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Displaying 20 of 27 results for "DLX2"
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  1. Transcription profiling of mouse branchial arches from Dlx2-/-, Dlx1/2 -/- or Dlx5/6 -/- ArrayExpress

    ID: E-GEOD-4774

    Description: first branchial arch (BA) of E10.5 wild type and Dlx2 -/- mutants. 2) Compare gene expression in the maxillary branch of the first BA of E10.5 wild type and Dlx1/2 -/- mutants. 3) Compare gene expression in wild type maxillary and mandibular branchial arches. 4) Compare gene expressionin mandibular branch of Dlx5/6 -/- mutants with wild type mandibular branch. The Dlx transcription factors are essential for controlling patterning of the brain and craniofacial primordia. In the brain, they control differentiation of GABAergic neurons of the basal ganglia. In the branchial arches, they control regional patterning. I hypothesize that there will be some conserved and some divergent mechanisms that the Dlx genes use in controlling brain and craniofacial development. We have already performed array analyses on Dlx function in the developing basal ganglia (with TGEN) by co...

  2. Transcription profiling of mouse branchial arches from Dlx2-/-, Dlx1/2 -/- or Dlx5/6 -/- OmicsDI

    ID: E-GEOD-4774

    Date Released: 06-10-2011

    Description: first branchial arch (BA) of E10.5 wild type and Dlx2 -/- mutants. 2) Compare gene expression in the maxillary branch of the first BA of E10.5 wild type and Dlx1/2 -/- mutants. 3) Compare gene expression in wild type maxillary and mandibular branchial arches. 4) Compare gene expressionin mandibular branch of Dlx5/6 -/- mutants with wild type mandibular branch. The Dlx transcription factors are essential for controlling patterning of the brain and craniofacial primordia. In the brain, they control differentiation of GABAergic neurons of the basal ganglia. In the branchial arches, they control regional patterning. I hypothesize that there will be some conserved and some divergent mechanisms that the Dlx genes use in controlling brain and craniofacial development. We have already performed array analyses on Dlx function in the developing basal ganglia (with TGEN) by co...

  3. DLX2_RAT UniProt:Swiss-Prot

    ID: Q64204

    Description: Homeobox protein DLX-2

    gene.name: Dlx2
  4. DLX2_ELECQ UniProt:Swiss-Prot

    ID: P87393

    Description: Homeobox protein DLX-2 Homeobox

    gene.name: DLX2
  5. MICROARRAY-BASED GENE EXPRESSION ANALYSIS OF HUMAN OSTEOBLASTS IN RESPONSE TO ROUGHNESS AND FLUORIDE TREATMENT OF TITANIUM IMPLANTS ArrayExpress

    ID: E-GEOD-22217

    Description: were classified as responsive genes to roughness; DLX2 and TUFT1 as responsive genes to fluoride treatment. COLL-I, PTHLH, HES1, FST, ENPP1 and THRA as responsive genes to both, roughness and fluoride treatment. In conclusion, our strategy was useful for identifying novel genes that might be involved in the early response of osteoblasts to roughness and fluoride treatment of titanium implants. Tissue response following implantation determines the success of the healing process. This response is not only dependent on the chemical properties of the implant surface but also by the surface topography or its roughness. Although in vitro and in vivo studies show improved results with rough- and fluoride-modified implants, the mechanisms behind these findings are still unknown. Here, we have used a two step procedure to identify novel genes related to the early cell response of primary human osteoblasts to roughness and fluoride-modified titanium implants. 217 genes were identified by microarray analysis as response genes to roughness and 198...

  6. Homo sapiens isolate:H1 human ESC : Generation of pure inhibitory neurons by transcription factor programming BioProject

    ID: PRJNA304184

    Keywords: raw sequence reads

    Access Type: download

    dataset.description: We performed RNA sequencing (RNA-seq) of two independent human Ascl1, Dlx2 and Myt1l-iN cell cultures
  7. Generation of pure inhibitory neurons by transcription factor programming BioProject

    ID: PRJNA382705

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: uencing (RNA-seq) of two independent human Ascl1, Dlx2 and Myt1l-iN cell cultures Overall design: The human induced neurons were co-cultured with mouse glia for 4 weeks and the whole transcriptome was ...
  8. Gene expression profiling in MCF-7 cells overexpressing distal-less homeobox 2 (Dlx-2) BioProject

