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Displaying 20 of 161 results for "DLL1"
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  1. Expression Profiling of Dll1 mutant mouse line OmicsDI

    ID: E-GEOD-12954

    Date Released: 05-04-2014

    Description: licated in distinct human diseases. Delta-like 1 (Dll1) is one of the known ligands of the Notch receptors. The role of the Notch ligands is less well understood. Loss-of-function of Dll1 leads to embryonic lethality, but reduction of Delta-like 1 protein levels has not been studied in adult stage. METHODOLOGY/PRINCIPAL FINDINGS: Here we present the haploinsufficient phenotype of Dll1 and a missense mutant Dll1 allele (Dll1(C413Y)). Haploinsufficiency leads ...

  2. Dll1 mice cloned by nuclear transfer OmicsDI

    ID: E-GEOD-20560

    Date Released: 05-01-2014

    Description: croarray analysis compared expression patterns of Dll1 ko versus Dll1 ko NT (NT = nuclear transfer) and wt versus wt NT of liver and spleen. The aim of this study was analysis of possible epigenetic effects by cloning in the offspring of the 3rd generation. If the 3rd generation cloned animals are indeed phenotypically equivalent to conventional transgenic mouse models then this would open the possibility to develop novel techniques of genetic engineering based on somatic gene targeting and nuclear replacement. four male animals of each cohort (Dll1 conventional transgenic mouse, Dll1 nuclear transfer mouse, wildtype, wildtye nuclear transfer mouse). Two technica...

  3. Dll1 marks early secretory progenitors in gut crypts that can revert to stem cells upon tissue damage BioProject

    ID: PRJNA172136

    Keywords: Transcriptome or Gene expression

    Access Type: download

  4. Dll1 mice cloned by nuclear transfer BioProject

    ID: PRJNA125209

    Keywords: Transcriptome or Gene expression

    Access Type: download

  5. Expression Profiling of Dll1 mutant mouse line BioProject

    ID: PRJNA110935

    Keywords: Transcriptome or Gene expression

    Access Type: download

  6. Expression Profiling of Dll1 mutant mouse line ArrayExpress

    ID: E-GEOD-12954

    Description: licated in distinct human diseases. Delta-like 1 (Dll1) is one of the known ligands of the Notch receptors. The role of the Notch ligands is less well understood. Loss-of-function of Dll1 leads to embryonic lethality, but reduction of Delta-like 1 protein levels has not been studied in adult stage. METHODOLOGY/PRINCIPAL FINDINGS: Here we present the haploinsufficient phenotype of Dll1 and a missense mutant Dll1 allele (Dll1(C413Y)). Haploinsufficiency leads ...

  7. Dll1 acts as a tumor suppressor in neural stem cells to induce an astroglial lineage-restricted glioblastoma BioProject

    ID: PRJNA146365

    Keywords: Transcriptome or Gene expression

    Access Type: download

  8. Dll1 mice cloned by nuclear transfer ArrayExpress

    ID: E-GEOD-20560

    Description: croarray analysis compared expression patterns of Dll1 ko versus Dll1 ko NT (NT = nuclear transfer) and wt versus wt NT of liver and spleen. The aim of this study was analysis of possible epigenetic effects by cloning in the offspring of the 3rd generation. If the 3rd generation cloned animals are indeed phenotypically equivalent to conventional transgenic mouse models then this would open the possibility to develop novel techniques of genetic engineering based on somatic gene targeting and nuclear replacement. four male animals of each cohort (Dll1 conventional transgenic mouse, Dll1 nuclear transfer mouse, wildtype, wildtye nuclear transfer mouse). Two technica...

  9. Dll1 acts as a tumor suppressor in neural stem cells to induce an astroglial lineage-restricted glioblastoma OmicsDI

    ID: E-GEOD-32293

    Date Released: 05-04-2014

    Description: on remain elusive. Here we show that Delta-like1 (Dll1) mutation induces the oncogenic transformation of neural stem cell–derived neurospheres into oncogenic spheres capable of generating histological and molecular human glioblastoma (GBM)-like tumors upon subcutaneous and intracranial transplantations into nude mice. Serial transplantation a...

  10. Dll1 marks early secretory progenitors in gut crypts that can revert to stem cells upon tissue damage OmicsDI

    ID: E-GEOD-39915

    Date Released: 05-03-2014

    Description: The introduction of GFP into the Dll1 locus has made it possible to isolate and study primary intestinal Dll1 positive cells, which constitute th...

