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Displaying 20 of 119 results for "DOK4"
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  1. DOK4_PONAB UniProt:Swiss-Prot

    ID: Q5RA30

    Description: Docking protein 4 PH IRS-type PTB DKFBH motif

  2. Canine Cutaneous Peripheral Nerve Sheath Tumours versus Fibrosarcomas can be Differentiated by Neuroectodermal Marker Genes in their Transcriptome ArrayExpress

    ID: E-GEOD-34382

    Description: e sheath tumors: FMN2, KIF1B, GLI1, ROBO1, NMUR2, DOK4 and HMG20B. Furthermore, eight genes associated with carcinogenesis were up-regulated in fibrosarcomas: FHL2, PLAGL1, FNBP1L, BAG2, HK1, CSK and Cox5A. Comparison of the fibrosarcoma and PNST transcriptome therefore identified PNST phenotype-associated genes involved in neuroectodermal differentiation which may be potential PNST markers. Furthermore, the identified fibrosarcoma phenotype-associated genes may be potential markers to differentiate fibrosarcomas from other tumor types and may be involved in their pathogenesis. The aim of the present study was to examine the differences in global gene expression of histologically prototypic fibrosarcomas and PNST. To this end, complete transcriptome microarray analyses were used to quantify differences in gene expression activity in both tumor types....

  3. Canine Cutaneous Peripheral Nerve Sheath Tumours versus Fibrosarcomas can be Differentiated by Neuroectodermal Marker Genes in their Transcriptome. BioProject

    ID: PRJNA149591

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: e sheath tumors: FMN2, KIF1B, GLI1, ROBO1, NMUR2, DOK4 and HMG20B. Furthermore, eight genes associated with carcinogenesis were up-regulated in fibrosarcomas: FHL2, PLAGL1, FNBP1L, BAG2, HK1, CSK and Cox5A. Comparison of the fibrosarcoma and PNST transcriptome therefore identified PNST phenotype-associated genes involved in neuroectodermal differentiation which may be potential PNST markers. Furthermore, the identified fibrosarcoma phenotype-associated genes may be potential markers to differentiate fibrosarcomas from other tumor types and may be involved in their pathogenesis. Overall design: The aim of the present study was to examine the differences in global gene expression of histologically prototypic fibrosarcomas and PNST. To this end, complete transcriptome microarray analyses were used to quantify differences in gene expression activity in both tumor types....
  4. Expression of microRNAs and their gene targets are dysregulated in pre-invasive breast cancer (mRNA) ArrayExpress

    ID: E-GEOD-24506

    Description: of CBX7 (which regulates E-cadherin expression), DOK4, NMT2, and EGR1. Augmentation of CBX7 by knockdown of miR-182 expression, in turn, positively regulated the expression of E-cadherin, a key protein involved in maintaining normal epithelial cell morphology which is commonly lost during neoplastic progression. Conclusions: These data provide the first miRNA expression profile of normal breast epithelium and of pre-invasive breast carcinoma. Further, we demonstrate that altered miRNA expression can modulate gene expression changes that characterize these early cancers. We conclude that miRNA dysregulation likely plays a substantial role in early breast cancer development. Two total samples were analyzed via Affymetrix U133A. Case numbers correspond to individual patients. Each sample is identified by case number, histologic lesion and corresponding microarray ID....

  5. Expression of microRNAs and their gene targets are dysregulated in pre-invasive breast cancer (microRNA) ArrayExpress

    ID: E-GEOD-24508

    Description: of CBX7 (which regulates E-cadherin expression), DOK4, NMT2, and EGR1. Augmentation of CBX7 by knockdown of miR-182 expression, in turn, positively regulated the expression of E-cadherin, a key protein involved in maintaining normal epithelial cell morphology which is commonly lost during neoplastic progression. Conclusions: These data provide the first miRNA expression profile of normal breast epithelium and of pre-invasive breast carcinoma. Further, we demonstrate that altered miRNA expression can modulate gene expression changes that characterize these early cancers. We conclude that miRNA dysregulation likely plays a substantial role in early breast cancer development. The expression of 365 microRNAs were measured in 19 total samples via multiplex reverse transcription PCR using the TaqMan Human MicroRNA Low Density Array. Patients age ranged from 42-75. Equal amounts of total RNA from 9 reduction mammoplasty samples (age range 42-75) were combined into a pooled RM control (PRM), this sample was run in triplicate. Remaining 16 samples consist of matched samples of ductal carcinoma in situ and adjacent histologically normal breast epithelium, these are identified by case number and histologic lesion....

