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Displaying 15 of 15 results for "GCLM"
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  1. Transcription profiling of Puga- tBHQ and arsenic treated GCLM-WT and KO mice ArrayExpress

    ID: E-MEXP-371

    Description: Evaluate the protective effect of prior tBHQ treatment from arsenic damage at two dosage levels of arsenic (2 and 20 uM), and compare to the effect of...

  2. Comparison of gene expression profiles of anaplastic glioma with or without the mutated IDH1/2 gene BioProject

    ID: PRJNA230506

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: ntative NRF2 target genes, including NQO1, HMOX1, GCLM, TXNRD1, and PRDX1. Overall design: 12 anaplastic gliomas with or without mutated IDH1/2....
  3. Comparison of gene expression profiles of anaplastic glioma with or without the mutated IDH1/2 gene ArrayExpress

    ID: E-GEOD-52942

    Description: ntative NRF2 target genes, including NQO1, HMOX1, GCLM, TXNRD1, and PRDX1. 12 anaplastic gliomas with or without mutated IDH1/2....

  4. Adaptative changes in protein expression and lysine acetylation induced by decreased glutathione levels in astrocytes OmicsDI

    ID: PXD001834

    Date Released: 10-24-2015

    Description: n the glutamate-cysteine ligase modifier subunit (GCLM). GCLM knockout astrocytes display an approximately 80% reduction in total glutathione levels. We identified potential molecular targets that are affected by the chronic decrease in glutathione levels and observed an adaptative response mediated by Nrf2 activation. In addition, sequence analysis of peptides more extensively acetylated in the absence of GCLM revealed an enrichment of cysteine residues immediately surrounding the site of acetylation; which suggests a potential specific regulation by decreased glutathione content. Pathway analysis revealed that some pathways exhibited both differential protein expression and lysine acetylation, revealing a coordinated response involving transcriptional and post-translational regulation....

  5. Transcription profiling of Puga- tBHQ and arsenic treated GCLM-WT and KO mice OmicsDI

    ID: E-MEXP-371

    Date Released: 05-03-2014

    Description: Evaluate the protective effect of prior tBHQ treatment from arsenic damage at two dosage levels of arsenic (2 and 20 uM), and compare to the effect of...

  6. Genome-wide map of BACH1 binding in HEK 293T cells ArrayExpress

    ID: E-GEOD-28051

    Description: , FTH1, ME1, SLC48A1) and redox regulation (GCLC, GCLM, SLC7A11), we also discovered BACH1 target genes effecting cell cycle and apoptosis pathways (ITPR2, CALM1, SQSTM1, TFE3, EWSR1, CDK6, BCL2L11, MAFG) as well as subcellular transport processes (CLSTN1, PSAP, MAPT, vault RNA). The newly identified impact of BACH1 on genes involved in neurodegenerative processes and proliferation provides an interesting basis for future dissection of BACH1-mediated gene repression in neurodegeneration and virus-induced cancerogenesis. Examination of BACH1 binding in HEK 293T cells by chromatin immunoprecipitation-sequencing (CHIP-seq) with input DNA as control....

  7. GSH0_BOVIN UniProt:Swiss-Prot

    ID: Q2T9Y6

    Description: Glutamate--cysteine ligase regulatory subunit Phosphoserine N6-acetyllysine

    gene.name: GCLM
  8. Comparison of gene expression profiles of anaplastic glioma with or without the mutated IDH1/2 gene OmicsDI

    ID: E-GEOD-52942

    Date Released: 08-25-2015

    Description: ntative NRF2 target genes, including NQO1, HMOX1, GCLM, TXNRD1, and PRDX1. 12 anaplastic gliomas with or without mutated IDH1/2....

  9. Transcription profiling of UV- or oxidized lipid treated dermal skin fibroblasts ArrayExpress

    ID: E-GEOD-13606

    Description: HO-1, glutamate-cysteine ligase modifier subunit (GCLM), aldo-keto reductases-1-C1 and -C2 (AKR1C1, AKR1C2), and interleukin 8 (IL8). These genes are members of the cellular stress response system termed “antioxidant response” or “Phase II detoxification”. Accordingly, the regulatory regions of all these genes contain binding sites for NF-E2-related factor 2 (Nrf2), a major regulator of the antioxidant response. Both UVA-1 irradiation and treatment with oxidized lipids led to increased nuclear accumulation of Nrf2. Silencing expression of Nrf2 using siRNA or using cells and tissue from Nrf2-deficient mice, we show that the induction of the co-regulated genes was suppressed. Expression of other canonical UVA-1-induced genes, including cyclooxygenase 2 (Cox2) and interleukin 6 (IL6) was unaltered in the absence of Nrf2. Together, our data show that UVA-1-mediated lipid oxidation induces induction of antioxidant response genes, whic...

