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Displaying 20 of 30 results for "DFFA"
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  1. NMR STRUCTURE OF DFF40 AND DFF45 N-TERMINAL DOMAIN COMPLEX PDB

    ID: PDB:1IBX

    Description: DNA FRAGMENTATION FACTOR 40/DNA FRAGMENTATION

  2. Crystal structure of cell death-inducing DFFA-like effector c PDB

    ID: PDB:4IKG

    Description: Cell death activator CIDE-3

  3. NMR STRUCTURE OF THE HETERODIMERIC COMPLEX BETWEEN CAD DOMAINS OF CAD AND ICAD PDB

    ID: PDB:1F2R

    Description: HETERODIMERIC COMPLEX BETWEEN CAD DOMAINS OF CAD AND ICAD

  4. The RNA-binding profile of Acinus, a peripheral component of the Exon junction complex, reveals its role in splicing regulation BioProject

    ID: PRJNA321672

    Keywords: Other

    Access Type: download

    dataset.description: confirmed the presence of Acinus as a peripheral factor of the EJC. RNA-seq was used to investigate changes in gene expression and alternative splicing following siRNA-mediated depletion of Acinus in HeLa cells. This analysis revealed that Acinus is preferentially required for the inclusion of specific alternative cassette exons and also controls the faithful splicing of a subset of introns. Moreover, a large number of splicing changes can be related to Acinus binding, suggesting a direct role of Acinus in exon and intron definition. In particular, Acinus regulates the splicing of DFFA/ICAD transcript, a major regulator of DNA fragmentation. Globally, the genome-wide identification of RNA targets of Acinus revealed its role in splicing regulatio...
  5. Identification of Hipk2 as a central regulator of white fat development ArrayExpress

    ID: E-GEOD-46077

    Description: oactivator 1a (Ppargc1a), and cell death-inducing DFFA-like effector a (Cidea). These changes are accompanied by increased insulin sensitivity in Hipk2 knock-out mice and reduced high fat diet-induced weight gain, highlighting a potential role for this kinase in diseases such as diabetes and obesity. Our study underscores the versatility and power of a readily available tissue, such as skin, for network modelling of systemic transcriptional programs involved in multiple pathways, including lipid metabolism and adipogenesis. Mammary fat pads from 115 distinct untreated 8 week old [FVB/N x Spret/Ei] x FVB/N Backcross mice...

  6. Blood expression profiles of fragile X premutation carriers identify genes involved in neurodegenerative and infertility phenotypes [FXTAS] ArrayExpress

    ID: E-GEOD-48873

    Description: RNAs (lncRNAs). Several deregulated genes (CASP3, DFFA, APP, AKT1, COX6C, COX7B, SOD1, RNF10, HDAC5, ATXN7, ATXN3 and EAP1) were validated in brain samples of a mouse model of FXTAS and in neuronal cells expressing the expanded FMR1 5’-UTR. One of the validated genes is the early at menopause 1 (EAP1) gene. We confirmed the EAP1 deregulation both in male and female fXPC. Down-regulation was stronger in female fXPC with POF1 compared with female fXPC without POF1. Increased levels of FMR1 mRNA were detected in all brain areas of the CGG-KI mouse model. EAP1 was significantly downregulated in the brainstem and cerebellum of the KI mouse, suggesting that EAP1 levels in certain brain areas could contribute to POF in thi...

  7. Differential gene expression in adipose tissue from obese human subjects during weight loss and weight maintenance ArrayExpress

    ID: E-GEOD-35411

    Description: of other candidates, such as cell death-inducing DFFA-like effector A (CIDEA) and stearoyl-CoA desaturase (SCD) were upregulated during weight loss but returned to baseline levels during weight maintenance. Conclusion. Genes in the adipose tissue are differentially expressed during weight loss and weight maintenance after weight loss. Genes that show sustained regulation may be of potential interest as markers of the beneficial effects of weight loss whereas others seem to be primarily involved in the process of weight loss itself. Nine participants were prescribed a low calorie diet (LCD) containing 1200 kcal/day for approximately three months (101 ± 26 days). Following the weight reduction phase the participants attended a six month follow-up period (167 ± 37 days). By protocol design, subjects were eligible to enter the study if they had lost at least 10% of their initial body weight during the LCD-period and maintained this weight (+5%) after group therapy. Subcutaneous adipose tissue samples were obtained at three time-points: (i) at baseline, (ii) after weight reduction when subjects were no longer losing weight, and (iii) after the group therapy weight maintenance phase....

  8. Blood expression profiles of fragile X premutation carriers identify genes involved in neurodegenerative and infertility phenotypes [SHSY5Y] ArrayExpress

    ID: E-GEOD-48902

    Description: RNAs (lncRNAs). Several deregulated genes (CASP3, DFFA, APP, AKT1, COX6C, COX7B, SOD1, RNF10, HDAC5, ATXN7, ATXN3 and EAP1) were validated in brain samples of a mouse model of FXTAS and in neuronal cells expressing the expanded FMR1 5’-UTR. One of the validated genes is the early at menopause 1 (EAP1) gene. We confirmed the EAP1 deregulation both in male and female fXPC. Down-regulation was stronger in female fXPC with POF1 compared with female fXPC without POF1. Increased levels of FMR1 mRNA were detected in all brain areas of the CGG-KI mouse model. EAP1 was significantly downregulated in the brainstem and cerebellum of the KI mouse, suggesting that EAP1 levels in certain brain areas could contribute to POF in thi...

