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Displaying 20 of 57 results for "DGAT2"
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  1. DGAT2_MOUSE UniProt:Swiss-Prot

    ID: Q9DCV3

    Description: Diacylglycerol O-acyltransferase 2 Cytoplasmic Helical Lumenal Helical Cyt...

  2. DGAT2_XENLA UniProt:Swiss-Prot

    ID: Q6PAZ3

    Description: Diacylglycerol O-acyltransferase 2 Cytoplasmic Helical Lumenal Helical Cyt...

  3. Toll-like receptor 2 and 4 agonists prolong triglyceride retention in macrophages ArrayExpress

    ID: E-GEOD-42190

    Description: ses in long chain acyl CoA synthase 1 (ACSL1) and diacylglycerol acyltransferase-2 (DGAT2) during the sustained response to TLR2/4 activation; decreases in adipose triglyceride lipase (ATGL, Pnpla2) and monoacylglycerol lipase (MgII) may also contribute. Stimulated murine macrophages that retained TAG carried out phagocytosis more effectively and were protected from saturated fatty acid-induced cell death (lipotoxicity). TLR agonist-induced TAG retention in macrophages is thus an active, sustained process that may have important adaptive functions. It may also contribute to the persistence of lipid-laden macrophages in infected tissues, host susceptibility to some microbial pathogens, and the pathogenesis of atherosclerosis. RNA from macrophage loaded with Fatty Acids, stimulated with bacterial lipopolysaccharides (LPS), or both compared to untreated controls (FA, LPS, FA+LPS, untreated). Replicates from 4 independent experiments....

  4. ves of Arabidopsis by Introducing a Chlamydomonas Diacylglycerol Acyltransferase 2... ArrayExpress

    ID: E-GEOD-38898

    Description: wable energy. Acyl-CoA-dependent TAG synthesis by diacylglycerol acyltransferases (DGATs) in oilseeds has been well characterized, but how the ectopic introduction of TAG synthesis in vegetative tissues of plants affects metabolism is largely unknown. Here we report the identification and characterization of several Chlamydomonas reinhardtii Diacylglycerol

  5. ves of Arabidopsis by Introducing a Chlamydomonas Diacylglycerol Acyltransferase 2... BioProject

    ID: PRJNA169157

    Keywords: Transcriptome or Gene expression

    Access Type: download

  6. Toll-like receptor 2 and 4 agonists prolong triglyceride retention in macrophages BioProject

    ID: PRJNA179268

    Keywords: Transcriptome or Gene expression

    Access Type: download

  7. Transcriptional profiling of triacylglycerol biosynthesis in rhodococci and identification of a key diacylglyceride O-acyltransferase BioProject

    ID: PRJNA309609

    Keywords: Transcriptome or Gene expression

    Access Type: download

  8. se and wax ester synthase/acyl-CoA:diacylglycerol acyltransferase gene knockouts on triacylglycerol accumulation and transcriptome expression in Gordonia sp. KTR9... ArrayExpress

    ID: E-GEOD-60245

    Description: Gene disruption of KTR9_0186 resulted in a 2-fold increase in TAG content in nitrogen starved cells. Lipase mutants subjected to carbon starvation, following nitrogen starvat...

  9. DGAT1 Inhibitor-Induced Gene Expression in Mouse Skin ArrayExpress

    ID: E-GEOD-49375

    Description: Inhibition of Diacylglycerol O-acyltransferase 1 (DGAT1) has been a mechanism of interest for metabolic dis...

  10. Additional file 2: of Analysis of triglyceride synthesis unveils a green algal soluble diacylglycerol acyltransferase Figshare

    ID: doi:10.6084/M9.FIGSHARE.C.3712726_D3

    Release Date: 03-10-2017

    Description: Number of LCAT superfamily homologous sequences identified in algae by HMMER iterative data mining. (XLSX 8 kb)

  11. se and wax ester synthase/acyl-CoA:diacylglycerol acyltransferase gene knockouts on triacylglycerol accumulation and transcriptome expression in Gordonia sp. KTR9.... BioProject

    ID: PRJNA257813

    Keywords: Transcriptome or Gene expression

    Access Type: download

  12. DGAT1 Inhibitor-Induced Gene Expression in Mouse Skin BioProject

    ID: PRJNA213738

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: Inhibition of Diacylglycerol O-acyltransferase 1 (DGAT1) has been a mechanism of interest for metabolic dis...
  13. Microarray profiling of WT or PDE10A KO mice treated with vehicle or a PDE10 inhibitor ArrayExpress

