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Displaying 20 of 22 results for "FMO3"
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  1. The TMAO Generating Enzyme Flavin Monooxygenase 3 is a Central Regulator of Cholesterol Balance BioProject

    ID: PRJNA270757

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: he TMAO-generating enzyme flavin monooxygenase 3 (FMO3) as a powerful modifier of cholesterol metabolism and RCT. Knockdown of FMO3 in cholesterol-fed mice alters biliary lipid secretion, blunts intestinal cholesterol absorption, and limits the production of hepatic oxysterols and cholesteryl esters. Furthermore, FMO3 knockdown stimulates basal and liver X receptor (LXR)-stimulated macrophage RCT, thereby improving cholesterol ba...
  2. The TMAO Generating Enzyme Flavin Monooxygenase 3 is a Central Regulator of Cholesterol Balance OmicsDI

    ID: E-GEOD-64326

    Date Released: 01-03-2015

    Description: he TMAO-generating enzyme flavin monooxygenase 3 (FMO3) as a powerful modifier of cholesterol metabolism and RCT. Knockdown of FMO3 in cholesterol-fed mice alters biliary lipid secretion, blunts intestinal cholesterol absorption, and limits the production of hepatic oxysterols and cholesteryl esters. Furthermore, FMO3 knockdown stimulates basal and liver X receptor (LXR)-stimulated macrophage RCT, thereby improving cholesterol ba...

  3. The TMAO Generating Enzyme Flavin Monooxygenase 3 is a Central Regulator of Cholesterol Balance ArrayExpress

    ID: E-GEOD-64326

    Description: he TMAO-generating enzyme flavin monooxygenase 3 (FMO3) as a powerful modifier of cholesterol metabolism and RCT. Knockdown of FMO3 in cholesterol-fed mice alters biliary lipid secretion, blunts intestinal cholesterol absorption, and limits the production of hepatic oxysterols and cholesteryl esters. Furthermore, FMO3 knockdown stimulates basal and liver X receptor (LXR)-stimulated macrophage RCT, thereby improving cholesterol ba...

  4. FMO3_BOVIN UniProt:Swiss-Prot

    ID: Q8HYJ9

    Description: Removed Dimethylaniline monooxygenase [N-oxide-forming] 3 FAD NADP Phosphoserine

    gene.name: FMO3
  5. FMO3_MOUSE UniProt:Swiss-Prot

    ID: P97501

    Description: Removed Dimethylaniline monooxygenase [N-oxide-forming] 3 FAD NADP Phosphoserine

    gene.name: Fmo3
  6. FMO3_PANTR UniProt:Swiss-Prot

    ID: Q7YS44

    Description: Removed Dimethylaniline monooxygenase [N-oxide-forming] 3 FAD NADP Phosphoserine

    gene.name: FMO3
  7. FMO3_CANLF UniProt:Swiss-Prot

    ID: Q95LA1

    Description: Removed Dimethylaniline monooxygenase [N-oxide-forming] 3 FAD NADP Phosphoserine

    gene.name: FMO3
  8. FMO3_MACMU UniProt:Swiss-Prot

    ID: Q8SPQ7

    Description: Removed Dimethylaniline monooxygenase [N-oxide-forming] 3 FAD NADP Phosphoserine

    gene.name: FMO3
  9. FMO3_RABIT UniProt:Swiss-Prot

    ID: P32417

    Description: Removed Dimethylaniline monooxygenase [N-oxide-forming] 3 FAD NADP (in Ref. 2; AA sequence) (in Ref. 2; AA sequence) (in Ref. 2; AA sequence) (in Re...

    gene.name: FMO3
  10. A genome-wide expression comparison of productive and unproductive airway epithelial repair OmicsDI

