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Displaying 9 of 9 results for "HSD17B2"
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  1. Gene expression profiles in liver of pigs with extreme high and low levels of androstenone ArrayExpress

    ID: E-GEOD-11073

    Description: es encoding 17beta-hydroxysteroid dehydrogenases (HSD17B2, HSD17B4, HSD17B11 and HSD17B13) and plasma proteins alpha-1-acid glycoprotein (AGP) and orosomucoid (ORM1). 17beta-hydroxysteroid dehydrogenases and plasma proteins regulate the availability of steroids by controlling the amount of active steroids accessible to receptors and available for metabolism. Differences in the expression of FMO1, NAT12, HSD17B2 and HSD17B13 were verified by quantitative real competitive PCR. CONCLUSIONS: A number of genes and pathways related to metabolism of androstenone in liver were identified, including new candidate genes involved in phase I oxidation metabolism, phase II conjugation metabolism, and regulation of steroid availability. The study is a first step towards a deeper understanding of enzymes and regulators involved in pathways of androstenone metabolism and may ultimately lead to the discovery of markers to reduce boar taint. Liver samples from 116 animals with extreme androstenone values, 29 high and 29 low from each of the two breeds Norwegian Landrace and Duroc, were used for this experiment. Each sample was hybridised together with a common refrence resulting in a total of 116 microarrays....

  2. Gene expression profiles in liver of pigs with extreme high and low levels of androstenone. BioProject

    ID: PRJNA107061

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: es encoding 17beta-hydroxysteroid dehydrogenases (HSD17B2, HSD17B4, HSD17B11 and HSD17B13) and plasma proteins alpha-1-acid glycoprotein (AGP) and orosomucoid (ORM1). 17beta-hydroxysteroid dehydrogenases and plasma proteins regulate the availability of steroids by controlling the amount of active steroids accessible to receptors and available for metabolism. Differences in the expression of FMO1, NAT12, HSD17B2 and HSD17B13 were verified by quantitative real competitive PCR. CONCLUSIONS: A number of genes and pathways related to metabolism of androstenone in liver were identified, including new candidate genes involved in phase I oxidation metabolism, phase II conjugation metabolism, and regulation of steroid availability. The study is a first step towards a deeper understanding of enzymes and regulators involved in pathways of androstenone metabolism and may ultimately lead to the discovery of markers to reduce boar taint. Overall design: Liver samples from 116 animals with extreme androstenone values, 29 high and 29 low from each of the two breeds Norwegian Landrace and Duroc, were used for this experiment. Each sample was hybridised together with a common refrence resulting in a total of 116 microarrays....
  3. Whole Genome Methylation Analysis of Metastatic Castration Resistant Prostate Cancer ArrayExpress

    ID: E-GEOD-34174

    Description: etion occurred in the tumor suppressor RB1 and in HSD17B2, responsible for testosterone metabolism. Establishment of a comprehensive methylation signature and coupling of epigenomic and structural analyses sheds light on the alterations that allow CRPC to circumvent hormonal therapy and may provide new drug targets for what is currently an incurable disease state. 15 tumor samples taken from 14 men with metastatic castration resistant prostate cancer were analyzed, including two samples from the same patient. No control samples were used for this experiment....

  4. Gene expression profiles in liver of pigs with extreme high and low levels of androstenone. OmicsDI

    ID: E-GEOD-11073

    Date Released: 05-01-2014

    Description: es encoding 17beta-hydroxysteroid dehydrogenases (HSD17B2, HSD17B4, HSD17B11 and HSD17B13) and plasma proteins alpha-1-acid glycoprotein (AGP) and orosomucoid (ORM1). 17beta-hydroxysteroid dehydrogenases and plasma proteins regulate the availability of steroids by controlling the amount of active steroids accessible to receptors and available for metabolism. Differences in the expression of FMO1, NAT12, HSD17B2 and HSD17B13 were verified by quantitative real competitive PCR. CONCLUSIONS: A number of genes and pathways related to metabolism of androstenone in liver were identified, including new candidate genes involved in phase I oxidation metabolism, phase II conjugation metabolism, and regulation of steroid availability. The study is a first step towards a deeper understanding of enzymes and regulators involved in pathways of androstenone metabolism and may ultimately lead to the discovery of markers to reduce boar taint. Liver samples from 116 animals with extreme androstenone values, 29 high and 29 low from each of the two breeds Norwegian Landrace and Duroc, were used for this experiment. Each sample was hybridised together with a common refrence resulting in a total of 116 microarrays....