  9. Blood expression profiles of fragile X premutation carriers identify genes involved in neurodegenerative and infertility phenotypes [SHSY5Y] BioProject

    ID: PRJNA212243

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: RNAs (lncRNAs). Several deregulated genes (CASP3, DFFA, APP, AKT1, COX6C, COX7B, SOD1, RNF10, HDAC5, ATXN7, ATXN3 and EAP1) were validated in brain samples of a mouse model of FXTAS and in neuronal cells expressing the expanded FMR1 5’-UTR. One of the validated genes is the early at menopause 1 (EAP1) gene. We confirmed the EAP1 deregulation both in male and female fXPC. Down-regulation was stronger in female fXPC with POF1 compared with female fXPC without POF1. Increased levels of FMR1 mRNA were detected in all brain areas of the CGG-KI mouse model. EAP1 was significantly downregulated in the brainstem and cerebellum of the KI mouse, suggesting that EAP1 levels in certain brain areas could contribute to POF in thi...
  10. Blood expression profiles of fragile X premutation carriers identify genes involved in neurodegenerative and infertility phenotypes [FXTAS] BioProject

    ID: PRJNA212067

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: RNAs (lncRNAs). Several deregulated genes (CASP3, DFFA, APP, AKT1, COX6C, COX7B, SOD1, RNF10, HDAC5, ATXN7, ATXN3 and EAP1) were validated in brain samples of a mouse model of FXTAS and in neuronal cells expressing the expanded FMR1 5’-UTR. One of the validated genes is the early at menopause 1 (EAP1) gene. We confirmed the EAP1 deregulation both in male and female fXPC. Down-regulation was stronger in female fXPC with POF1 compared with female fXPC without POF1. Increased levels of FMR1 mRNA were detected in all brain areas of the CGG-KI mouse model. EAP1 was significantly downregulated in the brainstem and cerebellum of the KI mouse, suggesting that EAP1 levels in certain brain areas could contribute to POF in thi...
  11. Differential gene expression in adipose tissue from obese human subjects during weight loss and weight maintenance BioProject

    ID: PRJNA152805

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: of other candidates, such as cell death-inducing DFFA-like effector A (CIDEA) and stearoyl-CoA desaturase (SCD) were upregulated during weight loss but returned to baseline levels during weight maintenance. Conclusion. Genes in the adipose tissue are differentially expressed during weight loss and weight maintenance after weight loss. Genes that show sustained regulation may be of potential interest as markers of the beneficial effects of weight loss whereas others seem to be primarily involved in the process of weight loss itself. Overall design: Nine participants were prescribed a low calorie diet (LCD) containing 1200 kcal/day for approximately three months (101 ± 26 days). Following the weight reduction phase the participants attended a six month follow-up period (167 ± 37 days). By protocol design, subjects were eligible to enter the study if they had lost at least 10% of their initial body weight during the LCD-period and maintained this weight (+5%) after group therapy. Subcutaneous adipose tissue samples were obtained at three time-points: (i) at baseline, (ii) after weight reduction when subjects were no longer losing weight, and (iii) after the group therapy weight maintenance phase....
  12. Identification of Hipk2 as an essential regulator of white fat development BioProject

    ID: PRJNA197207

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: oactivator 1a (Ppargc1a), and cell death-inducing DFFA-like effector a (Cidea). These changes are accompanied by increased insulin sensitivity in Hipk2 knock-out mice and reduced high fat diet-induced weight gain, highlighting a potential role for this kinase in diseases such as diabetes and obesity. Our study underscores the versatility and power of a readily available tissue, such as skin, for network modelling of systemic transcriptional programs involved in multiple pathways, including lipid metabolism and adipogenesis. Overall design: Mammary fat pads from 115 distinct untreated 8 week old [FVB/N x Spret/Ei] x FVB/N Backcross mice...
  13. NMR structure of DFF-C domain PDB

    ID: PDB:1KOY

    Description: DNA fragmentation factor alpha subunit

  14. Solution structure of the CIDE-N domain of human cell death activator CIDE-A PDB

    ID: PDB:2EEL

    Description: Cell death activator CIDE-A

    dataset.keywords: Cell death-inducing DFFA-like effector A
  15. NMR Structure Ensemble Of Dff-C Domain PDB

    ID: PDB:1IYR

    Description: DNA fragmentation factor alpha subunit

  16. Analysis of the cell death inducing DFFA like effector c (Cidec)-dependent transciptome in mouse white adipose tissue NURSA

    Keywords: WAT unspecified

    Description: Gonadal WAT was removed from 3 month old male Cidec KO and WT mice.

    ID: 10.1621/vLRHR6z6zB

  17. Analysis of the cell death inducing DFFA like effector c (Cidec) and leptin (Lep)-dependent transcriptome in mouse white adipose tissue (WAT) NURSA

    Keywords: WAT unspecified

    Description: Gonadal WAT was removed from 4 month old male Cidec/Lep double knockout and Lep knockout mice.

    ID: 10.1621/L0honIuQ7x

  18. ICAD_STAAW UniProt:Swiss-Prot

    ID: Q79ZV3

    Description: Poly-beta-1,6-N-acetyl-D-glucosamine synthesis protein IcaD Helical Helical

  19. ICAD_STAAC UniProt:Swiss-Prot

    ID: Q5HCN0

    Description: Poly-beta-1,6-N-acetyl-D-glucosamine synthesis protein IcaD Helical Helical

  20. ICAD_STAAM UniProt:Swiss-Prot

    ID: Q7A2K4

    Description: Poly-beta-1,6-N-acetyl-D-glucosamine synthesis protein IcaD Helical Helical


Displaying 20 of 30 results for "DFFA"