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Displaying 20 of 226 results for "GZMH"
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  1. Crystal structure of human granzyme H with an inhibitor PDB

    ID: PDB:3TJU

    Description: Granzyme H (E.C.3.4.21.-), Ac-PTSY-CMK inhibitor

  2. Crystal structure of human granzyme H with a peptidyl substrate PDB

    ID: PDB:3TJV

    Description: Granzyme H (E.C.3.4.21.-), synthetic peptide (PTSYAGDDSG)

  3. Crystal structure of active human granzyme H PDB

    ID: PDB:4GAW

    Description: Granzyme H (E.C.3.4.21.-)

  4. Crystal structure of human granzyme H PDB

    ID: PDB:3TK9

    Description: Granzyme H (E.C.3.4.21.-)

  5. PARK4blood : BLOOD BIOMARKERS OF RISK FOR SYNUCLEINOPATHY, A VARIANT OF PARKINSON’S DISEASE BioProject

    ID: PRJEB8960

    Keywords: Other

    Access Type: download

    dataset.description: poproteins, endocytosis, lysosome, cytokine, toll like receptor signalling and extracellular pathways. In PARK4 platelets, stimulus-triggered degranulation was impaired. Strong SPP1, GZMH, and PLTP mRNA upregulations were validated in PARK4. Analysing prodromal stages of general PD, only blood CPLX1 levels were altered in cases with REM sleep behaviour disorder (RBD). Validation experiments confirmed an inverse mutual regulation of SNCA and CPLX1 mRNA levels. In the 3’-UTR of the CPLX1 gene we identified a SNP that is significantly associated with PD risk. In summary, our data provide functional insights into the role and regulation of blood alpha-synuclein levels. The novel blood biomarkers of synucleinopathy may become useful for PD prediction....
  6. Age-related profiling of DNA methylation in CD8+ T cells reveals changes in immune response and transcriptional regulator genes BioProject

    ID: PRJNA254323

    Keywords: Epigenomics

    Access Type: download

    dataset.description: ell mediated immune response (LGALS1, IFNG, CCL5, GZMH, CCR7, CD27 and CD248) and differentiation (SATB1, TCF7, BCL11B and RUNX3). Our results thus suggest the link between age-related epigenetic changes and impaired T cell function. Overall design: The study includes 101 individuals, 50 young and 51 old, no replicates. From each individual there are CD4 and CD8 T-cell and peripheral blood samples extracted. The total number of samples is 296, of which 99 have CD4 T -cell, 100 have CD8 T-cell and 97 have peripheral blood data....
  7. Coprinopsis cinerea transcriptome in response to hyphal damage, nematode predation or bacterial co-cultivation ArrayExpress

    ID: E-MTAB-2763

    Description: -positive transcriptome of vegetative mycelium of C. cinerea confronted with nematode predation, hyphal mechanical damage or bacterial co-culture....

  8. Identification of the glycan target of the nematotoxic fungal galectin CGL2 in Caenorhabditis elegans PDB

    ID: PDB:2WKK

    Description: GALECTIN-2

  9. Transcription profiling by array of two Caenorhabditis elegans dnj-14 mutant strains compared to two control strains, N2 (Bristol) wild-type and CZ120... ArrayExpress

    ID: E-MTAB-3147

    Description: Transcriptional profiling of two C. elegans mutants of dnj-14, the worm homolog of cysteine string protein (CSP), compared to ...

  10. Expression Profile Of A Caenorhabditis Elegans Model Of Adult Onset Neuronal Ceroid Lipofuscinosis Reveals Down Regulation Of Ubiquitin E3 Ligase Comp... OmicsDI

    ID: E-MTAB-3147

    Date Released: 12-08-2014

    Description: Transcriptional profiling of two C. elegans mutants of dnj-14, the worm homolog of cysteine string protein (CSP), compared to ...

  11. A mutation in the c-Fos gene associated with congenital generalized lipodystrophy ArrayExpress

    ID: E-GEOD-39825

    Description: ology or development and severe congenital forms (CGL) lack adipose tissue. The ubiquitous immediate-early gene c-fos is one essential transcription factor to initiate adipocyte differentiation. In a CGL...