    ID: E-GEOD-17693

    Date Released: 03-27-2012

    Description: gene expression profile. Flavin monooxygenase 3 (Fmo3), paraoxonase 1 (Pon1), aldehyde oxidase 3 (Aox3), and claudin 10 (Cldn10) were identified as novel Clara cell markers. New and existing Clara cell marker genes were categorized into three classes based on their unique developmental expression pattern. Cldn10 was uniformly expressed in the epithelium at Embryonic Day (E)14.5 and became restricted to secretory cells at E18.5. This transition was defined by induction of Clara Cell Secretory Protein (CCSP). Maturation of secretory cells was associated with progressive increases in the expression of Fmo3, Pon1, Aox3, and Cyp2f2 between late embryonic and postnatal periods. Messenger RNA abundance of all categories of genes was dramatically decreased after naphthalene-induced airway injury, and displayed a sequence of temporal induction during repair that suggested sequential secretory cell maturation. We have defined a broader repertoire of Clara cell-specific genes that allows staging of epithelial maturation during development and repair. 32 samples were isolated and used to screen UniSet Mouse 20K I Bioarrays (total lung RNA Mus musculus). Control RNA was isolated from uninjured mice (N = 4 mice), and RNA was also isolated from mice exposed to naphthalene and recovered for 1, 2, 3, and 6 days (N = 4 mice per timepoint). Additionally, transgenic mice expressing HSV-tk under control of the mouse CCSP promoter were exposed to Ganciclovir (GCV) and recovered for 3, 6, and 9 days (N = 4 mice per timepoint)....

  11. A genome-wide expression comparison of productive and unproductive airway epithelial repair ArrayExpress

    ID: E-GEOD-17693

    Description: gene expression profile. Flavin monooxygenase 3 (Fmo3), paraoxonase 1 (Pon1), aldehyde oxidase 3 (Aox3), and claudin 10 (Cldn10) were identified as novel Clara cell markers. New and existing Clara cell marker genes were categorized into three classes based on their unique developmental expression pattern. Cldn10 was uniformly expressed in the epithelium at Embryonic Day (E)14.5 and became restricted to secretory cells at E18.5. This transition was defined by induction of Clara Cell Secretory Protein (CCSP). Maturation of secretory cells was associated with progressive increases in the expression of Fmo3, Pon1, Aox3, and Cyp2f2 between late embryonic and postnatal periods. Messenger RNA abundance of all categories of genes was dramatically decreased after naphthalene-induced airway injury, and displayed a sequence of temporal induction during repair that suggested sequential secretory cell maturation. We have defined a broader repertoire of Clara cell-specific genes that allows staging of epithelial maturation during development and repair. 32 samples were isolated and used to screen UniSet Mouse 20K I Bioarrays (total lung RNA Mus musculus). Control RNA was isolated from uninjured mice (N = 4 mice), and RNA was also isolated from mice exposed to naphthalene and recovered for 1, 2, 3, and 6 days (N = 4 mice per timepoint). Additionally, transgenic mice expressing HSV-tk under control of the mouse CCSP promoter were exposed to Ganciclovir (GCV) and recovered for 3, 6, and 9 days (N = 4 mice per timepoint)....

  12. Transcriptional profilling of female mice liver as a function of age ArrayExpress

    ID: E-MTAB-2782

    Description: hich 57% were metabolic enzymes, like Cyp2c29 and Fmo3, and 22% were transporters....

  13. Male and Female Mice Show Significant Temporal Differences in Hepatic Transcriptomic Response to TCDD OmicsDI

    ID: E-GEOD-61038

    Date Released: 03-07-2015

    Description: TCDD-responsive genes were identified, including Fmo3 and Nr1i3 upregulated in male mice and Sult3a1 downregulated in female mice; 5) functional analysis of these candidate genes showed various biological pathway enrichments in a sex-dependent manner. Our study shows that the sex-dependent sensitivities to TCDD exposure are associated with a set of sex-specific TCDD-responsive genes that are indirectly regulated by AHR activity. The exact roles of these genes in response to TCDD exposure are not clear and require further investigation. Adult male and female C57BL/6 mice were treated by gavage with one single-dose TCDD (125, 250, 500, or 1000 μg/kg) in corn oil or corn oil vehicle alone. Animals were euthanized at 96 hours after treatment and tissues were harvested. RNA was isolated from hepatic tissue and the transcriptome for each animal assayed on an individual microarray....

