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Displaying 20 of 54 results for "CTTN"
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  1. Solution structures of the SH3 domain of human Src substrate cortactin PDB

    ID: PDB:1X69

    Description: cortactin isoform a

  2. The crystal structure of the cortactin-SH3 domain and AMAP1-peptide complex PDB

    ID: PDB:2D1X

    Description: cortactin isoform a, proline rich region from development and differentiation enhancing factor 1

  3. Gene expression in HNSCC cell lines after knockdown of CTTN BioProject

    ID: PRJNA223233

    Keywords: Transcriptome or Gene expression

    Access Type: download

  4. Gene expression in HNSCC cell lines after knockdown of CTTN ArrayExpress

    ID: E-GEOD-51456

    Description: The gene expression level of CTTN was decreased in HPV-negative HNSCC cell line with an amplification and overexpression of CTTN by performin...

  5. Supplementary Movie 5. Invadopodia formation in SGEF KD cells. Dryad

    DateIssued: 02-20-2017

    Description: g SGEF targeting shRNA were infected with mCherry-cortactin adenovirus as in Supp Movie 1. At indicated times cells were stimulated to form invadopodia with PDBu. Images were captured at 15 sec intervals for th...

  6. Supplementary Movie 2. Invadopodia formation in Rac1 KO cells. Dryad

    DateIssued: 02-20-2017

    Description: ls were infected with adenovirus encoding mCherry-cortactin as in Supp Movie 1. At indicated times cells were stimulated to form invadopodia with PDBu. Images were captured at 15 sec intervals for th...

  7. Supplementary Movie 6. Invadopodia formation in RhoG KD/rescue cells. Dryad

    DateIssued: 02-20-2017

    Description: re co-infected with adenoviruses encoding mCherry-cortactin and shRNA resistant mycRhoG. At indicated times cells were stimulated to form invadopodia with PDBu. Images were captured at 15 sec intervals fo...

  8. Gene expression in HNSCC cell lines after knockdown of CTTN OmicsDI

    ID: E-GEOD-51456

    Date Released: 10-25-2014

    Description: The gene expression level of CTTN was decreased in HPV-negative HNSCC cell line with an amplification and overexpression of CTTN by performin...

  9. Supplementary Movie 3. Invadopodia formation in Rac1 KO/rescue cells. Dryad

    DateIssued: 02-20-2017

    Description: were co-infected with adenovirus encoding mCherry-cortactin and mycRac1. At indicated times cells were stimulated to form invadopodia with PDBu. Images were captured at 15 sec intervals for the duration...

  10. Supplementary Movie 4. Invadopodia in RhoG KD SUM159 cells. Dryad

    DateIssued: 02-20-2017

    Description: a RhoG targeting shRNA were infected with mCherry-cortactin adenovirus as in Supp Movie 1. At indicated times cells were stimulated to form invadopodia with PDBu. Images were captured at 15 sec intervals for the ...

  11. Supplementary Movie 7. Invadopodia formation in SGEF KD/rescue cells. Dryad

    DateIssued: 02-20-2017

    Description: were co-infected with adenovirus encoding mCherry-cortactin and shRNA resistant mycSGEF. At indicated times cells were stimulated to form invadopodia with PDBu. Images were captured at 15 sec intervals ...

  12. Lysozyme contamination facilitates crystallization of a hetero-trimericCortactin:Arg:Lysozyme complex PDB

    ID: PDB:3ULR

    Description: Lysozyme C (E.C.3.2.1.17), Src substrate cortactin, Abelson tyrosine-protein kinase 2

  13. Supplementary Movie 1. Invadopodia formation in CTRL SUM159 cells in response to PDBu. Dryad

    DateIssued: 02-20-2017

    Description: xpressing a CTRL shRNA were infected with mCherry-cortactin adenovirus and plated on glass-bottom coverslips 24 h after infection. Cells were imaged at 37°C in a CO2 and humidity controlled envi...

  14. Cell Image Library Dataset CIL:7439 CIL

    ID: 7439

    Description: th mouse antibody to Paxillin, rabbit antibody to cortactin, followed by anti-mouse Alexa 561 goat antibody for Cortactin (cblue), anti-rabbit Alexa 647 for Paxillin (green) and Alexa 488 phalloidin (red) to stain for F-actin. Images were collected on a Nikon Eclipse imaged with a cooled charge coupled device (CCD; Orca ...

