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Displaying 20 of 103 results for "CYR61"
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  1. Cyr61 promotes CD204 expression and migration of macrophages via MEK/Erk pathway in the microenvironment of human esophageal squamous cell carcinoma ArrayExpress

    ID: E-GEOD-59471

    Description: ent not only cancer cells but also TAMs expressed cysteine-rich, angiogenic inducer, 61 (Cyr61), induced by conditioned media of ESCC cells. Levels of Cyr61 expression were associated with CD204+ macrophage infiltration in ESCC tissue. Cyr61 promoted CD204 ex...

  2. Cyr61 promotes CD204 expression and migration of macrophages via MEK/Erk pathway in the microenvironment of human esophageal squamous cell carcinoma BioProject

    ID: PRJNA255400

    Keywords: Transcriptome or Gene expression

    Access Type: download

  3. Cyr61 promotes CD204 expression and migration of macrophages via MEK/Erk pathway in the microenvironment of human esophageal squamous cell carcinoma OmicsDI

    ID: E-GEOD-59471

    Date Released: 10-10-2014

    Description: ent not only cancer cells but also TAMs expressed cysteine-rich, angiogenic inducer, 61 (Cyr61), induced by conditioned media of ESCC cells. Levels of Cyr61 expression were associated with CD204+ macrophage infiltration in ESCC tissue. Cyr61 promoted CD204 ex...

  4. Data from: Potential role of Cyr61 induced degeneration of human Müller cells in diabetic retinopathy Dryad

    DateIssued: 10-27-2014

    Description: r. This study is to explore the potential role of Cyr61, a secreted signaling protein in extracellular matrix, in inducing human Müller cell degeneration in diabetic retinopathy (DR). Twenty patients with proliferative diabetic retinopathy (PDR) and twelve non-diabetic patients were recruited for this study. Vitreous fluid was...

  5. Tetracycline-Inducible Cyr61 effect on LN229 glioma cells BioProject

    ID: PRJNA140027

    Keywords: Transcriptome or Gene expression

    Access Type: download

  6. The matricellular protein CCN1 activates a pro-inflammatory genetic program in murine macrophages ArrayExpress

    ID: E-GEOD-19731

    Description: Effects of the matricellular protein CCN1 on macrophage inflammatory gene expression was tested in a macrophage cell line I-13.35. CCN1 (

  7. Atorvastatin effect on SaOS2 osteosarcoma cells OmicsDI

    ID: E-GEOD-24401

    Date Released: 05-02-2014

    Description: lls. Here, using microarray analysis, we identify cyr61/CCN1 as a new target of statins. Modulations of expression of cyr61 were performed in human and murine osteosarcoma cell lines to investigate in vitro cell viability, migratory potential and invasiveness. Cyr61 expression was evaluated in 231 tissue cores from osteosarcoma patients using tissue microarray. Tumor behavior and metastases occurence were analysed by IM injection of modified osteosarcoma cells to BALB/c mice. Results Transcriptome comparisons revealed that statins down-regulate cyr61 expression in SaOS2 cells. Cyr61 silencing in human and murine osteo...

  8. Tetracycline-Inducible Cyr61 effect on LN229 glioma cells ArrayExpress

    ID: E-GEOD-29384

    Description: ting, but is lacking efficacy in clinical trials. Cyr61, a secreted extracellular matrix protein which functions to promote angiogenesis, migration, proliferation and tumorigenesis, was found to be upregulated rapidly following oHSV infection. Here we show, using microarray analysis, that Cyr61 expression leads to the induction of several genes with type 1 interferon function. We show that <

  9. Atorvastatin effect on SaOS2 osteosarcoma cells ArrayExpress

    ID: E-GEOD-24401

    Description: lls. Here, using microarray analysis, we identify cyr61/CCN1 as a new target of statins. Modulations of expression of cyr61 were performed in human and murine osteosarcoma cell lines to investigate in vitro cell viability, migratory potential and invasiveness. Cyr61 expression was evaluated in 231 tissue cores from osteosarcoma patients using tissue microarray. Tumor behavior and metastases occurence were analysed by IM injection of modified osteosarcoma cells to BALB/c mice. Results Transcriptome comparisons revealed that statins down-regulate cyr61 expression in SaOS2 cells. Cyr61 silencing in human and murine osteo...

