HERC2 | bioCADDIE Data Discovery Index
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Displaying 17 of 17 results for "HERC2"
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  1. Structure of the first RCC1-like domain of HERC2 PDB

    ID: PDB:4L1M

    Description: E3 ubiquitin-protein ligase HERC2 (E.C.6.3.2.-)

  2. The third RLD domain of HERC2 PDB

    ID: PDB:3KCI

    Description: Probable E3 ubiquitin-protein ligase HERC2 (E.C.6.3.2.-)

  3. protein HS00059, cytochrome-b5-like domain of the HERC2 E3 ligase. Northeast structural genomics consortium (NESG) target ht98a... PDB

    ID: PDB:2KEO

    Description: Probable E3 ubiquitin-protein ligase HERC2 (E.C.6.3.2.-)

  4. HRC23_HUMAN UniProt:Swiss-Prot

    ID: Q9BVR0

    Description: Putative HERC2-like protein 3 MIB/HERC2 Poly-Arg In dbSNP:rs17134681. In dbSNP:rs4931826. (in Ref. 2; BC070076)

  5. Solution structure of Mib-herc2 domain in HECT domain containing protein 1 PDB

    ID: PDB:2DK3

    Description: E3 ubiquitin-protein ligase HECTD1

  6. EfEmSangerSequencingForDryad Dryad

    DateIssued: 07-22-2015

    Description: old2503 (the scaffold containing the orthologs of HERC2/OCAs) and aligned using EBioX...

  7. MIB1_XENLA UniProt:Swiss-Prot

    ID: Q6GNY1

    Description: E3 ubiquitin-protein ligase mib1 MIB/HERC2 1 MIB/HERC2 2 ANK 1 ANK 2 ANK 3 ANK 4 ANK 5 ANK 6 ANK 7 ANK 8 ANK 9 ZZ-type RING-type 1 RING-type 2 RING-t...

  8. MIB2_RAT UniProt:Swiss-Prot

    ID: Q68LP1

    Description: E3 ubiquitin-protein ligase MIB2 MIB/HERC2 1 MIB/HERC2 2 ANK 1 ANK 2 ANK 3 ANK 4 ANK 5 ANK 6 ANK 7 ANK 8 ANK 9 ZZ-type RING-type 1 RING-type 2 Phosph...

  9. MIB2_CHICK UniProt:Swiss-Prot

    ID: Q5ZIJ9

    Description: E3 ubiquitin-protein ligase MIB2 MIB/HERC2 1 MIB/HERC2 2 ANK 1 ANK 2 ANK 3 ANK 4 ANK 5 ANK 6 ANK 7 ANK 8 ANK 9 ZZ-type RING-type 1 RING-type 2...

  10. HECD1_MOUSE UniProt:Swiss-Prot

    ID: Q69ZR2

    Description: protein ligase HECTD1 ANK 1 ANK 2 ANK 3 ANK 4 MIB/HERC2 HECT K-box Poly-Lys Ser-rich Poly-Glu Glycyl thioester intermediate Phosphoserine Phosphoserine Phosphoserine Phosphoserine Phosphoserine ...

  11. RNA-seq Analysis of 15q Duplication and AS Deletion DPSC derived neurons. BioProject

    ID: PRJNA279008

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: ss, the finding of a significant increase in both HERC2 and UBE3A in 15q duplication neurons and significant decrease in these two genes in AS deletion neurons may impact the AS phenotype, at least in deletion cases. Overall design: RNA-seq Analysis of 3 15q Duplication, 3 Angelman syndrome deletion and 3 neurotypical control DPSC derived neurons (~3 weeks post maturation)...
  12. Differential Gene Expression in Angelman syndrome deletion vs. int dup(15) Human Lymphocytes ArrayExpress

    ID: E-GEOD-32563

    Description: for genes at the 15q locus like UBE3A, ATP10A and HERC2. A larger set of genes involved in chromatin remodeling, DNA repair and neurogenesis were found, at FAIRE peaks in AS deletion samples but had increased transcription in int dup(15) samples. There was a significant enhancement for genes with FOXP1 binding sites in the int dup(15) gene set and elevated FOXP1 protein could be detected in the nucleus of int dup(15) as compared to AS deletion cell lines. This analysis provides the first insights into transcriptional changes which may unveil new sets of genes and pathways contributing to both AS and autism pathogenesis. Gene expression was performed using 100ng of total RNA from each subject as starting material for amplification and cRNA synthesis in accordance Affymetrix protocols (). Hybridizations were performed to the Affy HumanGene_st_v1 chip and the signal data normalized using internal chip controls. Normalized expression data was then exported to a text file for subsequent expression analysis using the EXPANDER software analysis suite....