    Data Types: image

  15. Cell Image Library Dataset CIL:25704 CIL

    ID: 25704

    Description: l cotransfected with FAK siRNA (target B) and GFP-cortactin to visualize invadipodia dynamics. The corresponding FAK control experiments is CIL:25706 and CIL:25705 shows a different FAK siRN...

    Data Types: image

  16. Pak1-ATF2 signaling axis induces miR-132 to inhibit hematogenous metastasis ArrayExpress

    ID: E-GEOD-84298

    Description: proteins such as Filamin A, Paxillin, Caldesmon, Cortactin and Arp2/3. Pak1 also regulates microtubule dynamics via activation of tubulin cofactor B (TCoB) and DLC1, and inhibition of stathmin. In spite of a large body of work about the mechanism of Pak1 action in cancer, it remains unknown whether Pak1 signaling could potentially regulate the biology of regulatory miRNAs. This is particularly relevant for gastric cancer because Pak1 can activate many regulators of miRNAs expression in gastric cancer cells including NF-kappaB and ERK, and Pak1 signaling has profound phenotypic effects on the biology of gastric cancer cells. We constructed Pak1 knockdown stable cell lines. The stable Pak1 knockdown gastric cancer BGC823 cells and control cells were p...

  17. Chromosome 11q and its association with CCND1 gene amplification and tamoxifen resistance in premenopausal breast cancer ArrayExpress

    ID: E-GEOD-12759

    Description: in a subset of 56 breast cancer samples. Results: Cortactin and FADD overexpression was linked to CCND1 amplification, determined by FISH, but was not associated with a diminished effect of tamoxifen. However, deletion of distal chromosome 11q, defined as downregulation of the marker Chk1, was associated with an impaired tamoxifen response, and interestingly, also with low proliferative breast cancer of low grade. For Pak1 and cyclin D1 the protein expression corresponded to the gene expression data from the CGH analysis. Conclusions: The results indicate that many 11q13 associated gene products are overexpressed in conjunction with cyclin D1 but not linked to an agonistic effect of tamoxifen. Finally, the deletion of distal 11q, linked to 11q13 amplification, might be an important event affecting breast cancer outcome and tamoxifen response. Keywords: comparative genomic hybridisation 56 samples with 11q13 amplification have been analysed and compared with protein expression results from immunohistochemical analyses....

  18. Cell Image Library Dataset CIL:25705 CIL

    ID: 25705

    Description: MTLn3 cell cotransfected with FAK siRNA (target A) and GFP-cortactin.The corresponding FAK control experiment is CIL:25706, and an different target FA...

    Data Types: image

    cellularComponent.name: cortactin
  19. Cell Image Library Dataset CIL:25706 CIL

    ID: 25706

    Description: Ln3 cell cotransfected with control siRNA and GFP-cortactin to visualize invadipodia dynamics. The corresponding FAK knockdown experiments are CIL:25705 and CIL:25704. Fluorescence i...

    Data Types: image

  20. Chromosome 11q and its association with CCND1 gene amplification and tamoxifen resistance in premenopausal breast cancer BioProject

    ID: PRJNA111015

    Keywords: Variation

    Access Type: download

    dataset.description: in a subset of 56 breast cancer samples. Results: Cortactin and FADD overexpression was linked to CCND1 amplification, determined by FISH, but was not associated with a diminished effect of tamoxifen. However, deletion of distal chromosome 11q, defined as downregulation of the marker Chk1, was associated with an impaired tamoxifen response, and interestingly, also with low proliferative breast cancer of low grade. For Pak1 and cyclin D1 the protein expression corresponded to the gene expression data from the CGH analysis. Conclusions: The results indicate that many 11q13 associated gene products are overexpressed in conjunction with cyclin D1 but not linked to an agonistic effect of tamoxifen. Finally, the deletion of distal 11q, linked to 11q13 amplification, might be an important event affecting breast cancer outcome and tamoxifen response. Keywords: comparative genomic hybridisation Overall design: 56 samples with 11q13 amplification have been analysed and compared with protein expression results from immunohistochemical analyses....

Displaying 20 of 54 results for "CTTN"