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Displaying 20 of 36 results for "IL20RA"
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  1. IL20/IL201/IL20R2 Ternary Complex PDB

    ID: PDB:4DOH

    Description: Interleukin-20, Interleukin-20 receptor subunit beta, <...

  2. a from: Establishment of elevated serum levels of IL-10, IL-8 and TNF-beta as potential peripheral blood biomarkers in tubercular lymphadenitis: a prospective observ... Dryad

    DateIssued: 01-20-2016

    Description: a-pulmonary tuberculosis (TB) consisting about 15-20% of all TB cases. The currently available diagnostic modalities for (TL), are invasive and involve a high index of suspicion, having limited accuracy. We hypothesized that TL would have a distinct cyto...

  3. Additional file 5: of Capture Hi-C identifies a novel causal gene, IL20RA, in the pan-autoimmune genetic susceptibility region 6q23 Figshare

    ID: doi:10.6084/M9.FIGSHARE.C.3619565_D4

    Release Date: 12-15-2016

    Description: Contains the normalised expression values for CD8+ T-cells obtained from NRHV participants. (TXT 26 kb)

  4. Additional file 6: of Capture Hi-C identifies a novel causal gene, IL20RA, in the pan-autoimmune genetic susceptibility region 6q23 Figshare

    ID: doi:10.6084/M9.FIGSHARE.C.3619565_D6

    Release Date: 12-15-2016

    Description: Contains the cis-eQTLs with P valueâ

  5. Additional file 8: of Capture Hi-C identifies a novel causal gene, IL20RA, in the pan-autoimmune genetic susceptibility region 6q23 Figshare

    ID: doi:10.6084/M9.FIGSHARE.C.3619565_D1

    Release Date: 12-15-2016

    Description: Contains the cis-eQTLs with P valueâ

  6. Additional file 9: of Capture Hi-C identifies a novel causal gene, IL20RA, in the pan-autoimmune genetic susceptibility region 6q23 Figshare

    ID: doi:10.6084/M9.FIGSHARE.C.3619565_D7

    Release Date: 12-15-2016

    Description: Contains the normalised expression values for T-cells obtained from early undifferentiated arthritis patients. (TXT 125 kb)

  7. Additional file 7: of Capture Hi-C identifies a novel causal gene, IL20RA, in the pan-autoimmune genetic susceptibility region 6q23 Figshare

    ID: doi:10.6084/M9.FIGSHARE.C.3619565_D8

    Release Date: 12-15-2016

    Description: Contains the normalised expression values for B-cells obtained from early undifferentiated arthritis patients. (TXT 124 kb)

  8. Additional file 2: of Capture Hi-C identifies a novel causal gene, IL20RA, in the pan-autoimmune genetic susceptibility region 6q23 Figshare

    ID: doi:10.6084/M9.FIGSHARE.C.3619565_D2

    Release Date: 12-15-2016

    Description: Contains the cis-eQTLs with P valueâ

  9. Additional file 3: of Capture Hi-C identifies a novel causal gene, IL20RA, in the pan-autoimmune genetic susceptibility region 6q23 Figshare

    ID: doi:10.6084/M9.FIGSHARE.C.3619565_D5

    Release Date: 12-15-2016

    Description: Contains the normalised expression values for CD4+ T-cells obtained from NRHV participants. (TXT 26 kb)

  10. Additional file 4: of Capture Hi-C identifies a novel causal gene, IL20RA, in the pan-autoimmune genetic susceptibility region 6q23 Figshare

    ID: doi:10.6084/M9.FIGSHARE.C.3619565_D9

    Release Date: 12-15-2016

    Description: Contains the cis-eQTLs with P valueâ

  11. FAK and HAS3 inhibition affect the expression of several common genes ArrayExpress

    ID: E-GEOD-39168

    Description: egulated (CBS, DHRS3, EEPD1, ESPN, FAM46C, GRTP1, IL20RA, INHBE, SCNN1A) and 4 were up-regulated (ANXA1, MALL, RGS2, SNAI2). RT-PCR confirmed these findings. Among the genes affected by FAK or HAS3 inhibition were FOX genes (apoptosis, cell cycle regulation), ANXA1 (apoptosis, proliferation), IL8 (cell cycle regulation, adhesion, proliferation), RGS2 (cell cycle regulation), CEACAM6 (adhesion), SNAI2 (transcription regulation), and SFRP5 (apoptosis). Several genes were specific to either FAK or HAS3 inhibition and several were common to both. Gene expression profiles of samples isolated from human colorectal cancer cells (SW620). A comparison of gene expression between untreated cells and cells treated with 4mcM of Y15. A second comparison between cells transfected with siRNA to HAS3 (HAS3-silenced) and cells transfected with a scrambled control sequence (sc). Two replicates each....

