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Displaying 20 of 23 results for "EIF2AK2"
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  1. PKRI1_PONAB UniProt:Swiss-Prot

    ID: Q5R5J3

    Description: PRKR-interacting protein 1 Interaction with EIF2AK2 Required for RNA-binding Required for nuclear localization Poly-Ser Poly-Glu

  2. PKRI1_BOVIN UniProt:Swiss-Prot

    ID: Q2KIT1

    Description: PRKR-interacting protein 1 Interaction with EIF2AK2 Required for RNA-binding Required for nuclear localization

  3. Expression analysis of M.tb H37Rv after treatment with DTT (reduced) for 3 hrs ArrayExpress

    ID: E-GEOD-68350

    Description: Effect of Thiol reductive stress (DTT 1mM) on M.tb Rv was studied. DTT reduced at 1 mM concentration was added to log pahse culture of M.tb H37Rv. Aft...

  4. Signaling pathways in skeletal muscle of Amyotrophic Lateral Sclerosis mouse model BioProject

    ID: PRJNA173775

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: own-regulated genes (PIK3C2A, RIPK4, ID2, C1QDC1, EIF2AK2, RAC3, CDS1, INPPL1, TBL1X) at 40 days and also to one up- (PIK3CA) and five down-regulated genes (CD44, EEF2K, FZD2, CREBBP, PIKI3R1) at 80 days. Based on differentially expressed genes, analyses for gene priorization were performed and used to construct a network of protein-protein interaction. The network based on the genes of 40 and 80 days old mice was composed by 251 and 531 genes, respectively. GRB2 and SRC were identified as central genes of both networks. In conclusion, changes in gene expression of skeletal muscle from transgenic ALS mice in pre-symptomatic periods give further evidence of early neuromuscular abnormalities that precede motor neuron death. Overall design: We p...
  5. Genome wide host gene expression analysis in duck lungs infected with highly or low pathogenic H5N1 avian influenza virus ArrayExpress

    ID: E-GEOD-65230

    Description: tant antiviral immune genes IFIT5, IFITM5, RSAD2, EIF2AK2 (PKR), Mx, β-defensins, TRIM23 and SLC16A3 to AD2008 infection, but not in AD2011 infection, cause the host may fine-tune their innate immune responses and prevent from cytokines storms and tissue damage. Several immune related Gene ontology (GO) terms and immune pathways activated were qualitatively similar but quantitatively different to both virus infections. Based on these findings, we conclude that subtle differences in host immune responses may determine the different outcome of H5N1 infection in ducks. Agilent Custom Duck Gene Expression 8X60k (AMADID: G4102A_059612) designed by Genotypic Technology Private Limited , Labeling kit: Agilent Quick-Amp labeling Kit (p/n5190-0442)...

  6. Expression analysis of M.tb H37Rv after treatment with DTT (reduced) for 3 hrs BioProject

    ID: PRJNA282491

    Keywords: Transcriptome or Gene expression

    Access Type: download

  7. Differential expression profile of chicken embryo fibroblast DF-1 cells infected with cell-adapted Infectious Bursal Disease Virus ArrayExpress

    ID: E-GEOD-60268

    Description: tion to the reported regulatory factors including EIF2AK2, MX, OAS*A, GBP7 and IFIT, IBDV infection also triggered a IFIT5-IRF1/3-RSAD5 pathway in the DF-1 cells which potentially restricted the viral replication cycle in the early infection stage. Over-expression of LIPA and CH25H, together with the suppression of STARD4, LSS and AACS genes implied a modulation of membrane fluidity and lipid raft arrangement in the infected cells. Alternative splicing of the EFR3 homolog A gene was also through to be involved in the lipid membrane regulation, and these cumulative responses projected an inhibition of viral endocytosis. Recognition of viral RNA genomes and intermediates was presumably enhanced by the elevated levels of IFIH1, DHX58 and TRIM25 genes which possess properties on detecting viral dsRNA. On the other hand, the caIBDV arrested the host's apoptotic process by inducing the expression of apoptosis inhibitors including ...