  13. Differential Gene Expression in Angelman syndrome deletion vs. int dup(15) Human Lymphocytes BioProject

    ID: PRJNA147119

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: for genes at the 15q locus like UBE3A, ATP10A and HERC2. A larger set of genes involved in chromatin remodeling, DNA repair and neurogenesis were found, at FAIRE peaks in AS deletion samples but had increased transcription in int dup(15) samples. There was a significant enhancement for genes with FOXP1 binding sites in the int dup(15) gene set and elevated FOXP1 protein could be detected in the nucleus of int dup(15) as compared to AS deletion cell lines. This analysis provides the first insights into transcriptional changes which may unveil new sets of genes and pathways contributing to both AS and autism pathogenesis. Overall design: Gene expression was performed using 100ng of total RNA from each subject as starting material for amplification and cRNA synthesis in accordance Affymetrix protocols (http://tinyurl.com/3j7dcp6). Hybridizations were performed to the Affy HumanGene_st_v1 chip and the signal data normalized using internal chip controls. Normalized expression data was then exported to a text file for subsequent expression analysis using the EXPANDER software analysis suite....
  14. TUSC4 functions as a tumor suppressor by regulating BRCA1’s stability via the E3 ubiquitination pathway OmicsDI

    ID: E-GEOD-60535

    Date Released: 08-22-2014

    Description: C4 protein can physically interact with E3 ligase Herc2 and prevents BRCA1 degradation via ubiquitination pathway. Knockdown of TUSC4 expression enhanced BRCA1 polyubiquitination, leading to BRCA1 protein degradation and a marked reduction in HR repair efficiency. Notably, ectopic expression of TUSC4 effectively suppressed the proliferation, invasion, and colony formation of breast cancer cells in vitro and tumorigenesis in vivo. Furthermore, knockdown of TUSC4 expression transformed normal mammary epithelial cells and enhanced the sensitivity of U2OS cells to the treatment of poly(ADP-ribose) polymerase inhibitors. Therefore, TUSC4 may act as a bona fide tumor suppressor by regulating BRCA1 protein stability and function in breast cancer. Two groups of samples are included: 1.U2OS-shcontrol 2.U2OS-...

  15. Differential Gene Expression in Angelman syndrome deletion vs. int dup(15) Human Lymphocytes OmicsDI

    ID: E-GEOD-32563

    Date Released: 10-10-2014

    Description: for genes at the 15q locus like UBE3A, ATP10A and HERC2. A larger set of genes involved in chromatin remodeling, DNA repair and neurogenesis were found, at FAIRE peaks in AS deletion samples but had increased transcription in int dup(15) samples. There was a significant enhancement for genes with FOXP1 binding sites in the int dup(15) gene set and elevated FOXP1 protein could be detected in the nucleus of int dup(15) as compared to AS deletion cell lines. This analysis provides the first insights into transcriptional changes which may unveil new sets of genes and pathways contributing to both AS and autism pathogenesis. Gene expression was performed using 100ng of total RNA from each subject as starting material for amplification and cRNA synthesis in accordance Affymetrix protocols (http://tinyurl.com/3j7dcp6). Hybridizations were performed to the Affy HumanGene_st_v1 chip and the signal data normalized using internal chip controls. Normalized expression data was then exported to a text file for subsequent expression analysis using the EXPANDER software analysis suite....

  16. TUSC4 functions as a tumor suppressor by regulating BRCA1’s stability via the E3 ubiquitination pathway ArrayExpress

    ID: E-GEOD-60535

    Description: C4 protein can physically interact with E3 ligase Herc2 and prevents BRCA1 degradation via ubiquitination pathway. Knockdown of TUSC4 expression enhanced BRCA1 polyubiquitination, leading to BRCA1 protein degradation and a marked reduction in HR repair efficiency. Notably, ectopic expression of TUSC4 effectively suppressed the proliferation, invasion, and colony formation of breast cancer cells in vitro and tumorigenesis in vivo. Furthermore, knockdown of TUSC4 expression transformed normal mammary epithelial cells and enhanced the sensitivity of U2OS cells to the treatment of poly(ADP-ribose) polymerase inhibitors. Therefore, TUSC4 may act as a bona fide tumor suppressor by regulating BRCA1 protein stability and function in breast cancer. Two groups of samples are included: 1.U2OS-shcontrol 2.U2OS-...

  17. TUSC4 functions as a tumor suppressor by regulating BRCA1’s stability via the E3 ubiquitination pathway BioProject

    ID: PRJNA258497

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: C4 protein can physically interact with E3 ligase Herc2 and prevents BRCA1 degradation via ubiquitination pathway. Knockdown of TUSC4 expression enhanced BRCA1 polyubiquitination, leading to BRCA1 protein degradation and a marked reduction in HR repair efficiency. Notably, ectopic expression of TUSC4 effectively suppressed the proliferation, invasion, and colony formation of breast cancer cells in vitro and tumorigenesis in vivo. Furthermore, knockdown of TUSC4 expression transformed normal mammary epithelial cells and enhanced the sensitivity of U2OS cells to the treatment of poly(ADP-ribose) polymerase inhibitors. Therefore, TUSC4 may act as a bona fide tumor suppressor by regulating BRCA1 protein stability and function in breast cancer. Overall design: Two groups of samples are included: 1.U2OS-s...

Displaying 17 of 17 results for "HERC2"