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Displaying 20 of 75 results for "DUSP6"
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  1. Gene expression data of BCR-ABL1 transformed B cell precursors from Dusp6 wild-type and Dusp6 knockout mice BioProject

    ID: PRJNA150227

    Keywords: Transcriptome or Gene expression

    Access Type: download

  2. STRUCTURE OF ERK2 BINDING DOMAIN OF MAPK PHOSPHATASE MKP-3: STRUCTURAL INSIGHTS INTO MKP-3 ACTIVATION BY ERK2 PDB

    ID: PDB:1HZM

    Description: DUAL SPECIFICITY PROTEIN PHOSPHATASE 6 (E.C.3.1.3.48, 3.1.3.16)

  3. Gene expression data of BCR-ABL1 transformed B cell precursors from Dusp6 wild-type and Dusp6 knockout mice ArrayExpress

    ID: E-GEOD-34832

    Description: To elucidate the mechanism of Dusp6-mediated pre-B cell survival signaling, we investigated the gene expression pattern in BCR-ABL1-transformed Dusp6

  4. DUS6_BOVIN UniProt:Swiss-Prot

    ID: Q2KJ36

    Description: Dual specificity protein phosphatase 6 Rhodanese Tyrosine-protein

  5. Crystal structure of Erk2 complex with KIM peptide derived from MKP3 PDB

    ID: PDB:2FYS

    Description: itogen-activated protein kinase 1 (E.C.2.7.1.37), Dual specificity protein phosphatase 6 (E.C.3.1.3.48, 3.1.3.16)...

  6. Global MEF2 target gene analysis in cardiac and skeletal muscle reveals novel regulation of DUSP6 by p38MAPKMEF2 signaling ArrayExpress

    ID: E-GEOD-61207

    Description: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

  7. Global MEF2 target gene analysis in cardiac and skeletal muscle reveals novel regulation of DUSP6 by p38MAPKMEF2 signaling [ChIP-seq] BioProject

    ID: PRJNA260504

    Keywords: Epigenomics

    Access Type: download

  8. Global MEF2 target gene analysis in cardiac and skeletal muscle reveals novel regulation of DUSP6 by p38MAPKMEF2 signaling [RNA-seq] BioProject

    ID: PRJNA260505

    Keywords: Transcriptome or Gene expression

    Access Type: download

  9. CRYSTAL STRUCTURE OF PYST1 (MKP3) PDB

    ID: PDB:1MKP

    Description: PYST1

  10. Global MEF2 target gene analysis in cardiac and skeletal muscle reveals novel regulation of DUSP6 by p38MAPKMEF2 signaling [ChIP-seq] ArrayExpress

    ID: E-GEOD-61204

    Description: Identfification of MEF2A target genes using ChIP-exo in skeletla muscle and primary cardiomyocytes. Identfification of MEF2A target genes using ChIP-e...

  11. Expression microarray analysis of HaCaT epidermal keratinocyte treated with AdcaRAS/dnRAS, p53 siRNA, and/or TGF-beta BioProject

    ID: PRJNA259608

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: rt a model of mutual inhibition between ΔNp63α, DUSP6 and mutant p53 downstream of oncogenic Ras and TGF-β. Overall design: We used expression microarrays to evaluate the effect of caRAS/dnRAS, p53 siRNA, and/or TGF-beta in HaCaT epidermal keratinocyte....
  12. Global MEF2 target gene analysis in cardiac and skeletal muscle reveals novel regulation of DUSP6 by p38MAPKMEF2 signaling [RNA-seq] ArrayExpress

    ID: E-GEOD-61205

    Description: Identfification of MEF2A target genes using ChIP-exo and RNA-seq in skeletal muscle and primary cardiomyocytes. MEF2 plays a profound role in the regu...

  13. Gene expression data of BCR-ABL1 transformed B cell precursors from Dusp6 wild-type and Dusp6 knockout mice OmicsDI

    ID: E-GEOD-34832

    Date Released: 06-17-2013

    Description: To elucidate the mechanism of Dusp6-mediated pre-B cell survival signaling, we investigated the gene expression pattern in BCR-ABL1-transformed Dusp6

  14. Phosphatome profiling of estrogen receptor negative breast cancer ArrayExpress

    ID: E-GEOD-51999

    Description: erentially expressed phosphatases (like DUSP4 and DUSP6) share ERK as substrate, or regulate the PI3K pathway (INPP4B, PTEN). These observations are also confirmed by pathway and GSEA analysis. It is shown that both ER- ERBB2+ and triple negative breast cancers have a distinctive pattern of phosphatase RNA expression. Surgical specimens from primary breast cancers that were estrogen receptor negative according to immunohistochemistry...

