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Displaying 20 of 1,373 results for "IDH2"
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  1. AG-221 as an effective and on-target therapy in IDH2 mutant AML BioProject

    ID: PRJNA380630

    Keywords: Transcriptome or Gene expression

    Access Type: download

  2. Crystal Structure of Human Mitochondrial Isocitrate Dehydrogenase (IDH2) R140Q Mutant Homodimer in Complex with AG-221 (Enasidenib) Inhibitor. PDB

    ID: PDB:5I96

    Description: Isocitrate dehydrogenase [NADP], mitochondrial (E.C.1.1.1.42)

  3. IDH2 mutation induced histone and DNA hypermethylation is progressively reversed by small molecule inhibition BioProject

    ID: PRJNA222799

    Keywords: Epigenomics

    Access Type: download

  4. Induction of sarcomas by mutant IDH2 BioProject

    ID: PRJNA217989

    Keywords: Epigenomics

    Access Type: download

  5. Mutations in IDH1 and IDH2 are associated with DNA hypermethylation in intrahepatic cholangiocarcinomas BioProject

    ID: PRJNA154939

    Keywords: Epigenomics

    Access Type: download

  6. Structure of IDH2 mutant R172K PDB

    ID: PDB:5SVN

    Description: Isocitrate dehydrogenase [NADP], mitochondrial (E.C.1.1.1.42)

  7. Human SIRT5 bound to Succ-IDH2 and Carba-NAD PDB

    ID: PDB:4G1C

    Description: NAD-dependent protein deacylase sirtuin-5, mitochondrial (E.C.3.5.1.-), Succinylated IDH2 peptide

  8. Induction of sarcomas by mutant IDH2 OmicsDI

    ID: E-GEOD-50539

    Date Released: 11-25-2013

    Description: ns in either isocitrate dehydrogenase 1 (IDH1) or IDH2. In this study, we performed genome-wide CpG methylation sequencing of chondrosarcoma biopsies and found that IDH mutations were associated with DNA hypermethylation at CpG islands but not other genomic re...

  9. Induction of sarcomas by mutant IDH2 ArrayExpress

    ID: E-GEOD-50539

    Description: ns in either isocitrate dehydrogenase 1 (IDH1) or IDH2. In this study, we performed genome-wide CpG methylation sequencing of chondrosarcoma biopsies and found that IDH mutations were associated with DNA hypermethylation at CpG islands but not other genomic re...

  10. The IDH2 mutation cooperates with the NPM1 mutation to activate Hoxa9/Meis1 and hypoxia pathways in acute myeloid leukemia (MeDip-seq) BioProject

    ID: PRJNA268509

    Keywords: Epigenomics

    Access Type: download

  11. Structure of IDH2 mutant R140Q PDB

    ID: PDB:5SVO

    Description: Isocitrate dehydrogenase [NADP], mitochondrial (E.C.1.1.1.42)

  12. IDH2 mutation induced histone and DNA hypermethylation is progressively reversed by small molecule inhibition OmicsDI

    ID: E-GEOD-51352

    Date Released: 11-28-2014

    Description: Mutations of IDH1 (R132) and IDH2 (R172 and R140), which produce an oncometabolite 2-hydroxyglutarate (2HG), have been identified in several tumors including ac...

  13. IDH2 mutation induced histone and DNA hypermethylation is progressively reversed by small molecule inhibition ArrayExpress

    ID: E-GEOD-51352

    Description: Mutations of IDH1 (R132) and IDH2 (R172 and R140), which produce an oncometabolite 2-hydroxyglutarate (2HG), have been identified in several tumors including ac...

  14. The IDH2 mutation cooperates with the NPM1 mutation to activate Hoxa9/Meis1 and hypoxia pathways in acute myeloid leukemia (expression) BioProject

    ID: PRJNA268485

    Keywords: Transcriptome or Gene expression

    Access Type: download

  15. D-2-Hydroxyglutarate produced by mutant IDH2 causes cardiomyopathy and neurodegeneration in mice OmicsDI

    ID: E-GEOD-54838

    Date Released: 03-14-2014

    Description: and IDH2R172K alleles. Global induction of mutant IDH2 expression in adults resulted in dilated cardiomyopathy, white matter abnormalities throughout the central nervous system (CNS), and muscular dystrophy. Embryonic activation of mutant IDH2 resulted in more pronounced phenotypes, including runting, hydrocephalus, and shortened life span—recapitulating the abnormalities observed in D2HGA patients. The diseased hearts exhibited mitochondrial damage and glycogen accumulation with a concordant upregulation of genes involved in glycogen biosynthesis. Notably, mild cardiac hypertr...

  16. c signaling and reverse epigenetic dysfunction in IDH2- and TET2-mutant acute myeloid leukemia (RNA-Seq)... BioProject

    ID: PRJNA313222

    Keywords: Transcriptome or Gene expression

    Access Type: download

  17. c signaling and reverse epigenetic dysfunction in IDH2- and TET2-mutant acute myeloid leukemia... BioProject

    ID: PRJNA313219

    Access Type: download

  18. Transcription profiling by array of human oligodendroglioma tumor samples with IDH1 and IDH2 mutations ArrayExpress

    ID: E-MEXP-3239

    Description: endroglioma. Sequencing for mutations of IDH1 and IDH2 was done. Gene expression was compared between IDH wildtype vs. mutant samples...

  19. D-2-Hydroxyglutarate produced by mutant IDH2 causes cardiomyopathy and neurodegeneration in mice BioProject

    ID: PRJNA237792

    Keywords: Transcriptome or Gene expression

    Access Type: download

  20. Mutations in IDH1 and IDH2 are associated with DNA hypermethylation in intrahepatic cholangiocarcinomas ArrayExpress

    ID: E-GEOD-32079

    Description: genes encoding isocitrate dehydrogenase, IDH1 and IDH2, with 28 intrahepatic cholangiocarcinomas without these mutations. We profiled these samples with the Illumina HumanMethylation450 BeadChip, and characterized over 2,000 genes that were hypermethylated in tumors with mutations in IDH...


Displaying 20 of 1,373 results for "IDH2"