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Displaying 20 of 30 results for "FMO3"
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  1. The TMAO Generating Enzyme Flavin Monooxygenase 3 is a Central Regulator of Cholesterol Balance BioProject

    ID: PRJNA270757

    Keywords: Transcriptome or Gene expression

    Access Type: download

  2. The TMAO Generating Enzyme Flavin Monooxygenase 3 is a Central Regulator of Cholesterol Balance OmicsDI

    ID: E-GEOD-64326

    Date Released: 01-03-2015

    Description: ndipitously identified the TMAO-generating enzyme flavin monooxygenase 3 (FMO3) as a powerful modifier of cholesterol metabolism and RCT. Knockdown of FMO3 in cholesterol-fed mice alters biliary lipid secretion, blunts intestinal cholesterol absorption, and limits the production of hepatic oxysterols and cholesteryl esters. Furthermore, FMO3 knockdow...

  3. GSXL3_ARATH UniProt:Swiss-Prot

    ID: Q9SXD5

    Description: Flavin-containing monooxygenase FMO GS-OX-like 3 FAD NADP

  4. The TMAO Generating Enzyme Flavin Monooxygenase 3 is a Central Regulator of Cholesterol Balance ArrayExpress

    ID: E-GEOD-64326

    Description: ndipitously identified the TMAO-generating enzyme flavin monooxygenase 3 (FMO3) as a powerful modifier of cholesterol metabolism and RCT. Knockdown of FMO3 in cholesterol-fed mice alters biliary lipid secretion, blunts intestinal cholesterol absorption, and limits the production of hepatic oxysterols and cholesteryl esters. Furthermore, FMO3 knockdow...

  5. TEIN RESIDUES AND NADP(H) IN OXYGEN-ACTIVATION BY FLAVIN-CONTAINING MONOOXYGENASE: COMPLEX WITH 3-ACETYLPYRIDINE ADENINE DINUCLEOTIDE PHOSPHATE (A... PDB

    ID: PDB:2XLT

    Description: FLAVIN-CONTAINING MONOOXYGENASE (E.C.1.14.13.8)

  6. FMO3_BOVIN UniProt:Swiss-Prot

    ID: Q8HYJ9

    Description: Removed Dimethylaniline monooxygenase [N-oxide-forming] 3 FAD NADP Phosphoserine

  7. FMO3_MOUSE UniProt:Swiss-Prot

    ID: P97501

    Description: Removed Dimethylaniline monooxygenase [N-oxide-forming] 3 FAD NADP Phosphoserine

  8. JOINT-FUNCTIONS OF PROTEIN RESIDUES AND NADP(H) IN OXYGEN-ACTIVATION BY FLAVIN-CONTAINING MONOOXYGENASE: COMPLEX WITH THIONADP PDB

    ID: PDB:2XLU

    Description: FLAVIN-CONTAINING MONOOXYGENASE (E.C.1.14.13.8)

  9. FMO3_PANTR UniProt:Swiss-Prot

    ID: Q7YS44

    Description: Removed Dimethylaniline monooxygenase [N-oxide-forming] 3 FAD NADP Phosphoserine

  10. FMO3_CANLF UniProt:Swiss-Prot

    ID: Q95LA1

    Description: Removed Dimethylaniline monooxygenase [N-oxide-forming] 3 FAD NADP Phosphoserine

  11. FMO3_MACMU UniProt:Swiss-Prot

    ID: Q8SPQ7

    Description: Removed Dimethylaniline monooxygenase [N-oxide-forming] 3 FAD NADP Phosphoserine

  12. RNA deep sequencing reveals novel candidate genes and polymorphisms in boar testis and liver tissues with divergent androstenone levels ArrayExpress

    ID: E-GEOD-44171

    Description: s for low androstenone testis sample and genes in flavin monooxygenease family, cytochrome P450 family and hydroxysteroid dehydrogenase family as candidate genes for low androstenone liver sample. Additionally, the results revealed that mutations in genes IRG6, DSP, IFIT2 were specific for low androstenone testis tissues and mutations in genes FMO5, HIST1H4K and TSKU were specific for low androstenone liver samples. Testis and liver mRNA profile of high and low androstenone level were generated by RNA deep sequencing, in five animal for each group, Ilumina HiSeq 2000...

  13. Gene expression profiles in liver of pigs with extreme high and low levels of androstenone ArrayExpress

    ID: E-GEOD-11073

    Description: s belonging to the cytochrome P450 family and the flavin-containing monooxygenase FMO1. Additionally, phase II conjugation genes including UDP-glucuronosyltransferases UGT1A5, UGT2A1 and UGT2B15, sulfotransferase STE, N-acetyltransferase NAT12 and glutathione S-transferase were identified. Phase I and phase II metabolic reactions increase the water solubility of steroids and play a key role in their elimination. Differential expression was also found for genes encoding 17beta-hydroxysteroid dehydrogenases (HSD17B2, HSD17B4, HSD17B11 and HSD17B13) and plasma proteins alpha-1-acid glycoprotein (AGP) and orosomucoid (ORM1). 17beta-hydroxysteroid dehydrogenases and plasma proteins regulate the availability of steroids by controlling the amount of active steroids accessible to receptors and available for metabolism. Differences in the expression of FMO1, NAT12, HSD17B2 and HSD17B13 were verified by quantitative real competitive PCR. CONCLUSIONS: A number of genes and pathways related to metabolism of androstenone in liver were identified, including new candidate genes involved in phase I oxidation metabolism, phase II conjugation metabolism, and regulation of steroid availability. The study is a first step towards a deeper understanding of enzymes and regulato...

