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Displaying 20 of 48 results for "FCGR1A"
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  1. Genome-wide DNA methylation profiles of human hepatocellular carcinoma ArrayExpress

    ID: E-GEOD-44970

    Description: s (e.g Akt, IGF signaling) are often activated in high proliferating HCC. Among several genetic alterations, epigenetic changes seem to be involved in the development and progression of HCC. DNA hypermethylation of promoter regions is almost always associated with transcriptional silencing...

  2. High-resolution crystal structure of Fc bound to its human receptor Fc-gamma-RI PDB

    ID: PDB:4W4O

    Description: Ig gamma-1 chain C region, High affinity immunoglobulin gamma Fc receptor I...

  3. IgG1 Fc-FcgammaRI ecd complex PDB

    ID: PDB:4ZNE

    Description: High affinity immunoglobulin gamma Fc receptor I, Ig gamma-1 chain C regio...

  4. Crystal structure of Fc RI and its implication to high affinity immunoglobulin G binding PDB

    ID: PDB:3RJD

    Description: High affinity immunoglobulin gamma Fc receptor I

  5. Structure of FcgammaRI in complex with Fc reveals the importance of glycan recognition for high affinity IgG binding PDB

    ID: PDB:4X4M

    Description: IgG1 Fc chain A, FcgammaRI

  6. Genome-wide DNA methylation profiles of human hepatocellular carcinoma BioProject

    ID: PRJNA192663

    Keywords: Epigenomics

    Access Type: download

    dataset.description: s (e.g Akt, IGF signaling) are often activated in high proliferating HCC. Among several genetic alterations, epigenetic changes seem to be involved in the development and progression of HCC. DNA hypermethylation of promoter regions is almost always associated with transcriptional silencing...
  7. MiRNA-127 Inhibits IgG Immune Complex-induced Lung Inflammation by Targeting IgG Fcγ Receptor I BioProject

    ID: PRJNA138521

    Keywords: Transcriptome or Gene expression

    Access Type: download

  8. MiRNA-127 Inhibits IgG Immune Complex-induced Lung Inflammation by Targeting IgG Fcγ Receptor I OmicsDI

    ID: E-GEOD-27642

    Date Released: 06-26-2012

    Description: ulation of inflammation by miR-127, we found that IgG Fcγ Receptor I (FcγRI/CD64) was a target of miR-127, as evidenced by reduced CD64 protein expression in macrophages over-expressing miR-127. Furthermore, miR-127 significantly reduced the luciferase activity with a reporter construct containing the native 3’-UTR of CD64. Importantly, we demonstrated that miR-127 attenuated lung inflammation in an IgG immune complex (IgG IC) model in vivo. Collectively, these data show that miR-127 targets macrophage CD64 expression and ...

  9. Transcriptome profile of mouse lung dendritic cell subsets and macrophages. OmicsDI

    ID: E-GEOD-46680

    Date Released: 06-03-2014

    Description: sed of two subsets: FLT3- and IRF4-dependent CD24+CD64- DCs and contaminating CSF-1R-dependent CD24-CD64+ macrophages. CD11b+CD24+CD64- DCs are instrumental in inducing Th17 cell immune response in the steady state and upon Aspergillus fumigatus challenge. We also identified human CD1c+CD11b+ DCs as the functional homologue of mouse mucosal CD11b+ DCs. Our findings highlight the conservation of key immune functions across species and aid the translation of murine studies to human DC immunobiology. The data for the associated human studies have been stored within GSE35459. Gene Expression from to...

  10. Monocytic U937 cells and receptor cross-linking BioProject

    ID: PRJNA90859

    Keywords: Transcriptome or Gene expression

    Access Type: download

  11. MiRNA-127 Inhibits IgG Immune Complex-induced Lung Inflammation by Targeting IgG Fcγ Receptor I ArrayExpress

    ID: E-GEOD-27642

    Description: ulation of inflammation by miR-127, we found that IgG Fcγ Receptor I (FcγRI/CD64) was a target of miR-127, as evidenced by reduced CD64 protein expression in macrophages over-expressing miR-127. Furthermore, miR-127 significantly reduced the luciferase activity with a reporter construct containing the native 3’-UTR of CD64. Importantly, we demonstrated that miR-127 attenuated lung inflammation in an IgG immune complex (IgG IC) model in vivo. Collectively, these data show that miR-127 targets macrophage CD64 expression and ...

