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Displaying 20 of 53 results for "IGFBP2"
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  1. High IGFBP2 Expression Correlates with Tumor Severity in Pediatric Rhabdomyosarcoma ArrayExpress

    ID: E-GEOD-23196

    Description: ns. Insulin-like growth factor-binding protein 2 (IGFBP2) is strongly overexpressed in translocation-negative RMS. Because IGFBP2 is associated with tumorigenesis, we investigated its functional role in RMS. An analysis of IGFBP2 distribution in RMS cell lines revealed a strong accumulation in the Golgi complex, in which morphological characteristics appeared peculiarly modified. After silencing IGFBP2 expression, our microarray analysis revealed mostly cell cycle and ac...

  2. High IGFBP2 Expression Correlates with Tumor Severity in Pediatric Rhabdomyosarcoma. BioProject

    ID: PRJNA131545

    Keywords: Transcriptome or Gene expression

    Access Type: download

  3. Transcriptome profiling of breast cancer cells with Insulin like growth factor binding protein 2 (IGFBP2) knockdown BioProject

    ID: PRJNA174608

    Keywords: Transcriptome or Gene expression

    Access Type: download

  4. High IGFBP2 Expression Correlates with Tumor Severity in Pediatric Rhabdomyosarcoma. OmicsDI

    ID: E-GEOD-23196

    Date Released: 05-02-2014

    Description: ns. Insulin-like growth factor-binding protein 2 (IGFBP2) is strongly overexpressed in translocation-negative RMS. Because IGFBP2 is associated with tumorigenesis, we investigated its functional role in RMS. An analysis of IGFBP2 distribution in RMS cell lines revealed a strong accumulation in the Golgi complex, in which morphological characteristics appeared peculiarly modified. After silencing IGFBP2 expression, our microarray analysis revealed mostly cell cycle and ac...

  5. IGFBP2 driven glioma progression is prevented by blocking a clinically significant network of integrin, ILK, and NK-kB BioProject

    ID: PRJNA152343

    Keywords: Transcriptome or Gene expression

    Access Type: download

  6. IGFBP2 driven glioma progression is prevented by blocking a clinically significant network of integrin, ILK, and NK-kB ArrayExpress

    ID: E-GEOD-35467

    Description: Insulin-like growth factor-binding protein 2 (IGFBP2) is increasingly recognized as a glioma oncogene, emerging as a target for therapeutic intervention. In this study, we used ...

  7. IGFBP2 driven glioma progression is prevented by blocking a clinically significant network of integrin, ILK, and NK-kB OmicsDI

    ID: E-GEOD-35467

    Date Released: 05-04-2014

    Description: Insulin-like growth factor-binding protein 2 (IGFBP2) is increasingly recognized as a glioma oncogene, emerging as a target for therapeutic intervention. In this study, we used ...

  8. Transcriptome profiling of breast cancer cells with Insulin like growth factor binding protein 2 (IGFBP2) knockdown ArrayExpress

    ID: E-GEOD-40682

    Description: carried out to identify the genes regulated upon IGFBP2 modulation in breast cancer. This will help to understand the molecular targets and biological pathways targeted by IGFBP2

  9. Transcriptome profiling of breast cancer cells with Insulin like growth factor binding protein 2 (IGFBP2) knockdown OmicsDI

    ID: E-GEOD-40682

    Date Released: 06-02-2014

    Description: carried out to identify the genes regulated upon IGFBP2 modulation in breast cancer. This will help to understand the molecular targets and biological pathways targeted by IGFBP2

  10. Insulin-like growth factor-binding protein 2 Induces Epithelial-mesenchymal Transition via Activation of NF-κB Pathway in Pancreatic Ductal Adenocarc... ArrayExpress

    ID: E-GEOD-64611

    Description: IGFBP2 has been shown to act as an oncogene augmenting tumor progression in a number of malignancies. We sought to investigate role...

  11. Insulin-like growth factor-binding protein 2 Induces Epithelial-mesenchymal Transition via Activation of NF-κB Pathway in Pancreatic Ductal Adenocarc... OmicsDI

    ID: E-GEOD-64611

    Date Released: 01-24-2015

    Description: IGFBP2 has been shown to act as an oncogene augmenting tumor progression in a number of malignancies. We sought to investigate role...

