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Displaying 20 of 9,751 results for "GPNMB"
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  1. GPNMB_RAT UniProt:Swiss-Prot

    ID: Q6P7C7

    Description: Transmembrane glycoprotein NMB Extracellular Helical Cytoplasmic PKD Cell attachment site Pho...

  2. Neisseria meningitidis NMB : Neisseria meningitidis NMB Genome sequencing and assembly BioProject

    ID: PRJNA158391

    Keywords: Genome sequencing and assembly

    Access Type: download

  3. Generation and functional characterization of MDSC-like cells BioProject

    ID: PRJNA358618

    Keywords: Transcriptome or Gene expression

    Access Type: download

  4. Elevated gpNMB in type 1 Gaucher disease patients OmicsDI

    ID: PXD001598

    Date Released: 01-01-1000

    Description: expression of several proteins amongst which was gpNMB. This was confirmed by histochemistry and RNA quantification. Macrophages produce gpNMB as membrane protein but release soluble fragments. In plasma of symptomatic Gaucher patients (n=59) soluble gpNMB was next found to be on average 25-fold increased prior to treatment, without overlap with control values, (control mean: 20 ng/ml; range 11-34 ng/ml vs. GD mean: 495 ng/ml; range: 137-1283 ng/ml)....

  5. Identification of a biomarker in cerebrospinal fluid for neuronopathic forms of Gaucher disease OmicsDI

    ID: PXD001654

    Date Released: 06-24-2016

    Description: ral nervous system involvement. We now identify a protein, glycoprotein non-metastatic B (GPNMB), that acts as an authentic marker of brain pathology in neurological forms of Gaucher disease. Using three independent techniques, including quantitative global proteomic analysis of cerebrospinal fluid (CSF) in samples from Gaucher disease patients that display neurolo...

  6. RNA-seq analysis of RNA from DBA/2J retinal ganglion cells BioProject

    ID: PRJNA355294

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: nglion cells and control (age and sex-matched, D2-Gpnmb+) retinal ganglion cells Overall design: Retinal ganglion cell mRNA from 4 month (young) and 9 month (pre-glaucomatous) DBA/2J mice and age and sex-matched D2-Gpnmb+ contro...
  7. Gene expression profile of extraskeletal myxoid chondrosarcoma ArrayExpress

    ID: E-GEOD-4303

    Description: omas with 0.25% likelihood of false significance. NMB, DKK1, DNER, CLCN3, and DEF6 were the top five genes in this analysis. In situ hybridization for NMB gene expression on tissue microarrays (TMAs) containing a total of 1164 specimens representing 62 different sarcoma types and 15 different carcinoma types showed that NMB was highly expressed in 17 of 22 EMC cases and very rarely expressed in other tumours and thus could function as a novel diagnostic marker. High levels of expression of PPARG and the gene encoding its interacting protein, PPARGC1A, in most EMCs suggest activation of lipid metabolism pathways in this tumour. Small molecule inhibitors for PPARG exist and PPARG could be a potential therapeutic target for EMC. An all pairs experiment design type is where all labeled extracts are compared to every other labeled extract. Computed...

  8. Trans. Profiling of Immortalized Melanocyte Cell Lines Identifies GPNMB as a Melanoblast-Expressed, MITF-Dependent Gene OmicsDI

    ID: E-GEOD-10163

    Date Released: 05-01-2014

    Description: e of melan-Ink4a-b cells to endoplasmic reticulum protein-folding impairment. Additionally, a set of loci was identified that are expressed in a similar manner to known melanocyte genes. Importantly, the collection of 254 genes is enriched for expression in the multiple melanocyte lines relative to control cell populations. This set contains Tyr, Tyrp1, Dct, Si, Melna, Slc24a5, Slc45a2, Slc24a4, Mitf, and Sox10, in addition to genes not previously attributed to pigmentation and genes with unknown function. Further evaluation of one gene in this cohort, Gpnmb, demonstrated an expression pattern simil...

  9. Trans. Profiling of Immortalized Melanocyte Cell Lines Identifies GPNMB as a Melanoblast-Expressed, MITF-Dependent Gene BioProject

    ID: PRJNA108359

    Keywords: Transcriptome or Gene expression

    Access Type: download

  10. Trans. Profiling of Immortalized Melanocyte Cell Lines Identifies GPNMB as a Melanoblast-Expressed, MITF-Dependent Gene ArrayExpress

    ID: E-GEOD-10163

    Description: e of melan-Ink4a-b cells to endoplasmic reticulum protein-folding impairment. Additionally, a set of loci was identified that are expressed in a similar manner to known melanocyte genes. Importantly, the collection of 254 genes is enriched for expression in the multiple melanocyte lines relative to control cell populations. This set contains Tyr, Tyrp1, Dct, Si, Melna, Slc24a5, Slc45a2, Slc24a4, Mitf, and Sox10, in addition to genes not previously attributed to pigmentation and genes with unknown function. Further evaluation of one gene in this cohort, Gpnmb, demonstrated an expression pattern simil...

