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Displaying 18 of 18 results for "GZMA"
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  1. The Oligomeric Structure of Human Granzyme A Reveals the Molecular Determinants of Substrate Specificity PDB

    ID: PDB:1ORF

    Description: Granzyme A (EC=3.4.21.78), D-Phe,Pro,Arg chloromethyl ketone

    gene.name: GZMA
  2. A novel and divergent role of granzyme A and B in resistance to helminth infection BioProject

    ID: PRJNA118539

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: AxB and gzmB knock out (ko) mice, but enhanced in gzmA ko compared to wildtype (wt) mice. GzmA/B deficiency was associated with a defense-promoting Th2 cytokine and antibody shift and enhanced early inflammation gene expression, whereas gzmA deficiency was linked with alternatively activated macrophages and reduced inflammation. This suggests a novel and divergent role for gzms in helminth infection with gzmA contributing to resistance and gzmB promoting susceptibility. Keywords: knock out vs wild type Overall design: Two different knock out mice groups (Granzyme AxB KO and Granzyme A K...
  3. IL-27, PXN, CXCR4, GZMA, PRF1 and Foxp3 genes are differentially expressed in CD4+ T cells of HTLV-1-infected individuals ArrayExpress

    ID: E-GEOD-38537

    Description: T, HAC and HAM/TSP groups. The IL-27, PXN, CXCR4, GZMA, PRF1 and Foxp3 genes were differentially expressed between HAC and HAM/TSP groups and the frequency of CD4+Foxp3+ regulatory T cells (Treg) were higher in HTLV-1-infected individuals. These findings suggest that CD4+ T cells activity is distinct between HAC and HAM/TSP groups as expected. In order to study the transcriptional changes in CD4 T cell from HTLV-1-infected individuals, immunomagnetically purified CD4+ T-cells from the peripheral blood of 4 asymptomatic HTLV-1 carrier individuals (HAC) and 4 individuals with HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP), as well as from 4 healthy controls (CT) were isolated and processed the microarray assay according Agilent's protocol. The differential expressed genes, molecular characterization and networks analysis were evaluated using robust bioinformatic tools, then the real time PCR was done to validate the genes....

  4. IL-27, PXN, CXCR4, GZMA, PRF1 and Foxp3 genes are differentially expressed in CD4+ T cells of HTLV-1-infected individuals. BioProject

    ID: PRJNA168100

    Keywords: Transcriptome or Gene expression

    Access Type: download

  5. Crystal Structure of Human Granzyme A PDB

    ID: PDB:1OP8

    Description: Granzyme A (E.C.3.4.21.78)

  6. IL-27, PXN, CXCR4, GZMA, PRF1 and Foxp3 genes are differentially expressed in CD4+ T cells of HTLV-1-infected individuals. OmicsDI

    ID: E-GEOD-38537

    Date Released: 06-02-2014

    Description: T, HAC and HAM/TSP groups. The IL-27, PXN, CXCR4, GZMA, PRF1 and Foxp3 genes were differentially expressed between HAC and HAM/TSP groups and the frequency of CD4+Foxp3+ regulatory T cells (Treg) were higher in HTLV-1-infected individuals. These findings suggest that CD4+ T cells activity is distinct between HAC and HAM/TSP groups as expected. In order to study the transcriptional changes in CD4 T cell from HTLV-1-infected individuals, immunomagnetically purified CD4+ T-cells from the peripheral blood of 4 asymptomatic HTLV-1 carrier individuals (HAC) and 4 individuals with HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP), as well as from 4 healthy controls (CT) were isolated and processed the microarray assay according Agilent's protocol. The differential expressed genes, molecular characterization and networks analysis were evaluated using robust bioinformatic tools, then the real time PCR was done to validate the genes....