  12. Insulin-like growth factor-binding protein 2 Induces Epithelial-mesenchymal Transition via Activation of NF-κB Pathway in Pancreatic Ductal Adenocarc... BioProject

    ID: PRJNA271407

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: IGFBP2 has been shown to act as an oncogene augmenting tumor progression in a number of malignancies. We sought to investigate role...
  13. Solution Structure of the C-terminal Domain of Insulin-like Growth Factor Binding Protein 2 (IGFBP-2) PDB

    ID: PDB:2H7T

    Description: Insulin-like growth factor-binding protein 2

    gene.name: IGFBP2, BP2
  14. Low dose Leptin (25 ng/hr and 12.5 ng/hr) in ob/ob mice BioProject

    ID: PRJNA120669

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: with a similarly high potency. Over-expression of IGFBP2 by an adenovirus reversed diabetes in insulin resistant ob/ob, Ay/a and diet-induced obese mice (DIO), as well as insulin deficient streptozotocin-treated mice. Hyperinsulinemic clamp studies showed a three-fold improvement in hepatic insulin sensitivity following IGFBP2 treatment in ob/ob mice. These results show that IGFBP2 can regulate glucose metabolism, a finding with potential implications for the pathogenesis and treatment of diabetes. Overall design: n=3 for zero and 25 ng/hr. n=2 for 12.5 ng/hr...
  15. IBP2_XENLA UniProt:Swiss-Prot

    ID: Q5XHC5

    Description: Insulin-like growth factor-binding protein 2 IGFBP N-terminal Thyroglobulin type-1 Cell attachment site

    gene.name: igfbp2
  16. IBP2_SHEEP UniProt:Swiss-Prot

    ID: Q29400

    Description: Insulin-like growth factor-binding protein 2 IGFBP N-terminal Thyroglobulin type-1 Cell attachment site

    gene.name: IGFBP2
  17. PRC2 inhibition counteracts the culture-associated loss of engraftment potential of human cord blood-derived hematopoietic stem and progenitor cells ArrayExpress

    ID: E-GEOD-58461

    Description: dium together with SCF, TPO, FGF, with or without Igfbp2 and Angptl5 (STF/STFIA cocktails). As compared to the STF cocktail, the STFIA cocktail maintains in vivo repopulation capacity of cultured CD34+ cells. Upon expansion, CD34+ cells genome-wide remodel their epigenotype and depending on the cytokine cocktail, cells show different H3K4me3 and H3K27me3 levels. Expanding cells without Igfbp2 and Angptl5 leads to higher global H3K27me3 levels. ChIPseq analyses reveal a cytokine cocktail-dependent redistribution of H3K27me3 profiles. Inhibition of the PRC2 component EZH2 counteracts the culture-associated loss of NOD scid gamma (NSG) engraftment potential....

  18. Characterization of secretomes from brain microvascular endothelial cells after ischemia OmicsDI

    ID: PXD002292

    Date Released: 01-21-2016

    Description: epresented by OGD-secreted proteins. ANXA1, CLUS, IGFBP2, PRDX3, TIMP2 and COL1A2 were replicated by western blotting in 9 independent cell cultures. Five replicated proteins were analyzed in human serum samples of 38 ischemic stroke patients compared to 18 stroke-mimicking conditions and 18 healthy controls by ELISA. IGFBP2 showed increased blood levels when strokes were compared with stroke-mimicking patients (p<0.1). In conclusion, we characterized changes in the secretome of hCMEC/D3 after an ischemic insult and highlighted some candidates to become biomarkers for ischemic stroke diagnosis related to blood-brain-barrier disruption....

  19. IBP2_XENTR UniProt:Swiss-Prot

    ID: A4IIA2

    Description: Insulin-like growth factor-binding protein 2 IGFBP N-terminal Thyroglobulin type-1 Cell attachment site

    gene.name: igfbp2
  20. IBP2_ONCTS UniProt:Swiss-Prot

    ID: P83628

    Description: Insulin-like growth factor-binding protein 2 IGFBP N-terminal

    gene.name: igfbp2

Displaying 20 of 53 results for "IGFBP2"