    ID: PRJNA260071

    Keywords: Transcriptome or Gene expression

    Access Type: download

  9. CpG island hypermethylation in human astrocytomas ArrayExpress

    ID: E-GEOD-19391

    Description: P, SIM1, FYN, EN1, CHAT, GSX2, NKX6-1, RAX, PAX6, DLX2, were strongly enriched among genes frequently methylated in tumors. There was an overrepresentation of homeobox genes and 31% of the most commonly methylated genes represent targets of the Polycomb complex. We identified several chromosomal loci in which many (sometimes more than 20) consecutive CpG islands were hypermethylated in tumors. Seven of such loci were near homeobox genes, including the HOXC and HOXD clusters, and the BARHL2, DLX1, and PITX2 genes. Two other clusters of hypermethylated islands were at sequences of recent gene duplication events. Our analysis offers mechanistic insights into brain neoplasia suggesting that methylation of genes involved in neuronal differentiation, perhaps in cooperation with other oncogenic events, may shift the balance from regulated differentiation towards gliomagenesis. Comparison of methylation patterns of 30 astrocytomas and 6 controls...

  10. MICROARRAY-BASED GENE EXPRESSION ANALYSIS OF HUMAN OSTEOBLASTS IN RESPONSE TO ROUGHNESS AND FLUORIDE TREATMENT OF TITANIUM IMPLANTS BioProject

    ID: PRJNA128771

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: were classified as responsive genes to roughness; DLX2 and TUFT1 as responsive genes to fluoride treatment. COLL-I, PTHLH, HES1, FST, ENPP1 and THRA as responsive genes to both, roughness and fluoride treatment. In conclusion, our strategy was useful for identifying novel genes that might be involved in the early response of osteoblasts to roughness and fluoride treatment of titanium implants. Tissue response following implantation determines the success of the healing process. This response is not only dependent on the chemical properties of the implant surface but also by the surface topography or its roughness. Although in vitro and in vivo studies show improved results with rough- and fluoride-modified implants, the mechanisms behind these findings are still unknown. Here, we have used a two step procedure to identify novel genes related to the early cell response of primary human osteoblasts to roughness and fluoride-modified titanium implants. 217 genes were identified by microarray analysis as response genes to roughness and 198...
  11. Single-cell transcriptome analyses reveal signals to activate dormant neural stem cells ArrayExpress

    ID: E-GEOD-61288

    Description: al (E) cells, CD133+/GFAP+ neural stem (B) cells, Dlx2+ neuroblasts (A cells), and Sox10+ oligodendrocyte progenitors (O cells) in the adult mouse forebrain neurogenic zone. prominent hub genes of the gene network unique to ependymal CD133+/GFAP- quiescent cells are enriched for re...

  12. Single-cell transcriptome analyses reveal signals to activate dormant neural stem cells. OmicsDI

    ID: E-GEOD-61288

    Date Released: 08-19-2015

    Description: al (E) cells, CD133+/GFAP+ neural stem (B) cells, Dlx2+ neuroblasts (A cells), and Sox10+ oligodendrocyte progenitors (O cells) in the adult mouse forebrain neurogenic zone. prominent hub genes of the gene network unique to ependymal CD133+/GFAP- quiescent cells are enriched for re...

  13. MICROARRAY-BASED GENE EXPRESSION ANALYSIS OF HUMAN OSTEOBLASTS IN RESPONSE TO ROUGHNESS AND FLUORIDE TREATMENT OF TITANIUM IMPLANTS OmicsDI

    ID: E-GEOD-22217

    Date Released: 06-13-2011

    Description: were classified as responsive genes to roughness; DLX2 and TUFT1 as responsive genes to fluoride treatment. COLL-I, PTHLH, HES1, FST, ENPP1 and THRA as responsive genes to both, roughness and fluoride treatment. In conclusion, our strategy was useful for identifying novel genes that might be involved in the early response of osteoblasts to roughness and fluoride treatment of titanium implants. Tissue response following implantation determines the success of the healing process. This response is not only dependent on the chemical properties of the implant surface but also by the surface topography or its roughness. Although in vitro and in vivo studies show improved results with rough- and fluoride-modified implants, the mechanisms behind these findings are still unknown. Here, we have used a two step procedure to identify novel genes related to the early cell response of primary human osteoblasts to roughness and fluoride-modified titanium implants. 217 genes were identified by microarray analysis as response genes to roughness and 198...

  14. RNA-Seq analysis of Gtf2ird1 knockout epidermal tissue provides potential insights into molecular mechanisms underpinning Williams-Beuren syndrome OmicsDI

    ID: E-GEOD-81082

    Date Released: 08-05-2016

    Description: in organ development including Hey1, Myf6, Myog, Dlx2, Gli1, Gli2, Lhx2, Pou3f3, Sox2, and Foxp3. We also found that the absence of GTF2IRD1 is associated with increased expression of genes involved in cellular proliferation, including growth factors consistent with the observed phenotype of extreme thickening of the epidermis. At the same time, there was a decrease in the expression of genes involved in other signalling mechanisms, including the Wnt pathway, indicating dysregulation in the complex networks necessary for epid...

