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Displaying 20 of 21 results for "GPATCH2"
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  1. GPT11_BOVIN UniProt:Swiss-Prot

    ID: Q2KI19

    Description: G patch domain-containing protein 11 G

  2. GPKOW_CAEEL UniProt:Swiss-Prot

    ID: Q21924

    Description: G patch domain and KOW motifs-containing protein homolo...

  3. SUGP1_RAT UniProt:Swiss-Prot

    ID: Q68FU8

    Description: SURP and G-patch domain-containing protein 1 ...

  4. GPKOW_XENLA UniProt:Swiss-Prot

    ID: Q6NU07

    Description: G patch domain and KOW motifs-containing protein

  5. The yeast PP2A-CDC55 phosphatase regulates the transcriptional response to hyperosmolarity stress by regulating Msn2 and Msn4 [Time course 1] BioProject

    ID: PRJNA168218

    Keywords: Transcriptome or Gene expression

    Access Type: download

  6. Crystal structure of the zinc finger of ZGPAT PDB

    ID: PDB:4II1

    Description: Zinc finger CCCH-type with G patch domain-containing protein...

  7. The yeast PP2A-CDC55 phosphatase regulates the transcriptional response to hyperosmolarity stress by regulating Msn2 and Msn4 ArrayExpress

    ID: E-GEOD-38565

    Description: The yeast PP2A-Cdc55 Serine/Threonine phosphatase regulates transcription under certain conditions. It is required for full activation of the environmental stress respon...

  8. The yeast PP2A-CDC55 phosphatase regulates the transcriptional response to hyperosmolarity stress by regulating Msn2 and Msn4 [Time course 2] ArrayExpress

    ID: E-GEOD-42033

    Description: The yeast PP2A-Cdc55 Serine/Threonine phosphatase regulates transcription under certain conditions. It is required for full activation of the environmental stress respon...

  9. Involuted normal mammary gland in WAP-SV40 transgenic mice [gene expression] ArrayExpress

    ID: E-GEOD-33038

    Description: P2A-controlled mitogenic pathways in human breast cancer. In primiparous mice, WAP-promoter driven expression of SV40 proteins induces well and poorly differentiated mammary adenocarcinomas. We performed a correlative aCGH and gene expression analysis of 25 monofocal tumors, representing four histopathological grades, to explore the molecular traits of SV40-induced mammary tumors and to emphasize the rele...

  10. Sustained L-type Calcium Channel Blockade Alters Gene Regulation in the Adult Mouse Ventricle ArrayExpress

    ID: E-GEOD-8367

    Description: ng suggested no change in PKA, but it showed that protein phosphatase 2A (PP2A) mRNA increased, and immunoblots demonstrated that PP2Ac-alpha protein was significantly increased by sustained CCB. Consistent with elevated PP2Ac-alpha protein expression LTCC exhibited decreased phosphorylation of the C-terminal Ser1928 PKA substrate site. Conclusions: We conclude that sustained CCB elicits a spectrum of transcriptional events, including compensatory up-regulation of LTCC and PP2Ac-alpha. Although this study is restricted to mouse, these results suggest the new hypothesis that clinically-relevant sustained LTCC blockade in humans results in changes in gene regulation in the heart. Keywords: L-type calcium channel, calcium channel blockade, verapamil Female and male ICR mice (12-14 weeks age) weighing between 25 and 30 grams were anesthetized with a ketamine/xylazine mixture ( i.p.) allowing the subcutaneous implantation of miniosmotic pumps (Alzet, model 2001). The pumps were filled with either verapamil or vehicle (0.02% ascorbic acid). Control animals carried mini-pumps with vehicle and control animals were investigated in parallel with each set of experimental animals. Mini pumps delivered verapamil at 3.6 mg/kg/...

