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Displaying 20 of 31 results for "HAS2"
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  1. HYAS2_BOVIN UniProt:Swiss-Prot

    ID: O97711

    Description: Hyaluronan synthase 2 Cytoplasmic Helical; Name=1 Extracellular Helical; Name=2

  2. HYAS2_XENLA UniProt:Swiss-Prot

    ID: O57427

    Description: Hyaluronan synthase 2 Cytoplasmic Helical; Name=1 Extracellular Helical; Name=2

  3. HYAS2_RAT UniProt:Swiss-Prot

    ID: O35776

    Description: Hyaluronan synthase 2 Cytoplasmic Helical; Name=1 Extracellular Helical; Name=2

  4. alyzer : A Novel Unstable Duplication upstream of HAS2 predisposes to a Breed-defining Skin Phenotype and a Periodic Fever Syndrome in Chinese Shar-Pei Dogs... BioProject

    ID: PRJEB2448

    Keywords: Other

    Access Type: download

  5. Expression data from UMUC3 cells transduced with non-targeted shRNA and shRNA specific to AGL BioProject

    ID: PRJNA297052

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: dentified and validated that hyaluronic acid (HA) synthase 2 (HAS2) expression and subsequent HA synthesis is upregulated with AGL loss. We validated that HAS2 and consequent HA synthesis drive tumor growth and that genetic and pharmacologic inhibition of these respectively is a viable therapeutic option in xenograft models. We further established that bladder cancer patients with low AGL expression and high HAS2 expression have poor outcome. Together, this data provide preclinical evidence for personalized targeting of HAS2/HA signaling in patients with low AGL expres...
  6. Long noncoding RNA HAS2-AS1 mediates hypoxia-induced invasiveness of oral squamous cell carcinoma BioProject

    ID: PRJNA331169

    Access Type: download

  7. HYAS2_CHICK UniProt:Swiss-Prot

    ID: O57424

    Description: Hyaluronan synthase 2 Cytoplasmic Helical; Name=1 Extracellular Helical; Name=2

  8. HYAS2_HETGA UniProt:Swiss-Prot

    ID: G5AY81

    Description: Hyaluronan synthase 2 Cytoplasmic Helical; Name=1 Extracellular Helical; Name=2

  9. Long noncoding RNA HAS2-AS1 mediates hypoxia-induced invasiveness of oral squamous cell carcinoma ArrayExpress

    ID: E-GEOD-84807

    Description: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

  10. Hyaluronan and TLR4 Regulate Alveolar Stem Cell Renewal and Prevent Severe Pulmonary Fibrosis BioProject

    ID: PRJNA283423

    Keywords: Transcriptome or Gene expression

    Access Type: download

  11. Long noncoding RNA HAS2-AS1 mediates hypoxia-induced invasiveness of oral squamous cell carcinoma OmicsDI

    ID: E-GEOD-84807

    Date Released: 07-30-2016

    Description: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

  12. Novel gene expression profile of women with intrinsic skin youthfulness by transcriptome sequencing BioProject

    ID: PRJNA339576

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: rest are PHLDA1, a follicle stem cell marker, and HAS2-AS1, a non-coding gene. We demonstrate that immunologic gene sets are the most significantly altered in skin youthfulness,suggesting the immune system plays an important role in skin youthfulness, a finding that has notpreviously been recognized. Overall design: Identify genes associated with intrinsic skin youthfulness in healthy volunteers from sun protected skin....
  13. Dynamics of the Transcriptome in the Primate Ovulatory Follicle ArrayExpress

    ID: E-GEOD-22776

    Description: for EGF-like factors (AREG, EREG) and processes (HAS2, TNFAIP6) implicated in cumulus-oocyte maturation/expansion were also comparable between assays. Thus, several mRNAs displayed the expected expression pattern for purported theca (e.g., CYP17A, AREG), granulosa (CYP19A, FSHR), cumulus (HAS2, TNFAIP6) cell, and surface epithelium (HSD11B) related genes in the rodent/primate preovulatory follicle. This database will be of great value in analyzing molecular and cellular pathways associated with periovulatory events in the primate follicle (e.g. follicle rupture, luteinization, inflammatory response, and angiogenesis), and for identifying novel gene products controlling mammalian fertility. Keywords: time course Total RNA was prepared from individual follicles (n=4-8/timepoint). Dominant follicles were selected specific intervals (0, 12, 24, 36 hours) after exposure to an ovulatory (exogenous hCG) stimulus during the menstrual cycle....

  14. Comparative profiling of mRNA expression in human mesenchymal stem cells derived from adult adipose and lipoma tissues ArrayExpress

    ID: E-GEOD-12843

    Description: ls. The abundantly differentially expressed genes HAS2, VNN1, SLC16A6 and COL11A1 in LM6 cells were shown to be targets of miRNAs miR-99a and/or miR-152. Several additional genes were also found to be targets of miRNAs miR-99a and miR-152, as well as let-7g, let-7i, miR-199a, mir-134 and miR-374. The highly up-regulated expression of miRNA target genes such as SLC16A6, COL11A1 and TRHDE, as well as several other genes such as sushi domain containing 2, keratin associated proteins and tumor necrosis factor family, may explain the higher proliferation potential in LM6 cells compared with AM3 cells. Keywords: genetic modification The expression profiles of both mRNAs and miRNAs from the same RNA samples of AM3 and LM6 cells were determined and compared in order to understand the genetic bases for their similarities and differences....

