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Displaying 20 of 22 results for "FKBP6"
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  1. A role for Fkbp6 and the chaperone machinery in piRNA amplification and transposon silencing BioProject

    ID: PRJNA170205

    Keywords: Transcriptome or Gene expression

    Access Type: download

  2. A role for Fkbp6 and the chaperone machinery in piRNA amplification and transposon silencing ArrayExpress

    ID: E-GEOD-39203

    Description: y understood mechanism. Here, we identified mouse Fkbp6 as a factor in this biogenesis pathway delivering piRNAs to the Piwi protein Miwi2. Mice lacking Fkbp6 derepress LINE1 (L1) retrotransposon and display reduced DNA methylation due to deficient nuclear accumulation of Miwi2. Like other co-chaperones, Fkbp6 associates with the molecular chaperone Hsp90 via its tetratr...

  3. FKBP6.nex alignment Dryad

    DateIssued: 10-31-2016

  4. A role for Fkbp6 and the chaperone machinery in piRNA amplification and transposon silencing OmicsDI

    ID: E-GEOD-39203

    Date Released: 11-06-2012

    Description: y understood mechanism. Here, we identified mouse Fkbp6 as a factor in this biogenesis pathway delivering piRNAs to the Piwi protein Miwi2. Mice lacking Fkbp6 derepress LINE1 (L1) retrotransposon and display reduced DNA methylation due to deficient nuclear accumulation of Miwi2. Like other co-chaperones, Fkbp6 associates with the molecular chaperone Hsp90 via its tetratr...

  5. FKBP6_BOVIN UniProt:Swiss-Prot

    ID: A6QQ71

    Description: Inactive peptidyl-prolyl cis-trans isomerase FKBP6 PPIase FKBP-type TPR 1 TPR 2 TPR 3

  6. FKBP6_RAT UniProt:Swiss-Prot

    ID: D3ZQF4

    Description: Inactive peptidyl-prolyl cis-trans isomerase FKBP6 PPIase FKBP-type TPR 1 TPR 2 TPR 3

  7. FKBP6_HORSE UniProt:Swiss-Prot

    ID: F6PHZ6

    Description: Inactive peptidyl-prolyl cis-trans isomerase FKBP6 PPIase FKBP-type TPR 1 TPR 2 TPR 3 Associated with the impaired acrosomal reaction phenotype....

  8. Small RNA analysis for fetal testes of Hsp90-alpha knockout mice ArrayExpress

    ID: E-GEOD-54515

    Description: of MIWI2, a PIWI homolog. Whereas the mutation in Fkbp6 encoding a co-chaperone reduced piRNAs of 28-32 nucleotides in length, the Hsp90α mutation reduced piRNAs of 24-32 nucleotides, suggesting the presence of both FKBP6-dependent and -independent actions of HSP90α. Although DNA methylation and mRNA levels of L1 retrotransposon were largely unchanged in the Hsp90α mutant testes, the L1-encoded protein was increased, suggesting the presence of post-transcriptional regulation. This study revealed the specialized function of the HSP90α isofom in the piRNA biogenesis and repression of retrotransposons during the deve...

  9. Crystal structure of human FK506-Binding Protein 6 PDB

    ID: PDB:3B7X

    Description: FK506-binding protein 6 (E.C.5.2.1.8)

    gene.name: FKBP6, FKBP36
  10. Small RNA analysis for fetal testes of Hsp90-alpha knockout mice BioProject

    ID: PRJNA236752

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: of MIWI2, a PIWI homolog. Whereas the mutation in Fkbp6 encoding a co-chaperone reduced piRNAs of 28-32 nucleotides in length, the Hsp90α mutation reduced piRNAs of 24-32 nucleotides, suggesting the presence of both FKBP6-dependent and -independent actions of HSP90α. Although DNA methylation and mRNA levels of L1 retrotransposon were largely unchanged in the Hsp90α mutant testes, the L1-encoded protein was increased, suggesting the presence of post-transcriptional regulation. This study revealed the specialized function of the HSP90α isofom in the piRNA biogenesis and repression of retrotransposons during the deve...
  11. Small RNA analysis for fetal testes of Hsp90-alpha knockout mice OmicsDI

    ID: E-GEOD-54515

    Date Released: 12-10-2014

    Description: of MIWI2, a PIWI homolog. Whereas the mutation in Fkbp6 encoding a co-chaperone reduced piRNAs of 28-32 nucleotides in length, the Hsp90α mutation reduced piRNAs of 24-32 nucleotides, suggesting the presence of both FKBP6-dependent and -independent actions of HSP90α. Although DNA methylation and mRNA levels of L1 retrotransposon were largely unchanged in the Hsp90α mutant testes, the L1-encoded protein was increased, suggesting the presence of post-transcriptional regulation. This study revealed the specialized function of the HSP90α isofom in the piRNA biogenesis and repression of retrotransposons during the deve...

