GABRD | bioCADDIE Data Discovery Index
Mountain View
biomedical and healthCAre Data Discovery Index Ecosystem
help Advanced Search
Displaying 14 of 14 results for "GABRD"
i
  1. Cell Image Library Dataset CIL:9153 CIL

    ID: 9153

    Description: EM micrograph demonstrating the colocalization of GABA neurotransmitter (30 nm gold) and delta 1/2 glutamate receptors (10 nm gold) in the cerebellar cortex molec...

    Data Types: image

  2. ed with altered chromatin regulators of monoamine receptor gene expression in the striatum of selectively bred mice... BioProject

    ID: PRJNA340182

    Keywords: Transcriptome or Gene expression

    Access Type: download

  3. Transcription profiling of murine neurons in the nodose and dorsal root ganglia to elucidate molecular characteristics of different sensory neorons ArrayExpress

    ID: E-GEOD-2917

    Description: Microarray data) and fold-difference filtering. A total of 1996 genes were found to be differentially expressed in DRG versus NG, including 41 G-protein coupled receptors and 60 ion channels. Expression profiles obtained on laser-captured neurons were contrasted to those obtained on whole ganglia demonstrating striking differences and the need for microdissection when studying visceral sensory neurons because of dilution of the signal by somatic sensory neurons. Furthermore, a detailed catalogue of all adrenergic and cholinergic, GABA, glutamate, serotonin and dopamine receptors, voltage-gated potassium, sodium and calcium channels and transient receptor potential cation channels present in visceral afferents is provided. Our genome-wide expression profiling data provide novel insight into molecular signatures that underlie both functional differences and similarities between NG and DRG visceral sensory neur...

  4. Profiling of visceral sensory neurons in dorsal root and nodose ganglia in BALB/c mice. GEMMA

    ID: 241

    Keywords: functional genomics

    Description: Microarray data) and fold-difference filtering. A total of 1996 genes were found to be differentially expressed in DRG versus NG, including 41 G-protein coupled receptors and 60 ion channels. Expression profiles obtained on laser-captured neurons were contrasted to those obtained on whole ganglia demonstrating striking differences and the need for microdissection when studying visceral sensory neurons because of dilution of the signal by somatic sensory neurons. Furthermore, a detailed catalogue of all adrenergic and cholinergic, GABA, glutamate, serotonin and dopamine receptors, voltage-gated potassium, sodium and calcium channels and transient receptor potential cation channels present in visceral afferents is provided. Our genome-wide expression profiling data provide novel insight into molecular signatures that underlie both functional differences and similarities between NG and DRG visceral sensory neur...

  5. PRENATAL EXPOSURE TO CORTICOSTEROIDS: HYPOTHALAMIC CHANGES RELEVANT FOR POSTNATAL BEHAVIORAL IMPAIRMENTS ArrayExpress

    ID: E-GEOD-44858

    Description: caused sex-dependent changes in the dopaminergic/GABA/glutamatergic synapse genes:. In males, 10 dopaminergic (9%), 4 GABAergic (5%) and 5 glutamatergic synapse genes (5%) were down-regulated. While in females, 9 dopaminergic (8%), 3 GABAergic (4%) and 6 glutamatergic (6%) synapse genes were downregulated. The data indicate that in both sexes the dopaminergic synapse was the most affected. In contrast, in control animals, no significant differences between male and female were present in these synapse genes. Since the most noticeable transcritpomic changes were found in the transcriptome of DA glutamatergic synapse, we investigated the expression of tyrosine-hydroxylase (TH) NMDA receptor subunits in the ARC. The western blot analyses and immunohistochemistry confirmed the sex-specific differences between prenatally betamethasone-exposed and saline-exposed P15 rats. Accordingly to the changes in gene expression, prenatal exposure to synthetic corticosteroids was associated with postnatal changes in behavior and susceptibility to certain types of seizures. While we did not find any significant impairements in normal behavioral patterns (open field activity), there was a sex-specific change in the novel object recognition test. We found that behavioral lateralization in females is lost after prenatal betamethasone exposure and both male and female prenatally betamethasone exposed rats were avoiding novelty. This trait is similar to children with autism and suggests that certain elements of autistic behaviors can be present after prenatal exposure to synthetic corticosteroids. Additionally, there were changes in the search patterns in the Morris water maze as well as in the Barnes maze. In conclusion, our work is consistent with findings of profound reprogramming changes in the brain after prenatal corticosteroid expos...