  11. Genome-wide analysis of ex vivo gene expression of tumour pericytes and tumour endothelial cells obtained from 67NR mouse primary tumors ArrayExpress

    ID: E-GEOD-84008

    Description: mour angiogenesis. Endosialin (CD248) is a type I transmembrane glycoprotein highly expressed on pericytes in the tumour vasculature of most solid tumours, however it is low or negligibly expressed on normal tissue pericytes. Experiments using wild-type an...

  12. CONTRIBUTION OF A BURIED HYDROGEN BOND TO HIV-1 ENVELOPE GLYCOPROTEIN STRUCTURE AND FUNCTION PDB

    ID: PDB:1F23

    Description: TRANSMEMBRANE GLYCOPROTEIN

  13. CRYSTAL STRUCTURE OF THE HIV-1 NEUTRALIZING ANTIBODY D5 FAB BOUND TO THE GP41 INNER-CORE MIMETIC 5-HELIX PDB

    ID: PDB:2CMR

    Description: TRANSMEMBRANE GLYCOPROTEIN, D5

  14. Elevated gpNMB in type 1 Gaucher disease patients ProteomeXchange

    ID: PXD001598

    Instrument: Synapt MS

    Date Released: 09-27-2016

  15. Crystal structure of hiv-1 neutralizing human fab 4e10 in complex with a 16-residue peptide encompassing the 4e10 epitope on gp41 PDB

    ID: PDB:2FX7

    Description: pe polyprotein GP160 [Contains: Exterior membrane glycoprotein (GP120); Transmembrane glycoprotein (GP41)]...

  16. NMR Solution Structure of the Trp-Rich Peptide of HIV gp41 Bound to DPC Micelles PDB

    ID: PDB:1JAU

    Description: TRANSMEMBRANE GLYCOPROTEIN (GP41)

  17. Crystal Structure of the broadly neutralizing anti-HIV-1 antibody 2F5 in complex with a gp41 7mer epitope PDB

    ID: PDB:1TJG

    Description: tein GP160 precursor [Contains: Exterior membrane glycoprotein (GP120); Transmembrane glycoprotein (GP41)]...

  18. HIV-1 GP41 CORE PDB

    ID: PDB:1I5Y

    Description: TRANSMEMBRANE GLYCOPROTEIN (GP41)

  19. Gene expression profile of extraskeletal myxoid chondrosarcoma. BioProject

    ID: PRJNA94685

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: omas with 0.25% likelihood of false significance. NMB, DKK1, DNER, CLCN3, and DEF6 were the top five genes in this analysis. In situ hybridization for NMB gene expression on tissue microarrays (TMAs) containing a total of 1164 specimens representing 62 different sarcoma types and 15 different carcinoma types showed that NMB was highly expressed in 17 of 22 EMC cases and very rarely expressed in other tumours and thus could function as a novel diagnostic marker. High levels of expression of PPARG and the gene encoding its interacting protein, PPARGC1A, in most EMCs suggest activation of lipid metabolism pathways in this tumour. Small molecule inhibitors for PPARG exist and PPARG could be a potential therapeutic target for EMC. An all pairs experiment design type is where all labeled extracts are compared to every other labeled extract. Keywords: all_pairs Overall design: Computed...
  20. Gene Expression profiling in DBA/2J glaucoma BioProject

    ID: PRJNA156985

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: f gene expression changes was performed in DBA/2J-Gpnmb+, DBA/2J mice and irradiated DBA/2J mice at 8.5 and 10.5 months of age. Overall design: In this study (Howell et al, JCI, 2012), 50 samples (10 D2-Gpnmb+ control at 8.5 mos, 20 NOE DBA/2J at 8.5 mos, 10 radiation-treated DBA2J at 8.5 mos and 10 radiation-treated DBA/2J at 10.5 mos) were combined with 30 of ONH samples from the GSE26299 study (10 D2-Gpnmb+ and 20 NOE DBA/2J all at 10.5 mos). One D2-Gpnmb+ 8.5mo sample failed QC and was not included in the analysis. Quantile normalization was performed for all optic nerve head samples reported in the study. The complete dataset is linked below as a supplementary file....

Displaying 20 of 9,751 results for "GPNMB"