HOXC10 | bioCADDIE Data Discovery Index
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Displaying 20 of 48 results for "HOXC10"
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  1. HXC10_MACNE UniProt:Swiss-Prot

    ID: A2T6F8

    Description: Homeobox protein Hox-C10 Homeobox Phosphothreonine Phosphoserine Glycyl lysine isopeptide (Ly...

  2. HXC10_PONPY UniProt:Swiss-Prot

    ID: A2T7H7

    Description: Homeobox protein Hox-C10 Homeobox Phosphothreonine Phosphoserine Glycyl lysine isopeptide (Ly...

  3. HXC10_MACMU UniProt:Swiss-Prot

    ID: A2D635

    Description: Homeobox protein Hox-C10 Homeobox Phosphothreonine Phosphoserine Glycyl lysine isopeptide (Ly...

  4. Estrogen deprivation alters epigenetic modifications in breast cancer cells - HOXC10 loss in endocrine resistance BioProject

    ID: PRJNA171707

    Keywords: Epigenomics

    Access Type: download

  5. Estrogen deprivation alters epigenetic modifications in breast cancer cells - HOXC10 loss in endocrine resistance OmicsDI

    ID: E-GEOD-39783

    Date Released: 05-12-2014

    Description: and lost expression in both cell-line systems was HOXC10. Moreover, we found that HOXC10 is an estrogen-regulated gene and lack of ER regulation is associated with progressive epigenetic silencing through EZH2/H3K27me3 and DNA hypermethylation. Stable knockdown of HOXC10 in MCF-7 cells resulted in increased cell growth, reduced cell apoptosis, and increased cell motility. A preliminary study using AI-treated breast tumors did not show significant associations, however, the numbers were small. We identified HOXC10 methylation as a novel determinant of endocrine resistance. Also, we revealed that epigenetic reprogramming of genes involved in development may be a fundamental phenomenon in hormone resistance. Therefore, our study might provide the basis for the expansion of clinical markers for endocrine resistance and future clinical trials such as combination of endocrine and epigenetic therapies. Long-term estrogen deprived previously established MCF-7 cell clones termed C4-12 and LTED genomic DNA subjected to Methyl CpG Binding Domain (MBD) - pull down followed by affymetrix promoter array to detect promoter methylation patterns...

  6. Estrogen deprivation alters epigenetic modifications in breast cancer cells - HOXC10 loss in endocrine resistance ArrayExpress

    ID: E-GEOD-39783

    Description: and lost expression in both cell-line systems was HOXC10. Moreover, we found that HOXC10 is an estrogen-regulated gene and lack of ER regulation is associated with progressive epigenetic silencing through EZH2/H3K27me3 and DNA hypermethylation. Stable knockdown of HOXC10 in MCF-7 cells resulted in increased cell growth, reduced cell apoptosis, and increased cell motility. A preliminary study using AI-treated breast tumors did not show significant associations, however, the numbers were small. We identified HOXC10 methylation as a novel determinant of endocrine resistance. Also, we revealed that epigenetic reprogramming of genes involved in development may be a fundamental phenomenon in hormone resistance. Therefore, our study might provide the basis for the expansion of clinical markers for endocrine resistance and future clinical trials such as combination of endocrine and epigenetic therapies. Long-term estrogen deprived previously established MCF-7 cell clones termed C4-12 and LTED genomic DNA subjected to Methyl CpG Binding Domain (MBD) - pull down followed by affymetrix promoter array to detect promoter methylation patterns...

  7. Pitx1 broadly associates with limb enhancers and is enriched on hindlimb cis-regulatory elements ArrayExpress

    ID: E-GEOD-41591

    Description: ted that the hindlimb transcription factors Tbx4, HoxC10, and HoxC11 might be transcriptional targets of Pitx1, but definitive evidence for direct regulatory interactions has been lacking. Using ChIP-Seq on embryonic mouse hindlimbs, we have pinpointed the genome-wide location of Pitx1 binding sites during mouse hindlimb development and identified potential gene targets for Pitx1. We determined that Pitx1 binding is significantly enriched near genes involved in limb morphogenesis, incl...

