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Displaying 8 of 8 results for "GSTA4"
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  1. Transcription profiling of lung from mouse exposed to carbonyl chloride (phosgene) for different lengths of time to investigate the molecular mechanis... ArrayExpress

    ID: E-GEOD-2565

    Description: ted from air- or phosgene-exposed mice at 0.5, 1, 4, 8, 12, 24, 48, and 72 hr post-exposure. RNA was extracted from the lung and used as starting material for the probing of oligonucleotide microarrays to determine changes in gene expression following phosgene exposure. The data were analyzed using principal component analysis (PCA) to determine the greatest sources of data variability. A three-way analysis of variance (ANOVA) based on exposure, time, and sample was performed to identify the genes most significantly changed as a result of phosgene exposure. These genes were rank ordered by p-values and categorized based on molecular function and biological process. Some of the most significant changes in gene expression reflect changes in gl

  2. Phosgene exposure in the mouse lung GEMMA

    ID: 1507

    Keywords: functional genomics

    Description: ted from air- or phosgene-exposed mice at 0.5, 1, 4, 8, 12, 24, 48, and 72 hr post-exposure. RNA was extracted from the lung and used as starting material for the probing of oligonucleotide microarrays to determine changes in gene expression following phosgene exposure. The data were analyzed using principal component analysis (PCA) to determine the greatest sources of data variability. A three-way analysis of variance (ANOVA) based on exposure, time, and sample was performed to identify the genes most significantly changed as a result of phosgene exposure. These genes were rank ordered by p-values and categorized based on molecular function and biological process. Some of the most significant changes in gene expression reflect changes in gl

  3. Transcription profiling of mouse MC3T3-E1 preosteoblasts with HDIs (trichostatin A, MS-275, or valproic acid) or the vehicle control (DMSO) for 18 hou... ArrayExpress

    ID: E-GEOD-9247

    Description: tol dehydrogenase 1, a kinase anchor protein, and glutathione S-transferase alpha 4) were induced. Two genes (proteasome subunit, beta type 10 and adaptor-related protein complex AP-4 sigma 1) were suppressed. We also identified eight growth factors and growth factor receptor genes that are significantly altered by each of the HDIs, including Frizzled related proteins 1 and 4, which modulate the Wnt signaling pathway. Conclusions: This study identifies osteoblast genes that are regulated early by HDIs and indicates pathways that might promote osteoblast maturation following HDI exposure. One gene whose upregulation following HDI treatment is consistent with this notion is Slc9a3r1. Also known as NHERF1, Slc9a3r1 is required for optimal bone density. Similarly, the regulation of Wnt receptor genes indicates that this crucial pathway in osteoblast development is also affected by HDIs. These data support the hypothesis that HDIs regulate the expression of genes that promote osteoblast differentiation and maturation. Experiment Overall Design: To identify other osteoblast genes that are altered early by HDIs, we incubated MC3T3-E1 preosteoblasts with HDIs (trichostatin A, MS-275, or valproic acid) or the vehicle control (DMSO) for 18 hours in osteogenic conditions. Gene expression profiles relative to vehicle-treated cells were assessed in triplicate (in some cases quadruplicate) samples by microarray analysis with Affymetrix GeneChip 430 2.0 arrays....

  4. Expression differences between worker(female) and drone(male) honey bee antennae BioProject

    ID: PRJNA101639

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: 10 gustatory receptors; 10 carboxyl esterases; 7 glutathione S transferases; 6 chemosensory proteins (sensory appendage proteins); 5 lipocalins; 5 visual and non-visual opsins; 4 alpha-arrestins; 4 arrestins; 3 G-protein alpha subunits; 1 Pinocchio ortholog (a Drosophila melanogaster sensory-related protein); 1 sensory neuron membrane protein, and 4 housekeeping genes (cytoplasmic actin, EF1alpha, ribosomal protein 49, ribosomal protein S3), for a total of 313 genes. ArrayControl sense 70-mer oligonucleotides (Ambion) were printed as negative control spots. Four microarray hybridizations (replicates) were performed using mature drone antennal total RNA versus worker ant...
  5. Phosgene exposure in the mouse lung BioProject

    ID: PRJNA91969

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: ted from air- or phosgene-exposed mice at 0.5, 1, 4, 8, 12, 24, 48, and 72 hr post-exposure. RNA was extracted from the lung and used as starting material for the probing of oligonucleotide microarrays to determine changes in gene expression following phosgene exposure. The data were analyzed using principal component analysis (PCA) to determine the greatest sources of data variability. A three-way analysis of variance (ANOVA) based on exposure, time, and sample was performed to identify the genes most significantly changed as a result of phosgene exposure. These genes were rank ordered by p-values and categorized based on molecular function and biological process. Some of the most significant changes in gene expression reflect changes in gl
  6. Comparison of Differences in Gene Expression in the Ventral Tegmental Area of 5 Pairs of Rat Lines Selectively Bred for High or Low Alcohol Consumptio... ArrayExpress

    ID: E-GEOD-31695

    Description: irection) in at least 3 line-pairs, e.g., Crebl2, Gsta4, Itga9 & Itg2. In conclusion, the findings suggest that (a) different innate mechanisms may be contributing to vulnerability to high alcohol drinking behavior among the selectively bred lines, and (b) small contributions in expression of multiple genes within certain transmitter systems and intracellular signaling pathways may contribute to the disparate alcohol drinking characteristics of the 5 line-pairs. Comparison of Differences in Gene Expression in the Ventral Tegmental Area of 5 Pairs of Rat Lines Selectively Bred for High or Low Alcohol Consumption....

  7. Glutathione transferase A3-3 in complex with glutathione and delta-4- androstene-3-17-dione PDB

    ID: PDB:2VCV

    Description: GLUTATHIONE S-TRANSFERASE A3 (E.C.2.5.1.18)

  8. GLUTATHIONE TRANSFERASE A1-1 IN UNLIGANDED FORM PDB

    ID: PDB:1GSD

    Description: GLUTATHIONE TRANSFERASE A1-1


Displaying 8 of 8 results for "GSTA4"