  15. FAK and HAS3 inhibition affect the expression of several common genes ArrayExpress

    ID: E-GEOD-39168

    Description: Purpose: Focal adhesion kinase (FAK), hyaluronan (HA), and hyaluronan synthase-3 (HAS3) have been implicated in cancer growth and p...

  16. Dynamics of the Transcriptome in the Primate Ovulatory Follicle OmicsDI

    ID: E-GEOD-22776

    Date Released: 03-27-2012

    Description: for EGF-like factors (AREG, EREG) and processes (HAS2, TNFAIP6) implicated in cumulus-oocyte maturation/expansion were also comparable between assays. Thus, several mRNAs displayed the expected expression pattern for purported theca (e.g., CYP17A, AREG), granulosa (CYP19A, FSHR), cumulus (HAS2, TNFAIP6) cell, and surface epithelium (HSD11B) related genes in the rodent/primate preovulatory follicle. This database will be of great value in analyzing molecular and cellular pathways associated with periovulatory events in the primate follicle (e.g. follicle rupture, luteinization, inflammatory response, and angiogenesis), and for identifying novel gene products controlling mammalian fertility. Keywords: time course Total RNA was prepared from individual follicles (n=4-8/timepoint). Dominant follicles were selected specific intervals (0, 12, 24, 36 hours) after exposure to an ovulatory (exogenous hCG) stimulus during the menstrual cycle....

  17. RNAseq analysis of impact of PNN on gene expression and alternative splicing in corneal epithelial cells ArrayExpress

    ID: E-GEOD-73060

    Description: ration and ECM remodeling including: MMPs, ADAMs, HAS2, LAMA3, CXCRs and UNC5C. Genes down-regulated in response to PNN depletion included: IGFBP5. FGD3, FGFR2, PAX6, RARG and SOX10. AS events in PNN compared to controls was also more likely to be detected, and uregulated in PNN-knockdowns. In particular, 60% of exon skipping events detected in only one condition were detected in PNN-knockdowns and of the shared exon skipping events, 92% of those differentially expressed were more frequent in the PNN-knockdown. This suggests that in the absence of PNN the epithelial cells are dramatically transformed in the amount and composition of isoforms and that PNN plays a crucial role in the selection of which isoforms differentiating cells produce. Many of the genes affected by PNN-knockdown are known to affect epithelial phenotype. This window into the complexity of RNA splicing in the corneal epithelium implies that PNN exerts broad influence over the regulation and maintenance of epithelial cell phenotype. We used HCET cells that carry doxycycline-inducible PNN knockdown shRNA vector and performed RNA-seq to determine differential gene expression and differential alternative splicing events....

  18. Dynamics of the Transcriptome in the Primate Ovulatory Follicle BioProject

    ID: PRJNA128081

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: for EGF-like factors (AREG, EREG) and processes (HAS2, TNFAIP6) implicated in cumulus-oocyte maturation/expansion were also comparable between assays. Thus, several mRNAs displayed the expected expression pattern for purported theca (e.g., CYP17A, AREG), granulosa (CYP19A, FSHR), cumulus (HAS2, TNFAIP6) cell, and surface epithelium (HSD11B) related genes in the rodent/primate preovulatory follicle. This database will be of great value in analyzing molecular and cellular pathways associated with periovulatory events in the primate follicle (e.g. follicle rupture, luteinization, inflammatory response, and angiogenesis), and for identifying novel gene products controlling mammalian fertility. Keywords: time course Overall design: Total RNA was prepared from individual follicles (n=4-8/timepoint). Dominant follicles were selected specific intervals (0, 12, 24, 36 hours) after exposure to an ovulatory (exogenous hCG) stimulus during the menstrual cycle....
  19. Comparative profiling of mRNA expression in human mesenchymal stem cells derived from adult adipose and lipoma tissues BioProject

    ID: PRJNA111065

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: ls. The abundantly differentially expressed genes HAS2, VNN1, SLC16A6 and COL11A1 in LM6 cells were shown to be targets of miRNAs miR-99a and/or miR-152. Several additional genes were also found to be targets of miRNAs miR-99a and miR-152, as well as let-7g, let-7i, miR-199a, mir-134 and miR-374. The highly up-regulated expression of miRNA target genes such as SLC16A6, COL11A1 and TRHDE, as well as several other genes such as sushi domain containing 2, keratin associated proteins and tumor necrosis factor family, may explain the higher proliferation potential in LM6 cells compared with AM3 cells. Keywords: genetic modification Overall design: The expression profiles of both mRNAs and miRNAs from the same RNA samples of AM3 and LM6 cells were determined and compared in order to understand the genetic bases for their similarities and ...
  20. HYAS1_MOUSE UniProt:Swiss-Prot

    ID: Q61647

    Description: Hyaluronan synthase 1 Cytoplasmic Helical; Name=1 Extracellular Helical; Name=2 Cytoplasmic H...


Displaying 20 of 31 results for "HAS2"