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Displaying 20 of 104 results for "GNAS"
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  1. Effect of Gnas knockout on mouse skin OmicsDI

    ID: E-GEOD-58894

    Date Released: 07-14-2014

    Description: ells, compared with control mouse skin. Epidermal Gnas ablation leads to skin defects, including basal cell carcinoma (BCC). Results provide insight into role of Galpha s in the regulation of stem cells from the skin. Changes in gene expression following Gnas deletion from the mouse epidermis were analy...

  2. Effect of Gnas knockout on mouse skin ArrayExpress

    ID: E-GEOD-58894

    Description: ells, compared with control mouse skin. Epidermal Gnas ablation leads to skin defects, including basal cell carcinoma (BCC). Results provide insight into role of Galpha s in the regulation of stem cells from the skin. Changes in gene expression following Gnas deletion from the mouse epidermis were analy...

  3. A GNAS mutation found in pancreatic intraductal papillary mucinous neoplasms induces drastic alterations of gene expression profiles ... OmicsDI

    ID: E-GEOD-53350

    Date Released: 05-31-2014

    Description: GNAS, a gene encoding G-protein stimulating alpha subunit, is frequently mutated in intraductal papillary mucinous neoplasms (IPMNs...

  4. Effect of Gnas knockout on mouse skin BioProject

    ID: PRJNA253825

    Keywords: Transcriptome or Gene expression

    Access Type: download

  5. A GNAS mutation found in pancreatic intraductal papillary mucinous neoplasms induces drastic alterations of gene expression profiles ... ArrayExpress

    ID: E-GEOD-53350

    Description: GNAS, a gene encoding G-protein stimulating alpha subunit, is frequently mutated in intraductal papillary mucinous neoplasms (IPMNs...

  6. A GNAS mutation found in pancreatic intraductal papillary mucinous neoplasms induces drastic alterations of gene expression profiles ... BioProject

    ID: PRJNA231774

    Keywords: Transcriptome or Gene expression

    Access Type: download

  7. Reductions in hypothalamic Gfap expression, glial cells and α-tanycytes in lean and hypermetabolic Gnasxl-deficient mice ArrayExpress

    ID: E-GEOD-75878

    Description: alamic gliosis occurs in mouse models of obesity. Gnasxl constitutes an alternative transcript of the genomically imprinted Gnas locus and encodes a variant of the signalling protein Gαs, termed XLαs, which is expressed in defined areas of the hypothalamus. Gnasxl-deficient mice show postnatal growth retardation and undernutrition, while surviving adults remain lean and hypermetabolic with incre...

  8. Reductions in hypothalamic Gfap expression, glial cells and α-tanycytes in lean and hypermetabolic Gnasxl-deficient mice BioProject

    ID: PRJNA305587

    Keywords: Transcriptome or Gene expression

    Access Type: download

  9. mline PRKAR1A defects versus those due to somatic GNAS mutations... BioProject

    ID: PRJNA148273

    Keywords: Transcriptome or Gene expression

    Access Type: download

  10. mline PRKAR1A defects versus those due to somatic GNAS mutations... ArrayExpress

    ID: E-GEOD-33694

    Description: ar adrenocortical disease (PPNAD) whereas somatic GNAS activating mutations cause macronodular disease in the context of McCune-Albright syndrome (MAS), ACTH-independent hyperplasia (AIMAH) and, rarely, cortisol-producing adenomas (CPA). The whole-genome ...

  11. Molecular defects in pseudohypoparathyroidism or related disorders OmicsDI

    ID: phs000476.v1.p1

    Date Released:

    Description: caused by maternally inherited mutations in those GNAS exons that encode Gαs, while autosomal dominant PHP type Ib (AD-PHP-Ib) is caused by maternal inherited deletions within or up-stream of GNAS, which are associated with abnormal GNAS methylation. However, a large number of patients with PTH-resistance and thus hypocalcemia show GNAS methylation changes, but their underlying genetic defects have not yet been defined at the DNA level. These "sporadic" patients may be affected by an autosomal recessive form of PHP-Ib (AR-PHP-Ib), which is most likely not linked to the GNAS locus. In our studies, we propose to search through exome sequence analyses for novel genetic mutations responsible for novel autosomal dominant forms of HP that are not caused by mutations in the known disease-causing genes; some of these families are large enough to perform genetic linkage studies. We furthermore prop...

  12. The G-protein Alpha Subunit Gsα Is A Tumor Suppressor In Sonic Hedgehog-driven Medulloblastoma [RNA-Seq] OmicsDI

    ID: E-GEOD-60415

    Date Released: 09-01-2014

    Description: isease are not fully understood. Here we identify GNAS, encoding the G-protein Gs-alpha, as a potent tumor suppressor gene in medulloblastoma. GNAS specifically defines a subset of aggressive Sonic Hedgehog (Shh)-group medulloblastomas. Gnas loss-of-function in distinct lineage progenitors of the developing hindbrain suffices to initiate medulloblastoma. We find that Gs-alpha is highly enriched at primary cilia of granule neuron precursors and suppresses Shh signaling not only by regulating classic cAMP-dependent pathway but also controlling ciliary trafficking o...