  15. New functional signatures for understanding melanoma biology from tumor cell lineage-specific analysis [two channel experiments] BioProject

    ID: PRJNA280581

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: ors known to regulate neural development (TFAP2A, DLX2, ALX1, MITF, PAX3, SOX10, LEF1 and GAS7) and three miRNAs (211-5p, 221-3p, 10a-5p). The SCA signature effectively discriminated between two subpopulations of melanoma patients with significant difference in overall survival. Furthermore, it classified MEKi and BRAFi resistant and sensitive melanoma cell lines. The SCA algorithm is potentially applicable to any tumor cell type. Overall design: 23 melanoma cell lines are analyzed in two color. Only the test (Cy5) channel of these data sets were used for analysis....
  16. RNA-Seq analysis of Gtf2ird1 knockout epidermal tissue provides potential insights into molecular mechanisms underpinning Williams-Beuren syndrome ArrayExpress

    ID: E-GEOD-81082

    Description: in organ development including Hey1, Myf6, Myog, Dlx2, Gli1, Gli2, Lhx2, Pou3f3, Sox2, and Foxp3. We also found that the absence of GTF2IRD1 is associated with increased expression of genes involved in cellular proliferation, including growth factors consistent with the observed phenotype of extreme thickening of the epidermis. At the same time, there was a decrease in the expression of genes involved in other signalling mechanisms, including the Wnt pathway, indicating dysregulation in the complex networks necessary for epid...

  17. Single-cell transcriptome analyses reveal signals to activate dormant neural stem cells. BioProject

    ID: PRJNA260673

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: al (E) cells, CD133+/GFAP+ neural stem (B) cells, Dlx2+ neuroblasts (A cells), and Sox10+ oligodendrocyte progenitors (O cells) in the adult mouse forebrain neurogenic zone. prominent hub genes of the gene network unique to ependymal CD133+/GFAP- quiescent cells are enriched for re...
  18. CpG island hypermethylation in human astrocytomas BioProject

    ID: PRJNA121749

    Keywords: Epigenomics

    Access Type: download

    dataset.description: P, SIM1, FYN, EN1, CHAT, GSX2, NKX6-1, RAX, PAX6, DLX2, were strongly enriched among genes frequently methylated in tumors. There was an overrepresentation of homeobox genes and 31% of the most commonly methylated genes represent targets of the Polycomb complex. We identified several chromosomal loci in which many (sometimes more than 20) consecutive CpG islands were hypermethylated in tumors. Seven of such loci were near homeobox genes, including the HOXC and HOXD clusters, and the BARHL2, DLX1, and PITX2 genes. Two other clusters of hypermethylated islands were at sequences of recent gene duplication events. Our analysis offers mechanistic insights into brain neoplasia suggesting that methylation of genes involved in neuronal differentiation, perhaps in cooperation with other oncogenic events, may shift the balance from regulated differentiation towards gliomagenesis. Overall design: Comparison of methylation patterns of 30 astrocytomas and 6 controls...
  19. New functional signatures for understanding melanoma biology from tumor cell lineage-specific analysis [single channel experiments] BioProject

    ID: PRJNA280582

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: ors known to regulate neural development (TFAP2A, DLX2, ALX1, MITF, PAX3, SOX10, LEF1 and GAS7) and three miRNAs (211-5p, 221-3p, 10a-5p). The SCA signature effectively discriminated between two subpopulations of melanoma patients with significant difference in overall survival. Furthermore, it classified MEKi and BRAFi resistant and sensitive melanoma cell lines. The SCA algorithm is potentially applicable to any tumor cell type. Overall design: 21 melanoma cell lines are analyzed in single color...
  20. ruben-affy-mouse-187820 BioProject

    ID: PRJNA95657

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: first branchial arch (BA) of E10.5 wild type and Dlx2 -/- mutants. 2) Compare gene expression in the maxillary branch of the first BA of E10.5 wild type and Dlx1/2 -/- mutants. 3) Compare gene expression in wild type maxillary and mandibular branchial arches. 4) Compare gene expressionin mandibular branch of Dlx5/6 -/- mutants with wild type mandibular branch. The Dlx transcription factors are essential for controlling patterning of the brain and craniofacial primordia. In the brain, they control differentiation of GABAergic neurons of the basal ganglia. In the branchial arches, they control regional patterning. I hypothesize that there will be some conserved and some divergent mechanisms that the Dlx genes use in controlling brain and craniofacial development. We have already performed array analyses on Dlx function in the developing basal ganglia (with TGEN) by co...

Displaying 20 of 27 results for "DLX2"