  8. Signaling pathways in skeletal muscle of Amyotrophic Lateral Sclerosis mouse model ArrayExpress

    ID: E-GEOD-40328

    Description: own-regulated genes (PIK3C2A, RIPK4, ID2, C1QDC1, EIF2AK2, RAC3, CDS1, INPPL1, TBL1X) at 40 days and also to one up- (PIK3CA) and five down-regulated genes (CD44, EEF2K, FZD2, CREBBP, PIKI3R1) at 80 days. Based on differentially expressed genes, analyses for gene priorization were performed and used to construct a network of protein-protein interaction. The network based on the genes of 40 and 80 days old mice was composed by 251 and 531 genes, respectively. GRB2 and SRC were identified as central genes of both networks. In conclusion, changes in gene expression of skeletal muscle from transgenic ALS mice in pre-symptomatic periods give further evidence of early neuromuscular abnormalities that precede motor neuron death. We performed gene ex...

  9. PKR kinase domain-eIF2alpha Complex PDB

    ID: PDB:2A1A

    Description: Eukaryotic translation initiation factor 2 alpha subunit, Interferon-induced, double-stranded RNA-activated protein kinase (E.C.2.7.1.-)

    gene.name: PRKR, EIF2AK2, PKR
  10. Solution structure of the second DSRM domain in Interferon-induced, double-stranded RNA-activated protein kinase PDB

    ID: PDB:1X48

    Description: Interferon-induced, double-stranded RNA-activated protein kinase (E.C.2.7.1.-)

    gene.name: Prkr, Eif2ak2, Pkr, Tik
  11. Crystal structure of Apo-PKR kinase domain PDB

    ID: PDB:3UIU

    Description: Interferon-induced, double-stranded RNA-activated protein kinase (E.C.2.7.11.1, 2.7.10.2)

    gene.name: EIF2AK2, PKR, PRKR
  12. Solution structure of the first DSRM domain in Interferon-induced, double-stranded RNA-activated protein kinase PDB

    ID: PDB:1X49

    Description: Interferon-induced, double-stranded RNA-activated protein kinase (E.C.2.7.1.-)

    gene.name: Prkr, Eif2ak2, Pkr, Tik
  13. PKR kinase domain- eIF2alpha- AMP-PNP complex. PDB

    ID: PDB:2A19

    Description: Eukaryotic translation initiation factor 2 alpha subunit/ Interferon-induced, double-stranded RNA-activated protein kinase (E.C.2.7.1.-)

    gene.name: PRKR, EIF2AK2, PKR
  14. Brassica oleracea : Integrated AFLP and RFLP genetic map; A12xGD-206_2000 and NxG-97_2000 BioProject

    ID: PRJNA175418

    Keywords: map

    Access Type: download

  15. Differential expression profile of chicken embryo fibroblast DF-1 cells infected with cell-adapted Infectious Bursal Disease Virus BioProject

    ID: PRJNA257889

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: tion to the reported regulatory factors including EIF2AK2, MX, OAS*A, GBP7 and IFIT, IBDV infection also triggered a IFIT5-IRF1/3-RSAD5 pathway in the DF-1 cells which potentially restricted the viral replication cycle in the early infection stage. Over-expression of LIPA and CH25H, together with the suppression of STARD4, LSS and AACS genes implied a modulation of membrane fluidity and lipid raft arrangement in the infected cells. Alternative splicing of the EFR3 homolog A gene was also through to be involved in the lipid membrane regulation, and these cumulative responses projected an inhibition of viral endocytosis. Recognition of viral RNA genomes and intermediates was presumably enhanced by the elevated levels of IFIH1, DHX58 and TRIM25 genes which possess properties on detecting viral dsRNA. On the other hand, the caIBDV arrested the host's apoptotic process by inducing the expression of apoptosis inhibitors including ...
  16. HRI Protects Erythroid Precursors in iron deficiency and beta-Thalassemia by Maintaining GATA-1 and Fog-1 Expression BioProject

