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Displaying 20 of 44 results for "FHIT"
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  1. FHIT-APO PDB

    ID: PDB:4FIT

    Description: FRAGILE HISTIDINE TRIAD PROTEIN

  2. FHIT (FRAGILE HISTIDINE TRIAD PROTEIN) IN COMPLEX WITH ADENOSINE/SULFATE AMP ANALOG PDB

    ID: PDB:3FIT

    Description: FRAGILE HISTIDINE PROTEIN, ADENOSINE-5'-MONOPHOSPHATE

  3. Identification of transcriptional changes induced by FHIT in lung cancer cells NCI-H460 BioProject

    ID: PRJNA106293

    Keywords: Transcriptome or Gene expression

    Access Type: download

  4. SUBSTRATE ANALOG (IB2) COMPLEX WITH THE HIS 96 ASN SUBSTITUTION OF THE FRAGILE HISTIDINE TRIAD PROTEIN, FHIT PDB

    ID: PDB:2FHI

    Description: FRAGILE HISTIDINE TRIAD PROTEIN, P1-P2-METHYLENE-P3-THIO-DIADENOSINE TRIPHOSPHATE

  5. FHIT (FRAGILE HISTIDINE TRIAD PROTEIN) PDB

    ID: PDB:2FIT

    Description: FRAGILE HISTIDINE PROTEIN

  6. FHIT (FRAGILE HISTIDINE TRIAD PROTEIN) PDB

    ID: PDB:1FIT

    Description: FRAGILE HISTIDINE PROTEIN

  7. FHIT-SUBSTRATE ANALOG PDB

    ID: PDB:5FIT

    Description: FRAGILE HISTIDINE TRIAD PROTEIN, PHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER

  8. FHIT-TRANSITION STATE ANALOG PDB

    ID: PDB:6FIT

    Description: FRAGILE HISTIDINE TRIAD PROTEIN, ADENOSINE MONOTUNGSTATE

  9. SUBSTRATE ANALOG (IB2) COMPLEX WITH THE FRAGILE HISTIDINE TRIAD PROTEIN, FHIT PDB

    ID: PDB:1FHI

    Description: FRAGILE HISTIDINE TRIAD PROTEIN, P1-P2-METHYLENE-P3-THIO-DIADENOSINE TRIPHOSPHATE

  10. Mus musculus strain:C57BL/6 : Mus musculus strain:C57BL/6 Exome BioProject

    ID: PRJNA260539

    Keywords: exome

    Access Type: download

    dataset.description: FHIT gene expression is lost or decreased in >50% of human cancers, with loss occurring during the preneoplastic process. To furthe...
  11. Homo sapiens : Comprehensive Long Span Paired-End-Tag Mapping Reveals Recurrent Fusion Genes in Gastric Cancer Genomes BioProject

    ID: PRJNA234469

    Keywords: variation

    Access Type: download

    dataset.description: rent SVs involving tumor suppress genes, WWOX and FHIT. There were total 131 fusion genes predicted by somatic SVs and 99 of them could be validated by genomic PCR. The further RT-PCR results indicated the expression of 47 fusion genes and 11 of them were in frame fusion genes. Screening the in frame fusion genes in another 85 gastric primary tumors uncovered 5 recurrent fusion genes with at frequencies of 2-5%....
  12. Copy number variation analysis of human Barrett's esophagus stem cells (HumanOmniZhongHua-8 v1.1 Beadchip) BioProject

    ID: PRJNA283321

    Keywords: Variation

    Access Type: download

    dataset.description: ay. It has shown that deletions such as p16 and FHIT in BE stem cells are significantly detected, while amplifications in BE stem cells are not. Also, we found some of BE stem cells did not share these deletions, suggesting emerging of BE does not require specific CNV. Overall design: SNP array based copy number variation study was performed for BE and GC stem cells from human endoscopic biopsy (12 patients) to assess genomic stability at chromosomal level....
  13. Copy number variation analysis of human Barrett's esophagus stem cells (HumanOmniZhongHua-8 v1.1 Beadchip) ArrayExpress

    ID: E-GEOD-68663

    Description: ay. It has shown that deletions such as p16 and FHIT in BE stem cells are significantly detected, while amplifications in BE stem cells are not. Also, we found some of BE stem cells did not share these deletions, suggesting emerging of BE does not require specific CNV. SNP array based copy number variation study was performed for BE and GC stem cells from human endoscopic biopsy (12 patients) to assess genomic stability at chromosomal level....

