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Displaying 20 of 177 results for "CDKL5"
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  1. Crystal structure of the human CDKL5 kinase domain PDB

    ID: PDB:4BGQ

    Description: CYCLIN-DEPENDENT KINASE-LIKE 5 (E.C.2.7.11.22)

  2. ell clones expressing either wild-type or mutated CDKL5 gene to study the gene's role in transcriptional regulation... ArrayExpress

    ID: E-MTAB-2223

    Description: Mutations in the human CDKL5 gene have been associated with early onset seizure variant of Rett Syndrome. In order to investigate the potential involvemen...

  3. Transcription profiling by array of human clonal primary fibroblasts from patients with CDKL5 mutations ArrayExpress

    ID: E-MEXP-2833

    Description: Mutations in the human CDKL5 gene have been shown to cause infantile spasms, as well as Rett syndrome-like phenotype. Because

  4. ell clones expressing either wild-type or mutated CDKL5 gene to study the gene's role in transcriptional regulation... OmicsDI

    ID: E-MTAB-2223

    Date Released: 06-03-2014

    Description: Mutations in the human CDKL5 gene have been associated with early onset seizure variant of Rett Syndrome. In order to investigate the potential involvemen...

  5. Transcription profiling by array of human clonal primary fibroblasts from patients with CDKL5 mutations OmicsDI

    ID: E-MEXP-2833

    Date Released: 06-03-2014

    Description: Mutations in the human CDKL5 gene have been shown to cause infantile spasms, as well as Rett syndrome-like phenotype. Because

  6. CDK5_RAT UniProt:Swiss-Prot

    ID: Q03114

    Description: Cyclin-dependent-like kinase 5 Protein

  7. CDK5_CAEEL UniProt:Swiss-Prot

    ID: G5ECH7

    Description: Cyclin-dependent-like kinase 5 Protein

  8. CDK5_MOUSE UniProt:Swiss-Prot

    ID: P49615

    Description: Cyclin-dependent-like kinase 5 Protein

  9. Sequential elution interactome analysis of Mind bomb 1 and a novel role in dendritic spine outgrowth OmicsDI

    ID: PXD001255

    Date Released: 07-06-2016

    Description: ly demonstrated to interact with Mib1, as well as 5 proteins of particular interest to us: Usp9x, a deubiquitinase; alpha-, beta-, and delta-catenins; regulators of Wnt signaling; and CDKL5, which is mutated in EIEE2, a severe form of mental retardation. We demonstrated that Mib1 downregulates CDKL5, limits its effects on dendritic spine outgrowth, and inhibits spine outgrowth itself. These data further elaborate upon the signaling networks and biological functions influenced by this critical protein and expand our understanding of the signaling networks involved in neuronal development....

  10. Expression data from kidneys of rats with and without cisplatin treatment ArrayExpress

    ID: E-GEOD-85957

    Description: rofiling of the kidney cortex with microarrays 3, 5, 8, and 26 days after single administration of 3mg/kg Cp revealed a major profile pattern characterized by maximally increased and decreased mRNA levels on day 8, with clear changes already found 3 days after treatment for about half of the mRNAs. The mRNA expression pattern after administration of 1mg/kg Cp was overall similar, yet with a dose-dependent smaller fold-change. In summary we found 274 mRNAs showing significantly altered levels in the kidney of which 162 were increased and 112 decreased, respectively. Functional inter...

  11. Expression data from kidneys of rats with and without cisplatin treatment BioProject

    ID: PRJNA340304

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: rofiling of the kidney cortex with microarrays 3, 5, 8, and 26 days after single administration of 3mg/kg Cp revealed a major profile pattern characterized by maximally increased and decreased mRNA levels on day 8, with clear changes already found 3 days after treatment for about half of the mRNAs. The mRNA expression pattern after administration of 1mg/kg Cp was overall similar, yet with a dose-dependent smaller fold-change. In summary we found 274 mRNAs showing significantly altered levels in the kidney of which 162 were increased and 112 decreased, respectively. Functional inter...
  12. Transcription profiling of fission yeast timecourse mcs6 mutant ArrayExpress

    ID: E-MEXP-192

    Description: s6-Mcs2-Pmh1 complex (homologous to metazoan Cdk7-cyclin HMat1) performs dual functions: in cell cycle control, as a CDK-activating kinase; and in transcription by RNA polymerase (Po...

