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Displaying 14 of 14 results for "DEFA3"
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  1. CRYSTAL STRUCTURE OF DEFENSIN HNP-3, AN AMPHIPHILIC DIMER: MECHANISMS OF MEMBRANE PERMEABILIZATION PDB

    ID: PDB:1DFN

    Description: DEFENSIN HNP-3

  2. Transcription profiling by array of human blood samples taken from patients with critical Chronic Obstructive Pulmonary Disease (COPD) ArrayExpress

    ID: E-MEXP-3589

    Description: anscripts, being [cathepsin G (CTSG)], [elastase, neutrophil expressed (ELANE)], [proteinase 3 (PRTN3)], [myeloperoxidase (MPO)], [cathepsin D (CTSD)], [defensin, alpha 3, neutrophil-specific (DEFA3)], azurocidin 1 (AZU1)], [bactericidal/permeability-increasing protein (BPI)] the most representative ones. Proteins codified by these genes form part of the azurophilic granules of neutrophils and are involved in both antimicrobial defence and tissue damage. This ?neutrophil signature? was paralleled by necessity of advanced respiratory and vital support, and presence of bacterial infection.CONCLUSION: study of transcriptomic signatures in blood suggests a central role of neutrophil proteases in COPD patients with critical respiratory illness. Measurement / modulation of the expression of these genes could represent an option for clinical monitoring and treatment of severe COPD exacerbations. Keywords: COPD, critical, expression, gene, microarray, neutrophil, proteases....

  3. Transcription profiling by array of human blood samples taken from patients with critical Chronic Obstructive Pulmonary Disease (COPD) OmicsDI

    ID: E-MEXP-3589

    Date Released: 05-03-2014

    Description: anscripts, being [cathepsin G (CTSG)], [elastase, neutrophil expressed (ELANE)], [proteinase 3 (PRTN3)], [myeloperoxidase (MPO)], [cathepsin D (CTSD)], [defensin, alpha 3, neutrophil-specific (DEFA3)], azurocidin 1 (AZU1)], [bactericidal/permeability-increasing protein (BPI)] the most representative ones. Proteins codified by these genes form part of the azurophilic granules of neutrophils and are involved in both antimicrobial defence and tissue damage. This ?neutrophil signature? was paralleled by necessity of advanced respiratory and vital support, and presence of bacterial infection.
    CONCLUSION: study of transcriptomic signatures in blood suggests a central role of neutrophil proteases in COPD patients with critical respiratory illness. Measurement / modulation of the expression of these genes could represent an option for clinical monitoring and treatment of severe COPD exacerbations.

    Keywords: COPD, critical, expression, gene, microarray, neutrophil, proteases.

    ...

  4. Crystal structure of human alpha_defensin-2 (variant GLY16->D-ALA), P 32 2 1 space group ) PDB

    ID: PDB:1ZMI

    Description: Neutrophil defensin 2

  5. Crystal structure of human neutrophil peptide 2, HNP-2 (variant Gly16-> D-Ala) PDB

    ID: PDB:1ZMH

    Description: Neutrophil defensin 2

  6. Crystal structure of human alpha-defensin-2 (variant Gly16-> D-ALA), P 42 21 2 space group PDB

    ID: PDB:1ZMK

    Description: Neutrophil defensin 2

  7. Homeostatic tissue responses in skin biopsies from NOMID patients with constitutive overproduction of IL-1b. OmicsDI

    ID: E-GEOD-27864

    Date Released: 05-10-2012

    Description: . NOMID patients present with systemic and organ-specific inflammation of the skin, central nervous system and bony growth plates, and respond dramatically to treatment with IL-1 blocking agents. We compared the cellular infiltrates and transcriptome of skin biopsies from patients with NOMID (n=14) before treatment [lesional (LS) and non-lesional (pre-NL) skin] and after treatment (post-NL) with the IL-1 block...

  8. Homeostatic tissue responses in skin biopsies from NOMID patients with constitutive overproduction of IL-1b ArrayExpress

    ID: E-GEOD-27864

    Description: . NOMID patients present with systemic and organ-specific inflammation of the skin, central nervous system and bony growth plates, and respond dramatically to treatment with IL-1 blocking agents. We compared the cellular infiltrates and transcriptome of skin biopsies from patients with NOMID (n=14) before treatment [lesional (LS) and non-lesional (pre-NL) skin] and after treatment (post-NL) with the IL-1 block...

  9. USIA Poll # 1999-I99030: Crime/Security/Economy/Democracy/Elections/Politics/Government Institutions/United States Dataverse

    Description: wing issues and topics: Direction of the country (3); most serious problems facing the country (2); public security (3); National Police job performance (1); personal contact with <

    Person: United States Information Agency [USIA]

    Release Date: 08-23-2007

  10. Human alpha-defensin 1 derivative (HNP1) PDB

    ID: PDB:2PM5

    Description: Neutrophil defensin 1 (HNP-1) (HP-1) (HP1) (Defensin, alpha

  11. Homeostatic tissue responses in skin biopsies from NOMID patients with constitutive overproduction of IL-1b. BioProject

    ID: PRJNA138011

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: . NOMID patients present with systemic and organ-specific inflammation of the skin, central nervous system and bony growth plates, and respond dramatically to treatment with IL-1 blocking agents. We compared the cellular infiltrates and transcriptome of skin biopsies from patients with NOMID (n=14) before treatment [lesional (LS) and non-lesional (pre-NL) skin] and after treatment (post-NL) with the IL-1 block...
  12. Genotype Polymorphism effects on Cholera Vaccine responses. ImmPort

    ID: SDY23

    Description: Innate immunity gene products are known to be the first-line of host-defense and to control and assist the adaptive immune system. This research repre...

    dimension.description: s are designed for each SNP locus. Two oligos are specific to each allele of the SNP site, called the Allele-Specific Oligos (ASOs). A third oligo that hybridizes several bases downstream from the SNP site is the Locus-Specific Oligo (LSO). All three oligonucleotide sequences contain regions of genomic complementarity and universal PCR primer sites; the LSO also contains a unique address sequence that targets a particular bead type. Up to 1,536 SNPs may be interrogated simultaneously in this manner us...
  13. National Health and Nutrition Examination Survey (NHANES), 1999-2000 ICPSR

    ID: doi:10.3886/ICPSR25501.v4

    Description: o limited sample sizes for the two-year dataset. (3) Interview and Examination Sample Weight Variables: Sample weights are available for analyzing NHANES 1999-2000 data. For a complete listing of survey contents for all years of the NHANES see the document -- Survey Content -- NHANES 1999-2010....

    Creators: United States Department of Health and Human Services. Centers for Disease Control and Prevention. National Center for Health Statistics

  14. National Health and Nutrition Examination Survey (NHANES), 2001-2002 ICPSR

    ID: doi:10.3886/ICPSR25502.v5

    Description: limited sample sizes for the two-year data set. (3) Interview and Examination Sample Weight Variables: sample weights are available for analyzing NHANES 2001-2002 data. For a complete listing of survey contents for all years of the NHANES see the document -- Survey Content -- NHANES 1999-2010....

    Creators: United States Department of Health and Human Services. Centers for Disease Control and Prevention. National Center for Health Statistics


Displaying 14 of 14 results for "DEFA3"