  13. mline PRKAR1A defects versus those due to somatic GNAS mutations... OmicsDI

    ID: E-GEOD-33694

    Date Released: 11-21-2011

    Description: ar adrenocortical disease (PPNAD) whereas somatic GNAS activating mutations cause macronodular disease in the context of McCune-Albright syndrome (MAS), ACTH-independent hyperplasia (AIMAH) and, rarely, cortisol-producing adenomas (CPA). The whole-genome ...

  14. Additional file 1: of Reductions in hypothalamic Gfap expression, glial cells and α-tanycytes in lean and hypermetabolic Gnasxl-deficient mice Figshare

    ID: doi:10.6084/M9.FIGSHARE.C.3625724_D2

    Release Date: 12-15-2016

    Description: e expression changes in hypothalamus samples from Gnasxl m+/p- mice versus WT littermates. Genes are listed by their log2(fold change) from most up-regulated to most down-regulated. (XLSX 5507 kb)...

  15. The G-protein Alpha Subunit Gsα Is A Tumor Suppressor In Sonic Hedgehog-driven Medulloblastoma [Copy number analysis] OmicsDI

    ID: E-GEOD-60416

    Date Released: 09-01-2014

    Description: isease are not fully understood. Here we identify GNAS, encoding the G-protein Gs-alpha, as a potent tumor suppressor gene in medulloblastoma. GNAS specifically defines a subset of aggressive Sonic Hedgehog (Shh)-group medulloblastomas. Gnas loss-of-function in distinct lineage progenitors of the developing hindbrain suffices to initiate medulloblastoma. We find that Gs-alpha is highly enriched at primary cilia of granule neuron precursors and suppresses Shh signaling not only by regulating classic cAMP-dependent pathway but also controlling ciliary trafficking o...

  16. Additional file 1: of Genome-wide DNA methylation analysis of pseudohypoparathyroidism patients with GNAS imprinting defects Figshare

    ID: doi:10.6084/M9.FIGSHARE.C.3601310_D1

    Release Date: 12-14-2016

    Description: This contains additional files for Tables S1-S7.

  17. The G-protein Alpha Subunit Gsα Is A Tumor Suppressor In Sonic Hedgehog-driven Medulloblastoma [RNA-Seq] ArrayExpress

    ID: E-GEOD-60415

    Description: isease are not fully understood. Here we identify GNAS, encoding the G-protein Gs-alpha, as a potent tumor suppressor gene in medulloblastoma. GNAS specifically defines a subset of aggressive Sonic Hedgehog (Shh)-group medulloblastomas. Gnas loss-of-function in distinct lineage progenitors of the developing hindbrain suffices to initiate medulloblastoma. We find that Gs-alpha is highly enriched at primary cilia of granule neuron precursors and suppresses Shh signaling not only by regulating classic cAMP-dependent pathway but also controlling ciliary trafficking o...

  18. Homo sapiens : Homo sapiens Exome BioProject

    ID: PRJNA323818

    Keywords: exome

    Access Type: download

    dataset.description: Duplication/triplication in the GNAS region
  19. The G-protein Alpha Subunit Gsα Is A Tumor Suppressor In Sonic Hedgehog-driven Medulloblastoma [Copy number analysis] ArrayExpress

    ID: E-GEOD-60416

    Description: isease are not fully understood. Here we identify GNAS, encoding the G-protein Gs-alpha, as a potent tumor suppressor gene in medulloblastoma. GNAS specifically defines a subset of aggressive Sonic Hedgehog (Shh)-group medulloblastomas. Gnas loss-of-function in distinct lineage progenitors of the developing hindbrain suffices to initiate medulloblastoma. We find that Gs-alpha is highly enriched at primary cilia of granule neuron precursors and suppresses Shh signaling not only by regulating classic cAMP-dependent pathway but also controlling ciliary trafficking o...

  20. The G-protein Alpha Subunit Gsα Is A Tumor Suppressor In Sonic Hedgehog-driven Medulloblastoma [Microarray expression] OmicsDI

    ID: E-GEOD-60417

    Date Released: 09-01-2014

    Description: isease are not fully understood. Here we identify GNAS, encoding the G-protein Gs-alpha, as a potent tumor suppressor gene in medulloblastoma. GNAS specifically defines a subset of aggressive Sonic Hedgehog (Shh)-group medulloblastomas. Gnas loss-of-function in distinct lineage progenitors of the developing hindbrain suffices to initiate medulloblastoma. We find that Gs-alpha is highly enriched at primary cilia of granule neuron precursors and suppresses Shh signaling not only by regulating classic cAMP-dependent pathway but also controlling ciliary trafficking o...


Displaying 20 of 104 results for "GNAS"