  13. Transcription profiling of fission yeast timecourse pmh1 mutant ArrayExpress

    ID: E-MEXP-191

    Description: s6-Mcs2-Pmh1 complex (homologous to metazoan Cdk7-cyclin HMat1) performs dual functions: in cell cycle control, as a CDK-activating kinase; and in transcription by RNA polymerase (Po...

  14. Transcription profiling of fission yeast mutants sep10 and sep15 ArrayExpress

    ID: E-MEXP-193

    Description: s6-Mcs2-Pmh1 complex (homologous to metazoan Cdk7-cyclin HMat1) performs dual functions: in cell cycle control, as a CDK-activating kinase; and in transcription by RNA polymerase (Po...

  15. Cdk2/CyclinA complexed with a imidazo triazin-2-amine PDB

    ID: PDB:3EOC

    Description: Cell division protein kinase 2 (E.C.2.7.11.22), Cyclin-A2

  16. Shp2 Signaling Suppresses Senescence in PyMT-induced Mammary Gland Cancer in Mice [Mouse430A_2 array] ArrayExpress

    ID: E-GEOD-50516

    Description: tion of senescence-associated β-gal (SA-β-gal), cyclin-dependent kinase inhibitor 1B (p27), p53, and histone 3 trimethylated lysine 9 (H3K9me3). Senescence induction leads to inhibition of self-renewal of tumor cells and blockage of tumor formation and growth. A signaling cascade was identified that acts downstream of Shp2 to counter senescence: Src, Focal adhesion kinase and Map kinase inhibit...

  17. Shp2 Signaling Suppresses Senescence in PyMT-induced Mammary Gland Cancer in Mice [Mouse430A_2 array] BioProject

    ID: PRJNA217933

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: tion of senescence-associated β-gal (SA-β-gal), cyclin-dependent kinase inhibitor 1B (p27), p53, and histone 3 trimethylated lysine 9 (H3K9me3). Senescence induction leads to inhibition of self-renewal of tumor cells and blockage of tumor formation and growth. A signaling cascade was identified that acts downstream of Shp2 to counter senescence: Src, Focal adhesion kinase and Map kinase inhibit...
  18. Differential gene expression in adipose tissue from obese human subjects during weight loss and weight maintenance ArrayExpress

    ID: E-GEOD-35411

    Description: no further improvement during weight maintenance. Cyclin-dependent kinase inhibitor 2B (CDKN2B) and JAZF zinc finger 1 (JAZF1), associated with type 2 diabetes, were downregulated. We could also confirm the downregulation of candidates for obesity and related traits, such as tenomodulin (TNMD) and matrix metallopeptidase 9 (MMP9), with weight loss. The expression of other candidates, such as cell death-inducing DFFA-like effector A (CIDEA) and stearoyl-CoA desaturase (SCD) were upregulated during weight loss but returned to baseline levels during weight maintenance. Conclusion. Genes in the adipose tissue are differentially expressed during weight loss and weight maintenance after weight loss. Genes that show sustained regulation may be of potential interest as markers of the beneficial effects of weight loss whereas others seem to be primarily involved in the process of weight loss itself. Nine participants were prescribed ...

  19. CRYSTAL STRUCTURE OF THE HUMAN CDKL1 KINASE DOMAIN PDB

    ID: PDB:4AGU

    Description: CYCLIN-DEPENDENT KINASE-LIKE 1

  20. Differential gene expression in adipose tissue from obese human subjects during weight loss and weight maintenance BioProject

    ID: PRJNA152805

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: no further improvement during weight maintenance. Cyclin-dependent kinase inhibitor 2B (CDKN2B) and JAZF zinc finger 1 (JAZF1), associated with type 2 diabetes, were downregulated. We could also confirm the downregulation of candidates for obesity and related traits, such as tenomodulin (TNMD) and matrix metallopeptidase 9 (MMP9), with weight loss. The expression of other candidates, such as cell death-inducing DFFA-like effector A (CIDEA) and stearoyl-CoA desaturase (SCD) were upregulated during weight loss but returned to baseline levels during weight maintenance. Conclusion. Genes in the adipose tissue are differentially expressed during weight loss and weight maintenance after weight loss. Genes that show sustained regulation may be of potential interest as markers of the beneficial effects of weight loss whereas others seem to be primarily involved in the process of weight loss itself. Overall design: Nine participants ...

Displaying 20 of 177 results for "CDKL5"