FGF22 | bioCADDIE Data Discovery Index
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Displaying 18 of 18 results for "FGF22"
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  1. FGF22_MOUSE UniProt:Swiss-Prot

    ID: Q9ESS2

    Description: Fibroblast growth factor 22

  2. CD133+ and CD133- CSC lines in primary human GBM BioProject

    ID: PRJNA98331

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: We cultured tumor cells from 22 GBM under medium conditions favoring the growth of neural stem cells. 11 out of 15 primary GBM contained a si...
  3. Stimulation of endogenous FGFR1b and FGFR2b ArrayExpress

    ID: E-GEOD-48924

    Description: arrays contain 48324 features, with an average of 22 beads per feature (Standard Deviation of 5)...

  4. stoma-derived cancer stem cells show differential growth characteristics and expression profiles... ArrayExpress

    ID: E-GEOD-7181

    Description: We cultured tumor cells from 22 GBM under medium conditions favoring the growth of neural stem cells. 11 out of 15 primary GBM contained a si...

  5. EwingFGFR1 : Deep sequencing in conjunction with expression and functional analyses reveals activation of FGFR1 in Ewing sarcoma BioProject

    ID: PRJEB8907

    Keywords: Other

    Access Type: download

    dataset.description: Whole Exome Sequencing was performed on 50 ES and 22 matched normal tissues. A discovery data set of 14 of these tumor/normal pairs identified 232 somatic mutations. Recurrent non-synonymous muta- tions were validated in the 36 remaining exomes. Transcriptome analysis was performed in a subset of 14/50 ES and DNA copy number gain and expression of FGFR1 in 63/116 ES. Results: Relapsed tumors consistently showed a 2- to 3-fold increased number of mutations. We identified several recurrently mutated genes at low frequency (ANKRD30A, CCDC19, KIAA0319, KIAA1522, LAMB4, SLFN11, STAG2, TP53, UNC80, ZNF98). An oncogenic fibroblast growth factor receptor 1 (FGFR1) mutation (N546K) was detecte...
  6. Effect of a High Phosphorus Diet on Hepatic Gene Expressions in Rat ArrayExpress

    ID: E-GEOD-71201

    Description: ctivated receptor alpha (PPARα), a transcription factor for fatty acid β-oxidation. Evaluation of the upstream regulators of DEGs using Ingenuity Pathway Analysis indicated that PPARα was activated in the livers of HP diet-fed rats. Furthermore, the serum concentration of fibroblast growth factor 21, a hormone secreted from the liver that promotes fatty acid utilization in adipose tissue as a PPARα target gene, was higher (p = 0.054) in HP diet-fed rats than in control diet-fed rats. These data suggest that a HP diet enhances energy expenditure through the utilization of free fatty acids released via lipolysis of white adipose tissue. Male Wistar rats (4 weeks old) were purchased from Japan SLC Co. (Hamamatsu, Japan) and individually housed in metabolic cages under controlled conditions of 22±1°C and a 12-hour light/dark cycle (lights on from 08:00 to 20:00 daily). Two different diets containing 0.3% phosphorous (control diet) and 1.2% phosphorous (HP diet) were prepared based on the AIN-93G diet (Table 1).9) All rats were fed the control diet for a 7-day acclimatization period. After acclimatization, rats were divided into two groups of similar mean body weight (n = 5 each) and then fed either the control or the HP diet for 24 days. The animals were allowed to eat ad libitum and had free access to water (MilliQ water).The protocol for the animal experiments was approved by the Animal Use Committee of the Faculty of Agriculture at The University of Tokyo. Please note...

