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  1. Whole-genome DNA methylation profiling identifies epigenetic signatures of uterine carcinosarcoma BioProject

    ID: PRJNA342097

    Keywords: Epigenomics

    Access Type: download

    dataset.description: icrodissection and compared DNA methylomes of UCS with that of normal endometrium as well as methylomes derived from endometrioid carcinoma, serous endometrial carcinoma, and endometrial stromal sarcoma. We identified epigenetic lesions specific to carcinosarcoma, and specific to two components. Hallmarks of DNA methylation abnormality of UCS included global hypomethylation, especially in repetitive elements, and hypermethylation of tumor suppressor gene promoters. Among these, aberrant DNA methylation of MIR200 genes is a key feature of UCS. ...

Displaying 1 of 1 results for "FAM83F"