    ID: E-GEOD-40377

    Description: sphodiesterase 1C, glutamate decarboxylase 1, and diacylglycerol O-acyltransferase and a down-regulation of mRNAs encoding choline acetyltransferase and Kv1.6, suggesting long-term suppression of the PDE10A enzyme is consistent with altered striatal excitability and potential utility as a antipsychotic therapy. In addition, up-regulation of mRNAs encoding histone 3 (H3) and down-regulation of histone deacetylase 4, follistatin, and claspin mRNAs suggests activation of molecular cascades capable of neuroprotection. We used lentiviral delivery of cAMP response element (CRE)-luciferase reporter constructs into the striatum and live animal imaging of 2-{4-[-pyridin-4-yl-1-(2,2,2-trifluoro-ethyl)-1H-pyrazol-3-yl]-phenoxymethyl}-quinoline succinic acid (TP-10)-induced luciferase activity to further demonstrate PDE10 inhibition results in CRE-mediated transcription. Consistent with potential neuroprotectiv...

  14. Crystal structure of Antigen 85C co-crystallized with iodoacetamide PDB

    ID: PDB:4QDT

    Description: Diacylglycerol acyltransferase/mycolyltransferase Ag85C (E.C.2.3.1.122, 2.3.1.20)

  15. Crystal structure of Antigen 85C-S124A mutant PDB

    ID: PDB:4QEK

    Description: Diacylglycerol acyltransferase/mycolyltransferase Ag85C (E.C.2.3.1.122, 2.3.1.20)

  16. Crystal structure of Antigen 85C co-crystallized with ebselen PDB

    ID: PDB:4QDU

    Description: Diacylglycerol acyltransferase/mycolyltransferase Ag85C (E.C.2.3.1.122, 2.3.1.20)

  17. Transcription profiling by array of rat Sertoli cells after treatment with follicle-stimulating hormone ArrayExpress

    ID: E-GEOD-509

    Description: ured in the presence of 25 ng/ml ovine FSH. At 0, 2, 4, 8, and 24 h after the addition of FSH, total RNA was purified and used to prepare biotinylated target, which was hybridized to the U34A rat microarray containing approximately 9000 rat genes. Analysis identified 100-300 transcripts at each time point that were up-regulated or down-regulated by 2-fold or greater. Genes previously reported to be FSH or cAMP regulated in rat Sertoli cells were identified, in addition to numerous genes not reported to be expressed or FSH regulated in Sertoli cells. The expression patterns of five of these genes, encoding nerve growth factor inducible gene B, PRL-1, PC3 nerve growth factor-inducible antiproliferative putative secreted protein, diacylglycerol acyltransferase, and an expressed sequence tag, in FSH- and N,O'-dibutyryl cAMP-treated...

  18. Inhibiting Monoacylglycerol Acyltransferase 1 Ameliorates Hepatic Metabolic Abnormalities, but not Inflammation and Injury in Mice ArrayExpress

    ID: E-GEOD-60349

    Description: lcoholic steatohepatitis (NASH). Monoacylglycerol acyltransferase (MGAT) enzymes convert monoacylglycerol to diacylglycerol, which is the penultimate step in one pathway for triacylglycerol (TAG) synthesis. Hepatic expression of Mogat1, which encodes an MGAT enzym...

  19. Crystal structure of Antigen 85C-C209G mutant PDB

    ID: PDB:4QDX

    Description: Diacylglycerol acyltransferase/mycolyltransferase Ag85C (E.C.2.3.1.122, 2.3.1.20)

  20. The Path to Triacylglyceride Obesity in the sta6 Strain of Chlamydomonas reinhardtii ArrayExpress

    ID: E-GEOD-55253

    Description: hours post boost, ~425 genes are up-regulated ≥2-fold and ~875 genes are down-regulated ≥2-fold in each strain. Expression of a small subset of "sensitive" genes, encoding enzymes in the glyoxylate and Calvin Benson cycles, gluconeogenesis, and the pentose phosphate pathway, is responsive to culture conditions and genetic background as well as to boost. Four genes--encoding a diacylglycerol acyltransferase (DGTT2), a glycerol-3-P dehydrogenase (GPD3), and two candidate lipases (Cre03.g155250 and Cre17.g735600)--are selectively up-regulated in sta6. Although the bulk rate of acetate depletion from the medium is not boost-enhanced, three candidate acetate permease-encoding genes in the GPR1_FUN34_YaaH sup...


Displaying 20 of 57 results for "DGAT2"