  11. Transmission of survival signals through Delta-like 1 on activated CD4+ T cells OmicsDI

    ID: E-GEOD-76693

    Date Released: 01-25-2016

    Description: this report we demonstrate that the Notch ligand Dll1 on CD4+ T cells transduces signals required for the maintenance of activated CD4+ T cells without affecting Notch signaling in the same cells. T cell-specific Dll1-deficient (Dll1-/-) mice did not show any defect in T cell development in thymus or spleen. Co-transfer of CD4+ T cells from Dll1-/- and control mice into recipient mice followed by immunization revealed a rapid dec...

  12. Transmission of survival signals through Delta-like 1 on activated CD4+ T cells BioProject

    ID: PRJNA308329

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: this report we demonstrate that the Notch ligand Dll1 on CD4+ T cells transduces signals required for the maintenance of activated CD4+ T cells without affecting Notch signaling in the same cells. T cell-specific Dll1-deficient (Dll1-/-) mice did not show any defect in T cell development in thymus or spleen. Co-transfer of CD4+ T cells from Dll1-/- and control mice into recipient mice followed by immunization revealed a rapid dec...
  13. Expression Profiling of Dll1 mutant mouse lines on different genetic background OmicsDI

    ID: E-GEOD-11867

    Date Released: 05-01-2014

    Description: ssues in many vertebrates and invertebrates. The Dll1 gene was mutated by homologous recombination in embryonic stem cells such that amino acids 2-116 were replaced with an in-frame fusion of the lacZ gene of E.coli. Mouse Dll1 genomic clones were isolated from a strain 129/SvPas library. The replacement vector was constructed by inserting a 4 kb ClaI/XhoI fragment, which...

  14. Transmission of survival signals through Delta-like 1 on activated CD4+ T cells ArrayExpress

    ID: E-GEOD-76693

    Description: this report we demonstrate that the Notch ligand Dll1 on CD4+ T cells transduces signals required for the maintenance of activated CD4+ T cells without affecting Notch signaling in the same cells. T cell-specific Dll1-deficient (Dll1-/-) mice did not show any defect in T cell development in thymus or spleen. Co-transfer of CD4+ T cells from Dll1-/- and control mice into recipient mice followed by immunization revealed a rapid dec...

  15. Dll1 acts as a tumor suppressor in neural stem cells to induce an astroglial lineage-restricted glioblastoma ArrayExpress

    ID: E-GEOD-32293

    Description: on remain elusive. Here we show that Delta-like1 (Dll1) mutation induces the oncogenic transformation of neural stem cell–derived neurospheres into oncogenic spheres capable of generating histological and molecular human glioblastoma (GBM)-like tumors upon subcutaneous and intracranial transplantations into nude mice. Serial transplantation a...

  16. DL1 Dryad

    DateIssued: 11-22-2016

    Description: Illumina MiSeq data for control region fragment DL1

  17. Expression Profiling of Dll1 mutant mouse lines on different genetic background BioProject

    ID: PRJNA105675

    Keywords: Transcriptome or Gene expression

    Access Type: download

  18. Expression Profiling of Dll1 mutant mouse lines on different genetic background ArrayExpress

    ID: E-GEOD-11867

    Description: ssues in many vertebrates and invertebrates. The Dll1 gene was mutated by homologous recombination in embryonic stem cells such that amino acids 2-116 were replaced with an in-frame fusion of the lacZ gene of E.coli. Mouse Dll1 genomic clones were isolated from a strain 129/SvPas library. The replacement vector was constructed by inserting a 4 kb ClaI/XhoI fragment, which...

  19. Dll1 marks early secretory progenitors in gut crypts that can revert to stem cells upon tissue damage ArrayExpress

    ID: E-GEOD-39915

    Description: The introduction of GFP into the Dll1 locus has made it possible to isolate and study primary intestinal Dll1 positive cells, which constitute th...

  20. RNA-seq study of directed sclerotome, Lon non-coding RNA PEAT, and the embryonic Dll1 lineage form E9.0-9.5 BioProject

    ID: PRJNA340283

    Keywords: Transcriptome or Gene expression

    Access Type: download


Displaying 20 of 161 results for "DLL1"