  8. Pitx1 broadly associates with limb enhancers and is enriched on hindlimb cis-regulatory elements BioProject

    ID: PRJNA177636

    Keywords: Epigenomics

    Access Type: download

    dataset.description: ted that the hindlimb transcription factors Tbx4, HoxC10, and HoxC11 might be transcriptional targets of Pitx1, but definitive evidence for direct regulatory interactions has been lacking. Using ChIP-Seq on embryonic mouse hindlimbs, we have pinpointed the genome-wide location of Pitx1 binding sites during mouse hindlimb development and identified potential gene targets for Pitx1. We determined that Pitx1 binding is significantly enriched near genes involved in limb morphogenesis, incl...
  9. Pitx1 broadly associates with limb enhancers and is enriched on hindlimb cis-regulatory elements OmicsDI

    ID: E-GEOD-41591

    Date Released: 01-11-2013

    Description: ted that the hindlimb transcription factors Tbx4, HoxC10, and HoxC11 might be transcriptional targets of Pitx1, but definitive evidence for direct regulatory interactions has been lacking. Using ChIP-Seq on embryonic mouse hindlimbs, we have pinpointed the genome-wide location of Pitx1 binding sites during mouse hindlimb development and identified potential gene targets for Pitx1. We determined that Pitx1 binding is significantly enriched near genes involved in limb morphogenesis, incl...

  10. Transcription profiling of mouse embryonic autopods to identify differentially expressed genes in developing forlimb and hindlimb tissues ArrayExpress

    ID: E-GEOD-2560

    Description: e detected(T test, P<0.05), including Tbx4, Tbx5, Hoxc10 and Pitx1 which were previously shown to be differentially expressed in developing forelimb and hindlimb bud by in situ hybridization and SAGE study (Margulies 2001). RTPCR and in situ experiments confirmed several top differentially expressed genes which were newly discovered by our experiments. Vast amount of transcripts and its family members such as Bmp, Fgf, Epha, Wnt, T-box and Hox families detected to be highly expressed or differentially expressed in developing autopods, suggesting that the complexity of transcriptomes of developing autop...

  11. monomer of TALE type homeobox transcription factor MEIS1 complexes with specific DNA PDB

    ID: PDB:5BNG

    Description: Homeobox protein Meis2/DNA Complex

  12. HOXB13-MEIS1 heterodimer bound to DNA PDB

    ID: PDB:5EG0

    Description: Homeobox protein Meis1, Homeobox protein Hox-B13/DNA Complex

  13. Transcription profiling of mouse embryonic autopods to identify differentially expressed genes in developing forlimb and hindlimb tissues OmicsDI

    ID: E-GEOD-2560

    Date Released: 03-27-2012

    Description: e detected(T test, P<0.05), including Tbx4, Tbx5, Hoxc10 and Pitx1 which were previously shown to be differentially expressed in developing forelimb and hindlimb bud by in situ hybridization and SAGE study (Margulies 2001). RTPCR and in situ experiments confirmed several top differentially expressed genes which were newly discovered by our experiments. Vast amount of transcripts and its family members such as Bmp, Fgf, Epha, Wnt, T-box and Hox families detected to be highly expressed or differentially expressed in developing autopods, suggesting that the complexity of transcriptomes of developing autop...

  14. Homeobox transcription factor CDX2 bound to methylated DNA PDB

    ID: PDB:5LTY

    Description: Homeobox protein CDX-2/DNA Complex

  15. Homeobox transcription factor CDX1 bound to methylated DNA PDB

    ID: PDB:5LUX

    Description: Homeobox protein CDX-2/DNA Complex

  16. Crystal structure of a Nanog homeobox (NANOG) from Homo sapiens at 3.30 A resolution PDB

    ID: PDB:4RBO

    Description: Putative homeobox protein NANOGP8/DNA

  17. HOXB13-MEIS1 heterodimer bound to methylated DNA PDB

    ID: PDB:5EGO

    Description: Homeobox protein Meis1, Homeobox protein Hox-B13/DNA Complex

  18. Transcriptomes analysis of mouse developing forelimb and hindlimb autopods BioProject

    ID: PRJNA92175

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: e detected(T test, P<0.05), including Tbx4, Tbx5, Hoxc10 and Pitx1 which were previously shown to be differentially expressed in developing forelimb and hindlimb bud by in situ hybridization and SAGE study (Margulies 2001). RTPCR and in situ experiments confirmed several top differentially expressed genes which were newly discovered by our experiments. Vast amount of transcripts and its family members such as Bmp, Fgf, Epha, Wnt, T-box and Hox families detected to be highly expressed or differentially expressed in developing autopods, suggesting that the complexity of transcriptomes of developing autop...
  19. Crystal structure of a distal-less homeobox protein 5 (Dlx5) from Homo sapiens at 1.85 A resolution PDB

    ID: PDB:4RDU

    Description: Homeobox protein DLX-5

  20. Structure of Scr/Exd complex bound to a consensus Hox-Exd site PDB

    ID: PDB:2R5Y

    Description: Homeotic protein Sex combs reduced/Homeobox protein extradenticle/DNA Complex


Displaying 20 of 48 results for "HOXC10"