CYR61 | bioCADDIE Data Discovery Index
Mountain View
biomedical and healthCAre Data Discovery Index Ecosystem
help Advanced Search
Displaying 20 of 78 results for "CYR61"
i
  1. Data from: Potential role of Cyr61 induced degeneration of human Müller cells in diabetic retinopathy Dryad

    DateIssued: 10-27-2014

    Description: r. This study is to explore the potential role of Cyr61, a secreted signaling protein in extracellular matrix, in inducing human Müller cell degeneration in diabetic retinopathy (DR). Twenty patients with proliferative diabetic retinopathy (PDR) and twelve non-diabetic patients were recruited for this study. Vitreous fluid was...

  2. Tetracycline-Inducible Cyr61 effect on LN229 glioma cells BioProject

    ID: PRJNA140027

    Keywords: Transcriptome or Gene expression

    Access Type: download

  3. Tetracycline-Inducible Cyr61 effect on LN229 glioma cells ArrayExpress

    ID: E-GEOD-29384

    Description: ting, but is lacking efficacy in clinical trials. Cyr61, a secreted extracellular matrix protein which functions to promote angiogenesis, migration, proliferation and tumorigenesis, was found to be upregulated rapidly following oHSV infection. Here we show, using microarray analysis, that Cyr61 expression leads to the induction of several genes with type 1 interferon function. We show that <

  4. Tetracycline-Inducible Cyr61 effect on LN229 glioma cells OmicsDI

    ID: E-GEOD-29384

    Date Released: 08-12-2015

    Description: ting, but is lacking efficacy in clinical trials. Cyr61, a secreted extracellular matrix protein which functions to promote angiogenesis, migration, proliferation and tumorigenesis, was found to be upregulated rapidly following oHSV infection. Here we show, using microarray analysis, that Cyr61 expression leads to the induction of several genes with type 1 interferon function. We show that <

  5. experimental data Dryad

    DateIssued: 10-27-2014

    Description: data for the: (1) Vitreous levels of Cyr61 in PDR and non-diabetic patients were determined by ELISA;(2) Cyr61 expression in Müller cells was observ...

  6. Atorvastatin effect on SaOS2 osteosarcoma cells ArrayExpress

    ID: E-GEOD-24401

    Description: lls. Here, using microarray analysis, we identify cyr61/CCN1 as a new target of statins. Modulations of expression of cyr61 were performed in human and murine osteosarcoma cell lines to investigate in vitro cell viability, migratory potential and invasiveness. Cyr61 expression was evaluated in 231 tissue cores from osteosarcoma patients using tissue microarray. Tumor behavior and metastases occurence were analysed by IM injection of modified osteosarcoma cells to BALB/c mice. Results Transcriptome comparisons revealed that statins down-regulate cyr61 expression in SaOS2 cells. Cyr61 silencing in human and murine osteosarcoma cell lines ...

  7. Atorvastatin effect on SaOS2 osteosarcoma cells OmicsDI

    ID: E-GEOD-24401

    Date Released: 05-02-2014

    Description: lls. Here, using microarray analysis, we identify cyr61/CCN1 as a new target of statins. Modulations of expression of cyr61 were performed in human and murine osteosarcoma cell lines to investigate in vitro cell viability, migratory potential and invasiveness. Cyr61 expression was evaluated in 231 tissue cores from osteosarcoma patients using tissue microarray. Tumor behavior and metastases occurence were analysed by IM injection of modified osteosarcoma cells to BALB/c mice. Results Transcriptome comparisons revealed that statins down-regulate cyr61 expression in SaOS2 cells. Cyr61 silencing in human and murine osteosarcoma cell lines ...

  8. CYR61_PANTR UniProt:Swiss-Prot

    ID: A5A6L1

    Description: Protein CYR61 IGFBP N-terminal VWFC TSP type-1 CTCK Heparin-binding Phosphoserine

  9. CYR61_MOUSE UniProt:Swiss-Prot

    ID: P18406

    Description: Protein CYR61 IGFBP N-terminal VWFC TSP type-1 CTCK Heparin-binding Phosphoserine

  10. Cyr61 promotes CD204 expression and migration of macrophages via MEK/Erk pathway in the microenvironment of human esophageal squamous cell carcinoma ArrayExpress

    ID: E-GEOD-59471

    Description: expressed cysteine-rich, angiogenic inducer, 61 (Cyr61), induced by conditioned media of ESCC cells. Levels of Cyr61 expression were associated with CD204+ macrophage infiltration in ESCC tissue. Cyr61 promoted CD204 expression and migration of macrophages via MEK/Erk pathway in vitro. To identify the molecules specifically upregulated in TAM-like THP-1 cells, we performed a cDNA microarra...

  11. Cyr61 promotes CD204 expression and migration of macrophages via MEK/Erk pathway in the microenvironment of human esophageal squamous cell carcinoma BioProject

    ID: PRJNA255400

    Keywords: Transcriptome or Gene expression

    Access Type: download

  12. Atorvastatin effect on SaOS2 osteosarcoma cells BioProject

    ID: PRJNA132955

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: lls. Here, using microarray analysis, we identify cyr61/CCN1 as a new target of statins. Modulations of expression of cyr61 were performed in human and murine osteosarcoma cell lines to investigate in vitro cell viability, migratory potential and invasiveness. Cyr61 expression was evaluated in 231 tissue cores from osteosarcoma patients using tissue microarray. Tumor behavior and metastases occurence were analysed by IM injection of modified osteosarcoma cells to BALB/c mice. Results Transcriptome comparisons revealed that statins down-regulate cyr61 expression in SaOS2 cells. Cyr61 silencing in human and murine osteosarcoma cell lines...
  13. CYR61_RAT UniProt:Swiss-Prot

