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Displaying 15 of 15 results for "CHRNA7"
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  1. NMR structures of the alpha7 nAChR transmembrane domain. PDB

    ID: PDB:2MAW

    Description: CHRNA7-FAM7A fusion protein

  2. Genome wide gene expression in a patient with 15q13.3 homozygous microdeletion syndrome OmicsDI

    ID: E-GEOD-43583

    Date Released: 02-24-2013

    Description: were validated by qPCR using primers specific to CHRNA7 as previously described. 15 The extended family and comparison subjects were also screened using the CHRNA7 primers. Immortalized lymphoblastoid lines were created from the proband, his mother, father, a paternal half sister, a paternal half brother, a paternal grandmother and two paternal great uncles. Three lymphoblastoid lines from age- and sex- matched normally developing comparison subjects with normal chromosomes were obtained from the Coriell cell repository [(AG14724 (8 yo), AG14948 (10 yo), AG14980 (9 yo)] were used for gene expression comparison with the proband. The samples from the father, mother and paternal grandmother with heterozygous 15q13.3 deletions were compared to samples from lymphoblastoid cells from adult male and female subjects respectively (normal copy number for 15q13.3 determined by qPCR)....

  3. The effects of aging vs. alpha7 nAChR subunit deficiency on the mouse brain transcriptome ArrayExpress

    ID: E-GEOD-20411

    Description: -dependent changes were detected in only 3 genes, Chrna7 which encodes the alpha7 nAChR subunit, and two closely linked genes, likely due to a mouse background effect. Expression changes dependent on age-genotype interaction were detected in 207 genes (with a low significance threshold). Age-dependent differential expression levels were approved in all nine genes that were chosen for validation by real-time RT-PCR. Our results suggest that the robust effect of aging on brain transcription clearly overcomes the almost negligible effect of alpha7 nAChR subunit deletion, and that germline deficiency of this subunit has a minor effect on brain expression profile in aged mice. Total of 20 samples. 10 from young adult mice (8 weeks) and 10 from aged mice (2 years). In each age group, 5 were wild-type control mice and 5 alpha7 nAChR subunit defecient mice...

  4. ACHA7_CHICK UniProt:Swiss-Prot

    ID: P22770

    Description: Neuronal acetylcholine receptor subunit alpha-7 Extracellular Helical Helical Helical Cytoplasmic Helical N-linked (GlcNAc...) N-linked (GlcNAc...) N-...

    gene.name: CHRNA7
  5. Genome wide gene expression in a patient with 15q13.3 homozygous microdeletion syndrome BioProject

    ID: PRJNA186785

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: were validated by qPCR using primers specific to CHRNA7 as previously described. 15 The extended family and comparison subjects were also screened using the CHRNA7 primers. Immortalized lymphoblastoid lines were created from the proband, his mother, father, a paternal half sister, a paternal half brother, a paternal grandmother and two paternal great uncles. Three lymphoblastoid lines from age- and sex- matched normally developing comparison subjects with normal chromosomes were obtained from the Coriell cell repository [(AG14724 (8 yo), AG14948 (10 yo), AG14980 (9 yo)] were used for gene expression comparison with the proband. The samples from the father, mother and paternal grandmother with heterozygous 15q13.3 deletions were compared to samples from lymphoblastoid cells from adult male and female subjects respectively (normal copy number for 15q13.3 determined by qPCR)....
  6. Genome wide gene expression in a patient with 15q13.3 homozygous microdeletion syndrome ArrayExpress

    ID: E-GEOD-43583

    Description: were validated by qPCR using primers specific to CHRNA7 as previously described. 15 The extended family and comparison subjects were also screened using the CHRNA7 primers. Immortalized lymphoblastoid lines were created from the proband, his mother, father, a paternal half sister, a paternal half brother, a paternal grandmother and two paternal great uncles. Three lymphoblastoid lines from age- and sex- matched normally developing comparison subjects with normal chromosomes were obtained from the Coriell cell repository [(AG14724 (8 yo), AG14948 (10 yo), AG14980 (9 yo)] were used for gene expression comparison with the proband. The samples from the father, mother and paternal grandmother with heterozygous 15q13.3 deletions were compared to samples from lymphoblastoid cells from adult male and female subjects respectively (normal copy number for 15q13.3 determined by qPCR)....