  14. chromothripsis in neuroblastoma BioProject

    ID: PRJEB671

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: ith disrupted exon structure including ALK, NBAS, FHIT, PTPRD and ODZ4. RNA-seq analysis allowed the identification of abnormal transcripts expressed from genomic rearrangements that may be involved in neuroblastoma oncogenesis....
  15. Copy number variation analysis of human Barrett's esophagus stem cells (HumanOmniZhongHua-8 v1.0 Beadchip) BioProject

    ID: PRJNA283320

    Keywords: Variation

    Access Type: download

    dataset.description: ay. It has shown that deletions such as p16 and FHIT in BE stem cells are significantly detected, while amplifications in BE stem cells are not. Also, we found some of BE stem cells did not share these deletions, suggesting emerging of BE does not require specific CNV. Overall design: SNP array based copy number variation study was performed for BE and GC stem cells from human endoscopic biopsy (12 patients) to assess genomic stability at chromosomal level....
  16. CRYSTAL STRUCTURE OF THE C. ELEGANS NITFHIT PROTEIN PDB

    ID: PDB:1EMS

    Description: C. ELEGANS NITFHIT PROTEIN

    primaryPublication.title: Crystal structure of the worm NitFhit Rosetta Stone protein reveals a Nit tetramer binding two Fhit dimers.
  17. Affymetrix SNP array data for Primary Effusion Lymphoma samples ArrayExpress

    ID: E-GEOD-25839

    Description: both the fragile site tumor suppressors WWOX and FHIT. Alterations were also observed in: DERL1, ETV1, RASA4, TPK1, TRIM56 and VPS41 genes, which are yet to be characterized for their roles in cancer. Co-infection with EBV was associated with significantly fewer gross genomic aberrations. PEL could be segregated into EBV positive and EBV negative clusters on the basis of host chromosome alterations. The genomic signature of PEL cells in culture was analogous to those explanted from xenograft tumors. This suggests a model in which both host and virus contribute to the PEL phenotype. 17 samples (no replicate...

  18. RNA-seq of four neuroblastoma patient samples to identify abnormal transcripts expressed in each sample ArrayExpress

    ID: E-MTAB-1367

    Description: ith disrupted exon structure including ALK, NBAS, FHIT, PTPRD and ODZ4. RNA-seq analysis allowed the identification of abnormal transcripts expressed from genomic rearrangements that may be involved in neuroblastoma oncogenesis....

  19. Clonal evolution in relapsed NPM1 mutated acute myeloid leukemia ArrayExpress

    ID: E-GEOD-46951

    Description: es [ETV6 (n=3), TP53 (n=2), NF1 (n=2), WT1 (n=3), FHIT (n=2)] and homozygous FLT3 mutations acquired via UPD13q (n=7). DNMT3A mutations (DNMT3Amut) showed the highest stability (97%). Persistence of DNMT3Amut in 5 patients who lost NPM1mut at relapse suggests that DNMT3Amut may precede NPM1mut in AML pathogenesis. Of note, all relapse samples shared at least one genetic aberration with the matched primary AML sample implying common ancestral clones. In conclusion, our study reveals novel insights into clonal evolution in NPM1mut AML. Bone marrow or peripheral blood samples from diagnosis, remission and relapse of 53 NPM1 mutated AML patient were analyzed on the Affymetrix Genome-Wide Human SNP 6.0 Array. Raw data (CEL-Files) were transformed to genotyping files (CHP) with Genotyping Console Version 4.2 from Affymetrix. Bioinformatic evaluation of CNAs was performed using dChipSNP and circular binary segmentation ....

  20. Comparative genomic hybridization of human Burkitts lymphoma samples ArrayExpress

    ID: E-TABM-703

    Description: 14.1 <60.43-60.53> that removed the fifth exon of FHIT. Further investigations which combined gene expression and functional studies are essential to understand the lymphomagenesis mechanism and for the development of more effective, targeted therapeutic strategies...


Displaying 20 of 44 results for "FHIT"