    ID: PRJNA99213

    Keywords: Transcriptome or Gene expression

    Access Type: download

  17. Reconstitution of the RNAi response in human cells using drosophila gene products BioProject

    ID: PRJNA325894

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: unctional forms of both the human Dicer (dcr) and EIF2AK2 (pkr) gene. Upon expression of dDcr2, Loqs-PD and R2D2 in these human cells, we observed the production of ~21-nt long siRNAs, derived from a co-transfected double stranded RNA (dsRNA) expression vector, that were loaded into the human RNA-induced silencing complex (RISC) and were able to significantly reduce the expression of a cognate indicator gene. We conclude that it is possible to at least partly rescue the ability of mammalian somatic cells to express functional siRNAs by using gene products of invertebrate origin. Overall design: Combinations of Drosophila Dicer2 and cofactors were transfected into 425-PKR cells to determine whether they were sufficient for genesis of siRNAs in mammalian cells....
  18. Genome wide host gene expression analysis in duck lungs infected with highly or low pathogenic H5N1 avian influenza virus BioProject

    ID: PRJNA273456

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: tant antiviral immune genes IFIT5, IFITM5, RSAD2, EIF2AK2 (PKR), Mx, β-defensins, TRIM23 and SLC16A3 to AD2008 infection, but not in AD2011 infection, cause the host may fine-tune their innate immune responses and prevent from cytokines storms and tissue damage. Several immune related Gene ontology (GO) terms and immune pathways activated were qualitatively similar but quantitatively different to both virus infections. Based on these findings, we conclude that subtle differences in host immune responses may determine the different outcome of H5N1 infection in ducks. Overall design: Agilent Custom Duck Gene Expression 8X60k (AMADID: G4102A_059612) designed by Genotypic Technology Private Limited , Labeling kit: Agilent Quick-Amp labeling Kit (p/n5190-0442)...
  19. Genome wide host gene expression analysis in duck lungs infected with highly or low pathogenic H5N1 avian influenza virus OmicsDI

    ID: E-GEOD-65230

    Date Released: 01-09-2016

    Description: tant antiviral immune genes IFIT5, IFITM5, RSAD2, EIF2AK2 (PKR), Mx, β-defensins, TRIM23 and SLC16A3 to AD2008 infection, but not in AD2011 infection, cause the host may fine-tune their innate immune responses and prevent from cytokines storms and tissue damage. Several immune related Gene ontology (GO) terms and immune pathways activated were qualitatively similar but quantitatively different to both virus infections. Based on these findings, we conclude that subtle differences in host immune responses may determine the different outcome of H5N1 infection in ducks. Agilent Custom Duck Gene Expression 8X60k (AMADID: G4102A_059612) designed by Genotypic Technology Private Limited , Labeling kit: Agilent Quick-Amp labeling Kit (p/n5190-0442)...

  20. Differential expression profile of chicken embryo fibroblast DF-1 cells infected with cell-adapted Infectious Bursal Disease Virus OmicsDI

    ID: E-GEOD-60268

    Date Released: 10-04-2014

    Description: tion to the reported regulatory factors including EIF2AK2, MX, OAS*A, GBP7 and IFIT, IBDV infection also triggered a IFIT5-IRF1/3-RSAD5 pathway in the DF-1 cells which potentially restricted the viral replication cycle in the early infection stage. Over-expression of LIPA and CH25H, together with the suppression of STARD4, LSS and AACS genes implied a modulation of membrane fluidity and lipid raft arrangement in the infected cells. Alternative splicing of the EFR3 homolog A gene was also through to be involved in the lipid membrane regulation, and these cumulative responses projected an inhibition of viral endocytosis. Recognition of viral RNA genomes and intermediates was presumably enhanced by the elevated levels of IFIH1, DHX58 and TRIM25 genes which possess properties on detecting viral dsRNA. On the other hand, the caIBDV arrested the host's apoptotic process by inducing the expression of apoptosis inhibitors including ...


Displaying 20 of 23 results for "EIF2AK2"