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Displaying 20 of 73 results for "COL3A1"
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  1. T.truncatus COL3A1-like gene Dryad

    DateIssued: 09-26-2012

    Description: T. truncatus individuals of the DNA pool for the collagen type III alpha 1-like gene (COL3A1). There is one SNP in this fragment. Four individuals were s...

  2. The Tsk2/+ mouse fibrotic phenotype is due to a gain-of-function mutation in the PIIINP segment of the Col3a1 gene BioProject

    ID: PRJNA261965

    Keywords: Transcriptome or Gene expression

    Access Type: download

  3. The Tsk2/+ mouse fibrotic phenotype is due to a gain-of-function mutation in the PIIINP segment of the Col3a1 gene OmicsDI

    ID: E-GEOD-61728

    Date Released: 09-25-2015

    Description: e mutation to less than 3 megabases on chromosome 1. We performed both RNA sequencing of skin transcripts and genome capture DNA sequencing of the region spanning this interval in Tsk2/+ and wild-type littermates. A missense point mutation in the procollagen III amino terminal propeptide segment (PIIINP) of Col3a1 was found to be the best candidate for Tsk2, so both in vivo and in vitro genetic complementation tests were used to prove that this Col3a1 mutation is the Tsk2 gene. All previously docu...

  4. The Tsk2/+ mouse fibrotic phenotype is due to a gain-of-function mutation in the PIIINP segment of the Col3a1 gene ArrayExpress

    ID: E-GEOD-61728

    Description: e mutation to less than 3 megabases on chromosome 1. We performed both RNA sequencing of skin transcripts and genome capture DNA sequencing of the region spanning this interval in Tsk2/+ and wild-type littermates. A missense point mutation in the procollagen III amino terminal propeptide segment (PIIINP) of Col3a1 was found to be the best candidate for Tsk2, so both in vivo and in vitro genetic complementation tests were used to prove that this Col3a1 mutation is the Tsk2 gene. All previously docu...

  5. COCA1_NOTVI UniProt:Swiss-Prot

    ID: Q91145

    Description: Collagen alpha-1(XII) chain VWFA 1 Fibronectin type-

  6. COCA1_RABIT UniProt:Swiss-Prot

    ID: Q28902

    Description: Collagen alpha-1(XII) chain VWFA Fibronectin type-III <...

  7. Crystal structure of human type III collagen G982-G1023 containing C-terminal cystine knot PDB

    ID: PDB:3DMW

    Description: Collagen alpha-1(III) chain

  8. Mus musculus : Mus musculus Transcriptome or Gene expression BioProject

    ID: PRJNA262679

    Keywords: transcriptome

    Access Type: download

    dataset.description: e mutation to less than 3 megabases on chromosome 1. We performed both RNA sequencing of skin transcripts and genome capture DNA sequencing of the region spanning this interval in Tsk2/+ and wild-type littermates. A missense point mutation in the procollagen III amino terminal propeptide segment (PIIINP) of Col3a1 was found to be the best candidate for Tsk2, so both in vivo and in vitro genetic complementation tests were used to prove that this Col3a1 mutation is the Tsk2 gene. All previously docum...
  9. Crystal structure of Human fibrillar procollagen type III C- propeptide trimer PDB

    ID: PDB:4AE2

    Description: COLLAGEN ALPHA-1(III) CHAIN

  10. CO3A1_BOVIN UniProt:Swiss-Prot

    ID: P04258

    Description: Collagen alpha-1(III) chain Nonhelical region (N-terminal) Triple-helical ...

  11. Crystal structure of Human fibrillar procollagen type III C- propeptide trimer PDB

    ID: PDB:4AEJ

    Description: COLLAGEN ALPHA-1(III) CHAIN

  12. Structure of Type IV Collagen NC1 Domains PDB

    ID: PDB:1M3D

    Description: Alpha chains 1 and 2 - Type IV Collagen Noncollagenous Domains

  13. CO6A3_CHICK UniProt:Swiss-Prot

    ID: P15989

    Description: Collagen alpha-3(VI) chain VWFA 1 VWFA 2 VWFA 3 VWFA 4 VWFA 5 VWFA 6 VWFA 7 VWFA 8 VWFA 9 VWF...