  7. GRAA_BOVIN UniProt:Swiss-Prot

    ID: Q7YRZ7

    Description: Activation peptide Granzyme A Peptidase S1 Charge relay system Charge relay system Charge relay system N-linked (GlcNAc...)

    gene.name: GZMA
  8. Active FOXO1 is a Key Determinant of Isoform-Specific Progesterone Receptor Transactivation and Senescence Programming BioProject

    ID: PRJNA285098

    Access Type: download

    dataset.description: d-dependent upregulation of the PR-B target genes GZMA, IGFBP1, and p21, and induced cellular senescence. In the presence of endogenous active FOXO1, PR-A was phosphorylated on Ser294 and transactivated PR-B at PR-B target genes; these events were blocked by the FOXO1 inhibitor (AS1842856). PR isoform-specific regulation of the FOXO1/p21 axis recapitulated in human primary ovarian tumor explants treated with progestin; loss of progestin sensitivity correlated with high AKT activity. IMPLICATIONS: This study indicates FOXO1 as a critical component for progesterone signaling to promote cellular senescence and reveals a novel mechanism for transcription factor control of hormone sensitivity. This SuperSeries is composed of the SubSeries listed below. Overall design: Refer to individual Series...
  9. Active FOXO1 is a Key Determinant of Isoform-Specific Progesterone Receptor Transactivation and Senescence Programming BioProject

    ID: PRJNA285100

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: d-dependent upregulation of the PR-B target genes GZMA, IGFBP1, and p21, and induced cellular senescence. In the presence of endogenous active FOXO1, PR-A was phosphorylated on Ser294 and transactivated PR-B at PR-B target genes; these events were blocked by the FOXO1 inhibitor (AS1842856). PR isoform-specific regulation of the FOXO1/p21 axis recapitulated in human primary ovarian tumor explants treated with progestin; loss of progestin sensitivity correlated with high AKT activity. IMPLICATIONS: This study indicates FOXO1 as a critical component for progesterone signaling to promote cellular senescence and reveals a novel mechanism for transcription factor control of hormone sensitivity. Overall design: The study contains 6 different sample groups measured in triplicate, for a total of 18 individual samples (18 arrays). From parental T47D-Y human breast cancer cell lines (that is a naturally occurring PR-null variant of T47D cells), we created two stable clones expressing either (1) the wild type progesterone receptor isoform A (pSG5-PR-A), or (2) the wild type progesterone receptor isoform B (pSG5-PR-B). These three cell lines were treated with either (1) vehicle control (ethanol) or (2) R5020 10e-8 M for 24 hours before total RNA harvest. Thus, the experiment contains three cell lines and two treatments (6 sample groups), treated and analyzed in triplicate (18 microarrays). Standard Illumina HumanHT-12 V4.0 chip controls were used during hybridization....
  10. Active FOXO1 is a Key Determinant of Isoform-Specific Progesterone Receptor Transactivation and Senescence Programming BioProject

    ID: PRJNA285101

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: d-dependent upregulation of the PR-B target genes GZMA, IGFBP1, and p21, and induced cellular senescence. In the presence of endogenous active FOXO1, PR-A was phosphorylated on Ser294 and transactivated PR-B at PR-B target genes; these events were blocked by the FOXO1 inhibitor (AS1842856). PR isoform-specific regulation of the FOXO1/p21 axis recapitulated in human primary ovarian tumor explants treated with progestin; loss of progestin sensitivity correlated with high AKT activity. IMPLICATIONS: This study indicates FOXO1 as a critical component for progesterone signaling to promote cellular senescence and reveals a novel mechanism for transcription factor control of hormone sensitivity. Overall design: The study contains 6 different sample groups measured in triplicate, for a total of 18 individual samples (18 arrays). From parental ES-2 human ovarian cancer cell lines, we created three stable clones expressing either (1) an empty vector pIRES-neo3, or (2) the wild type progesterone receptor isoform A (pIRES-neo3-PR-A), or (3) the wild type progesterone receptor isoform B (pIRES-neo3-PR-B). These three cell lines were treated with either (1) vehicle control (ethanol) or (2) R5020 10e-8 M for 24 hours before total RNA harvest. Thus, the experiment contains three cell lines and two treatments (6 sample groups), treated and analyzed in triplicate (18 microarrays). Standard Illumina HumanHT-12 V4.0 chip controls were used during hybridization....
  11. Transcriptional profiling of disease progression in bovine tuberculosis and the identification of potential diagnostic biomarkers ArrayExpress

    ID: E-GEOD-33058

    Description: The definition of biomarkers correlating with disease progression could have impact on the rational design of novel diagnostic approaches for bovine t...

