CXCL12 | bioCADDIE Data Discovery Index
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Displaying 20 of 341 results for "CXCL12"
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  1. Data from: Down-regulation of CXCL12/CXCR4 expression alleviates ischemia-reperfusion-induced inflammatory pain via inhibiting glial TLR4 activation in the spina... Dryad

    DateIssued: 11-10-2016

    Description: chemia/reperfusion (IR) in spinal cord. Recently, C-X-C chemokine ligand 12 (CXCL12) and its receptor, C-X-C chemokine recep...

  2. CXCL12 Stimulation of CXCR4-WHIM Transduced Waldenstrom's Macroglobulinemia cell line BCWM.1 BioProject

    ID: PRJNA325279

    Keywords: Transcriptome or Gene expression

    Access Type: download

  3. CXCL12 Stimulation of CXCR4-WHIM Transduced Waldenstrom's Macroglobulinemia cell line BCWM.1 ArrayExpress

    ID: E-GEOD-83150

    Description: on to wild-type CXCR4, vectors with the mutations c.1013C>G (p.Ser338*), c.932_933insT (p.Thr311fs), and c.1030_1041delinsGT (p.Ser344fs) were generated. Cell lines were stimulated with 50nM of the CXCR4 ligand CXCL12 (SDF1A) (R&...

  4. Gene expression pattern in CXCR4+ and CXCR4- subpopulation of breast cancer cells BioProject

    ID: PRJNA117063

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: lation, CXCR4-positive subpopulation treated with SDF-1 (ligand for CXCR4, also called CXCL12) for one hour and CXCR4-negative subpopulation....
  5. Gene expression pattern in CXCR4+ and CXCR4- subpopulation of breast cancer cells ArrayExpress

    ID: E-GEOD-15893

    Description: lation, CXCR4-positive subpopulation treated with SDF-1 (ligand for CXCR4, also called CXCL12) for one hour and CXCR4-negative subpopulation....

  6. CXCL12/CXCR4 signaling mediates niche occupancy and tumor maintenance in T-cell leukemia ArrayExpress

    ID: E-GEOD-60367

    Description: at T-ALL cells express high surface levels of the chemokine receptor CXCR4. Intravital imaging of an intact tibia revealed T-ALL cells in direct contact with bone marrow stromal cells producing the CXCR4 ligand, CXCL12. Genetic targeting of CXCR4 on T-ALL cells resulted in a marked reduction of leukemia burden and prolonged disease remission, and disruption of the CXCL12/CXCR4 axis using small molecule inhibitors prevented T-ALL progression in a primary xenograft model. Finally, we were able to show that CXCR4 inhibition s...

  7. Gene expression profile of human ovarian cancer cell lines in vitro BioProject

    ID: PRJNA121557

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: y described how TNF-α, IL-6, CXCR4 and the CXCR4 ligand CXCL12 are expressed by human ovarian cancer cells in vitro. By comparing four ovarian cancer cell lines with varying leve...
  8. CXCL12/CXCR4 signaling mediates niche occupancy and tumor maintenance in T-cell leukemia BioProject

    ID: PRJNA258103

    Keywords: Transcriptome or Gene expression

    Access Type: download

  9. Structure of SDF-1/CXCL12 PDB

    ID: PDB:2KED

    Description: Stromal cell-derived factor 1-alpha

  10. EMT Alters Interstitial Fluid Flow-induced Signaling in ERBB2-positive Breast Cancer ArrayExpress

    ID: E-GEOD-64670

    Description: nsition (EMT), IFF-mediated invasion requires the chemokine receptor CXCR4, a gradient of its ligand CXCL12, and activity of the PI3K catalytic subunits p110a and β. In wild-type ERBB2 expressing cells, IFF-mediated invasion is chemokine receptor-independent and requires only p110a activation. To test whether cells undergoing EMT alter their signaling response to IFF, TGFb1 was used to induce EMT in wild-type ERBB2-expressing cells resulting in IFF-induced invasion dependent on CXCR4 and p110β. 2 cell lines (NeuN, NeuT), 2 conditions (flow, static), 3 replicates each, 12 samples total...

  11. Structure of SDF-1/CXCL12 PDB

    ID: PDB:2KEC

    Description: Stromal cell-derived factor 1-alpha

  12. Crystal structure of CXCL12 in complex with inhibitor PDB

    ID: PDB:4UAI

    Description: CXCL12

  13. Murine Bone Marrow Stromal Cell Response to Granulocyte Colony-Stimulating Factor ArrayExpress

    ID: E-GEOD-22925

    Description: the bone marrow. Constitutive expression of the chemokine CXCL12 by bone marrow stromal cells provides a key retention signal for neutrophils in the bone marrow through activation of its receptor CXCR4. Herein, we show that the ELR chemokines CXCL1 a...

  14. Gene expression profile of human ovarian cancer cell lines in vitro ArrayExpress

    ID: E-GEOD-18680

    Description: y described how TNF-α, IL-6, CXCR4 and the CXCR4 ligand CXCL12 are expressed by human ovarian cancer cells in vitro. By comparing four ovarian cancer cell lines with varying leve...

  15. Structure of SDF-1/CXCL12 PDB

    ID: PDB:2KEE

    Description: Stromal cell-derived factor 1-alpha

  16. Gene expression profile of ascites cell samples from patients with advanced ovarian cancer ArrayExpress

    ID: E-GEOD-18681

    Description: t the inflammatory cytokines TNF-α and IL-6, the chemokine receptor CXCR4 and its ligand CXCL12, are co-regulated in malignant cells. We named this co-regulation the TNF network. We had access to a unique set of ascites cell samples from patients with advanced ovarian cancer treated with the therapeutic anti-human TNF-α antibody infliximab. Serial samples pre and during treatment were obtained during ...

  17. Crystal structure of CXCL12 PDB

    ID: PDB:3HP3

    Description: CXCL12 protein

  18. CXCL12 (SDF) in trigonal space group PDB

    ID: PDB:3GV3

    Description: CXCL12 protein

  19. Structure of SDF1 in complex with the CXCR4 N-terminus containing a sulfotyrosine at postition 21 PDB

    ID: PDB:2K03

    Description: Stromal cell-derived factor 1 precursor (SDF-1) (C-X-C motif chemokine

  20. Development and Preclinical Characterization of a Humanized Antibody Targeting CXCL12 PDB

    ID: PDB:4LMQ

    Description: Stromal cell-derived factor 1, immunoglobulin G1 heavy chain, immunoglobulin G1 light chain


Displaying 20 of 341 results for "CXCL12"