HOXD13 | bioCADDIE Data Discovery Index
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Displaying 20 of 81 results for "HOXD13"
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  1. HXD13_HETFR UniProt:Swiss-Prot

    ID: Q9IA17

    Description: Homeobox protein Hox-D13 Homeobox

  2. HXD13_CARPS UniProt:Swiss-Prot

    ID: Q5EU41

    Description: Homeobox protein Hox-D13 Homeobox Ala-rich

  3. Focal amplification of HOXD-harboring chromosome region is implicated in multiple-walled carbon nanotubes-induced carcinogenicity BioProject

    ID: PRJNA200919

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: Amplificaition of HOXD9 and HOXD13 genes was found in MWCNTs induced carcinogencity. By overexpression or silence of of HOXD9 and HOXD13 gen...
  4. Focal amplification of HOXD-harboring chromosome region is implicated in multiple-walled carbon nanotubes-induced carcinogenicity ArrayExpress

    ID: E-GEOD-46542

    Description: Amplificaition of HOXD9 and HOXD13 genes was found in MWCNTs induced carcinogencity. By overexpression or silence of of HOXD9 and HOXD13 gen...

  5. Distinct Global Shifts in Genomic Binding Profiles of Limb Malformation Associated HOXD13 Mutations ArrayExpress

    ID: E-GEOD-44799

    Description: mechanism underlying a novel missense mutation in HOXD13 (Q317K) associated with a complex hand and foot malformation phenotype. The glutamine at position 317 (position 50 of the homeodomain) is conserved in most homeodomains, a notable exception being bicoid-type homeodomains that have K at this position. Our results show that the mutation results in a shift in the binding pro...

  6. Distinct Global Shifts in Genomic Binding Profiles of Limb Malformation Associated HOXD13 Mutations BioProject

    ID: PRJNA192680

    Keywords: Other

    Access Type: download

  7. Myelodysplastic syndrome: NUP98-HoxD13 (NHD13) expression effect on hematopoietic stem cells BioProject

    ID: PRJNA276285

    Keywords: Transcriptome or Gene expression

    Access Type: download

  8. HOX13 activity reprograms cis-regulatory modules during digit development (RNA-Seq) BioProject

    ID: PRJNA321344

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: tructures, the digits. Inactivation of HOXA13 and HOXD13 transcription factors (HOX13) leads to complete digit agenesis in mice, but how HOX13 regulate transcriptional outcomes and confer identity to the distal-most limb cells has remained elusive. Here we performed genome-wide profiling of HOX13 by chromatin immunoprecipitation and analyzed the transcriptome and chromatin state of wild type early and late-distal limb buds, as well as Hoxa13-/-;Hoxd13-/- compound mutant limb buds. Our resu...
  9. HOX13 activity reprograms cis-regulatory modules during digit development (ChIP-Seq) BioProject

    ID: PRJNA321345

    Keywords: Epigenomics

    Access Type: download

    dataset.description: tructures, the digits. Inactivation of HOXA13 and HOXD13 transcription factors (HOX13) leads to complete digit agenesis in mice, but how HOX13 regulate transcriptional outcomes and confer identity to the distal-most limb cells has remained elusive. Here we performed genome-wide profiling of HOX13 by chromatin immunoprecipitation and analyzed the transcriptome and chromatin state of wild type early and late-distal limb buds, as well as Hoxa13-/-;Hoxd13-/- compound mutant limb buds. Our resu...
  10. Focal amplification of HOXD-harboring chromosome region is implicated in multiple-walled carbon nanotubes-induced carcinogenicity OmicsDI

    ID: E-GEOD-46542

    Date Released: 06-03-2014

    Description: Amplificaition of HOXD9 and HOXD13 genes was found in MWCNTs induced carcinogencity. By overexpression or silence of of HOXD9 and HOXD13 gen...

  11. Distinct Global Shifts in Genomic Binding Profiles of Limb Malformation Associated HOXD13 Mutations OmicsDI

    ID: E-GEOD-44799

    Date Released: 05-03-2014

    Description: mechanism underlying a novel missense mutation in HOXD13 (Q317K) associated with a complex hand and foot malformation phenotype. The glutamine at position 317 (position 50 of the homeodomain) is conserved in most homeodomains, a notable exception being bicoid-type homeodomains that have K at this position. Our results show that the mutation results in a shift in the binding pro...

  12. Myelodysplastic syndrome: NUP98-HoxD13 (NHD13) expression effect on hematopoietic stem cells OmicsDI

    ID: E-GEOD-66264

    Date Released: 03-11-2016

    Description: atopoietic stem cells (HSCs) expressing the Nup98-HoxD13 (NHD13) fusion gene. NHD13 induces myelodysplastic syndrome (MDS) in mice. Results provide insight into the molecular basis of the myelodysplastic phenotype ...