  12. SOLUTION STRUCTURE OF FKBP, A ROTAMASE ENZYME AND RECEPTOR FOR FK506 AND RAPAMYCIN PDB

    ID: PDB:1FKR

    Description: FK506 AND RAPAMYCIN-BINDING PROTEIN (FKBP12) (NMR, 20 STRUCTURES)

  13. SOLUTION STRUCTURE OF FKBP, A ROTAMASE ENZYME AND RECEPTOR FOR FK506 AND RAPAMYCIN PDB

    ID: PDB:1FKT

    Description: FK506 AND RAPAMYCIN-BINDING PROTEIN (FKBP12) (NMR, MINIMIZED AVERAGE STRUCTURE)

  14. SOLUTION STRUCTURE OF FKBP, A ROTAMASE ENZYME AND RECEPTOR FOR FK506 AND RAPAMYCIN PDB

    ID: PDB:1FKS

    Description: FK506 AND RAPAMYCIN-BINDING PROTEIN (FKBP12) (NMR, MINIMIZED AVERAGE STRUCTURE EXCLUDING ELECTROSTATIC INTERACTIONS)

  15. Solution structure of the TbPIN1 PDB

    ID: PDB:2LJ4

    Description: Peptidyl-prolyl cis-trans isomerase/rotamase, putative (E.C.5.2.1.8)

  16. DESIGN, SYNTHESIS, AND KINETIC EVALUATION OF HIGH-AFFINITY FKBP LIGANDS, AND THE X-RAY CRYSTAL STRUCTURES OF THEIR COMPLEXES WITH FKBP12 PDB

    ID: PDB:1FKI

    Description: FK506 BINDING PROTEIN (FKBP) COMPLEX WITH ROTAMASE INHIBITOR (21S)-1-AZA-4,4-DIMETHYL-6,19-DIOXA-2,3,7,20-TETRAOXOBICYCLO[19.4.0]PENTACOSANE

  17. DESIGN, SYNTHESIS, AND KINETIC EVALUATION OF HIGH-AFFINITY FKBP LIGANDS, AND THE X-RAY CRYSTAL STRUCTURES OF THEIR COMPLEXES WITH FKBP12 PDB

    ID: PDB:1FKH

    Description: FK506 BINDING PROTEIN (FKBP) COMPLEX WITH ROTAMASE INHIBITOR (1R)-1-CYCLOHEXYL-3-PHENYL-1-PROPYL (2S)-1-(3,3-DIMETHYL-1,2-DIOXOPENTYL)-2-PIPERIDINECAR...

  18. CRYSTAL STRUCTURE OF an atypical cyclophilin (peptidylprolyl cis-trans isomerase) (TM1367) FROM THERMOTOGA MARITIMA AT 1.90 A RESOLUTION PDB

    ID: PDB:1ZX8

    Description: hypothetical protein TM1367

  19. DESIGN, SYNTHESIS, AND KINETIC EVALUATION OF HIGH-AFFINITY FKBP LIGANDS, AND THE X-RAY CRYSTAL STRUCTURES OF THEIR COMPLEXES WITH FKBP12 PDB

    ID: PDB:1FKG

    Description: FK506 BINDING PROTEIN (FKBP) COMPLEX WITH ROTAMASE INHIBITOR (1R)-1,3-DIPHENYL-1-PROPYL (2S)-1-(3,3-DIMETHYL-1,2-DIOXOPENTYL)-2-PIPERIDINECARBOXYLATE

  20. Allele-specific binding of ZFP57 in the regulation of imprinted and mono-allelic expression OmicsDI

    ID: E-GEOD-55382

    Date Released: 05-22-2015

    Description: nd we identify new imprinted genes, including the Fkbp6 gene with a critical function in mouse male germ cell development. Genetic-background specific sequence differences also influence ZFP57 binding. We show that genetic variation that disrupts the consensus binding motif and its methylation is associated with mono-allelic expression of neighbouring genes. The work described here uncovers further roles for ZFP57 mediated regulation of genomic imprinting and identifies a novel mechanism for genetically determined mono-allelic gene expression. Input and Zfp57 CHiP-Seq profiles of hybrid Black6/Cast ES cells were generated by sequencing using the Illumina GAIIx platform....


Displaying 20 of 22 results for "FKBP6"