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Displaying 20 of 86 results for "GBP5"
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  1. Gene Expression Analysis in Different Macrophage Phenotypes BioProject

    ID: PRJNA338235

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: phages were additionally evaluated. We identified guanylate-binding protein 5 (GBP5), which is associated with leucine-rich repeat protein 3-mediated inflammasome assembly in the M1 macrophages of both humans and mice. Notably, GBP5 protein expression was detected in cultured M1 macrophages by Western blot analysis. GBP5 is a useful candidate marker of the M1 phenotype. Overall design: CD14+ monocytes from human PBMC were cultured with GM-CSF(10 ng mL−1) or M-CSF (50 ng mL−1) for seven days to differentiate into macrophages.To induce macrophage subtypes [M1, M1(-), M2a, M2b, and M2c], the macrophages were further stimulated for 24 h with LPS (10 ng mL−1) + IFN-γ (50 ng mL−1), IFN-γ (50 ng mL−1), IL-4 ...
  2. Gene Expression Analysis in Different Macrophage Phenotypes OmicsDI

    ID: E-GEOD-85346

    Date Released: 08-10-2016

    Description: phages were additionally evaluated. We identified guanylate-binding protein 5 (GBP5), which is associated with leucine-rich repeat protein 3-mediated inflammasome assembly in the M1 macrophages of both humans and mice. Notably, GBP5 protein expression was detected in cultured M1 macrophages by Western blot analysis. GBP5 is a useful candidate marker of the M1 phenotype. CD14+ monocytes from human PBMC were cultured with GM-CSF(10 ng mL−1) or M-CSF (50 ng mL−1) for seven days to differentiate into macrophages.To induce macrophage subtypes [M1, M1(-), M2a, M2b, and M2c], the macrophages were further stimulated for 24 h with LPS (10 ng mL−1) + IFN-γ (50 ng mL−1), IFN-γ (50 ng mL−1), IL-4 (10 ng mL−1), ...

  3. Gene Expression Analysis in Different Macrophage Phenotypes ArrayExpress

    ID: E-GEOD-85346

    Description: phages were additionally evaluated. We identified guanylate-binding protein 5 (GBP5), which is associated with leucine-rich repeat protein 3-mediated inflammasome assembly in the M1 macrophages of both humans and mice. Notably, GBP5 protein expression was detected in cultured M1 macrophages by Western blot analysis. GBP5 is a useful candidate marker of the M1 phenotype. CD14+ monocytes from human PBMC were cultured with GM-CSF(10 ng mL−1) or M-CSF (50 ng mL−1) for seven days to differentiate into macrophages.To induce macrophage subtypes [M1, M1(-), M2a, M2b, and M2c], the macrophages were further stimulated for 24 h with LPS (10 ng mL−1) + IFN-γ (50 ng mL−1), IFN-γ (50 ng mL−1), IL-4 (10 ng mL−1), ...

  4. GCY5_CAEEL UniProt:Swiss-Prot

    ID: Q23682

    Description: Receptor-type guanylate cyclase gcy-5 Extracellular Helical Cytoplasmic Protein kinase Guanylate

  5. LRGUK_MOUSE UniProt:Swiss-Prot

    ID: Q9D5S7

    Description: Leucine-rich repeat and guanylate kinase domain-containing protein LRR 1 LRR 2 LRR 3 LRR 4 LRR 5 LRR 6 LRR 7 LRR 8 LR...

  6. MAGI3_XENTR UniProt:Swiss-Prot

    ID: A1A5G4

    Description: Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3 PDZ 1 Guanylate kinase-like WW 1 WW ...

  7. MAGI3_RAT UniProt:Swiss-Prot

    ID: Q9JK71

    Description: Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3 PDZ 1 Guanylate kinase-like WW 1 WW ...

  8. MAGI3_CHICK UniProt:Swiss-Prot

    ID: Q5F488

    Description: Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3 PDZ 1 Guanylate kinase-like WW 1 WW ...

  9. Mouse strain-specific responses to commensal gut bacteria at the mucosal gene expression level ArrayExpress

    ID: E-GEOD-45876

    Description: lipid degradation/catabolism, guanine nucleotide/guanylate binding and immune response were significantly enriched in differentially expressed genes. We had a closer look at the 56 genes with expression differences of < 4 and observed a higher expression in C57BL/10 mice of the genes coding for toll-like receptor 1 (4-fold) and angiogenin 4 (33-fold) which are involved in the recognition and response to gut bacteria. In contrast, a 70-fold higher expression of the phospholipase A2, group IIA-encoding gene (Pla2g2a) was detected in C3H mice. In addition, a number of interferon-inducible genes were higher expressed in C3H than in C57BL/10 mice including Gbp1 (18-fold), Mal (7-fold), Oasl2 (7-fold), Ifi202b (7-fold), Rtp4 (6-fold), Ly6g6c (5-fold), Ifi27l2a (5-fold), Usp18 (5-fold), Ifit1 (5-fold), Ifi44 (4-fold), and Ly6g (4-fold) indicating that these cytokines play an essential role in microbio...