  7. Stimulation of endogenous FGFR1b and FGFR2b BioProject

    ID: PRJNA212326

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: arrays contain 48324 features, with an average of 22 beads per feature (Standard Deviation of 5)...
  8. Effect of a High Phosphorus Diet on Hepatic Gene Expressions in Rat BioProject

    ID: PRJNA290572

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: ctivated receptor alpha (PPARα), a transcription factor for fatty acid β-oxidation. Evaluation of the upstream regulators of DEGs using Ingenuity Pathway Analysis indicated that PPARα was activated in the livers of HP diet-fed rats. Furthermore, the serum concentration of fibroblast growth factor 21, a hormone secreted from the liver that promotes fatty acid utilization in adipose tissue as a PPARα target gene, was higher (p = 0.054) in HP diet-fed rats than in control diet-fed rats. These data suggest that a HP diet enhances energy expenditure through the utilization of free fatty acids released via lipolysis of white adipose tissue. Overall design: Male Wistar rats (4 weeks old) were purchased from Japan SLC Co. (Hamamatsu, Japan) and individually housed in metabolic cages under controlled conditions of 22±1°C and a 12-hour light/dark cycle (lights on from 08:00 to 20:00 daily). Two different diets containing 0.3% phosphorous (control diet) and 1.2% phosphorous (HP diet) were prepared based on the AIN-93G diet (Table 1).9) All rats were fed the control diet for a 7-day acclimatization period. After acclimatization, rats were divided into two groups of similar mean body weight (n = 5 each) and then fed either the control or the HP diet for 24 days. The animals were allowed to eat ad libitum and had free access to water (MilliQ water).The protocol for the animal experiments was approved by the Animal Use Committee of the Faculty of Agriculture at The University of Tok...
  9. Homo sapiens : Molecular characterization of bladder cancer patient-derived xenografts with whole-exome sequencing BioProject

    ID: PRJNA352282

    Keywords: exome

    Access Type: download

    dataset.description: o study the mechanisms of secondary resistance, a fibroblast growth factor receptor 3 inhibitor BGJ398 prolonged PFS of PDX BL0293 from 9.5 days of the control to 18.5 days (p<0.0001), and serial biopsies revealed that the MAPK/ERK and PIK3CA-AKT pathways were activated upon resistance. Inhibition of these pathways significantly prolonged PFS from 12 day of the control to 22 days (p=0.001). To screen for effective chemotherapeutic drugs, four of the first six PDXs were sensitive to the cisplatin/gemcitabine combination, and chemoresistance to one drug could be overcome by the other drug. In conclusion, the PDX platform allows screening for multiple targeted therapy, chemotherapy, or combinations simultaneously for the most efficacious drugs or combination, serial biopsies during treatment to study drug resistance and for drug development, a task not possibly replicable at the clinical setting....
  10. Chromosomal aberrations in benign and malignant salivary gland myoepitheliomas BioProject

    ID: PRJNA110983

    Keywords: Variation

    Access Type: download

    dataset.description: uency gains (≥20%) were found mainly at loci of growth factors and growth factor receptors (e.g. PDGF, FGF(R)s, and EGFR). In myoepitheliomas, high frequency losses (≥20%) were detected at regions of proto-cadherins. Cluster analysis of the array CGH data identified three clusters. Differential copy numbers on chromosome arm 8q and chromosome 17 set the clusters apart. Cluster 1 contained a mixture of the two phenotypes (n=10), cluster 2 included mostly benign tumors (n=10), and cluster 3 only contained carcinomas (n=7). Supervised analysis between malignant and benign tumors revealed a 36 Mbp-region at 8q being more frequently gained in malignant tumors (p=0.007, FDR=0.05). This is the first study investigating genomic differences between benign and malignant myoepithelial tumors of the salivary glands at a genomic level. Both unsupervised and supervised analysis of the genomic profiles revealed chromosome arm 8q to be involved i...
  11. Over-expression of FGFR2b from a tetracycline-inducible expression vector ArrayExpress

    ID: E-GEOD-48927

    Description: al arrays contains 48324 features, with a mean of 22 beads per feature (Standard Deviation of 5)...

  12. FGF2 sustains NANOG and switches the outcome of BMP4 induced human embryonic stem cell differentiation ArrayExpress

    ID: E-GEOD-25973

    Description: tiation time course, with or without FGF2. Set 3 (22 samples) is 5ng/mL of BMP4 induced H1 cells differentiation time course, with or without FGF2....

