CTSE | bioCADDIE Data Discovery Index
Mountain View
biomedical and healthCAre Data Discovery Index Ecosystem
help Advanced Search
Displaying 20 of 133 results for "CTSE"
i
  1. Functional Plasticity of Regulatory T Cell Function ArrayExpress

    ID: E-GEOD-29262

    Description: 5 was compensated for by a concurrent increase in cathepsin E (CTSE) expression, enhanced TRAIL (Tnfsf10)expression and soluble TRAIL release, rendering IL-10/IL-35-double deficient Tregsfunctionally dependent on TRAIL in vitro and in vivo. Lastly, while C57BL/6 Tregs are IL-10/IL-35-dependent, Balb/c Tregs, which express high levels of CTSE and enhanced TRAIL expression, are TRAIL-dependent.These data reveal that cross-regulatory pathways exist, which control the utilization of suppressive mechanisms,thereby providing Tregfunctional plasticity. Isolate natural Tregs from the different knockout mouse...

  2. CATE_RABIT UniProt:Swiss-Prot

    ID: P43159

    Description: Activation peptide Cathepsin E Peptidase A1 N-linked (GlcNAc...) Interchain

  3. CATE_CAVPO UniProt:Swiss-Prot

    ID: P25796

    Description: Activation peptide Cathepsin E Peptidase A1 N-linked (GlcNAc...) Interchain

  4. Crystal Structure of an activation intermediate of Cathepsin E PDB

    ID: PDB:1TZS

    Description: Cathepsin E (E.C.3.4.23.34)/23-mer peptide from PelB-IgG kappa light chain fusion protein

  5. Functional Plasticity of Regulatory T Cell Function BioProject

    ID: PRJNA140267

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: 5 was compensated for by a concurrent increase in cathepsin E (CTSE) expression, enhanced TRAIL (Tnfsf10)expression and soluble TRAIL release, rendering IL-10/IL-35-double deficient Tregsfunctionally dependent on TRAIL in vitro and in vivo. Lastly, while C57BL/6 Tregs are IL-10/IL-35-dependent, Balb/c Tregs, which express high levels of CTSE and enhanced TRAIL expression, are TRAIL-dependent.These data reveal that cross-regulatory pathways exist, which control the utilization of suppressive mechanisms,thereby providing Tregfunctional plasticity. Overall design: Isolate natural Tregs from the different knockout mouse...
  6. Functional Plasticity of Regulatory T Cell Function OmicsDI

    ID: E-GEOD-29262

    Date Released: 06-26-2012

    Description: 5 was compensated for by a concurrent increase in cathepsin E (CTSE) expression, enhanced TRAIL (Tnfsf10)expression and soluble TRAIL release, rendering IL-10/IL-35-double deficient Tregsfunctionally dependent on TRAIL in vitro and in vivo. Lastly, while C57BL/6 Tregs are IL-10/IL-35-dependent, Balb/c Tregs, which express high levels of CTSE and enhanced TRAIL expression, are TRAIL-dependent.These data reveal that cross-regulatory pathways exist, which control the utilization of suppressive mechanisms,thereby providing Tregfunctional plasticity. Isolate natural Tregs from the different knockout mouse...

  7. Sessile serrated adenomas and conventional adenomas of the colon ArrayExpress

    ID: E-GEOD-12514

    Description: een polyp types. Further studies using QRT-PCR on Cathepsin E demonstrated a significantly (p< 0.05) higher expression in sessile serrated adenomas as compared to both other polyp types. Trefoil Factor 1, showed the same trend of expression for sessile serrated adenomas as compared to hyperplastic polyps, and was significantly higher in both polyps compared to tubular adenomas. Immunohistochemistry for both proteins demonstrated strong cytoplasmic staining of abnormal crypts in all sessile serrated adenomas while staining in tubular adenomas and hyperplastic polyps was weak a...

  8. Sessile serrated adenomas and conventional adenomas of the colon BioProject

    ID: PRJNA113267

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: een polyp types. Further studies using QRT-PCR on Cathepsin E demonstrated a significantly (p< 0.05) higher expression in sessile serrated adenomas as compared to both other polyp types. Trefoil Factor 1, showed the same trend of expression for sessile serrated adenomas as compared to hyperplastic polyps, and was significantly higher in both polyps compared to tubular adenomas. Immunohistochemistry for both proteins demonstrated strong cytoplasmic staining of abnormal crypts in all sessile serrated adenomas while staining in tubular adenomas and hyperplastic polyps was weak a...
  9. Unstable Foxp3+ regulatory T cells and altered antigen-presenting cells are associated with lipopolysaccharide-induced fetal loss in pregnant IL10 def... ArrayExpress

    ID: E-GEOD-71494

    Description: regnant Il10-/- mice, with elevated expression of Ctse (cathepsin E), Il1r1, Il12rb2 and Ifng. In vitro, Il10-/- Treg cells showed reduced steady state Foxp3 expression, and polyclonal stimulation caused greater loss of Foxp3 and reduced capacity to suppress IL17 in CD4+Foxp3- T cells. We conclude that despite a substantially expanded Treg cell pool, diminished stability of Treg cells, increased numbers of effector T cells, and altered phenotypes in dendritic cells and macrophages in pregnancy all potentially confer vulnerability to inflammation-induced fetal loss in Il10-/- mice. These findings suggest a pivotal role for IL10 in facilitating robust immune protection of the fetus from inflammatory challenge and suggest IL10 deficiency could contribute to human gestational disorders where altered T cell responses are implicated. RNA was extracted from CD4+CD25+ lymphocytes isolated from para-aortic LNs of day 9.5 pc pregnant Il10+/+ or Il10-/- mice using miRNeasy Mini ...