  12. Transcriptome profile of mouse lung dendritic cell subsets and macrophages ArrayExpress

    ID: E-GEOD-46680

    Description: sed of two subsets: FLT3- and IRF4-dependent CD24+CD64- DCs and contaminating CSF-1R-dependent CD24-CD64+ macrophages. CD11b+CD24+CD64- DCs are instrumental in inducing Th17 cell immune response in the steady state and upon Aspergillus fumigatus challenge. We also identified human CD1c+CD11b+ DCs as the functional homologue of mouse mucosal CD11b+ DCs. Our findings highlight the conservation of key immune functions across species and aid the translation of murine studies to human DC immunobiology. The data for the associated human studies have been stored within GSE35459. Gene Expression from to...

  13. Microbiota regulate the ability of lung dendritic cells to induce IgA class switch recombination and generate protective GI immune responses BioProject

    ID: PRJNA302059

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: ssion between CD103+ lung DCs, CD24+ lung DCs and CD64+ lung macrophages in Specific pathogen free (SPF) and germ free (GF) mice. Hypothesis tested was that the IgA class switching function of lung DCs i...
  14. Progesterone receptor-B enhances estrogen responsiveness of breast cancer cells via scaffolding PELP1- and estrogen receptor-... BioProject

    ID: PRJNA195464

    Keywords: Transcriptome or Gene expression

    Access Type: download

  15. Transcriptome profile of mouse lung dendritic cell subsets and macrophages. BioProject

    ID: PRJNA201505

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: sed of two subsets: FLT3- and IRF4-dependent CD24+CD64- DCs and contaminating CSF-1R-dependent CD24-CD64+ macrophages. CD11b+CD24+CD64- DCs are instrumental in inducing Th17 cell immune response in the steady state and upon Aspergillus fumigatus challenge. We also identified human CD1c+CD11b+ DCs as the functional homologue of mouse mucosal CD11b+ DCs. Our findings highlight the conservation of key immune functions across species and aid the translation of murine studies to human DC immunobiology. The data for the associated human studies have been stored within GSE35459. Overall design: Gene Ex...
  16. Adipose tissue stromal cells from lean, obese, and formerly obese mice BioProject

    ID: PRJNA339547

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: n. Male C57Bl/6 mice were fed normal diet (ND) or high fat diet (HFD) for 16 weeks. Weight loss (WL) mice were switched from the HFD to ND for 8 weeks. RNA was purified from FACS sorted cell populations (live cells only) obtained from gonadal/epididymal adipose tissue depots. ATMs were defined as CD11c+ (CD45+CD64+ CD11c+) or CD11c- (CD45+CD64+ CD11c-) ATMs. ATDC were defined as CD64- CD11c+. PA were defined as CD31- CD45- Sca1+ PDGFRA+. Overall design: For ATM and ATDC analysis, 2 pools of cells from 4 ND mice were analyzed and 3 pools of 3-4 HFD mice were analyzed. For PA, 3 pools of 3-4 ND and HFD mice were analyzed. Due to the paucity of cells, CD11c+ ATM in ND mice were not purified....
  17. Expression data from a variant monocyte population following dendritc cell depletion OmicsDI

    ID: E-GEOD-58263

    Date Released: 04-04-2015

    Description: of a variant population of splenic MHC Class II+ CD64+ Ly6C+ monocytes that are distinct from both circulating blood Ly6C+ monocytes and their tissue counterparts, but resemble Ly6C+ cells mobilized by exogenous G-CSF and Flt3L. The CD64+ Ly6C+ monocyte population is characterized by up-regulation of TLR signalling apparatus and an increased capacity to produce TNF-a following stimulation. Therefore, perturbation within the mononuclear phagocytic system in the absence of inflammation induces an alternative differentiation pathway that drives expansion of monocytes poised for innate immune activation. M...

  18. Cell Image Library Dataset CIL:33705 CIL

    ID: 33705

    Description: s been immunostained for the cell-surface antigen CD64. Nuclei are stained in blue. This image is part of a large collection of images generated from numerous specimens to characterize the distribution of CD64 in human prostate ...

    Data Types: image

  19. Cell Image Library Dataset CIL:33706 CIL

    ID: 33706

    Description: s been immunostained for the cell-surface antigen CD64. Nuclei are stained in blue. This image is part of a large collection of images generated from numerous specimens to characterize the distribution of CD64 in human prostate ...

    Data Types: image

  20. Transcrription profiling of human monocytic U937 cells and receptor cross-linking OmicsDI

    ID: E-GEOD-1537

    Date Released: 06-10-2011

    Description: Monocytic U937 cell lines and crosslinked CD32 & CD64 at different time points


Displaying 20 of 48 results for "FCGR1A"