  6. estabilizing mechanism of flavonoid derivative 2-(4′ benzyloxyphenyl)-3-hydroxy-chromen-4-one through docking and molecular dynamics simulations... Figshare

    ID: doi:10.6084/M9.FIGSHARE.1494566.V1

    Release Date: 03-11-2016

    Description:

  7. estabilizing mechanism of flavonoid derivative 2-(4′ benzyloxyphenyl)-3-hydroxy-chromen-4-one through docking and molecular dynamics simulations... Figshare

    ID: doi:10.6084/M9.FIGSHARE.1494566.V2

    Release Date: 03-11-2016

    Description:

  8. inding partners by CD-spectroscopic and molecular docking methods... Figshare

    ID: doi:10.6084/M9.FIGSHARE.858854.V6

    Release Date: 03-10-2016

    Description:

  9. inding partners by CD-spectroscopic and molecular docking methods... Figshare

    ID: doi:10.6084/M9.FIGSHARE.858854.V4

    Release Date: 03-10-2016

    Description:

  10. inding partners by CD-spectroscopic and molecular docking methods... Figshare

    ID: doi:10.6084/M9.FIGSHARE.858854

    Release Date: 03-10-2016

    Description:

  11. Expression of microRNAs and their gene targets are dysregulated in pre-invasive breast cancer (mRNA) BioProject

    ID: PRJNA133519

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: of CBX7 (which regulates E-cadherin expression), DOK4, NMT2, and EGR1. Augmentation of CBX7 by knockdown of miR-182 expression, in turn, positively regulated the expression of E-cadherin, a key protein involved in maintaining normal epithelial cell morphology which is commonly lost during neoplastic progression. Conclusions: These data provide the first miRNA expression profile of normal breast epithelium and of pre-invasive breast carcinoma. Further, we demonstrate that altered miRNA expression can modulate gene expression changes that characterize these early cancers. We conclude that miRNA dysregulation likely plays a substantial role in early breast cancer development. Overall design: Two total samples were analyzed via Affymetrix U133A. Case numbers correspond to individual patients. Each sample is identified by case number, histologic lesion and corresponding microarray ID....
  12. inding partners by CD-spectroscopic and molecular docking methods... Figshare

    ID: doi:10.6084/M9.FIGSHARE.858854.V7

    Release Date: 03-10-2016

    Description:

  13. inding partners by CD-spectroscopic and molecular docking methods... Figshare

    ID: doi:10.6084/M9.FIGSHARE.858854.V2

    Release Date: 03-10-2016

    Description:

  14. inding partners by CD-spectroscopic and molecular docking methods... Figshare

    ID: doi:10.6084/M9.FIGSHARE.858854.V8

    Release Date: 03-10-2016

    Description:

  15. inding partners by CD-spectroscopic and molecular docking methods... Figshare

    ID: doi:10.6084/M9.FIGSHARE.858854.V1

    Release Date: 03-10-2016

    Description:

  16. inding partners by CD-spectroscopic and molecular docking methods... Figshare

    ID: doi:10.6084/M9.FIGSHARE.858854.V3

    Release Date: 03-10-2016

    Description:

  17. inding partners by CD-spectroscopic and molecular docking methods... Figshare

    ID: doi:10.6084/M9.FIGSHARE.858854.V5

    Release Date: 03-10-2016

    Description:

  18. Identification of a novel insulin receptor-binding protein from Momordica charantia by transcriptomic, proteomic, and docking analyses BioProject

    ID: PRJNA171580

    Keywords: Transcriptome or Gene expression

    Access Type: download

  19. Identification of a novel insulin receptor-binding protein from Momordica charantia by transcriptomic, proteomic, and docking analyses ArrayExpress

    ID: E-GEOD-39689

    Description: f MC seeds (MCSE) by transcriptomic analysis. The protein ingredients aimed at the hypoglycemic target were further identified by proteomic, docking, and receptor-binding assays. Our data showed that MCSE, which was rich in small-molecular weight proteins, displayed hypoglycemic effects in normal and diabetic mice by glucose tolerance assay. MCSE significantly and primarily regulated the insulin signaling pathway in muscles and adipose tissues, suggesting that MCSE might target to insulin receptor (IR), stimulate the IR-downstream pathway, and subsequently display the ...

  20. Identification of a novel insulin receptor-binding protein from Momordica charantia by transcriptomic, proteomic, and docking analyses OmicsDI

    ID: E-GEOD-39689

    Date Released: 08-19-2015

    Description: f MC seeds (MCSE) by transcriptomic analysis. The protein ingredients aimed at the hypoglycemic target were further identified by proteomic, docking, and receptor-binding assays. Our data showed that MCSE, which was rich in small-molecular weight proteins, displayed hypoglycemic effects in normal and diabetic mice by glucose tolerance assay. MCSE significantly and primarily regulated the insulin signaling pathway in muscles and adipose tissues, suggesting that MCSE might target to insulin receptor (IR), stimulate the IR-downstream pathway, and subsequently display the ...


Displaying 20 of 119 results for "DOK4"