  15. Negative feedback enables oncogenic signaling in pre-B cells and represents a therapeutic target in acute lymphoblastic leukemia BioProject

    ID: PRJNA253306

    Keywords: Variation

    Access Type: download

    dataset.description: egulation of negative feedback regulators of Erk (DUSP6, SPRY2, ETV5) and Stat5 (CISH, SOCS2, SOCS3) signaling. Genetic deletion of the sprouty family Ras inhibitor Spry2, the Erk phosphatase Dusp6 or Etv5, a transcriptional activator of SPRY2/DUSP6, decreased robustness of negative feedback control and compromised oncogenic transformation. Likewise, ablation of the suppressors of cytokine signaling (SOCS) family molecules Cish, Socs2 and Socs3 reversed permissiveness of pre-B cells to oncogenic signaling. Searching for factors that limit permissiveness of normal pre-B cells to oncogene signaling, we identified the lymphoid transcription factor IKZF1, which functions as a critical tumor suppressor in pre-B ALL. IKZF1 binds directly to and transcriptionally represses
  16. Overcoming cetuximab resistance in HNSCC: The role of AURKB and DUSP proteins BioProject

    ID: PRJNA261312

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: nce, as witnessed by low expression of DUSP 5 and DUSP6, negative regulators of ERK1/2, and increased expression of AURKB, a key regulator of mitosis. Therefore, interrupting the RAS-MAPK pathway by an ERK1/2 inhibitor (apigenin) or an AURKB inhibitor (barasertib) might be a new strategy for overcoming cetuximab resistance in HNSCC Overall design: 4 head and neck squamous cell carcinoma (HNSCC) cell lines were treated with either 15 nM cetuximab or PBS during 13 hours. For each cell lin...
  17. Overcoming cetuximab resistance in HNSCC: The role of AURKB and DUSP proteins ArrayExpress

    ID: E-GEOD-61495

    Description: nce, as witnessed by low expression of DUSP 5 and DUSP6, negative regulators of ERK1/2, and increased expression of AURKB, a key regulator of mitosis. Therefore, interrupting the RAS-MAPK pathway by an ERK1/2 inhibitor (apigenin) or an AURKB inhibitor (barasertib) might be a new strategy for overcoming cetuximab resistance in HNSCC 4 head and neck squamous cell carcinoma (HNSCC) cell lines were treated with either 15 nM cetuximab or PBS during 13 hours. For each cell line, differential ...

  18. Differential gene expression profiles of side population and non-side population cells of malignant pleural mesothelioma ArrayExpress

    ID: E-GEOD-33734

    Description: with cancer stem cell (CSC) and drug resistance: DUSP6, SPRY2 and IL6, as well as multi-pathways, including the cancer stem cell-associated pathways Notch and c-Kit. Therefore, we believe that targeting CSC-specific genes and pathways in SP cells may hold the key to the discovery of effective treatments for reversing chemotherapeutic resistance to MPM treatment. 4 samples...

  19. DUS6_RAT UniProt:Swiss-Prot

    ID: Q64346

    Description: Dual specificity protein phosphatase 6 Rhodanese Tyrosine-protein

  20. Rat medial prefrontal cortex gene expression following heroin self-administration, abstinence, and extinction ArrayExpress

    ID: E-GEOD-13166

    Description: dminister heroin (0.06 mg/0.2 ml infusion) during 3 hour daily sessions for 14 days. Following the self-administration period, rats were reintroduced to the self-administration chambers for a 90-minute extinction session. The extinction session occurred either 1 day or 14 days following the final self-administration session. Behavioral data demonstrated incubation (increased expression) of heroin-seeking and goal-directed behavior after the 14 day abstinent period. Whole genome analysis was performed and selected results were confirmed by quantitative real-time PCR (RT-qPCR). Microarrays identified 66 genes whose expression was ide...


Displaying 20 of 75 results for "DUSP6"