  12. IL13_0-12h_RAIA_et_al ArrayExpress

    ID: E-GEOD-23591

    Description: B-1 or control cells. In our experimental setting interleukin-13 (IL13) stimulation levels remained constant over time. In MedB-1 cells surface IL13 receptor alpha 2 had a strong IL13-sequestering/decoy function. In both lymphoma cell lines we observed IL13-induced activation of interleukin-4 receptor alpha, JAK2 and STAT5, but not of STAT6, which was highly phosphorylated even without stimulus. Furthermore, the known STAT-inducible negative regulators CISH and SOCS3 were up-regulated within 2 hours in MedB-1 but not in L1236 cells. Global transcription profiling revealed 11 early and 16 sustained common genes up-regulated by IL13 in both lymphoma cell lines. Based on this detailed information we established two individual mathematical models, MedB-1 and L1236 model, which were able to describe the respective experimental data. Sensitivity analysis of the model identified six possible therapeutic targets able to reduce gene expression levels in L1236 cells and three in MedB-1 cells. By inhibition of STAT5 phosphorylation we successfull...

  13. IL13_0-12h_RAIA_et_al BioProject

    ID: PRJNA131727

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: B-1 or control cells. In our experimental setting interleukin-13 (IL13) stimulation levels remained constant over time. In MedB-1 cells surface IL13 receptor alpha 2 had a strong IL13-sequestering/decoy function. In both lymphoma cell lines we observed IL13-induced activation of interleukin-4 receptor alpha, JAK2 and STAT5, but not of STAT6, which was highly phosphorylated even without stimulus. Furthermore, the known STAT-inducible negative regulators CISH and SOCS3 were up-regulated within 2 hours in MedB-1 but not in L1236 cells. Global transcription profiling revealed 11 early and 16 sustained common genes up-regulated by IL13 in both lymphoma cell lines. Based on this detailed information we established two individual mathematical models, MedB-1 and L1236 model, which were able to describe the respective experimental data. Sensitivity analysis of the model identified six possible therapeutic targets able to reduce gene expression levels in L1236 cells and three in MedB-1 cells. By inhibition of STAT5 phosphorylation we successfull...
  14. FAK and HAS3 inhibition affect the expression of several common genes BioProject

    ID: PRJNA170130

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: egulated (CBS, DHRS3, EEPD1, ESPN, FAM46C, GRTP1, IL20RA, INHBE, SCNN1A) and 4 were up-regulated (ANXA1, MALL, RGS2, SNAI2). RT-PCR confirmed these findings. Among the genes affected by FAK or HAS3 inhibition were FOX genes (apoptosis, cell cycle regulation), ANXA1 (apoptosis, proliferation), IL8 (cell cycle regulation, adhesion, proliferation), RGS2 (cell cycle regulation), CEACAM6 (adhesion), SNAI2 (transcription regulation), and SFRP5 (apoptosis). Several genes were specific to either FAK or HAS3 inhibition and several were common to both. Overall design: Gene expression profiles of samples isolated from human colorectal cancer cells (SW620). A comparison of gene expression between untreated cells and cells treated with 4mcM of Y15. A second comparison between cells transfected with siRNA to HAS3 (HAS3-silenced) and cells transfected with a scrambled control sequence (sc). Two replicates each....
  15. IL-15R-alpha controls hepatic stellate cell fibrogenic potential during murine chronic liver injury BioProject

    ID: PRJNA195399

    Keywords: Transcriptome or Gene expression

    Access Type: download

  16. Transcription profiling of immature human monocytes (U937) following 12/15-lipoxygenase expression ArrayExpress

    ID: E-GEOD-8173

    Description: , we showed that induction of 12/15-expression by interleukin-4 profoundly alters the gene expression pattern of human peripheral monocytes, which led to a profound switch of the cellular phenotype. To explore, which of these changes might be a direct consequence of 12/15-LOX expression we stably transfected a permanent human monocytic cell line (U937) with a 12/15-LOX containing eukaryotic expression plasmid and an empty control vector (mock-control). After a multi-step selection procedure a viable clones (12/15-LOX transfectants and mock-transfectants) were isolated and further cultured. We found that 12/15-LOX expression did not significantly alter basic cellular functions and that the cells, which express th...