  12. Coprinopsis cinerea transcriptome in response to hyphal damage, nematode predation or bacterial co-cultivation BioProject

    ID: PRJEB8091

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: -positive transcriptome of vegetative mycelium of C. cinerea confronted with nematode predation, hyphal mechanical damage or bacterial co-culture....
  13. Solution Structure of the non-phosphorylated N-terminal region of Human Cysteine String Protein (CSP) PDB

    ID: PDB:2N05

    Description: DnaJ homolog subfamily C member 5

  14. Solution Structure of the phosphorylated N-terminal region of Human Cysteine String Protein (CSP) PDB

    ID: PDB:2N04

    Description: DnaJ homolog subfamily C member 5

  15. Data from: A lectin-mediated resistance of higher fungi against predators and parasites Dryad

    DateIssued: 08-21-2015

    Description: o longer toxic but still led to food avoidance by C. elegans. Finally, we show, in an ecologically more relevant scenario, that challenging the vegetative mycelium of Coprinopsis cinerea with the fungal-feeding nematode Aphelenchus avenae induces the expression of the nematotoxic fruiting body lectins CGL1 and CGL2. Based on these findings, we propose that filamentous fungi possess an inducible resistance against predators and parasites mediated by lectins that are specific for glycans of these antagonists....

  16. Transcription profiling by array of human non anaplastic T-cell lymphoma biopsies and cell lines ArrayExpress

    ID: E-TABM-702

    Description: | Affymetrix HG-U133 Plus 2.0 : 7 NKTCL biopsies, 2 NKTCL cell lines (SNK6, SNT8), 16 PTCL NOS biopsies, 2 NK cells samples | Biopsies and cell lines of NK/T-cell lymphoma, nasal-type (NKTCL) were subject to combined gene expression profiling and array-based c...

  17. CcP gateless cavity PDB

    ID: PDB:4XV5

    Description: Cytochrome c Peroxidase (E.C.1.11.1.5)

  18. More than the sum of their parts: Metabolic crossfeeding and interkingdom communication in dual-species biofilms of Streptococcus mutans and Candida a... ArrayExpress

    ID: E-GEOD-52543

    Description: Both species formed biofilms in monoculture, with C. albicans growing mainly in the virulence-associated hyphae form, and S. mutans forming a thick layer of extracellular polymeric substances (EPS). Biofilm growth was enhanced in dual-species biofilms, which reached twice the biomass of monospecies biofilms and higher cell numbers of both S. mutans and C. albicans. EPS production by S. mutans was strongly suppressed in dual-species biofilm...

  19. Tissue-specific transcriptomics, chromosomal localization, and phylogeny of chemosensory and odorant binding proteins from the red flour beetle Tribol... OmicsDI

    ID: E-GEOD-63162

    Date Released: 03-12-2015

    Description: nnotated OBPs are transcribed. Only six of the 20 CSP are significantly transcriptionally enriched in the main chemosensory tissues (antenna and/or mouthparts), whereas of the OBPs all eight members of the antenna binding proteins II (ABPII) subgroup, 18 of the 20 classic OBP subgroup, the C+OBP, and only five of the 21 C-OBPs show increased chemosensory tissue expression. By MALDI-TOF-TOF MS protein fingerprinting, we confirmed three CSPs, four ABPIIs, three classic OBPs, and four C-OBPs in the antennae.Most of the classic OBPs and all ABPIIs are involved in chemoreception. A few are also present in other tissues like odoriferous glands and testes and may be involved in release or transfer of chemical signals. The majority of the CSPs as well as the <...

  20. Data from: Comparative genomics and transcriptomics in ants provide new insights into the evolution and function of odorant binding and chemosensory p... Dryad

    DateIssued: 08-27-2014

    Description: at CSPs have replaced OBPs in ant olfaction. Both protein families have several highly conserved clades with a single ortholog in all eusocial hymenopterans, as well as clades with more dynamic evolution and many taxon-specific radiations. The dynamically evolving OBPs and CSPs have been hypothesized to function in chemical communication. Intriguingly, we find that seven members of the conserved clades are expressed specifically in the antennae of the clonal raider ant Cerapachys biroi, whereas only one dynamically evolving CSP is antenna specific. The orthologs of the conserved, antenna-specific C. biroi genes are also expressed in antennae of the ants Camponotus floridanus and Harpegnathos saltator, indicatin...


Displaying 20 of 226 results for "GZMH"