  14. Transcription profiling of mouse liver from wild-type or genetically deleted AHRs were treated with corn oil vehicle or TCDD reveals aryl hydrocarbon ... OmicsDI

    ID: E-GEOD-10082

    Date Released: 03-27-2012

    Description: r. The flavin-containing monooxygenases, Fmo2 and Fmo3, considered previously to be uninducible, were highly induced by TCDD in an AHR-dependent manner. The estrogen receptor alpha as well as two estrogen-receptor-related genes (alpha and gamma) exhibit AHR-dependent expression, thereby extending cross-talk opportunities between the intensively studied AHR and estrogen receptor pathways. p53 binding sites are over-represented in genes down-regulated by TCDD, suggesting that TCDD inhibits p53 transcriptional activity. Overall, our study identifies a wide range of genes that depend on the AHR, either for constitutive expression or for response to TCDD. Experiment Overall Design: Mice bearing wild-type or genetically deleted AHRs were treated with corn oil vehicle or TCDD, and their livers analyzed by expression arrays....

  15. A genome-wide expression comparison of productive and unproductive airway epithelial repair BioProject

    ID: PRJNA118479

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: gene expression profile. Flavin monooxygenase 3 (Fmo3), paraoxonase 1 (Pon1), aldehyde oxidase 3 (Aox3), and claudin 10 (Cldn10) were identified as novel Clara cell markers. New and existing Clara cell marker genes were categorized into three classes based on their unique developmental expression pattern. Cldn10 was uniformly expressed in the epithelium at Embryonic Day (E)14.5 and became restricted to secretory cells at E18.5. This transition was defined by induction of Clara Cell Secretory Protein (CCSP). Maturation of secretory cells was associated with progressive increases in the expression of Fmo3, Pon1, Aox3, and Cyp2f2 between late embryonic and postnatal periods. Messenger RNA abundance of all categories of genes was dramatically decreased after naphthalene-induced airway injury, and displayed a sequence of temporal induction during repair that suggested sequential secretory cell maturation. We have defined a broader repertoire of Clara cell-specific genes that allows staging of epithelial maturation during development and repair. Overall design: 32 samples were isolated and used to screen UniSet Mouse 20K I Bioarrays (total lung RNA Mus musculus). Control RNA was isolated from uninjured mice (N = 4 mice), and RNA was also isolated from mice exposed to naphthalene and recovered for 1, 2, 3, and 6 days (N = 4 mice per timepoint). Additionally, transgenic mice expressing HSV-tk under control of the mouse CCSP promoter were exposed to Ganciclovir (GCV) and recovered for 3, 6, and 9 days (N = 4 mice per timepoint)....
  16. Male and Female Mice Show Significant Temporal Differences in Hepatic Transcriptomic Response to TCDD ArrayExpress

    ID: E-GEOD-61038

    Description: TCDD-responsive genes were identified, including Fmo3 and Nr1i3 upregulated in male mice and Sult3a1 downregulated in female mice; 5) functional analysis of these candidate genes showed various biological pathway enrichments in a sex-dependent manner. Our study shows that the sex-dependent sensitivities to TCDD exposure are associated with a set of sex-specific TCDD-responsive genes that are indirectly regulated by AHR activity. The exact roles of these genes in response to TCDD exposure are not clear and require further investigation. Adult male and female C57BL/6 mice were treated by gavage with one single-dose TCDD (125, 250, 500, or 1000 μg/kg) in corn oil or corn oil vehicle alone. Animals were euthanized at 96 hours after treatment and tissues were harvested. RNA was isolated from hepatic tissue and the transcriptome for each animal assayed on an individual microarray....

