GTPBP4 | bioCADDIE Data Discovery Index
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Displaying 20 of 159 results for "GTPBP4"
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  1. Molecular Insight into Thiopurine Resistance: Transcriptomic Signature in Lymphoblastoid Cell Lines BioProject

    ID: PRJNA262657

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: genes predicting thiopurine resistance, including GTPBP4, a GTP-binding protein which is a p53 interactor. Besides, among the differentially expressed genes between resistant and sensitive cell lines, gene ontology analysis highlights the involvement of RNA processes and cell cycle in thiopurine resistance. A comprehensive pathway analysis revealed the overexpression of the ATM/p53/p21 pathway, which is activated in response to DNA damage and resulting in a cell cycle arrest. Furthermore, an increased expression of TNFRSF10D, a p53 target gene, or CCNG2, a negative regulator of cell cycle, could result in a cell cycle arrest and have associated with resistance. Finally, ARHGDIA under-expression in resistant cell lines could constitute a novel molecular mechanism contributing to thiopurine resistance in relation thiopurine pharmacodynamics, based on Rac1 inhibition and apoptosis. Our study represents a step to...
  2. cDNA microarray analysis of sulforaphane effect on mouse acute lung injury caused by hyperoxia BioProject

    ID: PRJNA253109

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: cle and protein metabolism (Actr1a, Wasf2, Ccne1, Gtpbp4) after hyperoxia in Nrf2+/+ mice. Nrf2-dependently modulated lung genes by sulforaphane and hyperoxia were associated with tissue development and hereditary disorders (Slc25a3, Pccb, Psmc3ip). Results demonstrate preventive roles of sulforaphane against oxidant lung injury in mice, and reveal potential downstream mechanisms. Our observations also suggest Nrf2-independent mechanisms of sulforaphane in prevention of acute lung injury. Overall design: Nrf 2 knockout and wild-type mice were dosed with 9 uM R-Sulforaphane before their continuous exposure to air (21% O2) or hyperoxia (100% O2) for 3 days in a whole-body inhalation chamber...
  3. Structure of apo BipA PDB

    ID: PDB:5A9V

    Description: GTP-BINDING PROTEIN

  4. Structure of Rheb-Y35A mutant in GDP- and GMPPNP-bound forms PDB

    ID: PDB:3SEA

    Description: GTP-binding protein Rheb

  5. Crystal Structure of the GTP-binding protein YsxC complexed with GDP PDB

    ID: PDB:1SVI

    Description: GTP-binding protein YsxC

  6. Structure of GDP bound BipA PDB

    ID: PDB:5A9X

    Description: GTP-BINDING PROTEIN

  7. Crystal structure of a GTP-binding protein from the hyperthermophilic archaeon Sulfolobus solfataricus in complex with GDP PDB

    ID: PDB:2QTH

    Description: GTP-binding protein

  8. Crystal structure of N-terminal GTP-binding domain of EngA from Thermus thermophilus HB8 PDB

    ID: PDB:2DYK

    Description: GTP-binding protein

  9. Crystal structure of Ypt31 in complex with yeast Rab-GDI PDB

    ID: PDB:3CPJ

    Description: Rab GDP-dissociation inhibitor, GTP-binding protein YPT31/YPT8

  10. Interaction of ERA,a GTPase protein, with the 3'minor domain of the 16S rRNA within the THERMUS THERMOPHILUS 30S subunit. PDB

    ID: PDB:1X1L

    Description: GTP-binding protein era/RNA Complex

  11. The crystal structure of the B. subtilis YphC GTPase in complex with GDP PDB

    ID: PDB:2HJG

    Description: GTP-binding protein engA

  12. Structure of GTP-Bound Rab4Q67L GTPase in complex with the central Rab binding domain of Rabenosyn-5 PDB

    ID: PDB:1Z0K

    Description: GTP-binding protein, FYVE-finger-containing Rab5 effector protein rabenosyn-5

  13. Cdc42 complexed with the GTPase binding domain of p21 activated kinase PDB

    ID: PDB:1E0A

    Description: G25K GTP-BINDING PROTEIN, PLACENTAL ISOFORM (GP), CDC42 HOMOLOG, SERINE/THREONINE-PROTEIN KINASE PAK-ALPHA (E.C.2.7.1.-)

  14. crystal structure of SsGBP and GDP complex PDB

    ID: PDB:3KXI

    Description: GTP-binding protein (HflX)

  15. Structure of Cdc42 in a complex with the GTPase-binding domain of the cell polarity protein, Par6 PDB

    ID: PDB:1NF3

    Description: G25K GTP-binding protein, placental isoform, PAR-6B, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER

  16. THE CRYSTAL STRUCTURE OF THE CORE DOMAIN OF RHOE/RND3 - A CONSTITUTIVELY ACTIVATED SMALL G PROTEIN PDB

    ID: PDB:1GWN

    Description: RHO-RELATED GTP-BINDING PROTEIN RHOE

  17. Structure of small GTPase human Rheb in complex with GDP PDB

    ID: PDB:1XTQ

    Description: GTP-binding protein Rheb

  18. MECHANISM OF MULTI-SITE PHOSPHORYLATION FROM A ROCK-I:RHOE COMPLEX STRUCTURE PDB

    ID: PDB:2V55

    Description: RHO-ASSOCIATED PROTEIN KINASE 1 (E.C.2.7.11.1), RHO-RELATED GTP-BINDING PROTEIN RHOE

  19. SOLUTION STRUCTURE OF CDC42HS COMPLEXED WITH A PEPTIDE DERIVED FROM P-21 ACTIVATED KINASE, NMR, 20 STRUCTURES PDB

    ID: PDB:1EES

    Description: GTP-BINDING PROTEIN/P21-ACTIVATED KINASE

  20. Crystal structure of GTP-bound LepA from Aquifex aeolicus PDB

    ID: PDB:2YWG

    Description: GTP-binding protein LepA


Displaying 20 of 159 results for "GTPBP4"