate cases, respectively. However, no mutations were found, pointing to a potential haploinsufficiency effect of these genes, considering their reduced expression in cases with deletions. This work thus describes differences and similarities in the landscape of genomic aberrations in the DLBCL subgroups in a large collection of cases, confirming already known targets, but also discovering novel copy number changes with possible pathogenetic relevance. Overall design: Affymetrix SNP arrays were performed according to the manufacturer's directions on DNA extracted from cryopreserved lymph node biopsies of tumor samples....
  16. HGU133A expression array data for diffuse large B cell lymphoma samples BioProject

    ID: PRJNA246864

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: essor genes emerging from the analysis, CASP3 and IL5RA, were sequenced in 10 and 16 candidate cases, respectively. However, no mutations were found, pointing to a potential haploinsufficiency effect of these genes, considering their reduced expression in cases with deletions. This work thus describes differences and similarities in the landscape of genomic aberrations in the DLBCL subgroups in a large collection of cases, confirming already known targets, but also discovering novel copy number changes with possible pathogenetic relevance. Overall design: Affymetrix HGU133A arrays were performed according to the manufacturer's directions on RNA extracted from cryopreserved lymph node biopsies of tumor samples....
  17. Interleukin-6 is a Potential Therapeutic Target in Interleukin-6 Dependent Estrogen Receptor-alpha Positive Breast Cancer [cell lines] BioProject

    ID: PRJNA236224

    Keywords: Transcriptome or Gene expression

    Access Type: download

  18. IL-6R identifies early differentiated human effector memory CD8+ T cells that potently expand and produce IL-2 and IL-13 ArrayExpress

    ID: E-GEOD-34562

    Description: ) CD8+ T cells that expressed high levels of IL-6 receptor in human peripheral blood. These cells which also expressed high levels of IL-7Ra (referred to as IL-6R high IL-7Rahigh cells) had the a distinct gene expression profil...

  19. CRYSTAL STRUCTURE OF THE COMPLETE EXTRACELLULAR DOMAIN OF THE BETA-COMMON RECEPTOR OF IL-3, IL-5, AND GM-CSF PDB

    ID: PDB:1GH7

    Description: CYTOKINE RECEPTOR COMMON BETA CHAIN

  20. 2.7 A structure of the extracellular domains of the human beta common receptor involved in IL-3, IL-5, and GM-CSF signalling PDB

    ID: PDB:2GYS

    Description: Cytokine receptor common beta chain


Displaying 20 of 73 results for "IL5RA"