  13. TUMOR INITIATING CELLS AND IGF/FGF SIGNALING CONTRIBUTE TO SORAFENIB RESISTANCE IN HEPATOCELLULAR CARCINOMA ArrayExpress

    ID: E-GEOD-73571

    Description: IGN: HCC xenograft mice treated with sorafenib (n=22) were explored for responsiveness (n=5) and acquired resistance (n=17). Mechanism of acquired resistance were assessed by: 1) Role of T-ICs by in vitro sphere formation and in vivo tumorigenesis assays using NOD/SCID mice, 2) Activation of alternative signaling pathways and 3) Efficacy of anti-FGF and anti-IGF drugs in experimental models. Gene expression (microarray, qRT-PCR) and protein analyses (immunohistochemistry, western blot) were condu...

  14. FGF2 sustains NANOG and switches the outcome of BMP4 induced human embryonic stem cell differentiation BioProject

    ID: PRJNA135449

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: tiation time course, with or without FGF2. Set 3 (22 samples) is 5ng/mL of BMP4 induced H1 cells differentiation time course, with or without FGF2....
  15. Over-expression of FGFR2b from a tetracycline-inducible expression vector BioProject

    ID: PRJNA212327

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: al arrays contains 48324 features, with a mean of 22 beads per feature (Standard Deviation of 5)...
  16. TUMOR INITIATING CELLS AND IGF/FGF SIGNALING CONTRIBUTE TO SORAFENIB RESISTANCE IN HEPATOCELLULAR CARCINOMA BioProject

    ID: PRJNA297348

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: IGN: HCC xenograft mice treated with sorafenib (n=22) were explored for responsiveness (n=5) and acquired resistance (n=17). Mechanism of acquired resistance were assessed by: 1) Role of T-ICs by in vitro sphere formation and in vivo tumorigenesis assays using NOD/SCID mice, 2) Activation of alternative signaling pathways and 3) Efficacy of anti-FGF and anti-IGF drugs in experimental models. Gene expression (microarray, qRT-PCR) and protein analyses (immunohistochemistry, western blot) were condu...
  17. Effect of a High Phosphorus Diet on Hepatic Gene Expressions in Rat OmicsDI

    ID: E-GEOD-71201

    Date Released: 05-21-2016

    Description: ctivated receptor alpha (PPARα), a transcription factor for fatty acid β-oxidation. Evaluation of the upstream regulators of DEGs using Ingenuity Pathway Analysis indicated that PPARα was activated in the livers of HP diet-fed rats. Furthermore, the serum concentration of fibroblast growth factor 21, a hormone secreted from the liver that promotes fatty acid utilization in adipose tissue as a PPARα target gene, was higher (p = 0.054) in HP diet-fed rats than in control diet-fed rats. These data suggest that a HP diet enhances energy expenditure through the utilization of free fatty acids released via lipolysis of white adipose tissue. Male Wistar rats (4 weeks old) were purchased from Japan SLC Co. (Hamamatsu, Japan) and individually housed in metabolic cages under controlled conditions of 22±1°C and a 12-hour light/dark cycle (lights on from 08:00 to 20:00 daily). Two different diets containing 0.3% phosphorous (control diet) and 1.2% phosphorous (HP diet) were prepared based on the AIN-93G diet (Table 1).9) All rats were fed the control diet for a 7-day acclimatization period. After acclimatization, rats were divided into two groups of similar mean body weight (n = 5 each) and then fed either the control or the HP diet for 24 days. The animals were allowed to eat ad libitum and had free access to water (MilliQ water).The protocol for the animal experiments was approved by the Animal Use Committee of the Faculty of Agriculture at The University of Tokyo. Please note...

  18. Single-muscle-cell transcriptome profiling along the planarian anteroposterior axis BioProject

    ID: PRJNA299816

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: ; n=35 cells); pre-pharyngeal (regions 2, 3, 4; n=22 cells) versus tail (region 10; n=12 cells)) identified transcripts of 99 genes as differentially expressed at p 2.58). Whole mount in situ hybridization to visualize gene expression patterns verified 44 genes as regionally expressed (mRGs) (35/44 with p<0.005 in any of anterior-versus-posterior SCDE analyses)....

Displaying 18 of 18 results for "FGF22"