  13. Integration of Shh and Fgf signaling in controlling Hox expression in cultured limb cells [4C-seq] BioProject

    ID: PRJNA358046

    Keywords: Other

    Access Type: download

    dataset.description: at both factors are required to get activation of Hoxd13 in limb mesenchymal cells. However, the analysis of the enhancer landscapes flanking the HoxD cluster reveals that the bimodal regulatory switch observed in vivo is not fully achieved under these in vitro conditions, suggesting the requirement for other factors. Overall design: 4C-seq analysis of Hoxd11 and Hoxd13 3D interactions in wt chick limbs, Ozd mutant limbs or cultured wt limb mesenchymal cells...
  14. A role for HOX13 proteins in the regulatory switch between TADs at the HoxD locus BioProject

    ID: PRJNA315567

    Keywords: Other

    Access Type: download

    dataset.description: on. Overall design: 4C-seq analysis of Hoxd11 and Hoxd13 3D interactions in proximal and distal limbs from E12.5 wt or Hoxa13-/-;Hoxd13-/- mutant embryos...
  15. aCGH assay in a Chinese family with syndactyly type 1-c ArrayExpress

    ID: E-GEOD-55181

    Description: tation of c.917G>A (p.R306Q) in the homodomain of HOXD13 was indentified. Family B was confirmed with genetic homogeneity and the mutation was c.916C>G (p.R306G). CNV analysis by array CGH excluded possible microdeletion or microduplication. SD1c patient sample in the SD1c family vs common control outside the family, healthy control sample in the SD1c family vs common control outside the family...

  16. Myelodysplastic syndrome: NUP98-HoxD13 (NHD13) expression effect on hematopoietic stem cells ArrayExpress

    ID: E-GEOD-66264

    Description: atopoietic stem cells (HSCs) expressing the Nup98-HoxD13 (NHD13) fusion gene. NHD13 induces myelodysplastic syndrome (MDS) in mice. Results provide insight into the molecular basis of the myelodysplastic phenotype ...

  17. Transcription profiling of mouse adult bone marrow cells reveals candidate genes form expansion and transformation of hematopoietic stem cells by NUP9... ArrayExpress

    ID: E-GEOD-9079

    Description: and NA10 and the AML-associated fusion gene NUP98-HOXD13 (ND13) have a virtually indistinguishable ability to transform myeloid progenitor cells in vitro and to induce leukemia in collaboration with MEIS1 in vivo. METHODOLOGY/PRINCIPAL FINDINGS: These findings provided a potentially powerful approach to identify key pathways mediating Hox-induced expansion and transformation of HSCs by identifying gene expression changes commonly induced by ND13 and NA10 but not by...

  18. Genome-wide maps of NUP98 fusion and MLL1 co-bound targets and their chromatin state in NUP98 fusion transformed cells. BioProject

    ID: PRJNA305933

    Keywords: Epigenomics

    Access Type: download

    dataset.description: wide direct binding sites of NUP98-HOXA9 or NUP98-HOXD13. To test whether NUP98 fusions and Mll1 were recruited to the same region of Hox genes promoters, Mll1 ChIP-seq analysis was carried out in murine NUP98-HOXA9 transformed cells using an anti-Mll1n antibody. In agreement with our results showing that NUP98-HOXA9 interacts with MLL1 in NSL/...
  19. aCGH assay in a Chinese family with syndactyly type 1-c BioProject

    ID: PRJNA238834

    Keywords: Variation

    Access Type: download

    dataset.description: tation of c.917G>A (p.R306Q) in the homodomain of HOXD13 was indentified. Family B was confirmed with genetic homogeneity and the mutation was c.916C>G (p.R306G). CNV analysis by array CGH excluded possible microdeletion or microduplication. Overall design: SD1c patient sample in the SD1c family vs common control outside the family, healthy control sample in the SD1c family vs common control outside the family...
  20. Integration of Shh and Fgf signaling in controlling Hox expression in cultured limb cells [ChIP-seq] BioProject

    ID: PRJNA358045

    Keywords: Epigenomics

    Access Type: download

    dataset.description: at both factors are required to get activation of Hoxd13 in limb mesenchymal cells. However, the analysis of the enhancer landscapes flanking the HoxD cluster reveals that the bimodal regulatory switch observed in vivo is not fully achieved under these in vitro conditions, suggesting the requirement for other factors. Overall design: ChIP-seq analysis of H3K27ac in cultured distal-anterior mesenchymal cells from chick forelimb buds at HH21....

Displaying 20 of 81 results for "HOXD13"