  10. Unstable Foxp3+ regulatory T cells and altered antigen-presenting cells are associated with lipopolysaccharide-induced fetal loss in pregnant IL10 def... BioProject

    ID: PRJNA291425

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: regnant Il10-/- mice, with elevated expression of Ctse (cathepsin E), Il1r1, Il12rb2 and Ifng. In vitro, Il10-/- Treg cells showed reduced steady state Foxp3 expression, and polyclonal stimulation caused greater loss of Foxp3 and reduced capacity to suppress IL17 in CD4+Foxp3- T cells. We conclude that despite a substantially expanded Treg cell pool, diminished stability of Treg cells, increased numbers of effector T cells, and altered phenotypes in dendritic cells and macrophages in pregnancy all potentially confer vulnerability to inflammation-induced fetal loss in Il10-/- mice. These findings suggest a pivotal role for IL10 in facilitating robust immune protection of the fetus from inflammatory challenge and suggest IL10 deficiency could contribute to human gestational disorders where altered T cell responses are implicated. Overall design: RNA was extracted from CD4+CD25+ lymphocytes isolated from para-aortic LNs of day 9.5 pc pregnant Il10+/+ or Il10-/- mice usin...
  11. CATD_CHICK UniProt:Swiss-Prot

    ID: Q05744

    Description: Activation peptide Cathepsin D Cathepsin D light chain Cathepsin D heavy chain Peptidase A1 N-linked (GlcNAc...)...

  12. CRYSTAL STRUCTURE OF THE CYSTEINE PROTEASE HUMAN CATHEPSIN K IN COMPLEX WITH THE COVALENT INHIBITOR E-64 PDB

    ID: PDB:1ATK

    Description: CATHEPSIN K, N-[N-[1-HYDROXYCARBOXYETHYL-CARBONYL]LEUCYLAMINO-BUTYL]-GUANIDINE

  13. Cathepsin K in complex with a non-selective 2-cyano-pyrimidine inhibitor PDB

    ID: PDB:3KWZ

    Description: Cathepsin K (E.C.3.4.22.38)

  14. Cathepsin K in complex with a selective 2-cyano-pyrimidine inhibitor PDB

    ID: PDB:3KX1

    Description: Cathepsin K (E.C.3.4.22.38)

  15. Cathepsin K covalently bound to a 2-cyano pyrimidine inhibitor with a benzyl P3 group. PDB

    ID: PDB:3O1G

    Description: Cathepsin K (E.C.3.4.22.38)

  16. 6-Phenyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile as cathepsin S inhibitors PDB

    ID: PDB:3N4C

    Description: Cathepsin S (E.C.3.4.22.27)

  17. 4-(3-Trifluoromethylphenyl)-pyrimidine-2-carbonitrile as cathepsin S inhibitors: N3, not N1 is critically important PDB

    ID: PDB:3N3G

    Description: Cathepsin S (E.C.3.4.22.27)

  18. X-ray structure of Cathepsin K covalently bound to a triazine ligand PDB

    ID: PDB:3KW9

    Description: Cathepsin K (E.C.3.4.22.38)

  19. Cathepsin B modulates lysosomal biogenesis and host defense against Francisella novicida infection ArrayExpress

    ID: E-GEOD-79508

    Description: Here, we identified a key cell-intrinsic role for cathepsin B as a negative feedback regulator of lysosomal biogenesis and autophagy. Mice and macrophages lacking cathepsin B activity had increased resistance to the cytosolic bacterial pathogen Francisella novicida. Genetic deletion or pharmacological inhibition of cathepsin

  20. Unstable Foxp3+ regulatory T cells and altered antigen-presenting cells are associated with lipopolysaccharide-induced fetal loss in pregnant IL10 def... OmicsDI

    ID: E-GEOD-71494

    Date Released: 08-20-2015

    Description: regnant Il10-/- mice, with elevated expression of Ctse (cathepsin E), Il1r1, Il12rb2 and Ifng. In vitro, Il10-/- Treg cells showed reduced steady state Foxp3 expression, and polyclonal stimulation caused greater loss of Foxp3 and reduced capacity to suppress IL17 in CD4+Foxp3- T cells. We conclude that despite a substantially expanded Treg cell pool, diminished stability of Treg cells, increased numbers of effector T cells, and altered phenotypes in dendritic cells and macrophages in pregnancy all potentially confer vulnerability to inflammation-induced fetal loss in Il10-/- mice. These findings suggest a pivotal role for IL10 in facilitating robust immune protection of the fetus from inflammatory challenge and suggest IL10 deficiency could contribute to human gestational disorders where altered T cell responses are implicated. RNA was extracted from CD4+CD25+ lymphocytes isolated from para-aortic LNs of day 9.5 pc pregnant Il10+/+ or Il10-/- mice using miRNeasy Mini ...


Displaying 20 of 133 results for "CTSE"