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Displaying 12 of 12 results for "CYP2C8"
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  1. Bisphosphonate related osteonecrosis of the jaw is associated with polymorphisms of the cytochrome P450 CYP2C8 in MM BioProject

    ID: PRJNA105805

    Keywords: Variation

    Access Type: download

  2. Bisphosphonate related osteonecrosis of the jaw is associated with polymorphisms of the cytochrome P450 CYP2C8 in MM ArrayExpress

    ID: E-GEOD-11948

    Description: 4980, rs1341162 and rs17110453) mapped within the Cytochrome P450-2C gene (CYP2C8) showed a different distribution between cases and controls with statistically significant differences (p=1.07x10-6, p=4.231x10-6, p=6.22x10-6 and p=2.15x10-5, respectively). SNP rs1934951 was significantly associated with a higher risk of ONJ development even after Bonferroni correction (P corrected value=0.02). Genotyping results displayed an overrepresentation of the T allele in cases as compared with controls (48% vs. 12%). Thus, individuals homozygous for the T allele had...

  3. CYP2C8dH complexed with montelukast PDB

    ID: PDB:2NNI

    Description: Cytochrome P450 2C8 (E.C.1.14.14.1)

  4. Crystal Structure of Human Drug Metabolizing Cytochrome P450 2C8 PDB

    ID: PDB:1PQ2

    Description: Cytochrome P450 2C8 (E.C.1.1414.1)

  5. CYP2C8dH complexed with felodipine PDB

    ID: PDB:2NNJ

    Description: Cytochrome P450 2C8 (E.C.1.14.14.1)

  6. CYP2C8dH complexed with 2 molecules of 9-cis retinoic acid PDB

    ID: PDB:2NNH

    Description: Cytochrome P450 2C8 (E.C.1.14.14.1)

  7. Transcription profiling by array of human female interstitial cystitis urothelial cells after inducing differentiation ArrayExpress

    ID: E-GEOD-11839

    Description: red at least 3-fold with p <0.01. PI3, SERPINB4, CYP2C8, EFEMP2 and SEPP1 were decreased in IC; AKR1C2 and MKNK1 were increased in IC. Conclusions: Differentiation-associated changes occurred in both IC and control cells. Comparing IC vs. control revealed very few differences. This study may have included IC patients with minimal urothelial deficiency and/or selected the cells that were most robust in culture. Also, the abnormal urothelium in IC may be due to post-translational changes and/or the bladder environment. Experiment Overall Design: Human female urothelial cell cultures, differentiated vs. non-differentiated,interstitial cystitis vs. control...

  8. Bisphosphonate related osteonecrosis of the jaw is associated with polymorphisms of the cytochrome P450 CYP2C8 in MM OmicsDI

    ID: E-GEOD-11948

    Date Released: 09-15-2011

    Description: 4980, rs1341162 and rs17110453) mapped within the Cytochrome P450-2C gene (CYP2C8) showed a different distribution between cases and controls with statistically significant differences (p=1.07x10-6, p=4.231x10-6, p=6.22x10-6 and p=2.15x10-5, respectively). SNP rs1934951 was significantly associated with a higher risk of ONJ development even after Bonferroni correction (P corrected value=0.02). Genotyping results displayed an overrepresentation of the T allele in cases as compared with controls (48% vs. 12%). Thus, individuals homozygous for the T allele had...

  9. Differentiation associated changes in gene expression profiles for interstitial cystitis and control urothelial cells BioProject

    ID: PRJNA105631

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: red at least 3-fold with p <0.01. PI3, SERPINB4, CYP2C8, EFEMP2 and SEPP1 were decreased in IC; AKR1C2 and MKNK1 were increased in IC. Conclusions: Differentiation-associated changes occurred in both IC and control cells. Comparing IC vs. control revealed very few differences. This study may have included IC patients with minimal urothelial deficiency and/or selected the cells that were most robust in culture. Also, the abnormal urothelium in IC may be due to post-translational changes and/or the bladder environment. Overall design: Human female urothelial cell cultures, differentiated vs. non-differentiated,interstitial cystitis vs. control...
  10. CYP2C8DH COMPLEXED WITH TROGLITAZONE PDB

    ID: PDB:2VN0

    Description: CYTOCHROME P450 2C8 (E.C.1.14.14.1)

  11. Differentiation associated changes in gene expression profiles for interstitial cystitis and control urothelial cells GEMMA

    ID: 1200

    Keywords: functional genomics

    Description: red at least 3-fold with p <0.01. PI3, SERPINB4, CYP2C8, EFEMP2 and SEPP1 were decreased in IC; AKR1C2 and MKNK1 were increased in IC. Conclusions: Differentiation-associated changes occurred in both IC and control cells. Comparing IC vs. control revealed very few differences. This study may have included IC patients with minimal urothelial deficiency and/or selected the cells that were most robust in culture. Also, the abnormal urothelium in IC may be due to post-translational changes and/or the bladder environment. Last Updated (by provider): Mar 15 2009 Contributers: Matt A Hersh Deborah R Erickson Justin K Dixon Steven Schwarze Curtis J Clark...

  12. Transcription profiling by array of human female interstitial cystitis urothelial cells after inducing differentiation OmicsDI

    ID: E-GEOD-11839

    Date Released: 08-27-2015

    Description: red at least 3-fold with p <0.01. PI3, SERPINB4, CYP2C8, EFEMP2 and SEPP1 were decreased in IC; AKR1C2 and MKNK1 were increased in IC. Conclusions: Differentiation-associated changes occurred in both IC and control cells. Comparing IC vs. control revealed very few differences. This study may have included IC patients with minimal urothelial deficiency and/or selected the cells that were most robust in culture. Also, the abnormal urothelium in IC may be due to post-translational changes and/or the bladder environment. Experiment Overall Design: Human female urothelial cell cultures, differentiated vs. non-differentiated,interstitial cystitis vs. control...


Displaying 12 of 12 results for "CYP2C8"