GNA15 | bioCADDIE Data Discovery Index
Mountain View
biomedical and healthCAre Data Discovery Index Ecosystem
help Advanced Search
Displaying 3 of 3 results for "GNA15"
i
  1. GNA15_RABIT UniProt:Swiss-Prot

    ID: Q9TU29

    Description: Guanine nucleotide-binding protein subunit alpha-

  2. GNA15_RAT UniProt:Swiss-Prot

    ID: O88302

    Description: Guanine nucleotide-binding protein subunit alpha-

  3. In utero exposure to maternal smoking is associated with DNA methylation alterations and reduced neuronal content in the developing fetal brain BioProject

    ID: PRJNA356257

    Keywords: Epigenomics

    Access Type: download

    dataset.description: ylated CpG Islands within the promoter regions of GNA15 and SDHAP3 of smoking-exposed fetuses. Furthermore, developmental up-regulation of SDHAP3 mRNA was delayed in smoking- exposed fetuses. DMRÕs passing FDR were found by interaction analysis between gestational age and smoking exposure annotated to SYCE3, C21orf56/LSS, SPAG1 and RNU12/POLDIP3. Utilizing established methods to estimate cell proportions by DNA methylation, we found that exposed DLPFC samples contained a lower proportion of neurons in samples from fetuses exposed to maternal smoking. We further showed that nicotine impedes the differentiation of neurons in vitro independent of cell death. Conclusions; We found evidence that intrauterine smoking exposure alters the developmental patterning of DNA methylation and gene expression and is associated with reduced mature neuronal content, effects that are likely driven by nicotine. Overall design: The Illumina Infinium HM450k Human DNA methylation Beadchip was used to obtain DNA methylation profiles across approximately 480,000 CpGs in 24 fetal samples dissected from the cortical plate in the region that becomes the DLPFC in order to ob...

Displaying 3 of 3 results for "GNA15"