  7. ACHA7_BOVIN UniProt:Swiss-Prot

    ID: P54131

    Description: Neuronal acetylcholine receptor subunit alpha-7 Extracellular Helical Helical Helical Cytoplasmic Helical N-linked (GlcNAc...) N-linked (GlcNAc...) N-...

    gene.name: CHRNA7
  8. ACHA7_MACMU UniProt:Swiss-Prot

    ID: Q866A2

    Description: Neuronal acetylcholine receptor subunit alpha-7 Extracellular Helical Helical Helical Cytoplasmic Helical N-linked (GlcNAc...) N-linked (GlcNAc...) N-...

    gene.name: CHRNA7
  9. Crystal Structures of the Ligand Binding Domain of a Pentameric Alpha7 Nicotinic Receptor Chimera PDB

    ID: PDB:3SQ9

    Description: Neuronal acetylcholine receptor subunit alpha-7, Acetylcholine-binding protein

    gene.name: CHRNA7
  10. Crystal Structures of the Ligand Binding Domain of a Pentameric Alpha7 Nicotinic Receptor Chimera with its Agonist Epibatidine PDB

    ID: PDB:3SQ6

    Description: Neuronal acetylcholine receptor subunit alpha-7, Acetylcholine-binding protein

    gene.name: CHRNA7
  11. Recurrent 15q13 microdeletions OmicsDI

    ID: E-GEOD-10189

    Date Released: 05-01-2014

    Description: x genes, including a candidate gene for epilepsy (CHRNA7) that is likely responsible for the observed seizure phenotype. The BP4-BP5 region undergoes frequent inversion, suggesting a possible link between this inversion polymorphism and recurrent deletion. The frequency of these microdeletions in mental retardation cases is ~0.3% (6/2082 tested), a prevalence comparable to that of the Williams, Angelman, and Prader-Willi syndromes. Keywords: microdeletion, genomic disorder, mental retardation, epilepsy Patients were intially screened by BAC array CGH (n=290) or qPCR (n=1040). Patients with potential 15q13 deletions were then analyzed on a custom oligonucleotide array targeted to the 15q13 region, results of which are shown here....

  12. Recurrent 15q13 microdeletions ArrayExpress

    ID: E-GEOD-10189

    Description: x genes, including a candidate gene for epilepsy (CHRNA7) that is likely responsible for the observed seizure phenotype. The BP4-BP5 region undergoes frequent inversion, suggesting a possible link between this inversion polymorphism and recurrent deletion. The frequency of these microdeletions in mental retardation cases is ~0.3% (6/2082 tested), a prevalence comparable to that of the Williams, Angelman, and Prader-Willi syndromes. Keywords: microdeletion, genomic disorder, mental retardation, epilepsy Patients were intially screened by BAC array CGH (n=290) or qPCR (n=1040). Patients with potential 15q13 deletions were then analyzed on a custom oligonucleotide array targeted to the 15q13 region, results of which are shown here....

  13. The effects of aging vs. alpha7 nAChR subunit deficiency on the mouse brain transcriptome BioProject

    ID: PRJNA125551

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: -dependent changes were detected in only 3 genes, Chrna7 which encodes the alpha7 nAChR subunit, and two closely linked genes, likely due to a mouse background effect. Expression changes dependent on age-genotype interaction were detected in 207 genes (with a low significance threshold). Age-dependent differential expression levels were approved in all nine genes that were chosen for validation by real-time RT-PCR. Our results suggest that the robust effect of aging on brain transcription clearly overcomes the almost negligible effect of alpha7 nAChR subunit deletion, and that germline deficiency of this subunit has a minor effect on brain expression profile in aged mice. Overall design: Total of 20 samples. 10 from young adult mice (8 weeks) and 10 from aged mice (2 years). In each age group, 5 were wild-type control mice and 5 alpha7 nAChR subunit defecient mice...
  14. The effects of aging vs. alpha7 nAChR subunit deficiency on the mouse brain transcriptome OmicsDI

    ID: E-GEOD-20411

    Date Released: 01-01-2011

    Description: -dependent changes were detected in only 3 genes, Chrna7 which encodes the alpha7 nAChR subunit, and two closely linked genes, likely due to a mouse background effect. Expression changes dependent on age-genotype interaction were detected in 207 genes (with a low significance threshold). Age-dependent differential expression levels were approved in all nine genes that were chosen for validation by real-time RT-PCR. Our results suggest that the robust effect of aging on brain transcription clearly overcomes the almost negligible effect of alpha7 nAChR subunit deletion, and that germline deficiency of this subunit has a minor effect on brain expression profile in aged mice. Total of 20 samples. 10 from young adult mice (8 weeks) and 10 from aged mice (2 years). In each age group, 5 were wild-type control mice and 5 alpha7 nAChR subunit defecient mice...

  15. Recurrent 15q13 microdeletions BioProject

    ID: PRJNA108297

    Keywords: Variation

    Access Type: download

    dataset.description: x genes, including a candidate gene for epilepsy (CHRNA7) that is likely responsible for the observed seizure phenotype. The BP4-BP5 region undergoes frequent inversion, suggesting a possible link between this inversion polymorphism and recurrent deletion. The frequency of these microdeletions in mental retardation cases is ~0.3% (6/2082 tested), a prevalence comparable to that of the Williams, Angelman, and Prader-Willi syndromes. Keywords: microdeletion, genomic disorder, mental retardation, epilepsy Overall design: Patients were intially screened by BAC array CGH (n=290) or qPCR (n=1040). Patients with potential 15q13 deletions were then analyzed on a custom oligonucleotide array targeted to the 15q13 region, results of which are shown here....

Displaying 15 of 15 results for "CHRNA7"