  5. Transcription profiling by array of human CD90 positive prostate stromal fibromuscular tumor cells ArrayExpress

    ID: E-GEOD-17906

    Description: L13, and PAGE4, bladder down-regulation of TRPA1, HSD17B2, IL24, and SALL1, and an up-regulation of CXC-chemokines. This study identified a group of differentially expressed genes in CD90+ reactive stromal cells that are potentially involved in organ development and smooth muscle cell differentiation. Experiment Overall Design: A total of 15 arrays were run for the following sample types obtained from 10 patients: Experiment Overall Design: 2 CD90+ prostate tumor-associated stromal: Experiment Overall Design: Patient 1: CP_Str_08-028_CD90posi Experiment Overall Design: Patient 2: 08-032_CP_strom_CD90posi Experiment Overall Design: 2 CD13+ normal bladder stromal: Experiment Overall Design: Patient 3: 06-125_NB_CD13posi Experiment Overall Design: Patient 4: 06-070_NB_str_CD13posi Experiment Overall Design: 1 CD13+ bladder tumor-associated stromal...

  6. Whole Genome Methylation Analysis of Metastatic Castration Resistant Prostate Cancer BioProject

    ID: PRJNA149609

    Keywords: Other

    Access Type: download

    dataset.description: etion occurred in the tumor suppressor RB1 and in HSD17B2, responsible for testosterone metabolism. Establishment of a comprehensive methylation signature and coupling of epigenomic and structural analyses sheds light on the alterations that allow CRPC to circumvent hormonal therapy and may provide new drug targets for what is currently an incurable disease state. Overall design: 15 tumor samples taken from 14 men with metastatic castration resistant prostate cancer were analyzed, including two samples from the same patient. No control samples were used for this experiment....
  7. Gene expression down-regulation in prostate tumor-associated stromal cells involves organ-specific genes BioProject

    ID: PRJNA119977

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: L13, and PAGE4, bladder down-regulation of TRPA1, HSD17B2, IL24, and SALL1, and an up-regulation of CXC-chemokines. This study identified a group of differentially expressed genes in CD90+ reactive stromal cells that are potentially involved in organ development and smooth muscle cell differentiation. Overall design: A total of 15 arrays were run for the following sample types obtained from 10 patients: 2 CD90+ prostate tumor-associated stromal: Patient 1: CP_Str_08-028_CD90posi Patient 2: 08-032_CP_strom_CD90posi 2 CD13+ normal bladder stromal: Patient 3: 06-125_NB_CD13posi Patient 4: 06-070_NB_str_CD13posi 1 CD13+ bladder tumor-associated stromal: Patient 5: 07-008_CB_str_CD13posi 5 whole tissue prostate cancer and 5 normal tissue from matched pairs: Patient 6: 05-206_CaP, 05-206_NP Patient 7: 05-213_CaP, 05-213_NP Patient 8: 05-214_CaP, 05-2...
  8. Whole Genome Methylation Analysis of Metastatic Castration Resistant Prostate Cancer OmicsDI

    ID: E-GEOD-34174

    Date Released: 05-04-2014

    Description: etion occurred in the tumor suppressor RB1 and in HSD17B2, responsible for testosterone metabolism. Establishment of a comprehensive methylation signature and coupling of epigenomic and structural analyses sheds light on the alterations that allow CRPC to circumvent hormonal therapy and may provide new drug targets for what is currently an incurable disease state. 15 tumor samples taken from 14 men with metastatic castration resistant prostate cancer were analyzed, including two samples from the same patient. No control samples were used for this experiment....

  9. Transcription profiling by array of human CD90 positive prostate stromal fibromuscular tumor cells OmicsDI

    ID: E-GEOD-17906

    Date Released: 05-03-2012

    Description: L13, and PAGE4, bladder down-regulation of TRPA1, HSD17B2, IL24, and SALL1, and an up-regulation of CXC-chemokines. This study identified a group of differentially expressed genes in CD90+ reactive stromal cells that are potentially involved in organ development and smooth muscle cell differentiation. Experiment Overall Design: A total of 15 arrays were run for the following sample types obtained from 10 patients: Experiment Overall Design: 2 CD90+ prostate tumor-associated stromal: Experiment Overall Design: Patient 1: CP_Str_08-028_CD90posi Experiment Overall Design: Patient 2: 08-032_CP_strom_CD90posi Experiment Overall Design: 2 CD13+ normal bladder stromal: Experiment Overall Design: Patient 3: 06-125_NB_CD13posi Experiment Overall Design: Patient 4: 06-070_NB_str_CD13posi Experiment Overall Design: 1 CD13+ bladder tumor-associated stromal...


Displaying 9 of 9 results for "HSD17B2"