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Displaying 12 of 12 results for "IFNL2"
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  1. Transcription profiling by array of human hepatic Huh7 cells stimulated with IL-28A or IL-29 compared to untreated cells ArrayExpress

    ID: E-MEXP-2861

    Description: m of this study was to compare the effects of the lambda interferons IL-28A and IL-29 regarding transcriptional activation/rep...

  2. Transcriptional respose at 18hrs in Interferon treated lungs from C57BL/6 wt mice BioProject

    ID: PRJNA289233

    Keywords: Transcriptome or Gene expression

    Access Type: download

  3. Transcription profiling by array of human hepatic Huh7 cells stimulated with IL-28A or IL-29 compared to untreated cells OmicsDI

    ID: E-MEXP-2861

    Date Released: 05-02-2014

    Description: m of this study was to compare the effects of the lambda interferons IL-28A and IL-29 regarding transcriptional activation/rep...

  4. Impact of Cirrhosis on Endogenous Interferons During HCV Treatment with Direct Acting Antivirals BioProject

    ID: PRJNA289523

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: rus (HCV) infection is now routinely treated with interferon (IFN)-free regimens composed of directly acting antiviral (DAA) agents. Changes in hepatic and peripheral innate and adaptive immune function...
  5. Homo sapiens : Homo sapiens Transcriptome or Gene expression BioProject

    ID: PRJNA290512

    Keywords: transcriptome

    Access Type: download

    dataset.description: rus (HCV) infection is now routinely treated with interferon (IFN)-free regimens composed of directly acting antiviral (DAA) agents. We have previously described distinct changes in hepatic and periphera...
  6. Induced Hepatocyte-Like Cells with Interferon timecourse ArrayExpress

    ID: E-MTAB-2477

    Description: riment investigates the transcriptional effect of Interferon Alpha or Interferon Lambda upon Induced Hepatocyte-Like Cells (iHLCs). Peginterferon

  7. Interferon-lambda is functionally an interferon but structurally related to the IL-10 family PDB

    ID: PDB:3HHC

    Description: Interleukin-28B

  8. The crystal structure of human interferon lambda 1 complexed with its high affinity receptor in space group P212121 PDB

    ID: PDB:3OG6

    Description: Interleukin-29, Interleukin 28 receptor, alpha (Interferon, lambda receptor)

  9. INTERFERON REGULATORY FACTOR-2 DNA BINDING DOMAIN, NMR, MINIMIZED AVERAGE STRUCTURE PDB

    ID: PDB:1IRF

    Description: INTERFERON REGULATORY FACTOR-2

  10. INTERFERON REGULATORY FACTOR-2 DNA BINDING DOMAIN, NMR, 20 STRUCTURES PDB

    ID: PDB:1IRG

    Description: INTERFERON REGULATORY FACTOR-2

  11. Prolonged activation of innate antiviral gene signature after childbirth is determined by IFNL3 genotype BioProject

    ID: PRJNA339836

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: of non-pregnant control subjects. Interestingly, interferon stimulated genes (ISGs) encoding proteins such as IFIT1, IFIT2, and IFIT3, as well as signaling proteins such as STAT1, STAT2, and MAVS, were enriched postpartum. Antiviral genes were primarily expressed in CD14+ cells and could be stratified according to genetic variation at the interferon-λ3 gene (IFNL3, also named IL28B) single nucleotide polymorphism (SNP) rs12979860. Antiviral gene expression was sustained beyond six months following delivery in mothers with a CT or TT genotype but resembled baseline non-pregnant control levels following delivery in mothers wi...
  12. Immunity to Grb10, a signal transduction molecule, inhibits the growth of breast cancer in mice. BioProject

    ID: PRJNA108273

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: , CA). Modification of LM fibroblasts to secrete IL-2. The fibroblasts were modified to secrete IL-2 before transfection (LM-IL-2 cells) as a means of augmenting their non-specific immunogenic properties, as described previously (30). Modification of the cytokine-secreting fibroblasts to express H-2Kb-class I-determinants, allogeneic in C3H/He mice. Allogeneic class I-determinants are strong immune adjuvants (32,33). To stimulate up take of the vaccine by dendritic cells of the tumor-bearing host, and to ensure rejection, the fibroblasts (H-2k) were modified to express H-2Kb-determinants, allogeneic in C3H/He mice (LM-IL-2Kb cells), as described previously (34, 35). Preparation of cDNA libraries from SB5b breast cancer cells. Guanidine isothiocyanate was used to recover total RNA from SB5b cells or from B16F1 melanoma cells. The mRNA, derived from approximately 1 x 107 cells, was isolated using an mRNA isolation system (Promega, Madison, WI). The cDNA-expression libraries were constructed with a Lambda Zap vector using a cDNA library kit (Stratgene, La Jolla, CA). cDNAs greater than 0.5 kb were selected by size fractionation via gel filtration and directionally cloned into a pBK-CMV vector with an EcoRI restriction site at the 5’ end and an XhoI site at the 3’ end. The expression libraries yielded approximately 4 x 105 PFU/µg cDNA with an individual cDNA insert. The size distribution of the cDNA transduced into the modified fibroblasts was 0.5-7.0 kb. Preparation of the cDNA-based cellular vaccines. LM-IL-2Kb cells were transduced with a cDNA library from SB5b cells, or, for use as a specificity control, with a cDNA library from B16F1 cells, using Lipfectamine 2000 (Invitrogen, Calsbad, CA) to aid cDNA uptake. In brief, 30 µg of cDNA from either of the cell types were mixed with 3 µg pcDNA6/Bla (Invitrogen), a plasmid specifying a gene conferring resistance to blasticidin, used for selection. Afterward, the cDNA/pcDNA6/Bla mixture was added to Lipfectamine 2000 and then to 2.0 x 107 LM-IL-2Kb cells divided into four 100 mm plastic cell culture dishes 24 hours previously. After incubation for 18 hours, the cells were divided into sixteen 100 mm dishes, and incubated for 14 days in fresh growth medium containing 5 ug/ml blasticidin and 500 ug/ml G418. The surviving blasticin/G418-resistant cells (at least 2 x 106 colonies) were pooled and maintained as cell lines for use in the experiments (LM-IL-2Kb/cSB5b and LM-IL-2Kb/B16F1 cells respectively). For use as a control, the same procedure was followed except that the fibroblasts were transduced with pcDNA/Bla alone (LM-IL-2Kb cells). Mouse interferon gamma (IFN-?) ELISPOT IFN-? assays. Mouse ELISPOT IFN-? assays were used to determine the number of r...

Displaying 12 of 12 results for "IFNL2"