    ID: Q9ES72

    Description: Protein CYR61 IGFBP N-terminal VWFC TSP type-1 CTCK Heparin-binding Phosphoserine

  14. CYR61_CHICK UniProt:Swiss-Prot

    ID: P19336

    Description: Protein CYR61 IGFBP N-terminal VWFC TSP type-1 CTCK

  15. Cyr61 promotes CD204 expression and migration of macrophages via MEK/Erk pathway in the microenvironment of human esophageal squamous cell carcinoma OmicsDI

    ID: E-GEOD-59471

    Date Released: 10-10-2014

    Description: expressed cysteine-rich, angiogenic inducer, 61 (Cyr61), induced by conditioned media of ESCC cells. Levels of Cyr61 expression were associated with CD204+ macrophage infiltration in ESCC tissue. Cyr61 promoted CD204 expression and migration of macrophages via MEK/Erk pathway in vitro. To identify the molecules specifically upregulated in TAM-like THP-1 cells, we performed a cDNA microarra...

  16. Transcription profiling of mouse SCCVII murine cell line reveals irradiated stroma selects for invasive and metastatic tumoc cells ArrayExpress

    ID: E-GEOD-11357

    Description: eriments, we identified the matricellular protein CYR61 and aVb5 integrin, as proteins cooperating to mediate these effects. Inhibition of aVb5 integrin suppressed invasion and metastasis induced by CYR61 and attenuated metastasis of tumors growing within a pre-irradiated field. These results represent a conceptual advance to the understanding of the tumor bed effect and identify CYR61 and aVb5 integrin as proteins that co-operate to mediate metastasis. They also indicate aV integrin inhibition a potential therapeutic approach for preventing metastasis in patients at risk for post-radiation recurrences, which can be promptly tested in the clinic. Experiment Overall Design: The overall experimental design consist of a single channel experiment where a total of 9 independent samples of 3 different conditions were analyzed. The SCCVII murine cell line were grown either in an iradiadiated (IR) or non-irradiated (NIR) environme...

  17. Analysis of altered gene expressions in valproate-treated Disc1-L100P mutant mice BioProject

    ID: PRJNA118389

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: tation L100P, which was verified by RT-PCR (Lcn2, Cyr61, Slc6a12, Slc40a1, Egr2), a few genes are affected by genotype and valproate (Dusp1 and Purb), suggesting their role in valproate-induced benificial effect on sensorimotor gaiting in Disc1-L100P mutant mice. The final conclusion will be drawn after series of RT-PCR co...
  18. Irradiated stroma selects for invasive and metastatic tumoc cells BioProject

    ID: PRJNA106577

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: eriments, we identified the matricellular protein CYR61 and aVb5 integrin, as proteins cooperating to mediate these effects. Inhibition of aVb5 integrin suppressed invasion and metastasis induced by CYR61 and attenuated metastasis of tumors growing within a pre-irradiated field. These results represent a conceptual advance to the understanding of the tumor bed effect and identify CYR61 and aVb5 integrin as proteins that co-operate to mediate metastasis. They also indicate aV integrin inhibition a potential therapeutic approach for preventing metastasis in patients at risk for post-radiation recurrences, which can be promptly tested in the clinic. Keywords: Tumour profiling Overall design: The overall experimental design consist of a single channel experiment where a total of 9 independent samples of 3 different conditions were analyzed. The SCCVII murine cell line were grown either in an iradiadiated (IR) or non-irradiated...
  19. Transcription profiling of mouse SCCVII murine cell line reveals irradiated stroma selects for invasive and metastatic tumoc cells OmicsDI

    ID: E-GEOD-11357

    Date Released: 03-27-2012

    Description: eriments, we identified the matricellular protein CYR61 and aVb5 integrin, as proteins cooperating to mediate these effects. Inhibition of aVb5 integrin suppressed invasion and metastasis induced by CYR61 and attenuated metastasis of tumors growing within a pre-irradiated field. These results represent a conceptual advance to the understanding of the tumor bed effect and identify CYR61 and aVb5 integrin as proteins that co-operate to mediate metastasis. They also indicate aV integrin inhibition a potential therapeutic approach for preventing metastasis in patients at risk for post-radiation recurrences, which can be promptly tested in the clinic. Experiment Overall Design: The overall experimental design consist of a single channel experiment where a total of 9 independent samples of 3 different conditions were analyzed. The SCCVII murine cell line were grown either in an iradiadiated (IR) or non-irradiated (NIR) environme...

  20. mRNAs translated at eIF4F ArrayExpress

    ID: E-GEOD-62

    Description: g c-myc and Pim-1. In addition, the mRNA encoding Cyr61, a secreted factor that can promote angiogenesis and tumor growth, was selectively mobilized into polysomes when eIF4F concentrations were reduced, although its overall abundance changed only slightly. Subsequent tests confirmed the presence of internal ribosome entry sites in the 5' noncoding regions of both Cyr61 and Pim-1 mRNAs. Overall, this study suggests that diverse mRNAs whose gene products have been implicated in a variety of stress responses, including inflammation, angiogenesis, and the response to serum, can use translational initiation mechanisms that require little or no intact cap binding protein complex eIF4F. This study is described more fully in Johannes G et al.(1999) Proc Natl Acad Sci U S A 96:13118-23....


Displaying 20 of 78 results for "CYR61"