  10. Tetracycline-Inducible Cyr61 effect on LN229 glioma cells OmicsDI

    ID: E-GEOD-29384

    Date Released: 08-12-2015

    Description: ting, but is lacking efficacy in clinical trials. Cyr61, a secreted extracellular matrix protein which functions to promote angiogenesis, migration, proliferation and tumorigenesis, was found to be upregulated rapidly following oHSV infection. Here we show, using microarray analysis, that Cyr61 expression leads to the induction of several genes with type 1 interferon function. We show that <

  11. experimental data Dryad

    DateIssued: 10-27-2014

    Description: data for the: (1) Vitreous levels of Cyr61 in PDR and non-diabetic patients were determined by ELISA;(2) Cyr61 expression in Müller cells was observ...

  12. The matricellular protein CCN1 activates a pro-inflammatory genetic program in murine macrophages BioProject

    ID: PRJNA122187

    Keywords: Transcriptome or Gene expression

    Access Type: download

  13. Atorvastatin effect on SaOS2 osteosarcoma cells BioProject

    ID: PRJNA132955

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: lls. Here, using microarray analysis, we identify cyr61/CCN1 as a new target of statins. Modulations of expression of cyr61 were performed in human and murine osteosarcoma cell lines to investigate in vitro cell viability, migratory potential and invasiveness. Cyr61 expression was evaluated in 231 tissue cores from osteosarcoma patients using tissue microarray. Tumor behavior and metastases occurence were analysed by IM injection of modified osteosarcoma cells to BALB/c mice. Results Transcriptome comparisons revealed that statins down-regulate cyr61 expression in SaOS2 cells. Cyr61 silencing in human and murine oste...
  14. The matricellular protein CCN1 activates a pro-inflammatory genetic program in murine macrophages OmicsDI

    ID: E-GEOD-19731

    Date Released: 03-27-2012

    Description: Effects of the matricellular protein CCN1 on macrophage inflammatory gene expression was tested in a macrophage cell line I-13.35. CCN1 (

  15. CYR61_PANTR UniProt:Swiss-Prot

    ID: A5A6L1

    Description: Protein CYR61 IGFBP N-terminal VWFC TSP type-1 CTCK Heparin-binding Phosphoserine

  16. CYR61_MOUSE UniProt:Swiss-Prot

    ID: P18406

    Description: Protein CYR61 IGFBP N-terminal VWFC TSP type-1 CTCK Heparin-binding Phosphoserine

  17. CYR61_RAT UniProt:Swiss-Prot

    ID: Q9ES72

    Description: Protein CYR61 IGFBP N-terminal VWFC TSP type-1 CTCK Heparin-binding Phosphoserine

  18. CYR61_CHICK UniProt:Swiss-Prot

    ID: P19336

    Description: Protein CYR61 IGFBP N-terminal VWFC TSP type-1 CTCK

  19. Transcription profiling of mouse SCCVII murine cell line reveals irradiated stroma selects for invasive and metastatic tumoc cells ArrayExpress

    ID: E-GEOD-11357

    Description: eriments, we identified the matricellular protein CYR61 and aVb5 integrin, as proteins cooperating to mediate these effects. Inhibition of aVb5 integrin suppressed invasion and metastasis induced by CYR61 and attenuated metastasis of tumors growing within a pre-irradiated field. These results represent a conceptual advance to the understanding of the tumor bed effect and identify CYR61 and aVb5 integrin as proteins that co-operate to mediate metastasis. They also indicate aV integrin inhibition a potential therapeutic approach for preventing metastasis in patients at risk for post-radiation recurrences, which can be promptly tested in the clinic. Experiment Overall Design: The overall experimental design consist of a single channel experiment where a total of 9 independent samples of 3 different conditions were analyzed. The SCCVII murine cell line were grown either in an iradiadiated (IR) or non-irradiated (NIR) environme...

  20. MMP10 degradomics in keratinocytes OmicsDI

    ID: PXD002474

    Date Released: 10-19-2015

    Description: position and identified the α6 integrin subunit, cysteine-rich angiogenic inducer 61 and dermokine as novel MMP10 substrates. Moreover, we confirmed the same MMP10-dependent processing of dermokine in vivo by TAILS analysis of epidermis from transgenic mice that overexpress a constitutively active mutant of MMP10 in basal keratinocytes. Since these substrates have been associated with cell adhesion, differentiation and senescence, MMP10 might contribute to modulation of these processes during skin repair....


Displaying 20 of 103 results for "CYR61"