  11. Microarray-based CGH in human cancer cell lines ArrayExpress

    ID: E-GEOD-16

    Description: cubated them overnight at 55 C in a 3 ml solution containing 0.01 M Tris, pH 7.5, 0.001 M EDTA, pH 8, 0.5% SDS and 0.1 g/l proteinase K. We added 1 ml of saturated NaCl solution and 10 ml of ethanol to the cell lysate and collected the DNA by spooling. We removed excess liquid and then dissolved the DNA in 1 ml of H2O. We isolated DNA from breast tumor specimens as described previously. We labeled DNA by nick translation or random priming. For nick translation, we used a 400 l reaction containing 10 g DNA, 50 mM Tris, pH 7.6, 5 mM MgCl2, 0.02 mM each dATP, dTTP and dGTP, 0.2 mM Cy3- or Cy5-dCTP (Amersham), 0.2 U DNA Polymerase I (Gibco BRL), and 30 l DNAseI/PolI enzyme mix (Gibco BRL). We incubated the reaction at 15 C for 60 min after which we stopped the reaction by incubation at 70 C for 10 min. We removed unincorporated nucleotides using a Sephadex G-50 spin column. We la...

  12. Transcriptional networks regulated by drugs of abuse in mouse striatum ArrayExpress

    ID: E-GEOD-15774

    Description: dynamically inducible transcriptional networks: (1) CREB/SRF-dependent gene pattern that appears to be related to drug-induced neuronal activity, (2) the pattern of genes controlled at least in part via release of glucocorticoids and androgens that are associated with rewarding and harmful drug effects. The discovery of co-expressed networks of genes allowed for the identif...

  13. Microarray-based CGH in human cancer cell lines BioProject

    ID: PRJNA84539

    Keywords: Variation

    Access Type: download

  14. Transcriptional networks regulated by drugs of abuse in mouse striatum BioProject

    ID: PRJNA116841

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: dynamically inducible transcriptional networks: (1) CREB/SRF-dependent gene pattern that appears to be related to drug-induced neuronal activity, (2) the pattern of genes controlled at least in part via release of glucocorticoids and androgens that are associated with rewarding and harmful drug effects. The discovery of co-expressed networks of genes allowed for the identif...
  15. Transcription profiling of marmoset laser capture microdissected suprachiasmatic nucleus after a single administration of MPTP ArrayExpress

    ID: E-GEOD-5176

    Description: was investigated after a single administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in common marmosets. In the MPTP model, gene expression of neither cyclin D1 nor PERP was altered. There were also few common alterations in gene expression between the MPTP and 6-OHDA models. This suggests that the mechanism of cell death may differ between these models, and extensive study in various Parkinsonian models should be performed to elucidate the mechanisms of dopaminergic cell death in Parkinson’s disease. Experiment Overall Design: Materials and methods Experiment Overall Design: 1. Animals Experiment Overall Design: Five 3-yea...

  16. Transcription profiling by array of mouse MES-13 cells after treatment with glucose or glucosamine ArrayExpress

    ID: E-GEOD-2557

    Description: ells. HG induces the expression of ~369 genes at >2-fold where 263 genes are up and 106 genes down regulated. Similarly, GlcN increases the expression of 120 genes and decreases 94 genes. Seventy-two genes are commonly regulated by HG and GlcN, in which 33 genes are up and 39 genes are down. The differential expressions of several genes found in the microarray are also confirmed by quantitative PCR. Significant pathways co-modulated by HG and GlcN are the thioredoxin system (a 20-fold increase in thioredoxin interacting protein expression), endoplasmic reticulum (ER) stress, extracellular matrix and interferon-inducible genes. Furthermore, HG and GlcN target various intracellular pathways including the mitogen-activated protein kinase, TOLL-like receptor, fructose and mannose metabolism, and...

  17. Microarray Studies in the Laser Capture Microdissected SNc after a Single Administration of MPTP in Common Marmosets BioProject

    ID: PRJNA96591

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: was investigated after a single administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in common marmosets. In the MPTP model, gene expression of neither cyclin D1 nor PERP was altered. There were also few common alterations in gene expression between the MPTP and 6-OHDA models. This suggests that the mechanism of cell death may differ between these models, and extensive study in various Parkinsonian models should be performed to elucidate the mechanisms of dopaminergic cell death in Parkinson’s disease. Keywords: time course Overall design: Materials and methods 1. Animals Five 3-year-old male common marmosets (Callithrix jacchus) weighi...
  18. Differential Gene Expression Profile in Pig Adipose Tissue Treated with/without Clenbuterol BioProject

