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Displaying 20 of 20 results for "DMTF1"
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  1. Solution NMR structure of the N-terminal myb-like 1 domain of the human cyclin-D- PDB

    ID: PDB:2LLK

    Description: Cyclin-D-binding Myb-like transcription

  2. Comparison of osteocyte-enriched bone from DMP1 cre Mbtps1 knockout mice with littermate controls. BioProject

    ID: PRJNA287321

    Keywords: Transcriptome or Gene expression

    Access Type: download

  3. Microarray on mouse soleus muscles from DMP1 Cre Mbtps1 knockout mice compared with littermate controls BioProject

    ID: PRJNA287347

    Keywords: Transcriptome or Gene expression

    Access Type: download

  4. A novel nonsense mutation in DMP1 gene identified by a genome-wide association study is responsible for inherited rickets in Corriedale sheep ArrayExpress

    ID: E-GEOD-26310

    Description: genes in this region, exon 6 of the dentin matrix protein 1 gene (DMP1) was sequenced to reveal 9 SNPs including a nonsense mutation 253T/C which introduced a stop codon (R145X) and could truncate C-terminal amino acids. Genotyping by PCR-RFLP for this mutation showed that, all 17 affected sheep were “T T” genotypes and the 27 phenotypically normal sheep were either “C T” or “C C”. This locus is not in complete linkage disequilibrium with the other 8 SNPs that can all be ruled out as candidates. Previous research has shown that mutations in DMP1 gene are responsible for autosomal recessive hypophosphatemic rickets in humans. Dmp1_knockout mice also exhibit ric...

  5. A novel nonsense mutation in DMP1 gene identified by a genome-wide association study is responsible for inherited rickets in Corriedale sheep BioProject

    ID: PRJNA136753

    Keywords: Variation

    Access Type: download

  6. Expression data from Dmp1-Cre targeted and non-targeted Cxcl12-abundant reticular (CAR) cells in mouse bone marrow BioProject

    ID: PRJNA321504

    Keywords: Transcriptome or Gene expression

    Access Type: download

  7. Expression data from Dmp1-Cre targeted and non-targeted Cxcl12-abundant reticular (CAR) cells in mouse bone marrow OmicsDI

    ID: E-GEOD-81399

    Date Released: 05-22-2016

    Description: may be differentiated from a subset of CAR cells. Dmp1-Cre targeted CAR cells are thought to enrich for a osteoblast progenitor population. We used microarrays to detail the gene expression profiles among Dmp1-Cre targeted and non-targeted CAR cells. Gene expression diffferences were compared to support the hypothesis that Dmp1-Cre targeted CAR cells may be enriched for osteoblast progenitors. Dmp1-Cr...

  8. Expression data from Dmp1-Cre targeted and non-targeted Cxcl12-abundant reticular (CAR) cells in mouse bone marrow ArrayExpress

    ID: E-GEOD-81399

    Description: may be differentiated from a subset of CAR cells. Dmp1-Cre targeted CAR cells are thought to enrich for a osteoblast progenitor population. We used microarrays to detail the gene expression profiles among Dmp1-Cre targeted and non-targeted CAR cells. Gene expression diffferences were compared to support the hypothesis that Dmp1-Cre targeted CAR cells may be enriched for osteoblast progenitors. Dmp1-Cr...

  9. Expression data from Dmp1-GFP sorted osteocytes OmicsDI

    ID: E-GEOD-41997

    Date Released: 07-07-2015

    Description: y) were generated by mating ERα floxed mice with Dmp1-Cre mice to determine functions of ERα in osteocytes. Trabecular bone mineral density of female, but not male ERαΔOcy/ΔOcy mice was significantly decreased. Bone formation parameters in ERαΔOcy/ΔOcy were significantly decreased while osteoclast parameters were unchanged. This suggests that ERα in osteocytes exerts osteoprotective function by positively controlling bone formation. To identify potential targets of ERα, gene array analysis of Dmp1-GFP o...

  10. Expression data from Dmp1-GFP sorted osteocytes BioProject

    ID: PRJNA178696

    Keywords: Transcriptome or Gene expression

    Access Type: download

  11. Expression data from Dmp1-GFP sorted osteocytes ArrayExpress

    ID: E-GEOD-41997

    Description: y) were generated by mating ERα floxed mice with Dmp1-Cre mice to determine functions of ERα in osteocytes. Trabecular bone mineral density of female, but not male ERαΔOcy/ΔOcy mice was significantly decreased. Bone formation parameters in ERαΔOcy/ΔOcy were significantly decreased while osteoclast parameters were unchanged. This suggests that ERα in osteocytes exerts osteoprotective function by positively controlling bone formation. To identify potential targets of ERα, gene array analysis of Dmp1-GFP o...

