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Displaying 20 of 581 results for "IL4R"
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  1. Crystal structure of the IL4-IL4R-IL13Ra ternary complex PDB

    ID: PDB:3BPN

    Description: Interleukin-4, Interleukin-4 receptor alpha chain (IL-4...

  2. Crystal structure of the IL4-IL4R-Common Gamma ternary complex PDB

    ID: PDB:3BPL

    Description: Interleukin-4 precursor, Interleukin-4 receptor alpha c...

  3. Crystal structure of the IL13-IL4R-IL13Ra ternary complex PDB

    ID: PDB:3BPO

    Description: Interleukin 13, Interleukin-4 receptor alpha chain, Interleukin

  4. Genome-wide expression profiling of B Lymphocytes reveals IL4R increase in allergic asthma BioProject

    ID: PRJNA229960

    Keywords: Transcriptome or Gene expression

    Access Type: download

  5. Genome-wide expression profiling of B Lymphocytes reveals IL4R increase in allergic asthma ArrayExpress

    ID: E-GEOD-52742

    Description: In this study we present the first genome-wide expression profiling of peripheral B cells by massive parallel RNA sequencing in patients with allergic...

  6. IL-13 Overexpression in IL4Ra^Flox Alb^Cre mice BioProject

    ID: PRJNA289397

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: ession. Overall design: 14 samples were analyzed. 4 Wildtype eGFP samples, 4 Alb-Cre eGFP samples, 3 IL-13 WT samples, and 3 Alb-Cre IL-13 samples....
  7. IL4RA_PIG UniProt:Swiss-Prot

    ID: Q863Z5

    Description: Interleukin-4 receptor subunit alpha Extracellular Helical Cytoplasmic Fibronectin type-III R...

  8. Smooth muscle IL-4 receptor activation induces airway hyper-responsiveness ArrayExpress

    ID: E-GEOD-26476

    Description: Selective stimulation of IL-4 receptor on smooth muscle induces airway hyper-responsiveness in mice. Abstract: Production of the cytokines ...

  9. Engineered Interleukin-13 bound to receptor PDB

    ID: PDB:5E4E

    Description: Interleukin-13, Interleukin-4 receptor subunit alpha, In

  10. Cytokine receptor modulation by interleukin-2 broadly regulates T helper cell lineage differentiation ArrayExpress

    ID: E-GEOD-27158

    Description: ferentiation to allow responsiveness to IL-12, IL-4, and IL-6, respectively. IL-2 via STAT5 controls Th2 differentiation by regulating the Th2 cytokine gene cluster and Il4ra expression. Here we show that IL-2 regulates Th1 differentiation, inducing STAT5-dependent IL-12Rβ2 and T-bet expression, with impaired human Th1 ...

  11. Priming for Th2 differentiation requires IL-2-mediated induction of IL-4 receptor alpha chain expression ArrayExpress

    ID: E-GEOD-12346

    Description: mmunity and host-defense to parasites. Whereas IL-4 drives Th2 differentiation and IL-2 is important later in this process by augmenting IL4 chromatin accessibility, we demonstrate that IL-2 serves an essent...

  12. Smooth muscle IL-4 receptor activation induces airway hyper-responsiveness BioProject

    ID: PRJNA136527

    Keywords: Transcriptome or Gene expression

    Access Type: download

  13. Cytokine receptor modulation by interleukin-2 broadly regulates T helper cell lineage differentiation BioProject

    ID: PRJNA137397

    Keywords: Epigenomics

    Access Type: download

  14. Identification of IL4 dependent genes involved in reinforcement stage of Th2 differentiation BioProject

    ID: PRJNA115451

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: ese, we have two groups, one where we add IL4 and IL4R neutralizing antibodies either on days 3 and 4 (For five day culture) [D5ABS_1 and D5ABS_2] or on days 3,4 and 5 (For six day culture) [D6ABS_1 and D6ABS_2] and next where we don't add neutralizing antibodies [D5_1 & D5_2 and D6_1 & D6_2]....
  15. IL13 and CCL2 drive disease in an inflammatory subset of Scleroderma [IL4] ArrayExpress

    ID: E-GEOD-24409

    Description: Scleroderma is a lethal and currently irreversible autoimmune disease characterized by widespread tissue fibrosis and vasculopathy. Using cross-specie...

  16. Priming for Th2 differentiation requires IL-2-mediated induction of IL-4 receptor alpha chain expression BioProject

    ID: PRJNA113171

    Keywords: Epigenomics

    Access Type: download

  17. Genetic deletion of P2X7 receptors causes genome-wide alteration of gene expression and results in antidepressant phenotype in mice amygdale ArrayExpress

    ID: E-GEOD-21218

    Description: significantly affected by the deficiency of P2X7 receptor. Validation experiments revealed that among these genes at least 30 genes could be associated to synaptic signaling, neuroplasticity and thereby to the pathogenesis of depression (e.g. beta and gamma subunits of GABAA receptor, ionotropic glutamate receptors, α2 adrenergic receptor, which were down regulated in KO mice). 287 transcripts were found be more than two-fold over-expressed in the LPS treated groups which can be classified according to their inflammatory biological function: Il4ra, Saa1, chemokine ligands. Intraperitoneal injection of LPS induced...

  18. IL13 and CCL2 drive disease in an inflammatory subset of Scleroderma [IL13] ArrayExpress

    ID: E-GEOD-24403

    Description: Scleroderma is a lethal and currently irreversible autoimmune disease characterized by widespread tissue fibrosis and vasculopathy. Using cross-specie...

  19. Immunoproteasome dysfunction augments alternative polarization of alveolar macrophages ArrayExpress

    ID: E-GEOD-72000

    Description: subunits LMP2, LMP7, and MECL-1. In contrast, IL-4 triggered alternative (M2) activation was accompanied by posttranscriptional upregulation of LMP2 and LMP7. Accordingly, immunoproteasome activity increased in M1 cells, and to some extent under M2 conditions. Analyzing the polarization capability from LMP7 deficient mice revealed no effect on the LPS/IFNγ triggered M1 profile, but uncovered a distorted M2 profile for IL-4 stimulated LMP7-/- alveolar macrophages as characterized by increased M2 marker gene expression and CCL17 cytokine release. This shift in immunoproteasome-dependent M2 polarization was accompanied by amplified AKT/STAT6 activation and IRF4 expression in LMP7-/- alveolar macrophages. IL-13 stimulation of LMP7 deficient ce...

  20. INTERLEUKIN-4 / RECEPTOR ALPHA CHAIN COMPLEX PDB

    ID: PDB:1IAR

    Description: INTERLEUKIN-4, INTERLEUKIN-4 RECEPTOR ALPHA CHAIN


Displaying 20 of 581 results for "IL4R"