  12. Transcription profiling of mouse splenocytes reveals immunodomination leads to selective expansion of the fittest CD8 T cells ArrayExpress

    ID: E-GEOD-2924

    Description: ofiles except for a few gene transcripts, such as Gzma, Sell, Il7r and Klrg1, that contribute to the fitness of effector CD8 T cells. The differences between HY- and H7a-specific CD8 T cells were validated by real-time PCR and flow cytometry analyses. We propose that, by leading to selective expansion of the fittest CD8 effector T cells, immunodominance may be beneficial to the host. Inhibition of T cell response to nondominant Ags would ensure that host resources (APCs, cytokines) for which T cells compete are devoted to T cells that have the best effector potential. One implication is that, in general, favouring expansion of the fittest effector T cells may be more important that increasing the diversity of the T cell repertoire. Experiment Overall Design: B10.H7b female mice were primed by i.p. injection of a cell mixture containing 2 x 107 B10 male splenocytes and 2 x 107 B10.H7b male splenocytes. On day 14 after priming,...

  13. Transcription profiling of mouse splenocytes reveals immunodomination leads to selective expansion of the fittest CD8 T cells OmicsDI

    ID: E-GEOD-2924

    Date Released: 06-10-2011

    Description: ofiles except for a few gene transcripts, such as Gzma, Sell, Il7r and Klrg1, that contribute to the fitness of effector CD8 T cells. The differences between HY- and H7a-specific CD8 T cells were validated by real-time PCR and flow cytometry analyses. We propose that, by leading to selective expansion of the fittest CD8 effector T cells, immunodominance may be beneficial to the host. Inhibition of T cell response to nondominant Ags would ensure that host resources (APCs, cytokines) for which T cells compete are devoted to T cells that have the best effector potential. One implication is that, in general, favouring expansion of the fittest effector T cells may be more important that increasing the diversity of the T cell repertoire. Experiment Overall Design: B10.H7b female mice were primed by i.p. injection of a cell mixture containing 2 x 107 B10 male splenocytes and 2 x 107 B10.H7b male splenocytes. On day 14 after priming,...

  14. Transcriptional profiling of disease progression in bovine tuberculosis and the identification of potential diagnostic biomarkers BioProject

    ID: PRJNA149543

    Keywords: Transcriptome or Gene expression

    Access Type: download

  15. Immunodomination leads to selective expansion of the fittest CD8 T cells BioProject

    ID: PRJNA92615

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: ofiles except for a few gene transcripts, such as Gzma, Sell, Il7r and Klrg1, that contribute to the fitness of effector CD8 T cells. The differences between HY- and H7a-specific CD8 T cells were validated by real-time PCR and flow cytometry analyses. We propose that, by leading to selective expansion of the fittest CD8 effector T cells, immunodominance may be beneficial to the host. Inhibition of T cell response to nondominant Ags would ensure that host resources (APCs, cytokines) for which T cells compete are devoted to T cells that have the best effector potential. One implication is that, in general, favouring expansion of the fittest effector T cells may be more important that increasing the diversity of the T cell repertoire. Keywords: comparative gene profile, cell type comparaison, H7a, HY Overall design: B10.H7b female mice were primed by i.p. injection of a cell mixture containing 2 x 107 B10 male splenocytes and 2 x...
  16. Transcriptional profiling of SIV-specific CXCR5+ and CXCR5- CD8+ lymphocytes in rhesus macaques infected with SIVmac251 and SIVE660 BioProject

    ID: PRJNA301407

    Keywords: Transcriptome or Gene expression

    Access Type: download

  17. Transcription profiling of human U-2 osteosarcoma cell lines expressing different glucocorticoid receptor isoforms - time series ArrayExpress

    ID: E-GEOD-6711

    Description: Glucocorticoids regulate diverse physiologic processes and synthetic derivatives of these natural hormones are widely used in the treatment of inflamm...

  18. Time course of glucocortiocid receptor isoforms BioProject

    ID: PRJNA99033

    Keywords: Transcriptome or Gene expression

    Access Type: download


Displaying 18 of 18 results for "GZMA"