  10. Genetic architecture of gene expression underlying variation in host response to porcine reproductive and respiratory syndrome virus infection BioProject

    ID: PRJNA313448

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: hat host genotype-dependent reduced expression of GBP5, CD1D, PAK1, and USP18 contribute to higher VL or lower WG in response to PRRSV infection. We also validated that cis-eQTLs of these candidate genes for host response to PRRSV infection generally acted by a mechanism involving allele-specific expression. Overall design: Sixteen pigs (8 AA and 8 AB individual at the WUR marker) were selected from the PHGC3 trial. Twenty-eight pigs (18 AA, 9 AB and 1 BB individuals at the WUR marker) were selected from the PHGC5 trial. After a seven-day acclimation period, pigs were challenged orally with PRRSV isolate NVSL 97-7985 and followed for 42 days post infection (dpi). RNA-Seq was performed using Illumina HiSeq on whole blood samples obtained from each individual at 0, 4, 7, 10, and 14 dpi. For individuals from the PHGC5 trial, RNA-Seq was performed on whole blood samples collected at 2 additional time-...
  11. ADCY5_RABIT UniProt:Swiss-Prot

    ID: P40144

    Description: Adenylate cyclase type 5 Cytoplasmic Helical Helical Helical Helical Helical Helical Cytoplasmic Helical Helical Helical Extracellular Helical Helical Hel...

  12. Cell Image Library Dataset CIL:24045 CIL

    ID: 24045

    Description: Starved Dictyostelium cells lacking cGMP-binding protein C (gbpC-; no guanylyl cyclase activity) and in medium supplemented with 60 µM LY294002 (a PI3K ...

    Data Types: image

  13. G12V MUTANT OF HUMAN PLACENTAL CDC42 GTPASE IN THE GDP FORM PDB

    ID: PDB:1A4R

    Description: G25K GTP-BINDING PROTEIN, GUANOSINE-5'-DIPHOSPHATE, AMINOPHOSPHONIC ACID-GUANYLATE ...

  14. Mouse strain-specific responses to commensal gut bacteria at the mucosal gene expression level BioProject

    ID: PRJNA196527

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: lipid degradation/catabolism, guanine nucleotide/guanylate binding and immune response were significantly enriched in differentially expressed genes. We had a closer look at the 56 genes with expression differences of < 4 and observed a higher expression in C57BL/10 mice of the genes coding for toll-like receptor 1 (4-fold) and angiogenin 4 (33-fold) which are involved in the recognition and response to gut bacteria. In contrast, a 70-fold higher expression of the phospholipase A2, group IIA-encoding gene (Pla2g2a) was detected in C3H mice. In addition, a number of interferon-inducible genes were higher expressed in C3H than in C57BL/10 mice including Gbp1 (18-fold), Mal (7-fold), Oasl2 (7-fold), Ifi202b (7-fold), Rtp4 (6-fold), Ly6g6c (5-fold), Ifi27l2a (5-fold), Usp18 (5-fold), Ifit1 (5-fold), Ifi44 (4-fold), and Ly6g (4-fold) indicating that these cytokines play an essential role in microbio...
  15. Crystal structure of guanylate kinase from Anaplasma phagocytophilum PDB

    ID: PDB:3LNC

    Description: Guanylate kinase (E.C.2.7.4.8)

  16. CRYSTAL STRUCTURE OF STAPHYLOCOCCUS AUREUS GUANYLATE MONOPHOSPHATE KINASE PDB

    ID: PDB:2J41

    Description: GUANYLATE KINASE (E.C.2.7.4.8)

  17. Crystal-structure of the N-terminal Large GTPase Domain of human Guanylate Binding protein 1 (hGBP1) in complex with GMP/AlF4 PDB

    ID: PDB:2B8W

    Description: Interferon-induced guanylate-binding protein 1

  18. Crystal-structure of the N-terminal large GTPase Domain of human Guanylate Binding protein 1 (hGBP1) in complex with GMP PDB

    ID: PDB:2D4H

    Description: Interferon-induced guanylate-binding protein 1

  19. Crystal-structure of the N-terminal Large GTPase Domain of human Guanylate Binding protein 1 (hGBP1) in complex with GDP/AlF3 PDB

    ID: PDB:2B92

    Description: Interferon-induced guanylate-binding protein 1

  20. Structure of Cdc42 in a complex with the GTPase-binding domain of the cell polarity protein, Par6 PDB

    ID: PDB:1NF3

    Description: G25K GTP-binding protein, placental isoform, PAR-6B, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER...


Displaying 20 of 86 results for "GBP5"