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Displaying 8 of 8 results for "DOCK4"
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  1. DOCK4_MOUSE UniProt:Swiss-Prot

    ID: P59764

    Description: Dedicator of cytokinesis protein 4 SH3 DHR-1 DHR-2 SH3-binding Ser-rich Pro-rich Phosphotyros...

  2. Transcriptome analysis of Stem Cells from Human Umbilical Cord Blood ArrayExpress

    ID: E-GEOD-4609

    Description: srupted in cancer, such as the recently described DOCK4 and SPARCL1 tumor suppressor genes. Quantitative real-time PCR analysis confirmed down-regulation of DOCK4 and SPARCL1 in E2-treated CD133+/CD34+ cells and parallel results were verified when comparing their expression in mononuclear blood cells of chronic myeloid leukemia patients and healthy individuals. The striking differential expression of cancer-associated genes found reveals potential molecular targets for oncogenic transformation of CD133+/CD34+ cells and strengthens the importance of pre-clinical studies assessing safety of stem cell expansion protocols for therapeutic application. Keywords: dose response Gene expression intensities were measured using CodeLink Human Whole Genome Bioarrays....

  3. Transcriptome analysis of Stem Cells from Human Umbilical Cord Blood OmicsDI

    ID: E-GEOD-4609

    Date Released: 05-02-2014

    Description: srupted in cancer, such as the recently described DOCK4 and SPARCL1 tumor suppressor genes. Quantitative real-time PCR analysis confirmed down-regulation of DOCK4 and SPARCL1 in E2-treated CD133+/CD34+ cells and parallel results were verified when comparing their expression in mononuclear blood cells of chronic myeloid leukemia patients and healthy individuals. The striking differential expression of cancer-associated genes found reveals potential molecular targets for oncogenic transformation of CD133+/CD34+ cells and strengthens the importance of pre-clinical studies assessing safety of stem cell expansion protocols for therapeutic application. Keywords: dose response Gene expression intensities were measured using CodeLink Human Whole Genome Bioarrays....

  4. Transcriptome analysis of Stem Cells from Human Umbilical Cord Blood BioProject

    ID: PRJNA94399

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: srupted in cancer, such as the recently described DOCK4 and SPARCL1 tumor suppressor genes. Quantitative real-time PCR analysis confirmed down-regulation of DOCK4 and SPARCL1 in E2-treated CD133+/CD34+ cells and parallel results were verified when comparing their expression in mononuclear blood cells of chronic myeloid leukemia patients and healthy individuals. The striking differential expression of cancer-associated genes found reveals potential molecular targets for oncogenic transformation of CD133+/CD34+ cells and strengthens the importance of pre-clinical studies assessing safety of stem cell expansion protocols for therapeutic application. Keywords: dose response Overall design: Gene expression intensities were measured using CodeLink Human Whole Genome Bioarrays....
  5. Rhabdoid Tumor: Gene Expression Clues to Pathogenesis and Potential Therapeutic Targets ArrayExpress

    ID: E-GEOD-11482

    Description: previously associated with SMARCB1 (ATP1B1, PTN, DOCK4, NQO1, PLOD1, PTP4A2, PTPRK). 28/114 top differentially expressed genes were involved with neural or neural crest development and were all sharply down-regulated. This was confirmed by Gene Set Enrichment Analysis (GSEA). Neural and neural crest stem cell marker proteins SOX10, ID3, CD133 and Musashi were negative by immunohistochemistry, whereas Nestin was positive. Decreased expression of CDKN1A, CDKN1B, CDKN1C, CDKN2A, and CCND1 was identified, while MYC-C was upregulated. GSEA of independent gene sets associated with bivalent histone modification and polycomb group targets in embryonic stem cells demonstrated significant negative enrichment in RT. Several differentially expressed genes were associated with tumor suppr...

  6. The proteome of human retrobulbar optic nerve OmicsDI

    ID: PXD001581

    Date Released: 01-01-1000

    Description: otection and regeneration (α crytallins A and B, dedicator of cytokinesis proteins, ciliary neurotrophic factor), proteins associated with open-angle glaucoma (thioredoxin, heat shock protein-70), and proteins associated with optic neuritis (aquaporin-4). Twenty-one unambiguous protein isoforms were identified in the optic nerve....

  7. Rhabdoid Tumor: Gene Expression Clues to Pathogenesis and Potential Therapeutic Targets BioProject

    ID: PRJNA106405

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: previously associated with SMARCB1 (ATP1B1, PTN, DOCK4, NQO1, PLOD1, PTP4A2, PTPRK). 28/114 top differentially expressed genes were involved with neural or neural crest development and were all sharply down-regulated. This was confirmed by Gene Set Enrichment Analysis (GSEA). Neural and neural crest stem cell marker proteins SOX10, ID3, CD133 and Musashi were negative by immunohistochemistry, whereas Nestin was positive. Decreased expression of CDKN1A, CDKN1B, CDKN1C, CDKN2A, and CCND1 was identified, while MYC-C was upregulated. GSEA of independent gene sets associated with bivalent histone modification and polycomb group targets in embryonic stem cells demonstrated significant negative enrichment in RT. Several differentially expressed genes were associ...
  8. Rhabdoid Tumor: Gene Expression Clues to Pathogenesis and Potential Therapeutic Targets OmicsDI

    ID: E-GEOD-11482

    Date Released: 05-02-2014

    Description: previously associated with SMARCB1 (ATP1B1, PTN, DOCK4, NQO1, PLOD1, PTP4A2, PTPRK). 28/114 top differentially expressed genes were involved with neural or neural crest development and were all sharply down-regulated. This was confirmed by Gene Set Enrichment Analysis (GSEA). Neural and neural crest stem cell marker proteins SOX10, ID3, CD133 and Musashi were negative by immunohistochemistry, whereas Nestin was positive. Decreased expression of CDKN1A, CDKN1B, CDKN1C, CDKN2A, and CCND1 was identified, while MYC-C was upregulated. GSEA of independent gene sets associated with bivalent histone modification and polycomb group targets in embryonic stem cells demonstrated significant negative enrichment in RT. Several differentially expressed genes were associated with tumor suppr...


Displaying 8 of 8 results for "DOCK4"