  17. Transcription profiling of mouse liver from wild-type or genetically deleted AHRs were treated with corn oil vehicle or TCDD reveals aryl hydrocarbon ... ArrayExpress

    ID: E-GEOD-10082

    Description: r. The flavin-containing monooxygenases, Fmo2 and Fmo3, considered previously to be uninducible, were highly induced by TCDD in an AHR-dependent manner. The estrogen receptor alpha as well as two estrogen-receptor-related genes (alpha and gamma) exhibit AHR-dependent expression, thereby extending cross-talk opportunities between the intensively studied AHR and estrogen receptor pathways. p53 binding sites are over-represented in genes down-regulated by TCDD, suggesting that TCDD inhibits p53 transcriptional activity. Overall, our study identifies a wide range of genes that depend on the AHR, either for constitutive expression or for response to TCDD. Experiment Overall Design: Mice bearing wild-type or genetically deleted AHRs were treated with corn oil vehicle or TCDD, and their livers analyzed by expression arrays....

  18. A genome-wide expression comparison of productive and unproductive airway epithelial repair GEMMA

    ID: 1378

    Keywords: functional genomics

    Description: gene expression profile. Flavin monooxygenase 3 (Fmo3), paraoxonase 1 (Pon1), aldehyde oxidase 3 (Aox3), and claudin 10 (Cldn10) were identified as novel Clara cell markers. New and existing Clara cell marker genes were categorized into three classes based on their unique developmental expression pattern. Cldn10 was uniformly expressed in the epithelium at Embryonic Day (E)14.5 and became restricted to secretory cells at E18.5. This transition was defined by induction of Clara Cell Secretory Protein (CCSP). Maturation of secretory cells was associated with progressive increases in the expression of Fmo3, Pon1, Aox3, and Cyp2f2 between late embryonic and postnatal periods. Messenger RNA abundance of all categories of genes was dramatically decreased after naphthalene-induced airway injury, and displayed a sequence of temporal induction during repair that suggested sequential secretory cell maturation. We have defined a broader repertoire of Clara cell-specific genes that allows staging of epithelial maturation during development and repair. Last Updated (by provider): Aug 17 2009 Contributers: Anna C Zemke Barry R Stripp Joshua C Snyder...

  19. Sex related differences in murine transcriptional response to TCDD toxicity BioProject

    ID: PRJNA260128

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: positive control, CYP1A1) were modest, with only FMO3 showing clear induction, and no genes with sex-differences. Thus, while male and female mice show transcriptional differences in their response to TCDD, their association with TCDD-induced toxicities remains unclear. Overall design: Adult male and female C57BL/6 mice were treated by gavage with either 500 ug/kg TCDD in corn oil or corn oil vehicle alone. Animals were euthanized at either 6, 24, 72 or 144 hours after treatment and tissues were harvested. RNA was isolated from hepatic tissue and the transcriptome for each animal assayed on an individual microarray. Please note that 7 samples (out of total 65 samples) were identified as outliers and therefore the data were processed without the outliers as well. The normalized data without outliers were provided in the 'normalized_data_without_outliers.txt' file....
  20. Aryl Hydrocarbon Receptor Regulates Distinct Dioxin-Dependent and Dioxin-Independent Gene Batteries BioProject

    ID: PRJNA108647

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: r. The flavin-containing monooxygenases, Fmo2 and Fmo3, considered previously to be uninducible, were highly induced by TCDD in an AHR-dependent manner. The estrogen receptor alpha as well as two estrogen-receptor-related genes (alpha and gamma) exhibit AHR-dependent expression, thereby extending cross-talk opportunities between the intensively studied AHR and estrogen receptor pathways. p53 binding sites are over-represented in genes down-regulated by TCDD, suggesting that TCDD inhibits p53 transcriptional activity. Overall, our study identifies a wide range of genes that depend on the AHR, either for constitutive expression or for response to TCDD. Keywords: treatment-control and mutant-wildtype Overall design: Mice bearing wild-type or genetically deleted AHRs were treated with corn oil vehicle or TCDD, and their livers analyzed by expression arrays....

Displaying 20 of 22 results for "FMO3"