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Displaying 13 of 13 results for "EIF5A2"
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  1. Crystal structure of eukaryotic translation initiation factor eIF-5A2 from Arabidopsis thaliana PDB

    ID: PDB:3HKS

    Description: Eukaryotic translation initiation factor 5A-2

  2. IF5A2_NICPL UniProt:Swiss-Prot

    ID: P24922

    Description: Eukaryotic translation initiation factor 5A-2 Hypusine

  3. Nuclear receptor coactivator 1 (NCOA1) is involved in the regulation of PCa cell migration via PRKD1 ArrayExpress

    ID: E-GEOD-75531

    Description: r, we found phospholipase A2, group7 (PLA2G7) and eukaryotic translation initiation factor 5A2 (EIF5A2), which might be involved in migration of PC3 cells. Further, we can clearly demonstrate that PRKD1 is negatively regulated by the AR/NCOA1 complex. In addition, immunhistochemical staining revealed a strong increase in NCOA1 expression in matched and unmatched patients’ samples, respectively between normal prostate and primary tumor. Regarding the PRKD1 staining, no final conclusion can be drawn in terms of a tumor suppressor function. Thus, our findings directly associate NCOA1/AR complex with PRKD1 regulation and further suggest NCOA1 as a potential therapeutic target also due to the effect on PC3 cell migration. Cell lines with a stable knockdown of NCOA1 were generated by lentiviral-based transduction of shRNA vectors. For each of the two cell lines MDA and PC3, gene expression profiles were generated for KO and CTRL samples with 3 biological replicates for...

  4. Nuclear receptor coactivator 1 (NCOA1) is involved in the regulation of PCa cell migration via PRKD1 OmicsDI

    ID: E-GEOD-75531

    Date Released: 06-26-2016

    Description: r, we found phospholipase A2, group7 (PLA2G7) and eukaryotic translation initiation factor 5A2 (EIF5A2), which might be involved in migration of PC3 cells. Further, we can clearly demonstrate that PRKD1 is negatively regulated by the AR/NCOA1 complex. In addition, immunhistochemical staining revealed a strong increase in NCOA1 expression in matched and unmatched patients’ samples, respectively between normal prostate and primary tumor. Regarding the PRKD1 staining, no final conclusion can be drawn in terms of a tumor suppressor function. Thus, our findings directly associate NCOA1/AR complex with PRKD1 regulation and further suggest NCOA1 as a potential therapeutic target also due to the effect on PC3 cell migration. Cell lines with a stable knockdown of NCOA1 were generated by lentiviral-based transduction of shRNA vectors. For each of the two cell lines MDA and PC3, gene expression profiles were generated for KO and CTRL samples with 3 biological replicates for...

  5. Nuclear receptor coactivator 1 (NCOA1) is involved in the regulation of PCa cell migration via PRKD1 BioProject

    ID: PRJNA304492

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: r, we found phospholipase A2, group7 (PLA2G7) and eukaryotic translation initiation factor 5A2 (EIF5A2), which might be involved in migration of PC3 cells. Further, we can clearly demonstrate that PRKD1 is negatively regulated by the AR/NCOA1 complex. In addition, immunhistochemical staining revealed a strong increase in NCOA1 expression in matched and unmatched patients’ samples, respectively between normal prostate and primary tumor. Regarding the PRKD1 staining, no final conclusion can be drawn in terms of a tumor suppressor function. Thus, our findings directly associate NCOA1/AR complex with PRKD1 regulation and further suggest NCOA1 as a potential therapeutic target also due to the effect on PC3 cell migration. Overall design: Cell lines with a stable knockdown of NCOA1 were generated by lentiviral-based transduction of shRNA vectors. For each of the two cell lines MDA and PC3, gene expression profiles were generated for KO and CTRL samples with 3 biologica...
  6. IF5A2_PONAB UniProt:Swiss-Prot

    ID: Q5R898

    Description: Removed Eukaryotic translation initiation factor 5A-2 N-acetylalanine Hypusine...

  7. IF5A2_MOUSE UniProt:Swiss-Prot

    ID: Q8BGY2

    Description: Removed Eukaryotic translation initiation factor 5A-2 N-acetylalanine Hypusine...

  8. IF5A2_CHICK UniProt:Swiss-Prot

    ID: Q07460

    Description: Removed Eukaryotic translation initiation factor 5A-2 N-acetylalanine Hypusine...

  9. EphA6 promotes angiogenesis and prostate cancer metastasis and is associated with human prostate cancer progression ArrayExpress

    ID: E-GEOD-66335

    Description: fied a panel of genes, such as PIK3IPA, AKT1, and EIF5A2, which could be associated with EphA6-regulated cancer progression. Conclusions: These findings identify EphA6 as a potentially novel metastasis gene, and increased EphA6 mRNA expression positively correlates with CaP progression. The mechanisms to inhibit EphA6 expression might suppress CaP metastatic aggressiveness. Knock-down of EphA6 induced gene expression in human prostate cell:PC-3M/shEphA6-1, PC3M/shControl, CWR22rv1/shEphA6-1, and CWR22rv1/shControl cell line....

  10. Crystal structure of human eukaryotic translation initiation factor EIF5A PDB

    ID: PDB:3CPF

    Description: Eukaryotic translation initiation factor 5A-1

  11. EphA6 promotes angiogenesis and prostate cancer metastasis and is associated with human prostate cancer progression BioProject

    ID: PRJNA276564

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: fied a panel of genes, such as PIK3IPA, AKT1, and EIF5A2, which could be associated with EphA6-regulated cancer progression. Conclusions: These findings identify EphA6 as a potentially novel metastasis gene, and increased EphA6 mRNA expression positively correlates with CaP progression. The mechanisms to inhibit EphA6 expression might suppress CaP metastatic aggressiveness. Overall design: Knock-down of EphA6 induced gene expression in human prostate cell:PC-3M/shEphA6-1, PC3M/shControl, CWR22rv1/shEphA6-1, and CWR22rv1/shControl cell line....
  12. EphA6 promotes angiogenesis and prostate cancer metastasis and is associated with human prostate cancer progression OmicsDI

    ID: E-GEOD-66335

    Date Released: 03-08-2015

    Description: fied a panel of genes, such as PIK3IPA, AKT1, and EIF5A2, which could be associated with EphA6-regulated cancer progression. Conclusions: These findings identify EphA6 as a potentially novel metastasis gene, and increased EphA6 mRNA expression positively correlates with CaP progression. The mechanisms to inhibit EphA6 expression might suppress CaP metastatic aggressiveness. Knock-down of EphA6 induced gene expression in human prostate cell:PC-3M/shEphA6-1, PC3M/shControl, CWR22rv1/shEphA6-1, and CWR22rv1/shControl cell line....

  13. PRJEB3090 BioProject

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: rRNA, 18S rRNA, 60S ribosomal protein L5 mRNA and eiF5a2 translation factor mRNA. The internal polyadenylation RNA truncation phenomenon is possibly related to a novel post-transcriptional control of gene expression in Leishmania and highlights the importance of evaluating this RNA modification in high-throughput transcriptome analyses in other species....

Displaying 13 of 13 results for "EIF5A2"