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Displaying 10 of 10 results for "COL8A1"
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  1. Microarray Analysis of Dupuytren's Disease Tissues ArrayExpress

    ID: E-GEOD-4457

    Description: D were upregulated significantly, including MafB, collagen type V, alpha-2 (COL5A2), collagen type VIII, alpha-1 (COL8A1), contactin I (CNTN1), and leucine-rich repeat containing 17 (LRRC17). These upregulated genes were compared with their known gene-expression profiles in other tissues and their purported functions. MafB was found to be of particular interest because of its prominent role in tissue development and cellular differentiation. MafB immunohistochemistry showed positive staining in 50% of the DD specimens but complete absence of MafB in all control tissues (adjacent control fascia, carpal tunnel fascia). Co-localization experiments with MafB and alpha-smooth muscle actin showed staining properties in similar regions but these 2 proteins were not confined solely to the same cells. CONCLUSIONS: Microarray analysis of DD tissue has identified significa...

  2. Transcription profiling by array of mouse Col8a1-Col8a2 deficient and wild type mesangial cells stimulated with TGF-beta1 ArrayExpress

    ID: E-MEXP-2658

    Description: Col8a1/Col8a2-deficient mesangial cells and wildtype cells are treated with TGFbeta-1 for 24h. This experiment w...

  3. Microarray Analysis of Dupuytren's Disease Tissues BioProject

    ID: PRJNA94693

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: D were upregulated significantly, including MafB, collagen type V, alpha-2 (COL5A2), collagen type VIII, alpha-1 (COL8A1), contactin I (CNTN1), and leucine-rich repeat containing 17 (LRRC17). These upregulated genes were compared with their known gene-expression profiles in other tissues and their purported functions. MafB was found to be of particular interest because of its prominent role in tissue development and cellular differentiation. MafB immunohistochemistry showed positive staining in 50% of the DD specimens but complete absence of MafB in all control tissues (adjacent control fascia, carpal tunnel fascia). Co-localization experiments with MafB and alpha-smooth muscle actin showed staining properties in similar regions but these 2 proteins were not confined solely to the same cells. CONCLUSIONS: Microarray analysis of DD tissue has identified significa...
  4. Transcription profiling by array of mouse Col8a1-Col8a2 deficient and wild type mesangial cells stimulated with TGF-beta1 OmicsDI

    ID: E-MEXP-2658

    Date Released: 05-02-2014

    Description: Col8a1/Col8a2-deficient mesangial cells and wildtype cells are treated with TGFbeta-1 for 24h. This experiment w...

  5. Microarray Analysis of Dupuytren's Disease Tissues OmicsDI

    ID: E-GEOD-4457

    Date Released: 03-27-2012

    Description: D were upregulated significantly, including MafB, collagen type V, alpha-2 (COL5A2), collagen type VIII, alpha-1 (COL8A1), contactin I (CNTN1), and leucine-rich repeat containing 17 (LRRC17). These upregulated genes were compared with their known gene-expression profiles in other tissues and their purported functions. MafB was found to be of particular interest because of its prominent role in tissue development and cellular differentiation. MafB immunohistochemistry showed positive staining in 50% of the DD specimens but complete absence of MafB in all control tissues (adjacent control fascia, carpal tunnel fascia). Co-localization experiments with MafB and alpha-smooth muscle actin showed staining properties in similar regions but these 2 proteins were not confined solely to the same cells. CONCLUSIONS: Microarray analysis of DD tissue has identified significa...

  6. CO8A1_RABIT UniProt:Swiss-Prot

    ID: P14282

    Description: Collagen alpha-1(VIII) chain Vastatin C1q Nonhelical region (NC2) Triple-h...

  7. Gene expression changes as a result of E-cadherin loss in an isogenic non-malignant MCF10A and MCF10A CDH1-/- breast cells ArrayExpress

    ID: E-GEOD-59317

    Description: volved in cell-substrate adhesion, notably ITGA1, COL8A1, COL4A2 and COL12A1, were significantly downregulated. Key EMT markers including CDH2, FN1, VIM and VTN were not upregulated although increased expression of proteolytic matrix metalloprotease and kallikrein genes was observed. Conclusions: Overall, our results demonstrated that E-cadherin loss alone was insufficient to induce an EMT or enhance transforming potential in the non-tumorigenic MCF10A cells but was associated with broad transcriptional changes associated with tissue remodelling. Examination of the impact of E-cadherin (CDH1) loss in an isogenic pair of breast cell lines....

  8. CO8A1_CHICK UniProt:Swiss-Prot

    ID: Q7LZR2

    Description: Collagen alpha-1(VIII) chain C1q Nonhelical region (NC2) Triple-helical re...

  9. Gene expression changes as a result of E-cadherin loss in an isogenic non-malignant MCF10A and MCF10A CDH1-/- breast cells BioProject

    ID: PRJNA255049

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: volved in cell-substrate adhesion, notably ITGA1, COL8A1, COL4A2 and COL12A1, were significantly downregulated. Key EMT markers including CDH2, FN1, VIM and VTN were not upregulated although increased expression of proteolytic matrix metalloprotease and kallikrein genes was observed. Conclusions: Overall, our results demonstrated that E-cadherin loss alone was insufficient to induce an EMT or enhance transforming potential in the non-tumorigenic MCF10A cells but was associated with broad transcriptional changes associated with tissue remodelling. Overall design: Examination of the impact of E-cadherin (CDH1) loss in an isogenic pair of breast cell lines....
  10. Gene expression changes as a result of E-cadherin loss in an isogenic non-malignant MCF10A and MCF10A CDH1-/- breast cells OmicsDI

    ID: E-GEOD-59317

    Date Released: 12-10-2014

    Description: volved in cell-substrate adhesion, notably ITGA1, COL8A1, COL4A2 and COL12A1, were significantly downregulated. Key EMT markers including CDH2, FN1, VIM and VTN were not upregulated although increased expression of proteolytic matrix metalloprotease and kallikrein genes was observed. Conclusions: Overall, our results demonstrated that E-cadherin loss alone was insufficient to induce an EMT or enhance transforming potential in the non-tumorigenic MCF10A cells but was associated with broad transcriptional changes associated with tissue remodelling. Examination of the impact of E-cadherin (CDH1) loss in an isogenic pair of breast cell lines....


Displaying 10 of 10 results for "COL8A1"