  17. IL13_0-12h_RAIA_et_al OmicsDI

    ID: E-GEOD-23591

    Date Released: 03-27-2012

    Description: B-1 or control cells. In our experimental setting interleukin-13 (IL13) stimulation levels remained constant over time. In MedB-1 cells surface IL13 receptor alpha 2 had a strong IL13-sequestering/decoy function. In both lymphoma cell lines we observed IL13-induced activation of interleukin-4 receptor alpha, JAK2 and STAT5, but not of STAT6, which was highly phosphorylated even without stimulus. Furthermore, the known STAT-inducible negative regulators CISH and SOCS3 were up-regulated within 2 hours in MedB-1 but not in L1236 cells. Global transcription profiling revealed 11 early and 16 sustained common genes up-regulated by IL13 in both lymphoma cell lines. Based on this detailed information we established two individual mathematical models, MedB-1 and L1236 model, which were able to describe the respective experimental data. Sensitivity analysis of the model identified six possible therapeutic targets able to reduce gene expression levels in L1236 cells and three in MedB-1 cells. By inhibition of STAT5 phosphorylation we successfull...

  18. Array-comparative genomic hybridization by using DualChip® human cancer 1.1 arrays BioProject

    ID: PRJNA106835

    Keywords: Variation

    Access Type: download

    dataset.description: zation. Cancer Genetics and Cytogenetics. 177(1): 20-29) and all 294 genes contained in DualChip® human cancer 1.1 arrays were present also in Agilent arrays, it has been possible to compare results obtained by the two different platforms. We assumed aCGH performed by Agilent slides as reference method to assess gene gains and losses in neuroblastoma samples. This approach allowed us to select 120 genes printed on DualChip® arrays as invariant genes (ABI2, ADAM9, ANGPT1, AREG, BAK1, BIK, BARD1, BCL2A1, BCL2L2, BMP1, CASP3, CASP8, CDH12, CFLAR, CTNNA1, CD34, CLK1, CGRRF1, COL6A1, CSF1R, CSPG2, CTGF, CXCL9, CCNA2, CCNB1, CCNG1, CCNH, CDKN1A, CDKN1C, CDKN2A, CDKN2B, CDKL1, DSP, E2F3, E2F5, EFNA1, EGF, EGR1, FASTK, FGF1, FGF2, FGFR1, FGR, FN1, GAS1, HGFAC, HMMR, IGF1R, IGFBP2, IK, IFNAR1, IFNGR1, ILK, IRF1, ITGA1, ITGA4, IL10, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6R, IL8, KDR, KISS1, LIF, MIF, MMP11, MMP14, MDH1, MAP2K1, MAP2K5, MAPK10, MAPK14, MCL1, NF2, NID1, NINJ1, NRG1, NTRK1, PGF, PDGFB, PDGFRA, PLAT, PLG, PDCD2, PPBP, PRODH, PTGES, PCDH1, PTK2, PURA, QSCN6, RIPK1, RRM1, ARHGDIA, SFRP2, SOD1, STAT1, TEK, TERT, THBS1, TIAM1, TNC, TANK, TGFA, TGFB2, XRCC6, TGFB3, TGFBR1, TMED10, TPBG, TYRO3, ERBB4, FLT4, FOS, VIL2)....
  19. Detection of novel amplification units in prostate cancer BioProject

    ID: PRJNA100409

    Keywords: Variation

    Access Type: download

    dataset.description: rom the amplified region comprising the two genes interleukin 11 receptor alpha (IL11-RA) and dynactin 3 (DCTN3). Using quantitative real time PCR (qPCR) we could demonstrate that IL11-RA is the gene with the highest copy number gain in the cell lines compared to DCTN3 suggesting IL11-RA to be the amplification target. Screening of 20 primary prostate carcinomas by qPCR revealed a high frequency of IL11-RA copy number gain in 75% of the tumors analyzed. Gain of DCTN3 was only found in two cases together with a gain of IL11-RA. Thus, IL11-RA is a frequently amplified gene in prostate cancer with amplification being supposed to be one mechanism of IL11-RA overexpression in this tumor type. Keywords: comparative genomic hybridization Overall design: whole genome array comparative genomic hybridization...
  20. Alterations in gene expression profiles of immature human monocytes (U937) following 12/15-lipoxygenase expression. BioProject

    ID: PRJNA101075

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: , we showed that induction of 12/15-expression by interleukin-4 profoundly alters the gene expression pattern of human peripheral monocytes, which led to a profound switch of the cellular phenotype. To explore, which of these changes might be a direct consequence of 12/15-LOX expression we stably transfected a permanent human monocytic cell line (U937) with a 12/15-LOX containing eukaryotic expression plasmid and an empty control vector (mock-control). After a multi-step selection procedure a viable clones (12/15-LOX transfectants and mock-transfectants) were isolated and further cultured. We found that 12/15-LOX expression did not significantly alter basic cellular functions and that the cells, which express th...

Displaying 20 of 36 results for "IL20RA"