  10. Genome-wide map of BACH1 binding in HEK 293T cells BioProject

    ID: PRJNA143131

    Keywords: Epigenomics

    Access Type: download

    dataset.description: , FTH1, ME1, SLC48A1) and redox regulation (GCLC, GCLM, SLC7A11), we also discovered BACH1 target genes effecting cell cycle and apoptosis pathways (ITPR2, CALM1, SQSTM1, TFE3, EWSR1, CDK6, BCL2L11, MAFG) as well as subcellular transport processes (CLSTN1, PSAP, MAPT, vault RNA). The newly identified impact of BACH1 on genes involved in neurodegenerative processes and proliferation provides an interesting basis for future dissection of BACH1-mediated gene repression in neurodegeneration and virus-induced cancerogenesis. Overall design: Examination of BACH1 binding in HEK 293T cells by chromatin immunoprecipitation-sequencing (CHIP-seq) with input DNA as control....
  11. Saccharomyces cerevisiae glutamate cysteine ligase in complex with Mg2+ and L-glutamate PDB

    ID: PDB:3IG5

    Description: Glutamate-cysteine ligase (E.C.6.3.2.2)

  12. UV- or oxidized lipid treated dermal skin fibroblasts BioProject

    ID: PRJNA110627

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: HO-1, glutamate-cysteine ligase modifier subunit (GCLM), aldo-keto reductases-1-C1 and -C2 (AKR1C1, AKR1C2), and interleukin 8 (IL8). These genes are members of the cellular stress response system termed “antioxidant response” or “Phase II detoxification”. Accordingly, the regulatory regions of all these genes contain binding sites for NF-E2-related factor 2 (Nrf2), a major regulator of the antioxidant response. Both UVA-1 irradiation and treatment with oxidized lipids led to increased nuclear accumulation of Nrf2. Silencing expression of Nrf2 using siRNA or using cells and tissue from Nrf2-deficient mice, we show that the induction of the co-regulated genes was suppressed. Expression of other canonical UVA-1-induced genes, including cyclooxygenase 2 (Cox2) and interleukin 6 (IL6) was unaltered in the absence of Nrf2. Together, our data show that UVA-1-mediated lipid oxidation induces induction of antioxidant response genes, which...
  13. Data from: Decreased brain levels of vitamin B12 in aging, autism and schizophrenia Dryad

    DateIssued: 02-02-2016

    Description: mate-cysteine ligase modulatory subunit knockout (GCLM-KO) mice, which exhibit low GSH levels. Thus our findings reveal a previously unrecognized decrease in brain vitamin B12 status across the lifespan that may reflect an adaptation to increasing antioxidant demand, while accelerated deficits due to GSH deficiency may contribute to neurodevelopmental and neuropsychiatric disorders....

  14. Genome-wide map of BACH1 binding in HEK 293T cells OmicsDI

    ID: E-GEOD-28051

    Date Released: 06-02-2014

    Description: , FTH1, ME1, SLC48A1) and redox regulation (GCLC, GCLM, SLC7A11), we also discovered BACH1 target genes effecting cell cycle and apoptosis pathways (ITPR2, CALM1, SQSTM1, TFE3, EWSR1, CDK6, BCL2L11, MAFG) as well as subcellular transport processes (CLSTN1, PSAP, MAPT, vault RNA). The newly identified impact of BACH1 on genes involved in neurodegenerative processes and proliferation provides an interesting basis for future dissection of BACH1-mediated gene repression in neurodegeneration and virus-induced cancerogenesis. Examination of BACH1 binding in HEK 293T cells by chromatin immunoprecipitation-sequencing (CHIP-seq) with input DNA as control....

  15. Transcription profiling of UV- or oxidized lipid treated dermal skin fibroblasts OmicsDI

    ID: E-GEOD-13606

    Date Released: 05-01-2014

    Description: HO-1, glutamate-cysteine ligase modifier subunit (GCLM), aldo-keto reductases-1-C1 and -C2 (AKR1C1, AKR1C2), and interleukin 8 (IL8). These genes are members of the cellular stress response system termed “antioxidant response” or “Phase II detoxification”. Accordingly, the regulatory regions of all these genes contain binding sites for NF-E2-related factor 2 (Nrf2), a major regulator of the antioxidant response. Both UVA-1 irradiation and treatment with oxidized lipids led to increased nuclear accumulation of Nrf2. Silencing expression of Nrf2 using siRNA or using cells and tissue from Nrf2-deficient mice, we show that the induction of the co-regulated genes was suppressed. Expression of other canonical UVA-1-induced genes, including cyclooxygenase 2 (Cox2) and interleukin 6 (IL6) was unaltered in the absence of Nrf2. Together, our data show that UVA-1-mediated lipid oxidation induces induction of antioxidant response genes, whic...


Displaying 15 of 15 results for "GCLM"