  14. FMO3_RABIT UniProt:Swiss-Prot

    ID: P32417

    Description: Removed Dimethylaniline monooxygenase [N-oxide-forming] 3 FAD NADP (in Ref. 2; AA sequence) (in Ref. 2; AA sequence) (in Ref. 2; AA se...

  15. A genome-wide expression comparison of productive and unproductive airway epithelial repair OmicsDI

    ID: E-GEOD-17693

    Date Released: 03-27-2012

    Description: d a return to steady-state levels by Recovery Day 3. Tnc was deposited by the peribronchiolar mesenchyme immediately after injury and was remodeled to basement membrane subtending the bronchiolar epithelium during epithelial repair. Epithelial restitution was accompanied by a decrease in Tnc mRNA and protein expression to steady-state levels. In contrast, abortive repair using a transgenic model allowing ablation of all reparative cells led to a progressive increase in Tnc mRNA within lung tissue and accumulation of its gene product within the subepithelial mesenchyme of both conducting airways and alveoli. These data demonstrate that the ECM is dynamically remodeled in response to selective epithelial cell injury and that this process is activated without resolution in the setting of defective airway epithelial repair. Bronchiolar Clara cells undergo phenotypic changes during development and in disease. These changes are poorly described due to a pauci...

  16. RNA deep sequencing reveals novel candidate genes and polymorphisms in boar testis and liver tissues with divergent androstenone levels. BioProject

    ID: PRJNA188941

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: s for low androstenone testis sample and genes in flavin monooxygenease family, cytochrome P450 family and hydroxysteroid dehydrogenase family as candidate genes for low androstenone liver sample. Additionally, the results revealed that mutations in genes IRG6, DSP, IFIT2 were specific for low androstenone testis tissues and mutations in genes FMO5, HIST1H4K and TSKU were specific for low androstenone liver samples. Overall design: Testis and liver mRNA profile of high and low androstenone level were generated by RNA deep sequencing, in five animal for each group, Ilumina HiSeq 2000...

  17. A genome-wide expression comparison of productive and unproductive airway epithelial repair ArrayExpress

    ID: E-GEOD-17693

    Description: d a return to steady-state levels by Recovery Day 3. Tnc was deposited by the peribronchiolar mesenchyme immediately after injury and was remodeled to basement membrane subtending the bronchiolar epithelium during epithelial repair. Epithelial restitution was accompanied by a decrease in Tnc mRNA and protein expression to steady-state levels. In contrast, abortive repair using a transgenic model allowing ablation of all reparative cells led to a progressive increase in Tnc mRNA within lung tissue and accumulation of its gene product within the subepithelial mesenchyme of both conducting airways and alveoli. These data demonstrate that the ECM is dynamically remodeled in response to selective epithelial cell injury and that this process is activated without resolution in the setting of defective airway epithelial repair. Bronchiolar Clara cells undergo phenotypic changes during development and in disease. These changes are poorly described due to a pauci...

  18. Transcriptional profilling of female mice liver as a function of age ArrayExpress

    ID: E-MTAB-2782

    Description: day old; 1W - 1 week old; 2W - 2 weeks old; 3W - 3 weeks old; 1M - 1 month old; 2M - 2 months old; 3M - 3 months old; 6M - 6 months old; 1Y - 1 year old; and 2Y - 2 years old). Liver, heart, kidney, lungs and brain were extracted from all 60 females in the study, and liver samples were processed for RNA extraction. Overall, 8.3% of pharmacological relevant genes changed their expression with age, of which 57% were metabolic enzymes, like Cyp2c29 and Fmo3, and 22% were transporters....

  19. Gene expression profiles in liver of pigs with extreme high and low levels of androstenone. BioProject

    ID: PRJNA107061

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: s belonging to the cytochrome P450 family and the flavin-containing monooxygenase FMO1. Additionally, phase II conjugation genes including UDP-glucuronosyltransferases UGT1A5, UGT2A1 and UGT2B15, sulfotransferase STE, N-acetyltransferase NAT12 and glutathione S-transferase were identified. Phase I and phase II metabolic reactions increase the water solubility of steroids and play a key role in their elimination. Differential expression was also found for genes encoding 17beta-hydroxysteroid dehydrogenases (HSD17B2, HSD17B4, HSD17B11 and HSD17B13) and plasma proteins alpha-1-acid glycoprotein (AGP) and orosomucoid (ORM1). 17beta-hydroxysteroid dehydrogenases and plasma proteins regulate the availability of steroids by controlling the amount of active steroids accessible to receptors and available for metabolism. Differences in the expression of FMO1, NAT12, HSD17B2 and HSD17B13 were verified by quantitative real competitive PCR. CONCLUSIONS: A number of genes and pathways related to metabolism of androstenone in liver were identified, including new candidate genes involved in phase I oxidation metabolism, phase II conjugation metabolism, and regulation of steroid availability. The study is a first step towards a deeper understanding of enzymes and regulato...

  20. COMPLEX OF THE HEME AND FMN-BINDING DOMAINS OF THE CYTOCHROME P450(BM-3) PDB

    ID: PDB:1BVY

    Description: PROTEIN (CYTOCHROME P450 (BM-3)) (1.14.14.1)

Displaying 20 of 30 results for "FMO3"

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