IL12RB1 | bioCADDIE Data Discovery Index
Mountain View
biomedical and healthCAre Data Discovery Index Ecosystem
help Advanced Search
Displaying 20 of 82 results for "IL12RB1"
i
  1. The Cytokines Interleukin-1 and Interferon-gamma Differentially Program Beta-glucan–activated Dendritic Cells via IkappaB-zeta Modulation BioProject

    ID: PRJNA179266

    Keywords: Transcriptome or Gene expression

    Access Type: download

  2. t of elevated serum levels of IL-10, IL-8 and TNF-beta as potential peripheral blood biomarkers in tubercular lymphadenitis: a prospective observational cohort study... Dryad

    DateIssued: 01-20-2016

    Description: sis Factor (TNF) -alpha, Interferon (IFN) -gamma, Interleukin (IL)-2, IL-12, IL-18, IL-1beta, IL-10, IL-6, IL-4, IL-1 Receptor antagonist (IL-1Ra), IL-8 and TNF-beta, which have a role in pathogenesis of tuberculosis, were tested as potential peripheral blood biomarkers to aid the diagnosis of TL when routine investigations prove to be of limited value. Methods and Findings: A prospective observational cohort study carried out during 2010-2013. This was a multi-center study with three participating hospitals in Delhi, India where through random sampling cohorts were established. The subjects were above 15 years of age, HIV-negative with no predisposing...

  3. Clostridioides difficile CD212 : Clostridioides difficile CD212 Genome sequencing and assembly BioProject

    ID: PRJNA85785

    Keywords: Genome sequencing and assembly

    Access Type: download

  4. I12R2_BOVIN UniProt:Swiss-Prot

    ID: Q9BEG2

    Description: Interleukin-12 receptor subunit beta-2 Extracellular Helical Cytoplasmic F...

  5. The Cytokines Interleukin-1 and Interferon-gamma Differentially Program Beta-glucan–activated Dendritic Cells via IkappaB-zeta Modulation ArrayExpress

    ID: E-GEOD-42189

    Description: the DC genome-wide gene expression in response to beta-glucan and its regulation by IL-1 receptor antagonist (IL-1RA) we used a whole genome microarray. Th...

  6. Transcriptional profiles of Th cells induced to polarize to Th1 or Th2 direction in the presence or absence of TGFbeta BioProject

    ID: PRJNA92301

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: ing through the TCR and cytokine receptors for IL-12 or IL-4. This leads to activation of complex signaling pathways, which are not known in detail. Disturbances in the balance between type 1 and type 2 responses can lead to certain immu...
  7. The Cytokines Interleukin-1 and Interferon-gamma Differentially Program Beta-glucan–activated Dendritic Cells via IkappaB-zeta Modulation OmicsDI

    ID: E-GEOD-42189

    Date Released: 06-02-2014

    Description: the DC genome-wide gene expression in response to beta-glucan and its regulation by IL-1 receptor antagonist (IL-1RA) we used a whole genome microarray. Th...

  8. Interleukin-1 receptor antagonist for recent-onset type 1 diabeties mellitus: a multicenter randomized, placebo-controlled trial BioProject

    ID: PRJNA157863

    Keywords: Transcriptome or Gene expression

    Access Type: download

  9. Inflammation driven by tumor-specific Th1 cells protects against B-cell cancer BioProject

    ID: PRJNA136175

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: nflammation and proinflammatory cytokines such as interleukin (IL)-1 and IL-6 are considered tumor-promoting. In contrast, the exact nature of protective antitumor immunity remains obscure. In this study, we have quantified loc...
  10. Gene expression profiling of effector and regulatory T-cells from peripheral blood of rheumatoid arthritis (RA) patients and healthy volunteers. BioProject

    ID: PRJNA272729

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: mokines by autologous LPS-activated monocytes (IL-1-beta, IL-1Ra, IL-7, CCL3, CCL4), but this was not true for all patients and other cytokines/chemokines (TNF-alpha, IL-6, IL-8, IL-12, IL-15, CCL5) were suppressed in the majority of patients similarly to HC. Finally, gene expression profiling of CD45RA+ or CD45RO+ Tregs from PB revealed no statistically significant differences between patients with RA and HC. Conclusions: Our findings suggest that Tregs isolated from PB of patients with RA are not intrinsically defective. Overall design: Sorted regulatory and effector T-cells were isolated from peripheral blood (6 healthy controls and 6 patients with rheumatoid arthritis). Total RNA was isolated and profiled using Affy HG-U133_Plus_2 chips....
  11. Transcription profiling of human Th cells induced to polarize to Th1 or Th2 direction in the presence or absence of TGFbeta ArrayExpress

    ID: E-GEOD-2770

    Description: ing through the TCR and cytokine receptors for IL-12 or IL-4. This leads to activation of complex signaling pathways, which are not known in detail. Disturbances in the balance between type 1 and type 2 responses can lead to certain immu...

  12. Innate immune repsonses to TREM-1 activation GEMMA

    ID: 2329

    Keywords: functional genomics

    Description: TREM-1 is an orphan immunoreceptor expressed on monocytes, macrophages, and neutrophils. TREM-1 associates with and s...