  12. A novel nonsense mutation in DMP1 gene identified by a genome-wide association study is responsible for inherited rickets in Corriedale sheep OmicsDI

    ID: E-GEOD-26310

    Date Released: 01-20-2012

    Description: genes in this region, exon 6 of the dentin matrix protein 1 gene (DMP1) was sequenced to reveal 9 SNPs including a nonsense mutation 253T/C which introduced a stop codon (R145X) and could truncate C-terminal amino acids. Genotyping by PCR-RFLP for this mutation showed that, all 17 affected sheep were “T T” genotypes and the 27 phenotypically normal sheep were either “C T” or “C C”. This locus is not in complete linkage disequilibrium with the other 8 SNPs that can all be ruled out as candidates. Previous research has shown that mutations in DMP1 gene are responsible for autosomal recessive hypophosphatemic rickets in humans. Dmp1_knockout mice also exhibit ric...

  13. Genome-wide dMTF-1-binding sites in Drosophila S2 cells in the absence or presence of copper or cadmium OmicsDI

    ID: E-GEOD-40535

    Date Released: 05-02-2014

    Description: e. Much of this regulation occurs at the level of transcription and the protein most responsible for this is the conserved metal responsive transcription factor, MTF-1. Interestingly, the nature of the changes in the gene expression profile depends on the type of exposure. The cell somehow senses the kind of metal challenge and responds appropriately. We have been using the Drosophila system to try to understand the mechanism of this metal discrimination. Using genome-wide mapping of MTF-1 binding under different metal stresses, we find that, surprisingly, MTF-1 chooses different DNA binding sites depending on the specific nature of the metal ins...

  14. Genome-wide dMTF-1-binding sites in Drosophila S2 cells in the absence or presence of copper or cadmium BioProject

    ID: PRJNA174232

    Keywords: Epigenomics

    Access Type: download

  15. Genome-wide dMTF-1-binding sites in Drosophila S2 cells in the absence or presence of copper or cadmium ArrayExpress

    ID: E-GEOD-40535

    Description: e. Much of this regulation occurs at the level of transcription and the protein most responsible for this is the conserved metal responsive transcription factor, MTF-1. Interestingly, the nature of the changes in the gene expression profile depends on the type of exposure. The cell somehow senses the kind of metal challenge and responds appropriately. We have been using the Drosophila system to try to understand the mechanism of this metal discrimination. Using genome-wide mapping of MTF-1 binding under different metal stresses, we find that, surprisingly, MTF-1 chooses different DNA binding sites depending on the specific nature of the metal ins...

  16. DMP1_BOVIN UniProt:Swiss-Prot

    ID: Q95120

    Description: Dentin matrix acidic phosphoprotein 1 Cell attachment site N-linked (GlcNAc...) N-linked (GlcNAc...) N-linked (GlcNAc...) N-linked (GlcNAc...)...

  17. DMP1_RAT UniProt:Swiss-Prot

    ID: P98193

    Description: Dentin matrix acidic phosphoprotein 1 Cell attachment site Poly-Pro N-linked (GlcNAc...) N-linked (GlcNAc...) N-linked (GlcNAc...)

  18. Novel Regulators of Fgf23 Expression and Mineralization in Hyp Bone OmicsDI

    ID: E-GEOD-14242

    Date Released: 06-02-2014

    Description: d Wnt-pathways contribute to increased Ffg23 gene transcription in Hyp bone. We found evidence in Hyp bone for increased expression of Fgf1, Fgf7, and Egr2 in the Fgf-signaling pathway and decrements in Sost and Cpz and increments in Sfrp1 and 4 in the Wnt-signaling pathway. Moreover, activation of Fgf and Wnt-signaling stimulated, whereas Tgf β inhibited Fgf23 promoter activ...

  19. Novel Regulators of Fgf23 Expression and Mineralization in Hyp Bone ArrayExpress

    ID: E-GEOD-14242

    Description: d Wnt-pathways contribute to increased Ffg23 gene transcription in Hyp bone. We found evidence in Hyp bone for increased expression of Fgf1, Fgf7, and Egr2 in the Fgf-signaling pathway and decrements in Sost and Cpz and increments in Sfrp1 and 4 in the Wnt-signaling pathway. Moreover, activation of Fgf and Wnt-signaling stimulated, whereas Tgf β inhibited Fgf23 promoter activ...

  20. Novel Regulators of Fgf23 Expression and Mineralization in Hyp Bone BioProject

    ID: PRJNA111165

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: d Wnt-pathways contribute to increased Ffg23 gene transcription in Hyp bone. We found evidence in Hyp bone for increased expression of Fgf1, Fgf7, and Egr2 in the Fgf-signaling pathway and decrements in Sost and Cpz and increments in Sfrp1 and 4 in the Wnt-signaling pathway. Moreover, activation of Fgf and Wnt-signaling stimulated, whereas Tgf β inhibited Fgf23 promoter activ...

Displaying 20 of 20 results for "DMTF1"