  6. Profiling of visceral sensory neurons in dorsal root and nodose ganglia in BALB/c mice. BioProject

    ID: PRJNA92603

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: Microarray data) and fold-difference filtering. A total of 1996 genes were found to be differentially expressed in DRG versus NG, including 41 G-protein coupled receptors and 60 ion channels. Expression profiles obtained on laser-captured neurons were contrasted to those obtained on whole ganglia demonstrating striking differences and the need for microdissection when studying visceral sensory neurons because of dilution of the signal by somatic sensory neurons. Furthermore, a detailed catalogue of all adrenergic and cholinergic, GABA, glutamate, serotonin and dopamine receptors, voltage-gated potassium, sodium and calcium channels and transient receptor potential cation channels present in visceral afferents is provided. Our genome-wide expression profiling data provide novel insight into molecular signatures that underlie both functional differences and similarities between NG and DRG visceral sensory neur...
  7. PRENATAL EXPOSURE TO CORTICOSTEROIDS: HYPOTHALAMIC CHANGES RELEVANT FOR POSTNATAL BEHAVIORAL IMPAIRMENTS BioProject

    ID: PRJNA192423

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: caused sex-dependent changes in the dopaminergic/GABA/glutamatergic synapse genes:. In males, 10 dopaminergic (9%), 4 GABAergic (5%) and 5 glutamatergic synapse genes (5%) were down-regulated. While in females, 9 dopaminergic (8%), 3 GABAergic (4%) and 6 glutamatergic (6%) synapse genes were downregulated. The data indicate that in both sexes the dopaminergic synapse was the most affected. In contrast, in control animals, no significant differences between male and female were present in these synapse genes. Since the most noticeable transcritpomic changes were found in the transcriptome of DA glutamatergic synapse, we investigated the expression of tyrosine-hydroxylase (TH) NMDA receptor subunits in the ARC. The western blot analyses and immunohistochemistry confirmed the sex-specific differences between prenatally betamethasone-exposed and saline-exposed P15 rats. Accordingly to the changes in gene expression, prenatal exposure to synthetic corticosteroids was associated with postnatal changes in behavior and susceptibility to certain types of seizures. While we did not find any significant impairements in normal behavioral patterns (open field activity), there was a sex-specific change in the novel object recognition test. We found that behavioral lateralization in females is lost after prenatal betamethasone exposure and both male and female prenatally betamethasone exposed rats were avoiding novelty. This trait is similar to children with autism and suggests that certain elements of autistic behaviors can be present after prenatal exposure to synthetic corticosteroids. Additionally, there were changes in the search patterns in the Morris water maze as well as in the Barnes maze. In conclusion, our work is consistent with findings of profound reprogramming changes in the brain after prenatal corticosteroid exposure associated with ...
  8. GBRD_MOUSE UniProt:Swiss-Prot

    ID: P22933

    Description: Gamma-aminobutyric acid receptor subunit delta Extracel...

  9. GBRD_RAT UniProt:Swiss-Prot

    ID: P18506

    Description: Gamma-aminobutyric acid receptor subunit delta Extracel...

  10. Alpha-synuclein deficiency affects brain Foxp1 expression and ultrasonic vocalization ArrayExpress

    ID: E-GEOD-19534

    Description: riplication events result in Parkinson's disease, a neurodegenerative disorder of old age with impaired movement and emotion control. Here, we systematically investigated the striatal as well as the cerebellar transcriptome profile of alpha-synuclein-deficient mice via a genome-wide microarray survey in order to gain hypothesis-free molecular insigh...

  11. Alpha-synuclein deficiency affects brain Foxp1 expression and ultrasonic vocalization BioProject

    ID: PRJNA122255

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: riplication events result in Parkinson's disease, a neurodegenerative disorder of old age with impaired movement and emotion control. Here, we systematically investigated the striatal as well as the cerebellar transcriptome profile of alpha-synuclein-deficient mice via a genome-wide microarray survey in order to gain hypothesis-free molecular insigh...
  12. Alpha-synuclein deficiency affects brain Foxp1 expression and ultrasonic vocalization GEMMA

    ID: 2618

    Keywords: functional genomics

    Description: riplication events result in Parkinson's disease, a neurodegenerative disorder of old age with impaired movement and emotion control. Here, we systematically investigated the striatal as well as the cerebellar transcriptome profile of alpha-synuclein-deficient mice via a genome-wide microarray survey in order to gain hypothesis-free molecular insigh...

  13. 351 Metabolomics

    Study Name: The alpha-1A adrenergic receptor agonist A61603 reduces cardiac polyunsaturatedfatty acid

    Grant ID: U01 DK097430-01

    Grant: NIH, Fondation Leducq

  14. 350 Metabolomics

    Study Name: The alpha-1A adrenergic receptor agonist A61603 reduces cardiac polyunsaturatedfatty acid

    Grant ID: U01 DK097430-01

    Grant: NIH, Fondation Leducq


Displaying 14 of 14 results for "GABRD"