  13. Innate immune repsonses to TREM-1 activation BioProject

    ID: PRJNA104009

    Keywords: Transcriptome or Gene expression

    Access Type: download

  14. Identification of a Serum Induced Transcriptional Signature Associated with Type 1 Diabetes in the BioBreeding Rat BioProject

    ID: PRJNA122259

    Keywords: Transcriptome or Gene expression

    Access Type: download

  15. Zymosan stimulation of MyD88-deficient bone marrow-derived macrophages BioProject

    ID: PRJNA99601

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: ave previously demonstrated the importance of the beta-glucan receptor Dectin-1 in the recognition of pathogenic fungi by macrophages and dendritic cells, and have elucidated some of the mechanisms by which Dectin-1 signals to coordinate the antifungal response. While...
  16. The probiotic mixture VSL#3 has differential effects on intestinal immune parameters in healthy female BALB/c and C57BL/ ArrayExpress

    ID: E-GEOD-62619

    Description: -regulation of Il13 and Epx, and up-regulation of Il12rb1, Ccr5, Cxcr3 and Cxcl10 in BALB/c mice, such effects were not observed in C57BL/6 mice. In BALB/c mice, a 2-fold increase in CD103+ CD11c+ dendritic cells was found both in PP and in MLN, 18 hours after the first treatment with VSL#3. Prolonged treatment with VSL#3 was associated with increased numbers of Th17 cells and Foxp3+ regulatory T cells in the MLN of these mice. In conclusion, these experiments in healthy mice show that probiotic bacteria may alter the immunological phenotype of the host; the nature of these effects is dependent on mouse strain. In conclusion, these experiments in healthy mice show that probiotic bacteria may alter the immunological phenotype of the host; the nature of these effects is dependent on mouse strain. 40 samples (4 experimental groups, 5 biological replicates), performed in two inbred mice strains...

  17. Beta-tubulin and Actin Filament-Associating Small GTPase GIMAP4 is Required for IFN-Ɣ Secretion During Early Human CD4+ T Cell Activation ArrayExpress

    ID: E-GEOD-45720

    Description: r 2h in TCR activating (antiCD3+antiCD28) plus IL-12 conditions was compared to total RNA from nonspecific control siRNA-treated cells. Samples from 3 biological replicates were analysed....

  18. Interferon beta-1a-induced changes in gene expression in PBMCs derived from CIS patients GEMMA

    ID: 1141

    Keywords: functional genomics

    Description: (MyD88), IL-1R-associated kinase (IRAK)4, and TNF receptor-associated factor (TRAF)6, while it inhibited the expression of IL-1R. Using siRNA TLR7 gene silencing, we confirmed that IFN?-1a-induced changes in MyD88, IRAK4 and IL-1R expression were dependent on TLR7. TLR7 expression was also necessary for the IFN?-1a-induced inhibition of IL-1? and IL-23, and the induction of IL-27 secretion by DCs. Supernatant (SN) transfer experiments confirmed that IFN?-1a-induced changes in DCs’ cytokine secretion inhibit Th17 cell differentiation as evidenced by the inhibition of retinoic acid-related orphan nuclear hormone receptor C (RORC) and IL-17A gene expression and IL-17A secretion. Our study has identified a n...

  19. Analysis of Gene Expression and Cytokine Release Profiles Reveals the Inter-depot and Intra-depot Genetic and Functional Heterogeneity of Human Adipos... BioProject

    ID: PRJNA159465

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: xA5, Tbx15, PI16, PITPNC1, FABP5, IL-6, IL-8, MCP-1, VEGF, MMP3, TFPI2, and ANXA10 were significantly different between Sc-ASC and V-ASC. Of the 27 cytokines measured, 14 (IL-2, IL-4, IL-5 IL-7, IL-9, IL-10, IL12, IL13, MIP1-α, MIP1-β, PDGF-ΒΒ, FGFbasic, GM-CSF, IP-10) were not released, whereas 13 were expressed (IL-1beta, IL-1ra, IL-15, IL-17, G-CSF, IFNγ, RANTES, TNF-α, Eotaxin, IL-8, MCP-1, VEGF, IL-6), and of these, MCP-1, Eotaxin, IL-1ra, FGFbasic, IL-6, IL-8, G-CSF, and VEGF were significantly different among ASCSVF, ASCCeiling and ASCBottom of the two adipose tissue depots. These results demonstrate the existence of genetically and functionally heterogeneous fat-derived ASC populations, which may add to the complexity and specificity of Sc and V adipose tissue in humans. Overall design: Total RNA was isolated from the ASC of 5 lean subjects. The quality and integrity of total RNA (RNA Integrity Number [RIN] ≥8.0) was evaluated on an Agilent Bioanalyzer (Agilent Technologies, Waldbronn, Germany). RNA was then processed for hybridization on Human Gene 1.0 ST Array chips (Affymetrix, High Wycombe, UK), covering 28,869 well-annotated genes with 764,885 di...
  20. LP to invesigate innate immune responses to TREM-1 activation... ArrayExpress

    ID: E-GEOD-9988

    Description: TREM-1 is an orphan immunoreceptor expressed on monocytes, macrophages, and neutrophils. TREM-1 associates with and s...


Displaying 20 of 82 results for "IL12RB1"