    ID: PRJNA100943

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: t t-test (P<0.5) in the microarray analyses which containing 3358 genes (ESTs).Theses 82 genes (ESTs) were divided into four groups according to their Gene Ontology Biological Process descriptions. 16 genes were cellular metabolism related genes (including five lipids metabolism related such as apolipoprotein D and apolipoprotein R), 10 were signal transduction related genes, 45 were expressed sequence tags (ESTs) and other 11 others were of various categories. Eleven of the 82 genes (ESTs) were chosen for real-time PCR analysis, with eight of them induced to express similar magnitudes as in the microarray analyses, two could not be detected and one expressed magnitudes that disagreed with the microarray results. Apolipoprotein R was also found to be up-regulated by the proteomic analysis. Conclusions Profound changes were observed in adipose cells after administration of clenbuterol in pigs by histological section and cDNA microarray techniques. The adipose cells became smaller with stimulation by clenbuterol. Changes in mRNA abundance indicated that DNA transcription and protein translation were enhanced in the adipose cells with clenbuterol sti...
  19. Transcriptome Profiling of High Glucose and Glucosamine-Induced Mouse Mesangial Cells BioProject

    ID: PRJNA92169

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: ells. HG induces the expression of ~369 genes at >2-fold where 263 genes are up and 106 genes down regulated. Similarly, GlcN increases the expression of 120 genes and decreases 94 genes. Seventy-two genes are commonly regulated by HG and GlcN, in which 33 genes are up and 39 genes are down. The differential expressions of several genes found in the microarray are also confirmed by quantitative PCR. Significant pathways co-modulated by HG and GlcN are the thioredoxin system (a 20-fold increase in thioredoxin interacting protein expression), endoplasmic reticulum (ER) stress, extracellular matrix and interferon-inducible genes. Furthermore, HG and GlcN target various intracellular pathways including the mitogen-activated protein kinase, TOLL-like receptor, fructose and mannose metabolism, and...
  20. Homo sapiens : VACCINATION STATUS AGAINST HEPATITIS B AMONG DOCTORS OF AYUB TEACHING HOSPITAL, ABBOTTABAD BioProject

    ID: PRJNA377938

    Keywords: other

    Access Type: download

    dataset.description: BLESTable 01: Genderwise distribution of ageTable 1:Ward wise distibution of Doctors 9Table 2: Duration of medical practice of doctors in ATH 10Table 3: Designation of doctors 11Table 4: Vaccination status in male and female doctors 12Table 5: Vaccination status in the different categories of doctors 13Table 6: Vaccination status with regard to risk of HBV infection to doctors 14Table 7: Vaccination status in doctors having needle stick or cutting injury 14Table 8: Vaccination status in doctors coming in contact with hepatitis B positive patients…………………..Table 9: Reason for vaccination…………………………………………………………………………………………………………..Table 10: Reason for non-vaccination………………………………………………………………………………Table 11: Opinion of doctors regarding HBV vaccination whether it should be made mandatory for doctors or not……………………………………………………………………………………………………………………………………LIST OF FIGUREFigure 1 Age wise distribution of doctors 9Figure 2: Gender of doctors 10Figure 3: Marital status 11Figure 4: Area of residence 12Figure 5:Percentage of doctors showing risk of HBV infection 13Figure 6: Percentage of doctors showing whether they have inflicted needle stick injury or not 14Figure 7: Percentage of doctors showing contact with HBV positive patients………………………………………Figure 8: Vaccination against HBV…………………………………………………………………………………………………….Figure 9: Frequency of HBV vaccine doses received by doctors……………………………………….............Figure 10: Frequency of doctors regarding screening for HBV infection…………………………………………Figure 11: Percentage of doctors showing their intention to HBV vaccination………………………………Abstract:Background:Hepatitis B is a major health problem for doctors all over the world, which is preventable by vaccination against HBV infection. Our study was conducted to assess the vaccination status of doctors working at Ayub Teaching Hospital and the possible reasons of vaccination and non vaccination.Methods:It was a cross sectional study c...

Displaying 20 of 21 results for "GPATCH2"