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Displaying 20 of 82 results for "GRB10"
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  1. Crystal structure of the SH2 domain of Grb10 PDB

    ID: PDB:1NRV

    Description: Growth factor receptor-bound protein 10

  2. Crystal structure of the Nedd4 C2/Grb10 SH2 complex PDB

    ID: PDB:3M7F

    Description: peptide, E3 ubiquitin-protein ligase NEDD4 (E.C.6.3.2.-), Growth factor receptor-

  3. Crystal Structure of the RA and PH Domains of Grb10 PDB

    ID: PDB:3HK0

    Description: Growth factor receptor-bound protein 10

  4. GRB10_RAT UniProt:Swiss-Prot

    ID: P0CE43

    Description: Growth factor receptor-bound protein 10

  5. Data from: Monoallelic loss of the imprinted gene Grb10 promotes tumor formation in irradiated Nf1+/- mice Dryad

    DateIssued: 08-18-2015

    Description: allele is sufficient to produce complete loss of protein expression. Genetic alterations are common in tumorigenesis but the role of imprinted genes in this process is not well understood. In earlier work we mutagenized mice heterozygous for the Neurofibromatosis I tumor suppressor ge...

  6. Grb10 sequence data Dryad

    DateIssued: 08-18-2015

    Description: This file contains Grb10 exomic sequences from tumors described in the manuscript.

  7. Regulation of Vascular Smooth Muscle Cell Dysfunction Under Diabetic Conditions By miRNA-504 BioProject

    ID: PRJNA300647

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: at miR-504 targets, including a signaling adaptor Grb10 and a transcription factor Egr2, could regulate growth factor signaling. We experimentally verified that miR-504 targets Grb10 and Egr2, and it enhanced ERK1/2 activation, proliferation and migration in VSMC. Silencing Grb10 by small interfering RNA also enhanced ERK1/2 activation, inflammatory gene expression and migration. Whereas, Egr2 silencing downregulated anti-inflammatory SOCS1 and increased inflammatory genes. Furthermore, treatment with high-glucose and palmitic acid upregulated miR-504, inhibited Grb10 and enhanced inflammatory genes in VSMC. Diabetes mis-regulates expression of several miRNAs including miR-504 involved in VSMC functions. Changes in miRNAs are sustained in non-diabetic conditions suggesting involvement of miRNA dependent mechanisms in metabolic memory implicated in vascular complications. Targeting such mechani...
  8. GRB14_BOVIN UniProt:Swiss-Prot

    ID: Q5ICW4

    Description: Removed Growth factor receptor-bound protein 14 Ras-associating...

  9. EH001: Lmx1a is an activator of Rgs4 and Gbr10 and is responsible for the correct specification of rostral and medial mdDA neurons ArrayExpress

    ID: E-GEOD-39174

    Description: The LIM homeodomain transcription factor Lmx1a is a very potential inducer of stem cells towards dopaminergic neurons. Despite several studies on the function of thi...

  10. Characterization of the Imprinting Signature of Mouse Embryo Fibroblasts by RNA Deep Sequencing ArrayExpress

    ID: E-GEOD-49538

    Description: ernal allele-specific transcription downstream of Grb10 and downstream of Meg3, Rtl1as and Rian in the Dlk1-Dio3 cluster, an imprinted domain implicated in development. We detected paternal allele-specific transcription downstream of Nespas, Peg3, Peg12 and Snurf/Snrpn. These imprinted transcript extensions were not unique to MEFs, but were also present in other somatic cells. Their 5’ end points did not carry opposing chromatin marks or parental allele-specific DNA methylation, suggesting that their parental allele-specific transcription is under the control of the extended genes. Based on the imprinting signature of MEFs, they provide valid models for understanding the biochemical aspects of genomic imprinting. Strand-specific and parental allele-specific RNA-seq was done in female mouse embryo fibroblasts....

  11. Janthinobacterium lividum strain:MEG1 : Janthinobacterium lividum MEG1 genome sequencing project BioProject

    ID: PRJNA284195

    Keywords: Genome sequencing and assembly

    Access Type: download

  12. Immunity to Grb10, a signal transduction molecule, inhibits the growth of breast cancer in mice. BioProject

    ID: PRJNA108273

    Keywords: Transcriptome or Gene expression

    Access Type: download

  13. Characterization of the Imprinting Signature of Mouse Embryo Fibroblasts by RNA Deep Sequencing BioProject

    ID: PRJNA214195

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: ernal allele-specific transcription downstream of Grb10 and downstream of Meg3, Rtl1as and Rian in the Dlk1-Dio3 cluster, an imprinted domain implicated in development. We detected paternal allele-specific transcription downstream of Nespas, Peg3, Peg12 and Snurf/Snrpn. These imprinted transcript extensions were not unique to MEFs, but were also present in other somatic cells. Their 5’ end points did not carry opposing chromatin marks or parental allele-specific DNA methylation, suggesting that their parental allele-specific transcription is under the control of the extended genes. Based on the imprinting signature of MEFs, they provide valid models for understanding the biochemical aspects of genomic imprinting. Overall design: Strand-specific and parental allele-specific RNA-seq was done in female mouse embryo fibroblasts....
  14. EH001: Lmx1a is an activator of Rgs4 and Gbr10 and is responsible for the correct specification of rostral and medial mdDA neurons BioProject

    ID: PRJNA170140

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: The LIM homeodomain transcription factor Lmx1a is a very potential inducer of stem cells towards dopaminergic neurons. Despite several studies on the function of thi...
  15. NMR structure of growth factor receptor binding protein SH2 domain complexed with the inhibitor PDB

    ID: PDB:1X0N

    Description: Growth factor receptor-bound protein 2

  16. Solution structure of the human Grb7-SH2 domain in complex with a 10 amino acid peptide pY1139 PDB

    ID: PDB:1MW4

    Description: Growth factor receptor-bound protein 7/

  17. Water refined solution structure of the human Grb7-SH2 domain in complex with the 10 amino acid peptide pY1139 PDB

    ID: PDB:2L4K

    Description: Growth factor receptor-bound protein 7,

  18. Gopher IRBP NJ tree Dryad

    DateIssued: 07-08-2015

  19. Crystal structures of a high-affinity macrocyclic peptide mimetic in complex with the Grb2 SH2 domain PDB

    ID: PDB:2AOB

    Description: Growth factor receptor-bound protein 2

  20. Crystal structures of a high-affinity macrocyclic peptide mimetic in complex with the Grb2 SH2 domain PDB

    ID: PDB:2AOA

    Description: Growth factor receptor-bound protein 2


Displaying 20 of 82 results for "GRB10"