  14. Crystal structure of Human fibrillar procollagen type III C- propeptide trimer PDB

    ID: PDB:4AK3

    Description: COLLAGEN ALPHA-1(III) CHAIN

  15. Chronic Inhaled LPS Exposure BioProject

    ID: PRJNA105383

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: antly enhanced mRNA expression of TGF-beta1, TIMP-1, fibronectin-1, and pro-collagen types I, III, and IV and show prominent submucosal expression of the myofibroblast markers desmin and alpha-smooth muscle actin. To identify novel candidate genes that contribute to airway fibroproliferation, we performed microarray analysis on total lung RNA from mice exposed to LPS for one week. This analysis revealed a distinct subset of genes known to regul...
  16. Dysregulation of the Transforming Growth Factor Beta Pathway in Induced Pluripotent Stem Cells Generated from Patients with Diamond Blackfan Anemia [H... ArrayExpress

    ID: E-GEOD-70348

    Description: n of TGF beta target genes, such as TGFBI, BAMBI, COL3A1 and SERPINE1 was significantly increased in the DBA iPSCs. We quantified intermediates in canonical and non-canonical TGF beta pathways and observed a significant increase in the levels of the non-canonical pathway mediator p-JNK in the DBA iPSCs. Moreover, when the mutant cells were corrected by ectopic expression of WT RPS19 or RPL5, levels of p-JNK returned to normal. Surprisingly, nuclear levels of SMAD4, a mediator of canonical TGF beta signaling, were decreased in DBA cells due to increased proteolytic turnover. We also observed the up-regulation of TGF beta 1R, TGF beta 2, CDKN1A and SERPINE1 mRNA, and the significant decrease of GATA1 mRNA in th...

  17. Microarray Analysis of the Developing Murine Prefrontal Cortex BioProject

    ID: PRJNA96777

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: : DNA methyltransferase 3A (Dnmt3a), procollagen, type III, alpha 1 (Col3a1), solute carrier family 16 (monocarboxylic acid transporters), member 1 (Slc16a1), MARCKS-like 1 (Marcksl1), nidogen 1 (Nid1) and 3-hydroxybutyrate dehydrogenase (heart, mitochondrial) (Bdh). Keywords: time course, development, mRNA expression Overall design: Single-channel affymetrix arrays were used to profile mRNA expression in the prefrontal cortex (PFC) of male mice at different time-points after birth (post-natal). Each array is an independent animal....
  18. IMPACT OF CARDIOMYOCYTE-SPECIFIC BMAL1 DELETION ON MYOCARDIAL GENE EXPRESSION, METABOLISM, AND CONTRACTILE FUNCTION ArrayExpress

    ID: E-GEOD-43073

    Description: is showed that Beta-hydroxybutyrate dehydrogenase 1 mRNA, protein, and enzymatic activity are markedly depressed in both CBK and CCM hearts, as is myocardial Beta-hydroxybutyrate oxidation, revealing a novel role for the circadian clock in ketone body utilization. A number of genes encoding for collagen isoforms were identified as oscillating in a time-of-day-dependent manner in wild-type, but not CBK, hearts, including col3a1, col4a1, and col4a2. Chronic induction of collagen isoform genes in CBK hearts was associated with severe age-dependent depression of cardiac function. Development of cardiomyopathy in CBK mice was associated with early mortality; all CBK mice die by one year of age. These studies highlight novel critical functions for BMAL1 in the heart, including regulation of ketone body metabolism and the extracellular ...

  19. Gene expression in articular cartilage - subchondral bone of FRZB knockout mice ArrayExpress

    ID: E-GEOD-33656

    Description: frizzled related protein (Frzb) compared to wild-type mice by transcriptome analysis. Methods : Gene-expression analysis of the articular cartilage and subchondral bone of 3 wild-type and 3 Frzb-/- mice was performed by microarray. Pathway analysis of differentially expressed genes between 3...

  20. Data from a time course study of gene expression in a mouse model of osteoarthritis ArrayExpress

    ID: E-GEOD-41342

    Description: cular extracellular matrix genes including Prelp, Col3a1 and fibromodulin.The results support a phasic development of OA with early matrix remodelling and transcriptional activity followed by a more quiescent period that is not maintained. A group of 9 mice was used for collection of RNA at time 0 (before surgery) when the animals were 12 weeks old. For the other time points, 9 DMM and 9 sham controls were sacrificed at 2, 4, 8, and 16 weeks after surgery for RNA isolation. The tissue included tibial plateau and femoral condyle articular cartilage, subchondral bone with any osteophytes, meniscus, and the joint capsule with synovium was used for RNA isolation. The tissue was treated with RNAlater® (Invitrogen) prior to freezing and storage at -800 C. RNA was extracted by homogenization using the Precellys 24 tissue homogenizer (Bertin Technologies purchased from MO BIO) and the amount and quality of the RNA was determined using an Agilent 2100 Bioanalyzer. RNA was pooled prior t...


Displaying 20 of 73 results for "COL3A1"